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Find video protocols related to scientific articles indexed in Pubmed.
Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis.
Am. J. Hum. Genet.
PUBLISHED: 01-07-2014
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In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human leukocyte antigen (HLA) region were imputed and tested. These analyses resulted in a model composed of six polymorphic amino acid positions and seven SNPs that explained the observed significant associations in the region. In addition, a replication step comprising 4,017 SSc cases and 5,935 controls was carried out for several selected non-HLA variants, reaching a total of 5,850 cases and 9,401 controls of European ancestry. Following this strategy, we identified and validated three SSc risk loci, including DNASE1L3 at 3p14, the SCHIP1-IL12A locus at 3q25, and ATG5 at 6q21, as well as a suggested association of the TREH-DDX6 locus at 11q23. The associations of several previously reported SSc risk loci were validated and further refined, and the observed peak of association in PXK was related to DNASE1L3. Our study has increased the number of known genetic associations with SSc, provided further insight into the pleiotropic effects of shared autoimmune risk factors, and highlighted the power of dense mapping for detecting previously overlooked susceptibility loci.
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Survival and predictors of mortality in systemic sclerosis associated pulmonary arterial hypertension: Outcomes from the PHAROS registry.
Arthritis Care Res (Hoboken)
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Objective: We sought to assess cumulative survival rates and identify independent predictors of mortality in patients with incident systemic sclerosis-pulmonary arterial hypertension (SSc-PAH) who have undergone routine screening for PAH at US SSc centers. Methods: Pulmonary Hypertension Assessment and Recognition of Outcomes in Scleroderma (PHAROS) is a prospective registry of SSc patients at high risk for PAH or with definite PH diagnosed by right heart catheterization (RHC) within 6 months of enrollment. Only patients with World Health Organization Group I PAH (mean pulmonary artery pressure (mPAP)?25 mmHg and pulmonary capillary wedge pressure?15 mmHg without significant interstitial lung disease) were included in these analyses. Results: 131 SSc patients with incident PAH were followed for a mean of 2.0±1.4 years. 1-, 2-, and 3-year cumulative survival was 93%, 88%, and 75%. On multivariate analysis, age>60 (HR 3.0, 95%CI 1.1-8.4), male gender (HR 3.9, 95%CI 1.1-13.9), functional class (FC) IV (HR 6.5, 95%CI 1.8-22.8) and diffusing capacity of carbon monoxide (DLCO)<39% predicted (HR 4.2, 95%CI 1.3-13.8) were significant predictors of mortality. Conclusions: This is the largest study describing survival in incident SSc-PAH patients followed at multiple US SSc centers who perform routine screening for PAH. Survival rates were better than those reported in other recently described SSc-PAH cohorts. Severely reduced DLCO and FC IV status at the time of PAH diagnosis portend a poor prognosis in these patients. © 2013 American College of Rheumatology.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.