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In Vivo Hemmung von MicroRNA zur Verringerung des Tumorwachstums bei Mäusen
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In Vivo Hemmung von MicroRNA zur Verringerung des Tumorwachstums bei Mäusen

Article DOI: 10.3791/59322-v • 07:02 min • August 23rd, 2019
August 23rd, 2019 •
1,2, 1, 1,2, 1,2, 1,2
1Instituto de Investigaciones Biomédicas, CSIC-UAM, 2Ciberonc, Instituto de Salud Carlos III

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Dieses Protokoll beschreibt Xenograft- und orthotopische Mausmodelle der menschlichen Schilddrüsentumorigenese als Plattform, um mikroRNA-basierte Inhibitorbehandlungen zu testen. Dieser Ansatz ist ideal, um die Funktion nicht-kodierender RNAs und ihr Potenzial als neue therapeutische Ziele zu untersuchen.

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Krebsforschung Ausgabe 150 miRNA-Hemmer Schilddrüse Tumorwachstum Mausmodelle miRNA-basierte Behandlung miR-146b Schilddrüsenkrebs
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