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Immunology and Infection

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Liposomi antigenici per la generazione di anticorpi specifici per la malattia

Article DOI: 10.3791/58285-v • 10:31 min • October 25th, 2018
October 25th, 2018 •
*1, *2,3, *3,4, 5, 6, 3,4, 5,7
1Janssen R&D, 2Department of Microbiology and Immunology, University of North Carolina, 3UNC Food Allergy Initiative, University of North Carolina, 4Department of Pediatrics, University of North Carolina, 5Department of Chemistry, University of Alberta, 6Department of Molecular Medicine, Scripps Research Institute, 7Department of Medical Microbiology and Immunology, University of Alberta
* These authors contributed equally

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Descritto è la preparazione di nanoparticelle liposomiale antigeniche e loro uso nella stimolante della B-cellula attivazione in vitro e in vivo. Risposte anticorpali coerente e stabile ha condotto allo sviluppo di un nuovo modello di allergia dell'arachide. Il protocollo per la generazione di liposomi antigenici può essere estesa a diversi antigeni e modelli di immunizzazione.

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Immunologia e infezione numero 140 nanoparticelle liposomi anafilassi allergia arachidi flusso di calcio citometria a flusso antigene specifico Ara h 2 allergia alimentare IgE
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