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Imaging Intracellulär Trafficking av APP med fotoaktiverbar GFP
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Imaging Intracellulär Trafficking av APP med fotoaktiverbar GFP

Article DOI: 10.3791/53153-v • 07:55 min • October 17th, 2015
October 17th, 2015 •
1, 1,2
1Department of Physiology and Pharmacology, Robarts Research Institute, Western University, 2Department of Clinical Neurological Sciences, Western University

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Medan transport av cellytproteiner är relativt lätt studeras, visualisera handeln med intracellulära proteiner är mycket svårare. Här använder vi konstruktioner innehåller fotoaktiverbara GFP och demonstrera en metod för att noggrant följa amyloidprekursorproteinet från Golgi-apparaten till nedströms fack och följer dess clearance.

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Cellulär Biology Amyloid prekursorprotein Foto-aktiverbara GFP Golgi Lysosomer Intracellulär handel Alzheimers sjukdom β-amyloid live-cell mikroskopi
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