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Chapters
- 00:05Title
- 02:41Stressing the Animals
- 04:09Measuring the PTSD Phenotype
- 05:37Measuring Plasma CORT Concentration
- 07:01Typical Physiological Changes in the PTSD Animal Model
- 07:48Conclusion
We describe a rat model of post traumatic stress disorder (PTSD) that reveals the persistent alterations in neuroendocrine function and the delayed long-term, exaggerated fear response, characteristic of PTSD patients. The animal model and methods described here are useful for correlating biomarkers in brain nuclei, which are mechanistic but cannot be measured in patients, with biomarkers in peripheral white blood cells, which can.
Tags
BiomarkersAnimal ModelNeural CorrelatesHematologic CorrelatesBehavioral CorrelatesPTSDPathophysiologyObjective DiagnosisTherapeutic EfficacyResilience To TraumaMolecular BiomarkersTraumatic Stress Induced ProteinsTranscriptomesGenomic VariancesGenetic ModulatorsBiologic SamplesBloodSalivaUrinePeripheral BiomarkersCentral BiomarkersBehavioral PhenotypeAnimal Model Of PTSDRestraint And Tail Shocks Model (ITS)Pathophysiology Of PTSD
