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Find video protocols related to scientific articles indexed in Pubmed.
Internal migration, mental health, and suicidal behaviors in young rural Chinese.
Soc Psychiatry Psychiatr Epidemiol
PUBLISHED: 11-10-2014
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There is a dearth of data on the association of internal migration with mental health in young rural Chinese. This study aims to explore the associations between migrant status, mental health, and suicidal behaviors in young rural Chinese.
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Electroconvulsive Therapy and Its Association With Demographic and Clinical Characteristics in Chinese Psychiatric Patients.
J ECT
PUBLISHED: 09-10-2014
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Little is known about the frequency of electroconvulsive therapy (ECT) use in China. This study examined the frequency of ECT and its relationship with demographic and clinical characteristics in a large psychiatric institution in China.
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Use of electroconvulsive therapy in older Chinese psychiatric patients.
Int J Geriatr Psychiatry
PUBLISHED: 06-23-2014
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Little is known about the use of electroconvulsive therapy (ECT) in older Chinese psychiatric patients. This study examined the frequency of ECT and the demographic and clinical correlates in older psychiatric patients hospitalized in a large psychiatric institution in Beijing, China.
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Antipsychotic polypharmacy in schizophrenia patients in China and its association with treatment satisfaction and quality of life: Findings of the third national survey on use of psychotropic medications in China.
Aust N Z J Psychiatry
PUBLISHED: 06-14-2014
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This study examined the use, demographic and clinical correlates of antipsychotic polypharmacy (APP) and its associations with treatment satisfaction and quality of life (QOL) in schizophrenia patients in China.
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Demographic and clinical differences between early- and late-onset major depressions in thirteen psychiatric institutions in China.
J Affect Disord
PUBLISHED: 05-09-2014
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Little is known about the demographic and clinical differences between early- and late-onset depressions (EOD and LOD, respectively) in Chinese patients. This study examined the demographic and clinical profile of EOD (<=25 years) compared to LOD (>25 years) in China.
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Prevalence of nurses' smoking habits in psychiatric and general hospitals in China.
Arch Psychiatr Nurs
PUBLISHED: 03-29-2014
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This study determined the prevalence of lifetime and current smoking and the correlates of current smoking in nurses working in psychiatric and general hospitals in China. Of 807 distributed questionnaires, 799 nurses who were working in two psychiatric hospitals (n=387, 48.4%), and one general hospital (n=412, 51.6%) had analyzable data. Socio-demographic, alcohol use and smoking data were collected with a self-reported questionnaire. Work-related stress was evaluated with the Nurse Stress Inventory. In the whole sample, the lifetime smoking prevalence was 7.6% (females=2.1% vs. males=48.9%, p<0.0001; psychiatric nurses=14.5% vs. non-psychiatric nurses=1.2%, p<0.0001). The prevalence of current smoking was 7.1% (females=2.1% vs. males=44.7%, p<0.0001; psychiatric nurses=13.4% vs. non-psychiatric nurses=1.2%, p<0.0001). In a multiple logistic regression analysis, age 30 years or older, male gender, having children, being a psychiatric nurse and alcohol consumption were positively associated with smoking, while being a nursing officer was negatively associated with smoking (r(2) = 0.513, p<0.0001). Considering the harmful effects of smoking as well as second-hand smoking in the presence of children, effective measures to promote smoking cessation for male, older and psychiatric nurses and those with children are warranted.
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Frequency of involuntary admissions and its associations with demographic and clinical characteristics in China.
Arch Psychiatr Nurs
PUBLISHED: 03-20-2014
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Involuntary admissions (IA) continue to be a controversial topic in psychiatry. There have been very few studies investigating the pattern of IA and contributing factors in Chinese psychiatric patients. This study examined the prevalence of IA and its relationships with demographic and clinical characteristics in a large psychiatric institution in Hunan province, China. A consecutively collected sample of 161 psychiatric inpatients was collected. The patients' basic socio-demographic and clinical data including admission types were collected. The frequency of IA was 53.1% in the whole sample. In multiple logistic regression analysis, IA was independently associated with female sex, more recent aggression prior to admission and poorer social function and insight into illness. IA was common in clinical practice in China, and its demographic and clinical correlates are similar to the findings reported from western settings.
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Bias in discriminating very mild dementia for older adults with different levels of education in Hong Kong.
Int Psychogeriatr
PUBLISHED: 02-26-2014
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Education has a profound effect on older adults' cognitive performance. In Hong Kong, some dementia screening tasks were originally designed for developed population with, on average, higher education.
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Structured interviews examining the burden, coping, self-efficacy and quality of life among family caregivers of persons with dementia in Singapore.
Dementia (London)
PUBLISHED: 02-19-2014
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Dementia is a global health issue and the effects on caregivers are substantial. The study aimed to examine the associations of burden, coping, self-efficacy with quality of life among family caregivers of persons with dementia in Singapore. Structured interviews were conducted in a convenience sample of 84 family caregivers caring and seeking clinical care for the persons with dementia in an outpatient clinic of a public hospital in Singapore. The outcome measures included the Family Burden Interview Schedule, Family Crisis Oriented Personal Evaluation Scale, General Perceived Self-Efficacy Scale, and World Health Organization Quality of Life Scale - Brief Version. In general, significant correlations were observed between the quality of life scores with coping strategy and family burden scores, but not between the coping strategy and family burden scores. Compared to demographic factors such as caregiver age and household income, psychosocial factors including family burden, coping strategies, and self-efficacy demonstrated greater association with quality of life in the participants. However, the dynamics of these associations will change with an increasing population of persons with dementia, decreasing nuclear family size, and predicted changes in family living arrangements for the persons with dementia in future. As such, it necessitates continuous study examining the needs and concerns of family caregivers and the relevance of ongoing interventions specific to caregivers of persons with dementia.
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The effect of artemether on psychotic symptoms and cognitive impairment in first-episode, antipsychotic drug-naive persons with schizophrenia seropositive to Toxoplasma gondii.
J Psychiatr Res
PUBLISHED: 02-14-2014
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The objective was to evaluate the efficacy and safety of add-on artemether in first-episode, untreated people with schizophrenia, who were Toxoplasma gondii seropositive, and explore the change in T. gondii antibodies during treatment. In this eight-week, double-blind, randomized, placebo-controlled trial, 100 T. gondii seropositive participants with schizophrenia were randomized to either the artemether or placebo group. Participants in the artemether group received 80 mg artemether once per day during the second week (days 8-14) and the fourth week (days 22-28). Participants in the placebo group received identical looking placebo capsules. Psychopathology, adverse side effects and cognitive function were measured using standardized instruments. The group × time interaction effects for the scores of the Positive and Negative Syndrome Scale (PANSS) subscales and performances on all cognitive components were not significant, only the main effect of group was significant. Compared to the placebo group, artemether group participants showed significantly greater reduction in the PANSS negative symptom scale (F(1,46) = 4.7, p = 0.03) and the Clinical Global Impressions Scale (F(1,96) = 6.2, p = 0.01) scores, but there were no significant differences in the PANSS positive symptom and general psychopathology scales (p > 0.05). There were also no significant differences between the two groups in performance on any of the Brief Assessment of Cognition in Schizophrenia (BACS) cognitive domains. The artemether-risperidone combination is safe and well tolerated, but artemether as an adjunct to risperidone does not appear to alleviate cognitive deficits of schizophrenia. Trial Registration Chinese Clinical Trial Register (ChiCTR) TRC-13003145.
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Quality of Life in Older Patients With Chronic Obstructive Pulmonary Disease (COPD) in Hong Kong: A Case-Control Study.
Perspect Psychiatr Care
PUBLISHED: 01-17-2014
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To date, there have been few studies examining quality of life (QOL) in older patients with chronic obstructive pulmonary disease (COPD) in China. The aim of the study was to assess QOL in Chinese older patients with COPD and explore its demographic and clinical correlates.
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Prospective memory performance in non-psychotic first-degree relatives of patients with schizophrenia: a controlled study.
PLoS ONE
PUBLISHED: 01-01-2014
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We aimed at investigating prospective memory and its socio-demographic and neurocognitive correlates in non-psychotic, first-degree relatives (FDRs) of patients with schizophrenia compared to patients with first episode schizophrenia (FES), and healthy controls (HCs).
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A multidimensional risk factor model for suicide attempts in later life.
Neuropsychiatr Dis Treat
PUBLISHED: 01-01-2014
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Elderly suicide is a public health problem worldwide, and the risk factors are multidimensional. Chronic mental health problems, personality traits, stressful life events, comorbid medical conditions, social isolation, unemployment, and poverty are associated with higher risk for suicide in later life. There was a relative paucity of data on the neurobiological markers of elderly suicide.
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The relationship between frontal lobe lesions, course of post-stroke depression, and 1-year prognosis in patients with first-ever ischemic stroke.
PLoS ONE
PUBLISHED: 01-01-2014
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Most studies on post-stroke depression (PSD) have focused on a certain time point after stroke instead of the time course of PSD. The aim of this study was to determine the relationship between frontal lobe lesions, course of PSD over a year following the stroke onset, and the 1-year prognosis in patients with first-ever ischemic stroke.
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Insomnia in Older Adults with Chronic Obstructive Pulmonary Disease (COPD) in Hong Kong: A Case-Control Study.
COPD
PUBLISHED: 12-30-2013
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Abstract This study aimed to determine the frequency and sociodemographic/clinical correlates of insomnia in Chinese patients aged ?60 years suffering from chronic obstructive pulmonary disease (COPD). In this case-control study of 142 outpatients with COPD and 218 sex- and age-matched control subjects, COPD patients were recruited from a prospective study sample hospitalized in Hong Kong for acute COPD exacerbation (?2 major COPD symptoms or >1 major+minor COPD symptoms for ?2 consecutive days). Controls were recruited from social centres in Hong Kong. Activity of daily living was assessed with the Instrumental Activities of Daily Living Scale, life events were evaluated using the Life Event Scale, depressive symptoms were ascertained with the Geriatric Depression Scale, and quality of life was measured using the Medical Outcomes Study Short Form-12. Early, middle and late insomnia were measured using items 4, 5 and 6 of the Hamilton Rating Scale for Depression. The frequency of ?1 type of insomnia was 47.2% in patients and 25.7% in controls; frequencies of early, middle and late insomnia in patients were 24.6%, 31.0%, and 26.1%, respectively, compared to 14.7%, 14.7% and 11.9% in controls. Group differences were non-significant after controlling for relevant covariates. However, in multiple logistic regression analysis, more physical illnesses (p = 0.02, OR = 1.3, 95% CI = 1.1-1.7) and more severe depressive symptoms (p = 0.009, OR = 1.1, 95% CI = 1.03-1.3) were independently associated with any type of insomnia in COPD patients, accounting for 21.3% of the variance. A significant proportion of older adult Chinese COPD patients suffer from insomnia that warrants more attention in clinical practice.
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Depressive disorders in older patients with chronic obstructive pulmonary disease (COPD) in Hong Kong: a controlled study.
Aging Ment Health
PUBLISHED: 11-21-2013
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Objective: There have been few studies examining the relationship between chronic obstructive pulmonary disease (COPD) and psychiatric morbidity in Hong Kong. This study aimed to examine the prevalence of depressive disorders (major depression, dysthymia and adjustment disorder with depressed mood) in Chinese patients with COPD and explore their demographic and clinical correlates.Method: A total of 146 patients aged 50 years and above with COPD and 220 age and gender matched control subjects without COPD formed the study sample. Data of demographic and clinical characteristics were collected by a form designed for this study. Activity of daily living was assessed by the Instrumental Activities of Daily Living Scale and life events were evaluated by the Life Event Scale. Depressive disorders were determined using the Chinese version of the Structured Clinical Interview for DSM-IV.Results: The point prevalence of DSM-IV depressive disorders in patients with COPD and controls were 15.1% and 3.6%, respectively. Multivariate analyses revealed that female sex and severe impairment in daily activity functioning were independently associated with depressive disorders. Only 22.7% of the depressed COPD patients had consulted psychiatrists in the past three months.Conclusion: Depressive disorders are significantly higher in COPD patients than controls. The low percentage of depressed patients with COPD seeking psychiatric treatment suggests that there is an unmet need in the psychiatric care of COPD patients.
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Frequency of Physical Restraint and Its Associations With Demographic and Clinical Characteristics in a Chinese Psychiatric Institution.
Perspect Psychiatr Care
PUBLISHED: 08-27-2013
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Physical restraint (PR) is a highly controversal topic in psychiatry. Little is known about PR among psychiatric inpatients in China. This study examined the frequency of PR and its relationships with demographic and clinical characteristics among a large psychiatric institution in the Hunan Province, China.
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A comparison of cognitive-behavioral therapy, antidepressants, their combination and standard treatment for Chinese patients with moderate-severe major depressive disorders.
J Affect Disord
PUBLISHED: 07-31-2013
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No study has examined the effect of cognitive-behavioral therapy (CBT) on moderate-severe major depressive disorders (MDD) in China. The objective of this study was to evaluate the effect of CBT, antidepressants alone (MED), combined CBT and antidepressants (COMB) and standard treatment (ST; i.e., receiving psycho-educational intervention and/or medication treatment determined by treating psychiatrists) on depressive symptoms and social functioning in Chinese patients with moderate-severe MDD.
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Frequency of Hyperprolactinemia and Its Associations With Demographic and Clinical Characteristics and Antipsychotic Medications in Psychiatric Inpatients in China.
Perspect Psychiatr Care
PUBLISHED: 07-16-2013
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No study has investigated hyperprolactinemia and its risk factors in Chinese psychiatric patients. This study examined the prevalence of hyperprolactinemia and its relationship with demographic and clinical characteristics in inpatients in a large psychiatric institution in Beijing, China.
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Guidance on the conversion of the Chinese versions of the Quick Inventory of Depressive Symptomatology-Self-Report (C-QIDS-SR) and the Montgomery-Asberg Scale (C-MADRS) in Chinese patients with major depression.
J Affect Disord
PUBLISHED: 05-07-2013
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The 16-item Quick Inventory of Depressive Symptomatology-Self-Report (QIDS-SR) is a newly introduced screening tool, while the Montgomery-Asberg Scale (MADRS) is commonly used in research and clinical practice in China. Converting the total scores between the two instruments could facilitate the comparison of different studies.
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Frequency and risk factors of workplace violence on psychiatric nurses and its impact on their quality of life in China.
Psychiatry Res
PUBLISHED: 04-16-2013
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This study examined the frequency of violence on nurses in Chinese psychiatric hospitals and explored its risk factors and impact on nurses quality of life (QOL). A survey was conducted with 387 frontline psychiatric nurses in China. Information about experience of workplace violence in the past 6 months, type of workplace violence, and demographic characteristics was collected by a questionnaire. Altogether 319 (82.4%) of 387 nurses reported having experienced at least one type of violent event in the past 6 months. The prevalence of sexual assault, physical and verbal harassment was 18.6%, 61.5% and 78.6%, respectively. Compared to those with no exposure to violence, nurses who were exposed to violence had lower QOL in both the physical and mental domains. Significant predictors of violence against nurses are male sex, receiving college level or higher education and working on rotating duty were independently associated with high risk of violence. Workplace violence against psychiatric nurses commonly occurs in China. Considering the deleterious effects of violence, comprehensive strategies from the perspective of nursing education and training, organizational policy, patient care and staff support are recommended to promote occupational safety in psychiatric settings in China.
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Executive function in children and adolescents with posttraumatic stress disorder 4 and 12 months after the Sichuan earthquake in China.
J Child Psychol Psychiatry
PUBLISHED: 04-16-2013
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While several studies have found executive function deficits in adults and maltreated children with posttraumatic stress disorder (PTSD), there are few data on executive function in children and adolescents with PTSD related to natural disasters. The objective of this study was to test executive function changes over time in children and adolescents with PTSD after a magnitude 8.0 earthquake in Sichuan, China.
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Gender differences in demographic and clinical features and prescribing patterns of psychotropic medications in patients with major depressive disorder in China.
Compr Psychiatry
PUBLISHED: 04-09-2013
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Little is known about gender differences associated with major depressive disorder (MDD) in China. This study examined gender differences associated with other demographic and clinical characteristics and psychotropic drug treatment in Chinese patients with MDD.
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The prevalence of insomnia and its socio-demographic and clinical correlates in older adults in rural China: a pilot study.
Aging Ment Health
PUBLISHED: 04-03-2013
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To investigate the prevalence of insomnia (DIS: difficulty initiating sleep; DMS: difficulty maintaining sleep; and EMA: early morning awakening), its socio-demographic and clinical correlates, and the treatment patterns in older adults in rural China.
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Structured assessment of mental capacity to make financial decisions in Chinese older persons with mild cognitive impairment and mild Alzheimer disease.
J Geriatr Psychiatry Neurol
PUBLISHED: 03-15-2013
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Previous studies suggested that patients with mild cognitive impairment (MCI) or dementia can have impaired and declining financial skills and abilities. The purpose of this study is to test a clinically applicable method, based on the contemporary legal standard, to examine directly the mental capacity to make financial decisions and its component decision-making abilities among patients with MCI and early dementia. A total of 90 patients with mild Alzheimer disease (AD), 92 participants with MCI, and 93 cognitively normal control participants were recruited for this study. Their mental capacity to make everyday financial decisions was assessed by clinician ratings and the Chinese version of the Assessment of Capacity for Everyday Decision-Making (ACED). Based on the clinician ratings, only 53.5% were found to be mentally competent in the AD group, compared with 94.6% in the MCI group. However, participants with MCI had mild but significant impairment in understanding, appreciating, and reasoning abilities as measured by the ACED. The ACED provided a reliable and clinically applicable structured framework for assessment of mental capacity to make financial decisions.
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Autism spectrum disorder in Chinese populations: a brief review.
Asia Pac Psychiatry
PUBLISHED: 03-12-2013
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This review summarizes the published work on the prevalence and incidence rates of autism spectrum disorder (ASD) in Chinese populations. The authors searched MEDLINE, Web of Science and the PsycINFO database and identified seven studies that were published in the English language. In mainland China, Li and colleagues reported an autism prevalence rate of 2.38/10,000 but admitted the possibility of underestimation. A higher prevalence of 11/10,000 was reported by Zhang and Ji based on a survey that was conducted in Tianjin, China. In Taiwan, Chien and colleagues reported that the cumulative prevalence of ASD increased from 1.79 to 28.72/10,000 from 1996 to 2005 and the annual incidence rate increased from 0.91 to 4.41/10,000 per year from 1997 to 2005. Another study based on the Taiwan national health insurance database reported a high prevalence rate of 122.8/10,000 for the year 2007. Two studies based on the Taiwan national disability registry data reported an increasing trend of ASD for the period 2000-2007 and 2004-2010, respectively. In Hong Kong, Wong and colleagues estimated that the incidence of ASD was 5.49/10,000 and the average prevalence over the 1986-2005 period was 16.1/10,000. We identified 12 studies through the searching of Chinese databases. The prevalences among these studies varied from 2.8 to 29.5/10,000. While existing data appear to suggest, it remains unclear whether there is a true rise in the prevalence of ASD in ethnic Chinese population across geographic sites. More collaborative research on this topic should be conducted in the future.
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Sleep duration and quality of life in young rural Chinese residents.
Behav Sleep Med
PUBLISHED: 03-05-2013
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The aim of this study was to determine the mean total sleep time (TST) and the relation between sleep duration (short sleep: < 7 hr per day; medium sleep: 7-8 hr per day; and long sleep: > 8 hr per day) and quality of life (QOL) in young Chinese rural residents. A sample of 1,632 participants was recruited in Mianyang, Sichuan province and interviewed. Expected and actual TSTs were asked using standardized questions. QOL was measured with the Chinese version of the World Health Organization Quality of Life Schedule-Brief. In the full sample, the mean expected TST was 8.8 ± 1.3 hr, and the mean actual TST was 8.3 ± 1.4 hr. Multivariate analyses revealed that compared to medium sleepers, short sleepers had lower QOL in the physical, psychological, and environmental domains, whereas long sleepers had higher QOL in the environmental domain. Being short or long sleepers was not associated with more major medical conditions. Given the significant associations between short sleep and poor QOL, more attention should be paid to young Chinese rural residents with short sleep.
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Detection of malingering: psychometric evaluation of the Chinese version of the structured interview of reported symptoms-2.
BMC Psychiatry
PUBLISHED: 02-27-2013
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Malingering detection has emerged as an important issue in clinical and forensic settings. The Structured Interview of Reported Symptoms-2 (SIRS-2) was designed to assess the feigned symptoms in both clinical and non-clinical subjects. The aim of the study was to examine the reliability and validity of the Chinese version of this scale.
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Sociodemographic and clinical features of bipolar disorder patients misdiagnosed with major depressive disorder in China.
Bipolar Disord
PUBLISHED: 02-27-2013
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Bipolar disorder (BD) is frequently misdiagnosed as major depressive disorder (MDD), which may lead to inappropriate treatment and poor outcomes. This study aimed to compare demographic and clinical features between patients with MDD and those with BD, but being misdiagnosed as MDD, in China.
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Prevalence of psychological symptoms in contemporary Chinese rural-to-urban migrant workers: an exploratory meta-analysis of observational studies using the SCL-90-R.
Soc Psychiatry Psychiatr Epidemiol
PUBLISHED: 02-22-2013
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(1) To estimate the pooled prevalence of psychological symptoms in Chinese migrant workers (CMWs), as measured using the Symptom Checklist-90-R (SCL-90-R) in observational studies conducted in China, and (2) to explore the potential variables associated with the SCL-90-R Global Severity Index (GSI), the overall mental health indicator of CMWs.
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Common use of high doses of antipsychotic medications in older Asian patients with schizophrenia (2001-2009).
Int J Geriatr Psychiatry
PUBLISHED: 01-27-2013
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This study aimed to examine the use of high doses of antipsychotic medications (?600?mg/day chlorpromazine equivalent) in older Asian patients with schizophrenia and its demographic and clinical correlates.
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Validation of the nine-item Patient Health Questionnaire to screen for major depression in a Chinese primary care population.
Asia Pac Psychiatry
PUBLISHED: 01-13-2013
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The aim of this study was to examine the reliability and validity of the nine-item Patient Health Questionnaire (PHQ-9) for screening depression in Chinese primary care settings.
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Use of clozapine in older Asian patients with schizophrenia between 2001 and 2009.
PLoS ONE
PUBLISHED: 01-01-2013
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To date there has been no large-scale international study that examined the use of clozapine in older patients with schizophrenia. This study examined the use of clozapine and its demographic and clinical correlates in older patients with schizophrenia in East Asia during the period between 2001 and 2009.
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Mental health system in China: history, recent service reform and future challenges.
World Psychiatry
PUBLISHED: 10-13-2011
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This paper summarizes the history of the development of Chinese mental health system; the current situation in the mental health field that China has to face in its effort to reform the system, including mental health burden, workforce and resources, as well as structural issues; the process of national mental health service reform, including how it was included into the national public health program, how it began as a training program and then became a treatment and intervention program, its unique training and capacity building model, and its outcomes and impacts; the barriers and challenges of the reform process; future suggestions for policy; and Chinese experiences as response to the international advocacy for the development of mental health.
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Clozapine use in schizophrenia: findings of the Research on Asia Psychotropic Prescription (REAP) studies from 2001 to 2009.
Aust N Z J Psychiatry
PUBLISHED: 09-03-2011
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Optimizing treatment and outcomes for people with schizophrenia requires understanding of how evidence-based treatments are utilized. Clozapine is the most effective antipsychotic drug for treatment-refractory schizophrenia, but few studies have investigated trends and patterns of its use over time internationally. This study examined the prescription patterns of clozapine and its demographic and clinical correlates in Asia from 2001 to 2009.
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Cigarette smoking in community-dwelling patients with schizophrenia in China.
J Psychiatr Res
PUBLISHED: 05-11-2011
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This study examined the prevalence of cigarette smoking and its socio-demographic and clinical characteristics in Chinese schizophrenia patients. A sample of 540 community-dwelling patients (female/male: 50.4% vs. 49.6%) with schizophrenia was interviewed using standardized assessment instruments. The patients basic socio-demographic and clinical data including smoking were collected. The prevalence of cigarette smoking was 28.5% in the whole sample, and 53.6% and 4.0% for men and women, respectively. In univariate analyses, male sex, use of first generation antipsychotics (FGAs) and alcohol consumption were significantly associated with smoking. In multiple logistic regression analysis, male sex, alcohol consumption, older age and lower level of education were independently associated with smoking. The prevalence of smoking in Chinese schizophrenia patients is considerably lower than most figures reported from Western settings. The dramatic differences between males and females underscore the influence of cultural norms on smoking.
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The low frequency of reported sexual dysfunction in Asian patients with schizophrenia (2001-2009): low occurrence or ignored side effect?
Hum Psychopharmacol
PUBLISHED: 05-06-2011
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The purpose of the study was to evaluate the frequency of reported sexual dysfunction (SD) in schizophrenia and its associations with sociodemographic and clinical variables in selected Asian countries.
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Examining the association between late-life leisure activity participation and global cognitive decline in community-dwelling elderly Chinese in Hong Kong.
Int J Geriatr Psychiatry
PUBLISHED: 04-28-2011
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This study examines the association between late-life leisure activity participation and global cognitive decline in community-dwelling elderly Chinese in Hong Kong.
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Association of insight with sociodemographic and clinical factors, quality of life, and cognition in Chinese patients with schizophrenia.
Compr Psychiatry
PUBLISHED: 04-05-2011
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The aims of this study were to assess insight in Chinese patients with schizophrenia and to identify its relationship with sociodemographic and clinical factors, cognition, and quality of life (QOL).
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Depression care management for late-life depression in China primary care: protocol for a randomized controlled trial.
Trials
PUBLISHED: 03-15-2011
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As a major public health issue in China and worldwide, late-life depression is associated with physical limitations, greater functional impairment, increased utilization and cost of health care, and suicide. Like other chronic diseases in elders such as hypertension and diabetes, depression is a chronic disease that the new National Health Policy of China indicates should be managed in primary care settings. Collaborative care, linking primary and mental health specialty care, has been shown to be effective for the treatment of late-life depression in primary care settings in Western countries. The primary aim of this project is to implement a depression care management (DCM) intervention, and examine its effectiveness on the depressive symptoms of older patients in Chinese primary care settings.
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Sex differences in use of psychotropic drugs and drug-induced side effects in schizophrenia patients: findings of the Research on Asia Psychotropic Prescription (REAP) studies.
Aust N Z J Psychiatry
PUBLISHED: 12-13-2010
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The aim of this study was to investigate the sex differences in prescribing patterns of psychotropic drugs and drug-induced side effects in schizophrenia patients in Asia using the data of the Research on Asian Psychotropic Prescription Pattern (REAP) surveys.
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Neuropsychiatric symptoms are associated with increased risks of progression to dementia: a 2-year prospective study of 321 Chinese older persons with mild cognitive impairment.
Age Ageing
PUBLISHED: 11-23-2010
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studies have suggested that neuropsychiatric (NP) symptoms influence the development of dementia among older adults. But, the results are inconsistent and there is limited information about NP symptoms in population-based samples.
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Association of demographic characteristics, symptomatology, retrospective and prospective memory, executive functioning and intelligence with social functioning in schizophrenia.
Aust N Z J Psychiatry
PUBLISHED: 11-13-2010
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The objective of this study was to explore the influence of socio-demographic and clinical factors and neurocognitive variables (i.e. prospective and retrospective memory, executive functioning, and intelligence) on social functioning in Chinese schizophrenia patients.
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Socio-demographic and clinical profiles of paranoid and nonparanoid schizophrenia: a prospective, multicenter study in China.
Perspect Psychiatr Care
PUBLISHED: 11-03-2010
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This study aimed to explore the socio-demographic and clinical characteristics of paranoid and nonparanoid subtypes of schizophrenia.
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Predictors of relapse in Chinese schizophrenia patients: a prospective, multi-center study.
Soc Psychiatry Psychiatr Epidemiol
PUBLISHED: 10-18-2010
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Relapse prevention is the main goal of maintenance treatment in schizophrenia. This study aimed to determine the rate and the socio-demographic and clinical predictors of relapse in Chinese schizophrenia patients following treatment of the acute phase of the illness.
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Prevalence of neuropsychiatric symptoms in chinese older persons with mild cognitive impairment-a population-based study.
Am J Geriatr Psychiatry
PUBLISHED: 09-03-2010
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To estimate the point prevalence and correlates of neuropsychiatric (NP) symptoms among older adults with mild cognitive impairment (MCI) and normal cognition (NC) in a Chinese community.
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Prospective memory deficits in patients with bipolar disorder: a preliminary study.
Arch Clin Neuropsychol
PUBLISHED: 08-16-2010
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Prospective memory (PM) is the ability to remember to do something in the future without explicit prompts. To date, little has been known about PM deficits in bipolar disorder (BD). This study examined the nature and correlates of PM in patients with BD. Forty clinically stable BD patients and 40 matched healthy controls formed the study sample. Socio-demographic characteristics, PM, psychosocial functioning, retrospective memory (RM), and IQ were measured in all participants, whereas clinical condition was measured in patients with standardized assessment instruments. Patients performed significantly more poorly on the time-based PM task than controls (10.6 ± 5.0 vs. 14.6 ± 3.0, p < .001). In correlation analyses, older age, lower education, more severe depressive and manic symptoms, poor psychosocial functioning, poor RM, and lower scores in IQ were significantly associated with poor performance in the time-based PM task, whereas poor RM and lower scores in IQ associated with poorer performance in the event-based PM task in patients. In multivariate analyses, severity of depression and older age significantly contributed to poor performance in the time-based PM task, whereas poor RM contributed to poor performance in the event-based PM task in patients. The time-based PM is impaired in BD patients. Depressive symptoms, age, and RM were determinants of certain aspects of impaired PM performance in BD patients.
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Independent association of prospective memory with retrospective memory and intelligence in schizophrenia: a controlled study.
Arch Clin Neuropsychol
PUBLISHED: 08-16-2010
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Prospective memory (PM) refers to the ability to remember to do something in the future. This study examined the relationship between three PM subtypes, and intelligence and retrospective memory (RM) in schizophrenia patients and healthy controls. The study sample comprised 110 schizophrenia patients and 110 healthy controls matched according to age, sex, and level of education. The patients clinical condition was evaluated with the Brief Psychiatric Rating Scale. Time-, event-, and activity-based PM and RM (immediate and delayed Logical Memory subtests of the Wechsler Memory Scales-Revised), executive functioning (Design Fluency Test, Tower of London-4 disk, and Wisconsin Card Sorting Test), and intelligence (Ravens Progressive Matrices) tests were administered to all participants. Correlation analyses showed time- and event-based PM to be significantly associated with RM in both the patients and controls, but with intelligence only in the patients. After controlling for covariates, only time-based PM was associated with RM in the controls and only event-based PM with intelligence in the patients. In schizophrenia, PM deficit may arise from the impairments of the retrospective components of memory.
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Combined clinical and cognitive criteria to identify mild cognitive impairment in a southern chinese community.
Alzheimer Dis Assoc Disord
PUBLISHED: 08-10-2010
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Mild Cognitive Impairment (MCI) is a recognized risk condition for clinical dementia. This paper attempted to explore the applicability of a combined cognitive and clinical approach to identify older Chinese adults at-risk of cognitive decline. Seven hundred forty randomly recruited community dwelling participants (aged 60 or over) were assessed at baseline and 2 years with Clinical Dementia Rating (CDR) and a cognitive battery. Baseline MCI groups were categorized by CDR-MCI, cognitive function (Cog-MCI), and a combined CDR-Cog approach. The cognitive approach adopted the Mayo clinic criteria. For the combined approach, nonamnestic MCI combined CDR 0.5 plus nonmemory cognitive deficits. The overall concordance between CDR and Cognitive test ratings were 65.3% (? =256.4, P<0.001, ?=0.44). With a combined approach, 424(57%) participants were classified as normal. CDR-MCI group had higher cognitive scores compared with MCI groups by other criteria (1 way analysis of variance or ANOVA). At 2 years, the combined CDR-Cog MCI group identified all dementia (N=24) converters although group differences were not significant. Cognitive function and CDR identified participants potentially at-risk for furthermore decline, but exhibited some differences in detection profiles. A combined approach may be more practical in screening for MCI participants with diverse educational and cultural background.
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A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimers disease.
Neurobiol. Aging
PUBLISHED: 05-12-2010
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Alzheimers disease (AD), the most common form of dementia, is characterized by the presence of neurofibrillary tangles composed of tau and senile plaques of amyloid-beta peptides (A?) derived from amyloid precursor protein (APP). Pin1 is a unique prolyl isomerase that has been shown to protect against age-dependent neurodegeneration by acting on phosphorylated tau and APP to suppress tangle formation and amyloidogenic APP processing. Here we report a functional polymorphism, rs2287839, in the Pin1 promoter that is significantly associated with a 3-year delay in the average age at onset (AAO) of late-onset AD in a Chinese population. More significantly, the Pin1 polymorphism rs2287839 is located within the consensus binding motif for the brain-selective transcription factor, AP4 (CAGCTG) and almost completely abolishes the ability of AP4 to bind and suppress the Pin1 promoter, as shown by chromatin immunoprecipitation, electrophoretic mobility shift assay, and promoter luciferase assay. Moreover, overexpression or knockdown of AP4 resulted in an 80% reduction or 2-fold increase in endogenous Pin1 levels, respectively. Thus, AP4 is a novel transcriptional repressor of Pin1 expression and the Pin1 promoter single nucleotide polymorphism (SNP) identified in this study that prevents such suppression is associated with delayed onset of AD. These results indicate that regulation of Pin1 by AP4 plays a critical role in determining age at onset of AD and might be a novel therapeutic target to delay the onset of AD.
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Cigarette smoking in patients with schizophrenia in China: prospective, multicentre study.
Aust N Z J Psychiatry
PUBLISHED: 04-20-2010
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The aim of the present study was to explore the rate of cigarette smoking and its sociodemographic and clinical characteristics in Chinese schizophrenia patients.
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Interim follow-up of a randomized controlled trial comparing Chinese style mind body (Tai Chi) and stretching exercises on cognitive function in subjects at risk of progressive cognitive decline.
Int J Geriatr Psychiatry
PUBLISHED: 02-21-2010
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We reported the interim findings of a randomized controlled trial (RCT) to examine the effects of a mind body physical exercise (Tai Chi) on cognitive function in Chinese subjects at risk of cognitive decline.
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Sex differences in patients with schizophrenia: A prospective, multi-center study.
Psychiatry Res
PUBLISHED: 01-26-2010
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This study aimed to determine sex differences in socio-demographic and clinical characteristics of Chinese schizophrenia patients. In a multi-center, randomized, controlled, longitudinal study, 404 clinically stable patients with schizophrenia were randomly assigned to a maintenance group (optimal therapeutic doses continued throughout the study), a 26-week group (optimal therapeutic doses continued for 26 weeks, followed by a 50% dose reduction maintained until the end of the study), or a 4-week group (optimal therapeutic doses continued for 4 weeks, followed by a 50% dose reduction maintained until the end of the study). Participants were interviewed regularly using standardized assessment instruments, and followed up for 12-26 months. In the univariate analyses, the following factors were significantly associated with the male sex: not married, smoking, younger age, earlier age at onset, higher body mass index (BMI) at baseline, and more severe negative and hostility-excitement symptoms at baseline. The following factors were independently associated with the male sex in the multivariate analyses: not being married, smoking, a higher BMI at baseline, less deterioration in disorganized thoughts (4-week group) and positive symptoms (26-week group) and less increase in BMI in all three treatment groups over the study period. The majority of the sex differences in schizophrenia patients in this study are in accordance with results of previous studies worldwide suggesting that sex differences seen in schizophrenia are not dependent on cultural differences between geographically separate patients.
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Diagnosis of schizophrenia: reliability of an operationalized approach to praecox-feeling.
Psychopathology
PUBLISHED: 01-21-2010
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H.C. Rumke coined the term praecox-feeling to denote a specific unease experienced by the clinician reflecting the impossibility of empathy and lack of exchange of affect that has been reported to occur early on when examining schizophrenia patients. There is ample evidence that praecox-feeling is still relevant in modern clinical practice. This study examined the reliability of operationalized praecox-feeling against the background of modern diagnostic criteria and assessment methods.
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Socio-demographic and clinical determinants of quality of life in Chinese patients with schizophrenia: a prospective study.
Qual Life Res
PUBLISHED: 01-05-2010
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The aim of the study was to assess the changes in the quality of life (QOL) of Chinese schizophrenia patients and to identify their predictors over a 1-year follow-up.
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What does psychological autopsy study tell us about charcoal burning suicide--a new and contagious method in Asia?
Suicide Life Threat Behav
PUBLISHED: 12-08-2009
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Charcoal burning suicides in Hong Kong between 2002-2004 in the 15 to 59-year-old age group were investigated using the psychological autopsy method. The psychopathological profiles of charcoal burning suicides (N = 53) were compared against "other suicides" (N = 97). The two groups did not differ significantly in the prevalence of DSM-IV axis I diagnoses with the exception of schizophrenic spectrum disorder which was less frequently associated with charcoal burning suicides. Score on "neuroticism" in the NEO-five Factor Inventory (NEO-FFI) was significantly higher in victims of charcoal burning suicide. There was also a trend toward higher score on "conscientiousness" in the NEO-FFI among charcoal burners than victims of other suicide.
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Induction of neuronal apoptosis inhibitory protein expression in response to androgen deprivation in prostate cancer.
Cancer Lett.
PUBLISHED: 10-15-2009
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A mechanism for survival of prostate cancer cells in an androgen-deprived environment remains elusive. Here, we find that expression of neuronal apoptosis inhibitory protein (NAIP) was significantly increased in vivo and in vitro in response to androgen deprivation therapy (ADT). Increased expression of NAIP corresponded to increased DNA-binding activity of NF-kappaB that physically associated to previously uncharacterized kappaB-like sites in the NAIP locus. Importantly, expression of NAIP was significantly increased (p=0.04) in clinical samples of prostate cancer from patients receiving ADT. Expression of NAIP may be associated with enhanced survival of prostate cancer in response to castration.
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Serum zinc is decreased in Alzheimers disease and serum arsenic correlates positively with cognitive ability.
Biometals
PUBLISHED: 10-15-2009
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Zinc, copper, and iron aggregate Abeta and accumulate in Alzheimers disease (AD) plaques. Some metals are increased in AD vs. control serum. The authors examined levels of 12 metals in serum of 44 AD and 41 control subjects. Zinc decreased from 12.3 to 10.9 micromol/L (means, p = 0.0007). Arsenic positively correlated with Mini-Mental State Examination score (p < 0.0001). Zinc deposition in brain amyloid might deplete zinc from other body compartments, such as serum. The arsenic correlation might be caused by the major contribution of seafood consumption to intake of both arsenic and docosahexaenoic acid, of which the latter may delay AD.
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Examining the association between participation in late-life leisure activities and cognitive function in community-dwelling elderly Chinese in Hong Kong.
Int Psychogeriatr
PUBLISHED: 09-29-2009
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Growing evidence suggests that participation in late-life leisure activity may have beneficial effects on cognitive function. The objective of the study was to evaluate the association between leisure activity participation and cognitive function in an elderly population of community-dwelling Hong Kong Chinese.
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Predictors of change in health-related quality of life among older people with depression: a longitudinal study.
Int Psychogeriatr
PUBLISHED: 09-28-2009
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Depression is a common psychological problem among older people. Health-related quality of life (HRQoL) is now recognized by healthcare providers as an important treatment goal for people with depression. This study aimed to identify predictors of change in HRQoL among older people with depression.
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Modality of physical exercise and cognitive function in Hong Kong older Chinese community.
Int J Geriatr Psychiatry
PUBLISHED: 08-07-2009
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We reported the association between modality of Physical Exercise and cognitive function in 782 older Chinese adults assessed in the second phase of a population survey for dementia in Hong Kong.
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Predicting changes in the health-related quality of life of Chinese depressed older people.
Int J Geriatr Psychiatry
PUBLISHED: 08-07-2009
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To identify predictors of change in Health Related Quality of Life (HRQoL) among community dwelling Chinese older people with depression.
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Population-attributable risk of suicide conferred by axis I psychiatric diagnoses in a Hong Kong Chinese population.
Psychiatr Serv
PUBLISHED: 08-04-2009
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This study was conducted to determine the population-attributable risk (PAR) of completed suicide among Hong Kong Chinese with axis I psychiatric diagnoses.
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Subjective health-related quality of life of Chinese older persons with depression in Shanghai and Hong Kong: relationship to clinical factors, level of functioning and social support.
Int J Geriatr Psychiatry
PUBLISHED: 08-04-2009
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This study aimed to measure and compare the perceptions of HRQoL amongst Chinese older people with depression between Hong Kong and Shanghai and to explore the association of HRQoL with clinical factors, level of functioning and social support in the two sites.
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Psychometric properties of the Chinese version of the Self-Reporting Questionnaire 20 (SRQ-20) in community settings.
Int J Soc Psychiatry
PUBLISHED: 07-10-2009
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Community mental health services in China are in need of a brief, valid instrument to identify mental disorders. Many studies support the Self-Reporting Questionnaire 20 (SRQ-20) as a cost-effective instrument with which to measure community mental health, but there have been no previous studies conducted with the Chinese version of SRQ-20. In this paper, the psychometric properties of the Chinese version of SRQ-20 in community settings were investigated.
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Polymorphisms of the estrogen receptor alpha (ESR1) gene and the risk of Alzheimers disease in a southern Chinese community.
Int Psychogeriatr
PUBLISHED: 07-09-2009
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Alzheimers disease (AD) is a neurodegenerative disease with a higher prevalence in women. Expression of estrogen receptor 1 (ESR1) gene has been identified throughout the brain. Owing to the putative neuroprotective effects of estrogen, estrogen receptor gene is a potential candidate modulating the development of AD. Preliminary associations between two polymorphisms of ESR1 (PvuII and XbaI) gene and AD have been reported.
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Capacity to make treatment decisions in Chinese older persons with very mild dementia and mild Alzheimer disease.
Am J Geriatr Psychiatry
PUBLISHED: 04-25-2009
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This study aims at assessing mental competence in Chinese patients with mild and very mild dementia with a semistructured assessment method and the impact of repeated presentations of information on patients mental competence.
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Cholesterol 24-hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: a two-year follow up study.
Int J Geriatr Psychiatry
PUBLISHED: 02-13-2009
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We previously found that the polymorphisms of cholesterol 24-hydroxylase (CYP46A1) gene were associated with the risk of Alzheimers disease (AD) in Chinese. However, its effect in predicting progression of cognitive decline remains unknown.
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Lifetime prevalence of suicidal ideation, suicide plans and attempts in rural and urban regions of Beijing, China.
Aust N Z J Psychiatry
PUBLISHED: 01-21-2009
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There has been no large-scale survey of suicide-related behaviours including suicidal ideations, plans and attempts in China involving both rural and urban areas and using standardized assessment tools. The aim of the present study was to determine the lifetime prevalence of suicide-related behaviour and its relationship with sociodemographic factors and psychiatric disorders in the rural and urban regions of Beijing, China.
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JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.