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A Rat Dry Eye Model with Lacrimal Gland Dysfunction Induced by Scopolamine
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Medicine
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JoVE Journal Medicine
A Rat Dry Eye Model with Lacrimal Gland Dysfunction Induced by Scopolamine

A Rat Dry Eye Model with Lacrimal Gland Dysfunction Induced by Scopolamine

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04:06 min

February 09, 2024

DOI:

04:06 min
February 09, 2024

38 Views
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Transcript

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The process of developing a dry eye animal model is a long one. It requires continuous subcutaneous injection of scopolamine in the hind legs of rice to suppress the secretion of the lacrymal gland in rice. So, experimenters need to have enough patience to administer the medication regularly over a long period of time.

Our protocol is a very useful method that can created different degrees of dry eye models based on different drug concentrations. It can make it easiest for the future researchers to study the treatment of dry eye disease. Our team will continue to explore the field of lacrimal gland regeneration, very excited to work on reconstructing 3D and conducting transplantation experiments.

Our ultimate goal is to develop more advanced and efficient treatment options for individuals suffering from dry eye syndrome.

Summary

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Here, we establish a rat model of lacrimal gland dysfunction to provide a basis for the study of aqueous-deficient dry eye.

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