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Find video protocols related to scientific articles indexed in Pubmed.
Index of contrast sensitivity (ICS) in pseudophakic eyes with different intraocular lens designs.
Acta Ophthalmol
PUBLISHED: 08-27-2014
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To evaluate the index of contrast sensitivity (ICS) in eyes after cataract surgery with various intraocular lens designs and to compare with the area under log contrast sensitivity curve (AULCSF).
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Lattice corneal dystrophy type 1: an epithelial or stromal entity?
Cornea
PUBLISHED: 07-24-2014
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To evaluate the question whether lattice corneal dystrophy type 1 (LCD1) is of epithelial or stromal origin.
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Correlation of corneal thickness, endothelial cell density and anterior chamber depth with ocular surface temperature in normal subjects.
Z Med Phys
PUBLISHED: 06-20-2014
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To analyze corneal surface temperature profile in a young and healthy study population and to determine the impact of corneal thickness (CT), anterior chamber depth (ACD), and endothelial cell density (ECD) on surface temperature.
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Diagnostic capacity of the keratoconus match index and keratoconus match probability in subclinical keratoconus.
J Cataract Refract Surg
PUBLISHED: 04-06-2014
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To evaluate the diagnostic capacity of the Ocular Response Analyzer's keratoconus match index (KMI) and keratoconus match probability (KMP) classification in keratoconus-suspect eyes.
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Aganirsen antisense oligonucleotide eye drops inhibit keratitis-induced corneal neovascularization and reduce need for transplantation: the I-CAN study.
Ophthalmology
PUBLISHED: 03-30-2014
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Eye drops of aganirsen, an antisense oligonucleotide preventing insulin receptor substrate-1 expression, inhibited corneal neovascularization in a previous dose-finding phase II study. We aimed to confirm these results in a phase III study and investigated a potential clinical benefit on visual acuity (VA), quality of life (QoL), and need for transplantation.
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Effect of biometric characteristics on the change of biomechanical properties of the human cornea due to cataract surgery.
Biomed Res Int
PUBLISHED: 03-09-2014
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To determine the impact of biometric characteristics on changes of biomechanical properties of the human cornea due to standard cataract surgery using biomechanical analysis.
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Diagnostic capacity of biomechanical indices from a dynamic bidirectional applanation device in pellucid marginal degeneration.
J Cataract Refract Surg
PUBLISHED: 03-06-2014
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To evaluate the diagnostic capacity of the keratoconus match index (KMI) and keratoconus match probability (KMP) classification from a dynamic bidirectional applanation device (Ocular Response Analyzer) in eyes with pellucid marginal degeneration (PMD).
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Reproducibility of the optical Biometer OA-1000 (Tomey).
Biomed Res Int
PUBLISHED: 02-27-2014
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The OA-1000 (Tomey, Japan) is a new optical biometer, which measures axial length (AL), anterior chamber depth (ACD), and central corneal thickness (CT) utilizing optical interference technology. The aim of this study was to prove the reproducibility which is considered fundamental for other clinical investigations.
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Analysis of the changes in keratoplasty indications and preferred techniques.
PLoS ONE
PUBLISHED: 01-01-2014
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Recently, novel techniques introduced to the field of corneal surgery, e.g. Descemet membrane endothelial keratoplasty (DMEK) and corneal crosslinking, extended the therapeutic options. Additionally contact lens fitting has developed new alternatives. We herein investigated, whether these techniques have affected volume and spectrum of indications of keratoplasties in both a center more specialized in treating Fuchs' dystrophy (center 1) and a second center that is more specialized in treating keratoconus (center 2).
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Efficiencies of internet-based digital and paper-based scientific surveys and the estimated costs and time for different-sized cohorts.
PLoS ONE
PUBLISHED: 01-01-2014
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To evaluate the relative efficiencies of five Internet-based digital and three paper-based scientific surveys and to estimate the costs for different-sized cohorts.
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Aqueous humor glycation marker and plasma homocysteine in macular degeneration.
Clin. Chem. Lab. Med.
PUBLISHED: 09-06-2013
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We investigated concentrations of total homocysteine (tHcy) in elderly people without and those with age-related macular degeneration (AMD). In addition, we tested the association between plasma tHcy and one glycation marker in aqueous humor.
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Vignetting and Field of View with the KAMRA Corneal Inlay.
Biomed Res Int
PUBLISHED: 09-05-2013
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Purpose. To evaluate the effect of the KAMRA corneal inlay on the retinal image brightness in the peripheral visual field. Methods. A KAMRA inlay was "implanted" into a theoretical eye model in a corneal depth of 200 microns. Corneal radius was varied to a steep, normal, and flat (7.37, 7.77, and 8.17?mm) version keeping the proportion of anterior to posterior radius constant. Pupil size was varied from 2.0 to 5.0?mm. Image brightness was determined for field angles from -70° to 70° with and without KAMRA and proportion of light attenuation was recorded. Results. In our parameter space, the attenuation in brightness ranges in between 0 and 60%. The attenuation in brightness is not affected by corneal shape. For large field angles where the incident ray bundle is passing through the peripheral cornea, brightness is not affected. For combinations of small pupil sizes (2.0 and 2.5?mm) and field angles of 20-40°, up to 60% of light may be blocked with the KAMRA. Conclusion. For combinations of pupil sizes and field angles, the attenuation of image brightness reaches levels up to 60%. Our theoretical findings have to be clinically validated with detailed investigation of this vignetting effect.
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Amniotic Membrane Transplantation for the Treatment of Infectious Ulcerative Keratitis Before Elective Penetrating Keratoplasty.
Cornea
PUBLISHED: 08-27-2013
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Emergency keratoplasties for inflamed eyes are considered to have a worse prognosis because of immunologic graft rejection. Amniotic membranes have antiinflammatory and antiangiogenic abilities. Therefore, amniotic membrane transplantation (AMT) was performed to stabilize the situation of eyes with severe infectious keratitis before elective penetrating keratoplasty (PK).
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Diurnal and zonal analysis of corneal surface temperature in young healthy adults.
Eur J Ophthalmol
PUBLISHED: 08-01-2013
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To determine diurnal changes and zonal differences of corneal surface temperature in young healthy adults following blinking.?
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Comparison of the new biometer OA-1000 with IOLMaster and Tomey AL-3000.
Curr. Eye Res.
PUBLISHED: 07-10-2013
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The OA-1000 (Tomey, Japan) is a new optical biometer, which allows measurements of axial length (AL), anterior chamber depth (ACD) and corneal thickness (CT) due to partial coherence interferometry (PCI) technology. The aim of this study was to compare the OA-1000 results with those obtained with the IOLMaster and contact applanation A-scan ultrasonography.
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Interaction between topographic/tomographic parameters and dry eye disease in keratoconus patients.
Curr. Eye Res.
PUBLISHED: 06-14-2013
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Abstract Purpose: To determine the interaction between corneal topographic and tomographic parameters and dry eye syndrome (DES) in keratoconus (KC) patients. Methods: Seventy-seven eyes of 49 patients with KC (age 34.4?±?11.6 years) were enrolled in this study. In these 77 eyes we recorded surface regularity index (SRI), surface asymmetry index (SAI) and Klyce/Maeda KC index (KCI) using the Topographic Modeling System (TMS-5, Tomey, Tennenlohe, Germany), Index of Surface Variance (ISV), Index of Vertical Asymmetry (IVA), KC Index (KI), Center KC Index (CKI), Index of Height Asymmetry (IHA) and Index of Height Decentration (IHD) using Pentacam (Pentacam HR, Oculus, Germany). Patients were subdivided into mild (grade 1-2) and severe stage (grade 3-4) KC groups according to Pentacam grading. To analyse tear film parameters we assessed in 77 KC eyes McMonnies questionnaire, Schirmer test and break-up time and in 26 eyes (10 eyes with mild KC, 16 eyes with severe KC) high-speed videokeratoscopy (during interblinking interval) using a novel commercially not available system (Tear Inspect). With Tear Inspect the analysed tear film parameters were (1) time of first irregularities of Placido rings and (2) time of eyelid closure. Patients were also subdivided into McMonnies questionnaire positive and negative groups. Results: We did not find significant difference between patients with mild and severe KC in any of the examined tear film parameters (p?>?0.66). There was no significant difference in SRI, SAI, KCI, ISV, IVA, KI, CKI, IHA and IHD in McMonnies test positive and negative KC patients (p?>?0.07). There was no correlation between SRI, SAI, KCI, ISV, IVA, KI, CKI, IHA and IHD and any of the examined tear film parameters (without high-speed videokeratoscopy) neither in 77 KC patients nor in mild or severe KC eyes (r?
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Morphological and immunohistochemical changes after corneal cross-linking.
Cornea
PUBLISHED: 06-08-2013
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To present light and electron microscopic as well as immunohistochemical findings after corneal cross-linking (CXL).
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Comparison between the effects of diallyl tetrasulfide on human retina pigment epithelial cells (ARPE-19) and HCT116 cells.
Biochim. Biophys. Acta
PUBLISHED: 05-08-2013
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Diallyl mono- and polysulfanes from garlic are known to induce an adaptive cell response and the formation of antioxidants in cancer cells. In the case of a severe ER stress and a failure in the response, cancer cells eventually go into apoptosis. Only little is known about the response of normal cells upon treatment.
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Biomechanical diagnosis of keratoconus: evaluation of the keratoconus match index and the keratoconus match probability.
Acta Ophthalmol
PUBLISHED: 04-05-2013
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To evaluate the diagnostic capacity of the Ocular Response Analysers keratoconus match index (KMI) and keratoconus match probability (KMP) classification in a sample of keratoconus (KC) patients.
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Calculation of power and field of view of keratoprostheses.
Ophthalmic Physiol Opt
PUBLISHED: 02-08-2013
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To demonstrate a mathematical algorithm for calculating the refractive power of keratoprostheses and to estimate vignetting effects.
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Theoretical image performance with customized aspheric and spherical IOLs - when do we get a benefit from customized aspheric design?
Z Med Phys
PUBLISHED: 01-31-2013
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BACKGROUND & PURPOSE: Implantation of an artificial intraocular lens (IOL) during cataract surgery significantly changes the balance of aberrations in the eye. We demonstrate the theoretical superiority of customized aspheric IOL designs over standard spherical IOLs for different values of corneal curvature, asphericity and axial length. METHODS: For a selected set of corneal surfaces we calculated a best-fit equiconvex spherical IOL. In a second step we customized the IOL back surface to correct the wavefront aberrations of the cornea. Then we calculated a quadric approximation of the IOL back surface to retrieve the aspheric parameters of the customized lens in terms of radius of curvature and asphericity/conic constant. The optical performance of the three IOL models was monitored in terms of lateral ray spread (LRS) at retinal plane for variations of corneal curvatures, asphericity and axial lengths of the pseudophakic eye. RESULTS: The LRS of customized aspheric IOLs was significantly smaller compared to that of spherical IOLs (typically between 10 and 25dB). For high aspheric coefficients the LRS increased with spherical IOLs. With aspheric IOLs LRS was higher for steep corneas paired with high aspheric coefficients, mostly due to the fitting error of the quadratic function. For several combinations of corneal curvature and aspheric coefficients the focal point of the aspheric IOL was up to 400 times smaller than the spherical one. CONCLUSION: This study appeals to the reader for the potential benefit of customized aspheric IOL design instead of the principle of a one size fits all aspheric coefficient as used currently in clinical practice. A benefit with customized IOLs is less depending from the axial length and can be achieved with corneas of a moderate prolate aspheric shape with an equal or more negative Q value than the average of -0.22. Longer eyes seem to benefit less than short eyes.
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Repeat corneal graft failure due to graft-to-host herpetic infection.
J Ophthalmic Inflamm Infect
PUBLISHED: 01-28-2013
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Herein, we present the case of a young female patient with keratoconus, who was subjected twice to repeat keratoplasty, and each time, she experienced a corneal graft failure.
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Eye-tracker-guided non-mechanical excimer laser assisted penetrating keratoplasty.
Sensors (Basel)
PUBLISHED: 01-04-2013
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The purpose of the study was to implement a new eye tracking mask which could be used to guide the laser beam in automated non-mechanical excimer laser assisted penetrating keratoplasty.
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Macular hole formation in a patient with Irvine-Gass syndrome: coincidence or rare complication?
Clin Ophthalmol
PUBLISHED: 01-01-2013
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Macular edema (ME) is caused by abnormal retinal capillary permeability and has also been described as a postoperative complication of cataract surgery (Irvine-Gass syndrome).
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Experimental femtosecond laser-assisted nanosurgery of anterior lens capsule.
Eur J Ophthalmol
PUBLISHED: 07-28-2011
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To investigate femtosecond laser-assisted nanosurgery of the anterior lens capsule in a prospective in vitro study.
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Consensus statement on indications for anti-angiogenic therapy in the management of corneal diseases associated with neovascularisation: outcome of an expert roundtable.
Br J Ophthalmol
PUBLISHED: 06-28-2011
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The cornea is the clear window at the front of the eye and is the eyes main refractive medium. Its transparency is essential for vision. Corneal neovascularisation is a common clinical problem with serious consequences for vision; it can compromise corneal transparency and plays a major role in corneal graft rejection by breaching corneal immune privilege. In this review, we formulate a consensus on the unmet medical needs in the management of corneal neovascularisation and outline a framework for the clinical research that is needed to identify suitable agents to meet these needs.
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A new tool for the transfection of corneal endothelial cells: calcium phosphate nanoparticles.
Acta Biomater
PUBLISHED: 06-17-2011
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Calcium phosphate nanoparticles (CaP-NP) are ideal tools for transfection due to their high biocompatibility and easy biodegradability. After transfection these particles dissociate into calcium and phosphate ions, i.e. physiological components found in every cell, and it has been shown that the small increase in intracellular calcium level does not affect cell viability. CaP-NP functionalized with pcDNA3-EGFP (CaP/DNA/CaP/DNA) and stabilized using different amounts of poly(ethylenimine) (PEI) were prepared. Polyfect®-pcDNA3-EGFP polyplexes served as a positive control. The transfection of human and murine corneal endothelial cells (suspensions and donor tissue) was optimized by varying the concentration of CaP-NP and the duration of transfection. The transfection efficiency was determined as EGFP expression detected by flow cytometry and fluorescence microscopy. To evaluate the toxicity of the system the cell viability was detected by TUNEL staining. Coating with PEI significantly increased the transfection efficiency of CaP-NP but decreased cell viability, due to the cytotoxic nature of PEI. The aim of this study was to develop CaP-NP with the highest possible transfection efficiency accompanied by the least apoptosis in corneal endothelial cells. EGFP expression in the tissues remained stable as corneal endothelial cells exhibit minimal proliferative capacity and very low apoptosis after transfection with CaP-NP. In summary, CaP-NP are suitable tools for the transfection of corneal endothelial cells. As CaP-NP induce little apoptosis these nanoparticles offer a safe alternative to viral transfection agents.
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Customized aspheric IOL design by raytracing through the eye containing quadric surfaces.
Curr. Eye Res.
PUBLISHED: 05-20-2011
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The purpose of the present study was to demonstrate a method of how to calculate intraocular lenses with a customized asphericity and how to apply this strategy to clinical examples in cases where biometric data of the cornea (front and back surface topography) as well as distances in the eye are known.
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Ipsilateral posterior subcapsular cataract in a young patient with hourglass-like narrowing of the inferior temporal retinal artery.
Case Rep Ophthalmol
PUBLISHED: 05-03-2011
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We present an interesting and rare case of subcapsular cataract coexisting with ipsilateral narrowing of the inferior temporal retinal artery in a young woman. The possible role of retinal vessel malformation in cataract pathophysiology is discussed.
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Stage-related therapy of corneal dystrophies.
Dev Ophthalmol
PUBLISHED: 04-26-2011
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Corneal dystrophies typically result in a gradual bilateral loss of vision in a primary white eye - often in conjunction with epithelial defects in later stages. Treatment of corneal dystrophies needs to be stage-related. To ensure a stage-related therapeutic approach, an adequate classification based on clinical, histopathological and genetic knowledge is indispensable. In principle, topical medications, contact lenses and various microsurgical approaches are applicable. In case of predominantly superficial dystrophies of the epithelium, basal membrane and/or Bowmans layer (map-dot-fingerprint, Meesmann, Lisch, Reis-Bücklers, Thiel-Behnke), recurrent epithelial defects may complicate the clinical picture. If conservative therapy with gels/ointments, application of therapeutic contact lenses and/or conventional corneal abrasion are not successful, phototherapeutic keratectomy (PTK) using a 193-nm excimer laser is the method of choice today. PTK can be repeated several times, thus post poning corneal transplantation (lamellar or even penetrating) for a long time. Three major goals may be achieved by PTK depending on the diagnosis: (1) to remove superficial opacities; (2) to regularize the surface and treat irregular astigmatism, and (3) to improve the adherence of the epithelium. In dystrophies with depositions predominantly in the stroma (e.g. granular, lattice, macular, recurrence on the graft), PTK may be a reasonable alternative to anterior lamellar or penetrating keratoplasty (PKP) depending on the exact localization of the lesions. Besides exact determination of the depth of depositions using a slit lamp, a preoperative topography analysis is indispensable. The therapy of endothelial dystrophies depends on diagnosis and age: Fuchs endothelial corneal dystrophy will need corneal transplantation (e.g. when visual acuity drops below 0.4). In contrast, transplantation will only be very rarely necessary in posterior polymorphous corneal dystrophy, but the intraocular pressure has to be checked frequently. Especially in elderly patients with reduced compliance, posterior lamellar keratoplasty - preferably in the form of Descemet stripping automated endothelial keratoplasty - may be performed instead of PKP. In case of congenital hereditary endothelial dystrophy, the best time point of PKP has to be determined with regard to amblyopia (surgery too late) and inadequate follow-up (surgery too early) together with parents and pediatric ophthalmologists on an individual basis. In conclusion, for stage-related therapy of corneal dystrophies, besides contact lenses, PTK and PKP, various techniques of lamellar keratoplasties represent an indispensable enrichment of our corneal microsurgical spectrum today.
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The clinical landmarks of corneal dystrophies.
Dev Ophthalmol
PUBLISHED: 04-26-2011
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The International Committee for Classification of Corneal Dystrophies, briefly IC3D, was founded to develop a new, internationally accepted classification of corneal dystrophies (CDs) based on modern clinical, histological and genetical knowledge. Being members of the IC3D, the authors of this chapter present a clinical landmark survey of the different CDs. The ophthalmologist is the first to examine and to diagnose a new patient with a probable CD using a slit lamp. The presented landmarks are supposed to be a bridge for the ophthalmologists to precisely define the corneal opacities of a presumed CD. This bridge makes it easier for them to study the IC3D publication and to get more information including adequate differential diagnosis.
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Histological and biochemical findings in membranous cataract.
Ophthalmic Res.
PUBLISHED: 02-23-2011
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In this report we present a patient with unilateral membranous cataract and describe the histological and biochemical findings accompanying this rare condition.
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Simultaneous amniotic membrane patch in high-risk keratoplasty.
Cornea
PUBLISHED: 02-10-2011
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To analyze the short- and intermediate-term results of simultaneous transplantation of amniotic membrane with high-risk keratoplasty.
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Late-onset anterior dislocation of a posterior chamber intraocular lens in a patient with pseudoexfoliation syndrome.
Case Rep Ophthalmol
PUBLISHED: 01-04-2011
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Here, we report on a patient with pseudoexfoliation syndrome who developed acute angle-closure glaucoma with a marked myopic shift due to anterior dislocation of the posterior chamber intraocular lens almost 16 months after an uneventful phacoemulsification. Examination with a Scheimpflug camera was extremely useful in confirming the diagnosis. This is the fist case of late-onset angle-closure glaucoma with a significant myopic shift due to anterior dislocation of the posterior chamber intraocular lens, which resulted in a permanent alteration of the postoperative target refraction.
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A serious refractive multifocal intraocular lens complication in Menieres disease.
Optom Vis Sci
PUBLISHED: 04-09-2010
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To report an unfortunate case of patient selection for multifocal intraocular lens (MIOL) implantation.
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Solid corneal dermoids and subconjunctival lipodermoids: impact of differentiated surgical therapy on the functional long-term outcome.
Cornea
PUBLISHED: 06-11-2009
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The functional long-term outcome after differentiated surgical therapy of solid corneal dermoids and subconjunctival lipodermoids with special regard to determinants for amblyopia will be assessed.
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GS-101 antisense oligonucleotide eye drops inhibit corneal neovascularization: interim results of a randomized phase II trial.
Ophthalmology
PUBLISHED: 04-01-2009
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Pathologic corneal neovascularization not only reduces corneal transparency and visual acuity, but also is one of the most significant preoperative and postoperative risk factors for graft rejection after corneal transplantation. The aim of this study was to test tolerability and efficacy of gene signal (GS)-101 eye drops, an antisense oligonucleotide against insulin receptor substrate-1, versus placebo on inhibition of progressive corneal neovascularization.
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Spontaneous bilateral late-onset Descemet membrane detachment after successful cataract surgery.
J Cataract Refract Surg
PUBLISHED: 03-24-2009
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We report the case of a 68-year-old man who developed bilateral Descemet membrane detachment (DMD) 4 weeks after successful cataract surgery and discuss the possible role of an underlying predisposition to DMD. Surgical intervention with gas injection in the anterior chamber resulted in excellent visual acuity restoration in the patient. To our knowledge, this is the first report of spontaneous bilateral DMD in the late postoperative period after cataract extraction.
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Elevated intraocular pressure in the early postoperative period following excimer laser penetrating keratoplasty for keratoconus.
Ophthalmic Surg Lasers Imaging
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To assess the incidence of elevated intraocular pressure (IOP) in the early postoperative period after excimer laser penetrating keratoplasty for keratoconus and reveal potential associations with anterior segment parameters.
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Bilateral Fusarium oxysporum keratitis after laser in situ keratomileusis.
J Cataract Refract Surg
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We report the successful management of a rare case of bilateral post-laser in situ keratomileusis (LASIK) Fusarium oxysporum keratitis and propose a therapeutic strategy. A 19-year-old white man with no systemic diseases was referred to our emergency service 3 days after microkeratome-assisted myopic bilateral LASIK correction. He complained of blurred-vision, photophobia, and ocular pain. Clinical findings (satellite lesions, hypopyon) suggested fungal keratitis. Flaps were immediately lifted and rinsed with povidone-iodine 10%, and intensive topical and systemic and combined antifungal and antibacterial treatment was introduced. Topical cortisone drops were administered after 3 days. Despite initial deterioration of the clinical picture, all symptoms resolved quickly. Polymerase chain reaction indicated F oxysporum. Relapse occurred in the left eye, which was successfully managed. The final uncorrected distance visual acuity was 20/20 in both eyes. Fusarium oxysporum post-LASIK keratitis may occur in the early phase. Prompt diagnosis, interface irrigation with povidone-iodine solution, and intensive long-term treatment contribute to a favorable outcome.
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Biomechanical profile of the cornea in primary congenital glaucoma.
Acta Ophthalmol
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The aim of our study was to investigate the biomechanical properties of the cornea in primary congenital glaucoma (PCG) and to identify the potential ocular determinants, which affect the corneal biomechanical metrics.
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A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis.
Ann. Neurol.
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Based on findings in animal models of autoimmune optic nerve inflammation, we have assessed the safety and efficacy of erythropoietin in patients presenting with a first episode of optic neuritis.
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Precision of ocular response analyzer.
Curr. Eye Res.
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To evaluate the repeatability of corneal hysteresis (CH) and corneal resistance measurements as well as the consistency of the four shots within each measurement using the ocular response analyzer (ORA, Reichert Ophthalmic Instruments, Depew, NY) and to generate a pool of data of a normal population.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.