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毛细管气溶胶发生器在连续生产受控气溶胶中的应用,用于非临床研究
JoVE Journal
Engineering
This content is Free Access.
JoVE Journal
Engineering
Use of Capillary Aerosol Generator in Continuous Production of Controlled Aerosol for Non-Clinical Studies
Please note that all translations are automatically generated.
Click here for the English version.
毛细管气溶胶发生器在连续生产受控气溶胶中的应用,用于非临床研究
DOI:
10.3791/61021-v
•
08:33 min
•
April 12, 2022
•
Didier Goedertier
,
Sandra Schorderet Weber
,
Francesco Lucci
,
Tom Lee
,
Wei Teck Tan
,
Falk Radtke
,
Subash Krishnan
,
Patrick Vanscheeuwijck
,
Arkadiusz K. Kuczaj
3
,
Julia Hoeng
1
PMI R&D
,
Philip Morris Products S.A.
,
2
PMI R&D
,
Philip Morris Research Laboratories Pte. Ltd.
,
3
Applied Mathematics
,
University of Twente
Chapters
00:04
Introduction
01:08
CAG System Assembly
03:14
Calculation of CAG Aerosol Concentration and Dilution
04:12
CAG Aerosol Generation
05:28
Determination of Aerosol Collected Mass (ACM)
06:32
Results: Reproducibility and Particle Size Distribution of CAG Generated Aerosols
07:49
Conclusion
Summary
Automatic Translation
English (Original)
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Automatic Translation
该协议描述了毛细管气溶胶发生器的设置和使用,用于从多物种液体溶液中连续产生受控气溶胶,适用于稳定的大体积气溶胶输送(例如,
体内
吸入研究)。
Tags
Capillary Aerosol Generator
CAG
Aerosol Generation
Inhalation Toxicology
Electronic Cigarette
Liquid Composition
Temperature Control
Air Flow
Nucleation
Condensation
Protocol
Assembly
Heating Elements
Thermocouple
Push-in Fittings
O-rings
Peak Adapter
Coupling
Peristaltic Pump
Compressed Air
Article
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