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Find video protocols related to scientific articles indexed in Pubmed.
Fenofibrate ameliorates cardiac hypertrophy by activation of peroxisome proliferator-activated receptor-? partly via preventing p65-NF?B binding to NFATc4.
Mol. Cell. Endocrinol.
PUBLISHED: 02-06-2013
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Fenofibrate, a specific peroxisome proliferator-activated receptor alpha (PPAR-?) agonist, was reported to inhibit cardiac hypertrophy. However, the detailed molecular mechanisms and particularly the transcriptional components that are decisive in this process remain to be elucidated. Here we found that fenofibrate ameliorated cardiac hypertrophy in vitro and in vivo. Fenofibrate prevented nuclear translocation of nuclear factor of activated T-cells c4 (NFATc4) and p65 subunit of nuclear factor-kappa B (p65-NF?B) induced by pressure overload or angiotensinII (AngII). Moreover, fenofibrate increased the association of PPAR-? with NFATc4 in nucleus, which inhibited the interaction of NFATc4 with p65-NF?B. Our results suggested that the anti-hypertrophic effect of fenofibrate may be partially attributed to activation of PPAR-?, which decreases the binding of p65-NF?B to NFATc4 and thereby inhibits transactivation of NFATc4.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.