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Find video protocols related to scientific articles indexed in Pubmed.
The impacts of obstructive sleep apnea hypopnea syndrome severity and surgery intervention on psychological and behavioral abnormalities and postoperative recovery in pediatric patients.
Med. Sci. Monit.
PUBLISHED: 08-19-2014
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The aim of this study was to investigate the degree of impact of obstructive sleep apnea hypopnea syndrome (OSAHS) severity on pediatric psychological and behavioral abnormalities.
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Aqueous synthesis of internally doped Cu:ZnSe/ZnS core-shell nanocrystals with good stability.
Nanotechnology
PUBLISHED: 05-20-2011
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To prepare biologically available Zn-based NCs in aqueous solution, we herein reported the synthesis of aqueous Cu:ZnSe/ZnS NCs with internally doped aqueous Cu:ZnSe NCs as the core template. Due to the dual protection of Cu impurities by the ZnSe core and ZnS shells, the as-prepared Cu:ZnSe/ZnS NCs show excellent stability in the open air, which overcomes the intrinsic instability of traditional aqueous Cu:ZnSe NCs. The as-prepared Cu:ZnSe/ZnS NCs possess extremely good stability, good biocompatibility and lower cytotoxicity, and thus can be used as a promising candidate for fluorescent NC-based biological applications.
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Decrease in the CO2 uptake capacity in an ice-free Arctic Ocean basin.
Science
PUBLISHED: 07-22-2010
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It has been predicted that the Arctic Ocean will sequester much greater amounts of carbon dioxide (CO2) from the atmosphere as a result of sea ice melt and increasing primary productivity. However, this prediction was made on the basis of observations from either highly productive ocean margins or ice-covered basins before the recent major ice retreat. We report here a high-resolution survey of sea-surface CO2 concentration across the Canada Basin, showing a great increase relative to earlier observations. Rapid CO2 invasion from the atmosphere and low biological CO2 drawdown are the main causes for the higher CO2, which also acts as a barrier to further CO2 invasion. Contrary to the current view, we predict that the Arctic Ocean basin will not become a large atmospheric CO2 sink under ice-free conditions.
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Forkhead transcription factor FOXO3a protein activates nuclear factor ?B through B-cell lymphoma/leukemia 10 (BCL10) protein and promotes tumor cell survival in serum deprivation.
J. Biol. Chem.
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FOXO3a, a member of the Forkhead box O (FoxO) transcription factor family, is believed to be a tumor suppressor because it was found that FOXO3a inactivation promoted cell transformation and tumor progression. There are also a few studies showing that FOXO3a protected cells under stress conditions, including oxidative stress, serum deprivation, and hypoxia. It was reported that FOXO3a promoted invasion of cancer cells. Thus, the role of FOXO3a in cancer is complicated. Here, we report that FOXO3a is a positive regulator of nuclear factor ?B (NF-?B) signaling. We found that overexpression of FOXO3a increased and knockdown of FOXO3a repressed NF-?B activities. Mechanistic studies indicate that FOXO3a activated NF-?B via inducing expression of B-cell lymphoma/leukemia 10 (BCL10), an upstream regulator of I?B kinase (IKK)/NF-?B signaling. We found that the serum deprivation activated NF-?B, which was blocked by inhibition of FOXO3a. Knockdown of FOXO3a enhanced cell apoptosis under serum-free conditions, which was inhibited by overexpression of BCL10. These results suggest that FOXO3a promotes cell survival via BCL10/NF-?B in serum starvation. Our findings may add another layer to the complexity of the role of FOXO3a in cancer. Therefore, caution should be taken when FOXO3a is employed as a target for cancer therapy.
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Antitumor activities of quercetin and quercetin-5,8-disulfonate in human colon and breast cancer cell lines.
Food Chem. Toxicol.
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This study is designed to compare the anticancer effects of quercetin and its water-soluble sulfated derivative, quercetin-5,8-disulfonate (QS), in human colon cancer LoVo cells and breast cancer MCF-7 cells. It was found that both quercetin and QS can inhibit the growth of cancer cells in a dose-dependent manner, with the IC(50) values of 40.2 and 28.0 ?M for LoVo cells and 30.8 and 19.9 ?M for MCF-7 cells, respectively, suggesting QS was more effective against the cancer cells than quercetin. Moreover, flow cytometric assay revealed that quercetin and QS could mediate the cell-cycle arrest principally in the S phase after 24h of treatment with the two tumor cells. It was also found that 69.6% of LoVo cells and 90.6% of MCF-7 cells entered the early phase of apoptosis when treated with 100 ?M QS for 48 h. Furthermore, we firstly found the generation of ROS is a critical mediator in QS-induced cell growth inhibition. Taken together, the novel sulfated derivative of quercetin possesses strong antitumor activity via a ROS-dependent apoptosis pathway, and has the excellent potential to be developed into an antitumor precursor compound.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.