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Journal / Genetics / CRISPR-vermittelten Reorganisation der…
JoVE Journal
Genetics

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JoVE Journal Genetics
CRISPR-vermittelten Reorganisation der Chromatinstruktur mit Schleife
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CRISPR-vermittelten Reorganisation der Chromatinstruktur mit Schleife

Article DOI: 10.3791/57457-v • 09:20 min • September 14th, 2018
September 14th, 2018 •
*1,2, *1, 1, 3, 4, 5, 1, 1, 1, 5, 3, 1,2,6
1Department of Dermatology, Program in Epithelial Biology, Stanford University School of Medicine, 2Program in Cancer Biology, Stanford University School of Medicine, 3Canary Center for Cancer Early Detection, Department of Radiology, Stanford University School of Medicine, 4Department of Biology, Bridgewater State University, 5System Biosciences, 6Veterans Affairs Healthcare System
* These authors contributed equally

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Chromatin looping spielt eine bedeutende Rolle in der Genregulation; Allerdings gab es keine technologische Fortschritte, die eine selektive und reversible Änderung des Chromatins Schleifen ermöglichen. Hier beschreiben wir ein leistungsfähiges System für Chromatin Schleife Reorganisation Loci gezielt mit CRISPR-dCas9 (CLOuD9) gezeigt, um selektiv und reversibel Genexpression zu modulieren.

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Genetik Ausgabe 139 Chromatin-Loops Falten Gen Ausdruck CRISPR dCas9 Chromatin Genregulation reversible Dimerisierung dynamische chromosomale Umstellung.
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