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JoVE Journal Cancer Research
Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures (Video) | JoVE
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Modeling Brain Tumors In Vivo Using Electroporation-Based Delivery of Plasmid DNA Representing Patient Mutation Signatures (Video) | JoVE

In Vivo Brain Tumor Modeling via Electroporation-Based Delivery of Plasmid DNA

Article DOI: 10.3791/65286-v • 02:03 min • June 23rd, 2023
June 23rd, 2023 •
*1, *1,2,3,4,5
1Board of Governor’s Regenerative Medicine Institute, Cedars-Sinai Medical Center, 2Center for Neural Sciences in Medicine, Cedars-Sinai Medical Center, 3Department of Biomedical Sciences, Cedars-Sinai Medical Center, 4Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 5Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles
* These authors contributed equally

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Modelado Tumores Cerebrales In Vivo Administración Basada en Electroporación ADN de Plásmido Firmas de Mutación del Paciente Modelos Tumorales Pruebas Preclínicas Inmunoterapia Modelo de Ratón Poblaciones de Tumores Poblaciones de Células Inmunitarias Respuesta al Tratamiento Trasplante Ortotópico Líneas Celulares Tumorales Establecidas Representación Personalizada Mutaciones Tumorales Específicas del Paciente Construcciones de ADN Células Precursoras Neurales (NPC) Análisis de Mosaico con Intercambio de Cassette Mediado por Recombinasa Dual (MADR) Mutagénesis Somática Mutaciones conductoras crías de ratón recién nacidas células en división ventrículos laterales microinyección de plásmidos de ADN transposones SgRNA dirigido por CRISPR
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