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Advancements in CAR-T Cell Manufacturing and Gene Therapy Production (Video) | JoVE

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Journal (Medicine)

Implementation of In Vitro Drug Resistance Assays: Maximizing the Potential for Uncovering Clinically Relevant Resistance Mechanisms

Noninvasive Intratracheal Intubation to Study the Pathology and Physiology of Mouse Lung

Journal (Medicine)

Noninvasive Intratracheal Intubation to Study the Pathology and Physiology of Mouse Lung

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Advancements in CAR-T Cell Manufacturing and Gene Therapy Production (Video) | JoVE

Automated Processor for Clinical-Scale CAR-T Cell Manufacturing

Article DOI: 10.3791/65488-v • 01:25 min • August 18th, 2023

August 18th, 2023 •

Rene Machietto¹, Nicholas Giacobbe¹, Jessica Perazzelli², Ted J. Hofmann², Allison Barz Leahy^2,3, Stephan A. Grupp^1,2,3, Yongping Wang^1,3,4, Stephan Kadauke^1,3,4

¹Cell and Gene Therapy Laboratory, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia, ²Division of Oncology, Department of Pediatrics, Children’s Hospital of Philadelphia, ³Perelman School of Medicine at the University of Pennsylvania, ⁴Division of Transfusion Medicine, Department of Pathology and Laboratory Medicine, Children’s Hospital of Philadelphia

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चिमेरिक एंटीजन रिसेप्टर टी सेल सीएआर-टी सेल इम्यूनोथेरेपी ऑटोमेटेड सेल प्रोसेसर क्लिनीएमएसीएस प्रोडिजी सेल थेरेपी विनिर्माण बंद प्रणाली संदूषण जोखिम टी सेल ट्रांसडक्शन वायरल वेक्टर सीडी 4 + / सीडी 8 + टी सेल संवर्धन सक्रियण विस्तार फसल गतिविधि मैट्रिक्स अनुकूलन अच्छा विनिर्माण अभ्यास (सीजीएमपी) जांच नई दवा (आईएनडी) रिलीज परीक्षण

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