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Journal / Cancer Research / ケノハブディティス・エレガンスを用いたEGFRおよびRAS阻害剤の同定…
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Cancer Research

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JoVE Journal Cancer Research
ケノハブディティス・エレガンスを用いたEGFRおよびRAS阻害剤の同定
Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection
Journal (Cancer Research)
Implementation of Minimally Invasive Brain Tumor Resection in Rodents for High Viability Tissue Collection
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
Journal (Cancer Research)
Defining Gene Functions in Tumorigenesis by Ex vivo Ablation of Floxed Alleles in Malignant Peripheral Nerve Sheath Tumor Cells
 
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ケノハブディティス・エレガンスを用いたEGFRおよびRAS阻害剤の同定

Article DOI: 10.3791/61788-v • 08:12 min • October 5th, 2020
October 5th, 2020 •
1,2, 1, 1, 1, 2, 1
1Department of Diagnostic and Biomedical Sciences, School of Dentistry, University of Texas Health Science Center, 2Department of Integrative Biology and Pharmacology, McGovern Medical School, University of Texas Health Science Center

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遺伝的に難解な線虫カ エノハブディティスエレガンス は、創薬のためのシンプルで安価なモデルとして使用することができます。ここで説明するプロトコルは、RASおよびEGFRタンパク質の下流シグナル伝達を阻害する抗癌治療を同定するプロトコルである。

Tags

がん研究、問題164、 カエノハブディティスエレガンス、LET-60、LET-23、K-RAS、EGFR、GFP
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