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Find video protocols related to scientific articles indexed in Pubmed.
Temporal inferior vein submerging into intrachoroidal cavitation and gamma zone.
Retin Cases Brief Rep
PUBLISHED: 11-06-2014
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To describe the appearance of the temporal inferior vein submerging into the parapapillary region with characteristics of parapapillary gamma zone and parapapillary beta zone.
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UNILATERAL PERIPAPILLARY INTRACHOROIDAL CAVITATION AND OPTIC DISK ROTATION.
Retina (Philadelphia, Pa.)
PUBLISHED: 10-10-2014
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To examine the morphology of the optic nerve head in patients with unilateral peripapillary intrachoroidal cavitations (PICCs).
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[Subfoveal choroidal thickness of Chinese aged over 50 years and patients with diabetes mellitus and glaucoma].
Zhonghua Yan Ke Za Zhi
PUBLISHED: 09-23-2014
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To investigate the subfoveal choroidal thickness (SFCT) and its relationship to associated diseases, including diabetes mellitus, diabetic retinopathy, and glaucoma.
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Reversibility of Retinal Pigment Epithelium Detachment Parallel to Acute Intraocular Pressure Rise.
J. Glaucoma
PUBLISHED: 09-01-2014
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To report on a reversibility of a retinal pigment epithelium (RPE) detachment in association with marked short-term changes in intraocular pressure (IOP).
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Prevalence of myopia in school children in greater Beijing: the Beijing Childhood Eye Study.
Acta Ophthalmol
PUBLISHED: 08-29-2014
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To determine the prevalence of myopia in school children in Greater Beijing.
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INTRAVITREAL VASCULAR ENDOTHELIAL GROWTH FACTOR CONCENTRATION AND AXIAL LENGTH.
Retina (Philadelphia, Pa.)
PUBLISHED: 08-25-2014
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To examine the intravitreal concentration of vascular endothelial growth factor (VEGF) in dependence of the axial length in eyes without intraocular neovascularization.
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POSTERIOR SCLERAL REINFORCEMENT AND VITRECTOMY FOR MYOPIC FOVEOSCHISIS IN EXTREME MYOPIA.
Retina (Philadelphia, Pa.)
PUBLISHED: 08-08-2014
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To evaluate the effect of surgical posterior scleral reinforcement in extremely myopic patients (axial length ?30 mm) with myopic foveoschisis.
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Intraocular pressure and estimated cerebrospinal fluid pressure. The Beijing Eye Study 2011.
PLoS ONE
PUBLISHED: 08-08-2014
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To examine a potential association between intraocular pressure (IOP) and cerebrospinal fluid pressure (CSFP) in a population-based setting.
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Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
Nat Commun
PUBLISHED: 08-04-2014
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Glaucoma is characterized by irreversible optic nerve degeneration and is the most frequent cause of irreversible blindness worldwide. Here, the International Glaucoma Genetics Consortium conducts a meta-analysis of genome-wide association studies of vertical cup-disc ratio (VCDR), an important disease-related optic nerve parameter. In 21,094 individuals of European ancestry and 6,784 individuals of Asian ancestry, we identify 10 new loci associated with variation in VCDR. In a separate risk-score analysis of five case-control studies, Caucasians in the highest quintile have a 2.5-fold increased risk of primary open-angle glaucoma as compared with those in the lowest quintile. This study has more than doubled the known loci associated with optic disc cupping and will allow greater understanding of mechanisms involved in this common blinding condition.
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Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.
Christopher J L Murray, Katrina F Ortblad, Caterina Guinovart, Stephen S Lim, Timothy M Wolock, D Allen Roberts, Emily A Dansereau, Nicholas Graetz, Ryan M Barber, Jonathan C Brown, Haidong Wang, Herbert C Duber, Mohsen Naghavi, Daniel Dicker, Lalit Dandona, Joshua A Salomon, Kyle R Heuton, Kyle Foreman, David E Phillips, Thomas D Fleming, Abraham D Flaxman, Bryan K Phillips, Elizabeth K Johnson, Megan S Coggeshall, Foad Abd-Allah, Semaw Ferede Abera, Jerry P Abraham, Ibrahim Abubakar, Laith J Abu-Raddad, Niveen Me Abu-Rmeileh, Tom Achoki, Austine Olufemi Adeyemo, Arsène Kouablan Adou, José C Adsuar, Emilie Elisabet Agardh, Dickens Akena, Mazin J Al Kahbouri, Deena Alasfoor, Mohammed I Albittar, Gabriel Alcalá-Cerra, Miguel Angel Alegretti, Zewdie Aderaw Alemu, Rafael Alfonso-Cristancho, Samia Alhabib, Raghib Ali, François Alla, Peter J Allen, Ubai Alsharif, Elena Alvarez, Nelson Alvis-Guzmán, Adansi A Amankwaa, Azmeraw T Amare, Hassan Amini, Walid Ammar, Benjamin O Anderson, Carl Abelardo T Antonio, Palwasha Anwari, Johan Arnlöv, Valentina S Arsic Arsenijevic, Ali Artaman, Rana J Asghar, Reza Assadi, Lydia S Atkins, Alaa Badawi, Kalpana Balakrishnan, Amitava Banerjee, Sanjay Basu, Justin Beardsley, Tolesa Bekele, Michelle L Bell, Eduardo Bernabé, Tariku Jibat Beyene, Neeraj Bhala, Ashish Bhalla, Zulfiqar A Bhutta, Aref Bin Abdulhak, Agnes Binagwaho, Jed D Blore, Berrak Bora Basara, Dipan Bose, Michael Brainin, Nicholas Breitborde, Carlos A Castañeda-Orjuela, Ferrán Catalá-López, Vineet K Chadha, Jung-Chen Chang, Peggy Pei-Chia Chiang, Ting-Wu Chuang, Mercedes Colomar, Leslie Trumbull Cooper, Cyrus Cooper, Karen J Courville, Benjamin C Cowie, Michael H Criqui, Rakhi Dandona, Anand Dayama, Diego De Leo, Louisa Degenhardt, Borja del Pozo-Cruz, Kebede Deribe, Don C Des Jarlais, Muluken Dessalegn, Samath D Dharmaratne, Ugur Dilmen, Eric L Ding, Tim R Driscoll, Adnan M Durrani, Richard G Ellenbogen, Sergey Petrovich Ermakov, Alireza Esteghamati, Emerito Jose A Faraon, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Daniel Obadare Fijabi, Mohammad H Forouzanfar, Urbano Fra Paleo, Lynne Gaffikin, Amiran Gamkrelidze, Fortuné Gbètoho Gankpé, Johanna M Geleijnse, Bradford D Gessner, Katherine B Gibney, Ibrahim Abdelmageem Mohamed Ginawi, Elizabeth L Glaser, Philimon Gona, Atsushi Goto, Hebe N Gouda, Harish Chander Gugnani, Rajeev Gupta, Rahul Gupta, Nima Hafezi-Nejad, Randah Ribhi Hamadeh, Mouhanad Hammami, Graeme J Hankey, Hilda L Harb, Josep Maria Haro, Rasmus Havmoeller, Simon I Hay, Mohammad T Hedayati, Ileana B Heredia Pi, Hans W Hoek, John C Hornberger, H Dean Hosgood, Peter J Hotez, Damian G Hoy, John J Huang, Kim M Iburg, Bulat T Idrisov, Kaire Innos, Kathryn H Jacobsen, Panniyammakal Jeemon, Paul N Jensen, Vivekanand Jha, Guohong Jiang, Jost B Jonas, Knud Juel, Haidong Kan, Ida Kankindi, Nadim E Karam, André Karch, Corine Kakizi Karema, Anil Kaul, Norito Kawakami, Dhruv S Kazi, Andrew H Kemp, André Pascal Kengne, Andre Keren, Maia Kereselidze, Yousef Saleh Khader, Shams Eldin Ali Hassan Khalifa, Ejaz Ahmed Khan, Young-Ho Khang, Irma Khonelidze, Yohannes Kinfu, Jonas M Kinge, Luke Knibbs, Yoshihiro Kokubo, S Kosen, Barthélemy Kuate Defo, Veena S Kulkarni, Chanda Kulkarni, Kaushalendra Kumar, Ravi B Kumar, G Anil Kumar, Gene F Kwan, Taavi Lai, Arjun Lakshmana Balaji, Hilton Lam, Qing Lan, Van C Lansingh, Heidi J Larson, Anders Larsson, Jong-Tae Lee, James Leigh, Mall Leinsalu, Ricky Leung, Yichong Li, Yongmei Li, Graça Maria Ferreira De Lima, Hsien-Ho Lin, Steven E Lipshultz, Shiwei Liu, Yang Liu, Belinda K Lloyd, Paulo A Lotufo, Vasco Manuel Pedro Machado, Jennifer H MacLachlan, Carlos Magis-Rodríguez, Marek Majdan, Christopher Chabila Mapoma, Wagner Marcenes, Melvin Barrientos Marzan, Joseph R Masci, Mohammad Taufiq Mashal, Amanda J Mason-Jones, Bongani M Mayosi, Tasara T Mazorodze, Abigail Cecilia Mckay, Peter A Meaney, Man Mohan Mehndiratta, Fabiola Mejia-Rodriguez, Yohannes Adama Melaku, Ziad A Memish, Walter Mendoza, Ted R Miller, Edward J Mills, Karzan Abdulmuhsin Mohammad, Ali H Mokdad, Glen Liddell Mola, Lorenzo Monasta, Marcella Montico, Ami R Moore, Rintaro Mori, Wilkister Nyaora Moturi, Mitsuru Mukaigawara, Kinnari S Murthy, Aliya Naheed, Kovin S Naidoo, Luigi Naldi, Vinay Nangia, K M Venkat Narayan, Denis Nash, Chakib Nejjari, Robert G Nelson, Sudan Prasad Neupane, Charles R Newton, Marie Ng, Muhammad Imran Nisar, Sandra Nolte, Ole F Norheim, Vincent Nowaseb, Luke Nyakarahuka, In-Hwan Oh, Takayoshi Ohkubo, Bolajoko O Olusanya, Saad B Omer, John Nelson Opio, Orish Ebere Orisakwe, Jeyaraj D Pandian, Christina Papachristou, Angel J Paternina Caicedo, Scott B Patten, Vinod K Paul, Boris Igor Pavlin, Neil Pearce, David M Pereira, Aslam Pervaiz, Konrad Pesudovs, Max Petzold, Farshad Pourmalek, Dima Qato, Amado D Quezada, D Alex Quistberg, Anwar Rafay, Kazem Rahimi, Vafa Rahimi-Movaghar, Sajjad Ur Rahman, Murugesan Raju, Saleem M Rana, Homie Razavi, Robert Quentin Reilly, Giuseppe Remuzzi, Jan Hendrik Richardus, Luca Ronfani, Nobhojit Roy, Nsanzimana Sabin, Mohammad Yahya Saeedi, Mohammad Ali Sahraian, Genesis May J Samonte, Monika Sawhney, Ione J C Schneider, David C Schwebel, Soraya Seedat, Sadaf G Sepanlou, Edson E Servan-Mori, Sara Sheikhbahaei, Kenji Shibuya, Hwashin Hyun Shin, Ivy Shiue, Rupak Shivakoti, Inga Dora Sigfusdottir, Donald H Silberberg, Andrea P Silva, Edgar P Simard, Jasvinder A Singh, Vegard Skirbekk, Karen Sliwa, Samir Soneji, Sergey S Soshnikov, Chandrashekhar T Sreeramareddy, Vasiliki Kalliopi Stathopoulou, Konstantinos Stroumpoulis, Soumya Swaminathan, Bryan L Sykes, Karen M Tabb, Roberto Tchio Talongwa, Eric Yeboah Tenkorang, Abdullah Sulieman Terkawi, Alan J Thomson, Andrew L Thorne-Lyman, Jeffrey A Towbin, Jefferson Traebert, Bach X Tran, Zacharie Tsala Dimbuene, Miltiadis Tsilimbaris, Uche S Uchendu, Kingsley N Ukwaja, Selen Begüm Uzun, Andrew J Vallely, Tommi J Vasankari, N Venketasubramanian, Francesco S Violante, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Stephen Waller, Mitchell T Wallin, Linhong Wang, Xiaorong Wang, Yanping Wang, Scott Weichenthal, Elisabete Weiderpass, Robert G Weintraub, Ronny Westerman, Richard A White, James D Wilkinson, Thomas Neil Williams, Solomon Meseret Woldeyohannes, John Q Wong, Gelin Xu, Yang C Yang, Yuichiro Yano, Gokalp Kadri Yentur, Paul Yip, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Younis, Chuanhua Yu, Kim Yun Jin, Maysaa El Sayed Zaki, Yong Zhao, Yingfeng Zheng, Maigeng Zhou, Jun Zhu, Xiao Nong Zou, Alan D Lopez, Theo Vos.
Lancet
PUBLISHED: 07-22-2014
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The Millennium Declaration in 2000 brought special global attention to HIV, tuberculosis, and malaria through the formulation of Millennium Development Goal (MDG) 6. The Global Burden of Disease 2013 study provides a consistent and comprehensive approach to disease estimation for between 1990 and 2013, and an opportunity to assess whether accelerated progress has occured since the Millennium Declaration.
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Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.
Hum. Mol. Genet.
PUBLISHED: 06-20-2014
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Age-related cataract is a leading cause of blindness worldwide, especially in developing countries where access to cataract surgery remains limited. Previous linkage and candidate gene studies suggested genetic influences on age-related nuclear cataract but few genetic markers have been identified thus far. We conducted genome-wide association studies on 4569 Asians (including 2369 Malays and 2200 Indians), and replicated our analysis in 2481 Chinese from two independent cohorts (1768 Chinese in Singapore and 803 Chinese in Beijing). We confirmed two genome-wide significant loci for nuclear cataract in the combined meta-analysis of four cohorts (n = 7140). The first locus was at chromosome 3q25.31 in KCNAB1 (rs7615568, fixed-effect Pmeta = 2.30 × 10(-8); random-effect Pmeta = 1.08 × 10(-8)). The second locus was at chromosome 21 in the proximity of CRYAA (rs11911275, fixed-effect Pmeta = 2.77 × 10(-8); random-effect Pmeta = 1.98 × 10(-9)), a major protein component of eye lens. The findings were further supported by up-regulation and down-regulation of KCNAB1 and CRYAA in human lens capsule, respectively, as the severity of nuclear cataract increases. The results offer additional insights into the pathogenesis of nuclear cataract in Asians.
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Resting heart rate and risk of hypertension: results of the Kailuan cohort study.
J. Hypertens.
PUBLISHED: 06-01-2014
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Resting heart rate (RHR) is a predictive risk factor of the development of cardiovascular diseases, but its association with arterial hypertension has remained unclear. This study investigated the relationship between RHR and new-onset hypertension (NOH) in an Asian population.
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Intraocular pressure and associated factors in children: the Shandong children eye study.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 05-31-2014
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We examined the distribution of intraocular pressure (IOP) and its associated factors in children.
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Global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013: a systematic analysis for the Global Burden of Disease Study 2013.
Marie Ng, Tom Fleming, Margaret Robinson, Blake Thomson, Nicholas Graetz, Christopher Margono, Erin C Mullany, Stan Biryukov, Cristiana Abbafati, Semaw Ferede Abera, Jerry P Abraham, Niveen M E Abu-Rmeileh, Tom Achoki, Fadia S AlBuhairan, Zewdie A Alemu, Rafael Alfonso, Mohammed K Ali, Raghib Ali, Nelson Alvis Guzman, Walid Ammar, Palwasha Anwari, Amitava Banerjee, Simón Barquera, Sanjay Basu, Derrick A Bennett, Zulfiqar Bhutta, Jed Blore, Norberto Cabral, Ismael Campos Nonato, Jung-Chen Chang, Rajiv Chowdhury, Karen J Courville, Michael H Criqui, David K Cundiff, Kaustubh C Dabhadkar, Lalit Dandona, Adrian Davis, Anand Dayama, Samath D Dharmaratne, Eric L Ding, Adnan M Durrani, Alireza Esteghamati, Farshad Farzadfar, Derek F J Fay, Valery L Feigin, Abraham Flaxman, Mohammad H Forouzanfar, Atsushi Goto, Mark A Green, Rajeev Gupta, Nima Hafezi-Nejad, Graeme J Hankey, Heather C Harewood, Rasmus Havmoeller, Simon Hay, Lucia Hernandez, Abdullatif Husseini, Bulat T Idrisov, Nayu Ikeda, Farhad Islami, Eiman Jahangir, Simerjot K Jassal, Sun Ha Jee, Mona Jeffreys, Jost B Jonas, Edmond K Kabagambe, Shams Eldin Ali Hassan Khalifa, André Pascal Kengne, Yousef Saleh Khader, Young-Ho Khang, Daniel Kim, Ruth W Kimokoti, Jonas M Kinge, Yoshihiro Kokubo, Soewarta Kosen, Gene Kwan, Taavi Lai, Mall Leinsalu, Yichong Li, Xiaofeng Liang, Shiwei Liu, Giancarlo Logroscino, Paulo A Lotufo, Yuan Lu, Jixiang Ma, Nana Kwaku Mainoo, George A Mensah, Tony R Merriman, Ali H Mokdad, Joanna Moschandreas, Mohsen Naghavi, Aliya Naheed, Devina Nand, K M Venkat Narayan, Erica Leigh Nelson, Marian L Neuhouser, Muhammad Imran Nisar, Takayoshi Ohkubo, Samuel O Oti, Andrea Pedroza, Dorairaj Prabhakaran, Nobhojit Roy, Uchechukwu Sampson, Hyeyoung Seo, Sadaf G Sepanlou, Kenji Shibuya, Rahman Shiri, Ivy Shiue, Gitanjali M Singh, Jasvinder A Singh, Vegard Skirbekk, Nicolas J C Stapelberg, Lela Sturua, Bryan L Sykes, Martin Tobias, Bach X Tran, Leonardo Trasande, Hideaki Toyoshima, Steven van de Vijver, Tommi J Vasankari, J Lennert Veerman, Gustavo Velásquez-Meléndez, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Theo Vos, Claire Wang, Xiaorong Wang, Elisabete Weiderpass, Andrea Werdecker, Jonathan L Wright, Y Claire Yang, Hiroshi Yatsuya, Jihyun Yoon, Seok-Jun Yoon, Yong Zhao, Maigeng Zhou, Shankuan Zhu, Alan D Lopez, Christopher J L Murray, Emmanuela Gakidou.
Lancet
PUBLISHED: 05-29-2014
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In 2010, overweight and obesity were estimated to cause 3·4 million deaths, 3·9% of years of life lost, and 3·8% of disability-adjusted life-years (DALYs) worldwide. The rise in obesity has led to widespread calls for regular monitoring of changes in overweight and obesity prevalence in all populations. Comparable, up-to-date information about levels and trends is essential to quantify population health effects and to prompt decision makers to prioritise action. We estimate the global, regional, and national prevalence of overweight and obesity in children and adults during 1980-2013.
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Choroidal Thickness in Non-Arteritic Anterior Ischemic Optic Neuropathy.
Am. J. Ophthalmol.
PUBLISHED: 05-20-2014
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To examine choroidal thickness in non-arteritic anterior ischemic optic neuropathy (AION).
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Estimated trans-lamina cribrosa pressure difference versus intraocular pressure as biomarker for open-angle glaucoma. The Beijing Eye Study 2011.
Acta Ophthalmol
PUBLISHED: 05-17-2014
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To examine whether an estimated trans-lamina cribrosa pressure difference (TLCPD) better than intraocular pressure (IOP) correlated with markers for glaucoma.
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Global, regional, and national levels and causes of maternal mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.
Nicholas J Kassebaum, Amelia Bertozzi-Villa, Megan S Coggeshall, Katya A Shackelford, Caitlyn Steiner, Kyle R Heuton, Diego Gonzalez-Medina, Ryan Barber, Chantal Huynh, Daniel Dicker, Tara Templin, Timothy M Wolock, Ayse Abbasoglu Ozgoren, Foad Abd-Allah, Semaw Ferede Abera, Ibrahim Abubakar, Tom Achoki, Ademola Adelekan, Zanfina Ademi, Arsène Kouablan Adou, José C Adsuar, Emilie E Agardh, Dickens Akena, Deena Alasfoor, Zewdie Aderaw Alemu, Rafael Alfonso-Cristancho, Samia Alhabib, Raghib Ali, Mazin J Al Kahbouri, François Alla, Peter J Allen, Mohammad A AlMazroa, Ubai Alsharif, Elena Alvarez, Nelson Alvis-Guzmán, Adansi A Amankwaa, Azmeraw T Amare, Hassan Amini, Walid Ammar, Carl A T Antonio, Palwasha Anwari, Johan Arnlöv, Valentina S Arsic Arsenijevic, Ali Artaman, Majed Masoud Asad, Rana J Asghar, Reza Assadi, Lydia S Atkins, Alaa Badawi, Kalpana Balakrishnan, Arindam Basu, Sanjay Basu, Justin Beardsley, Neeraj Bedi, Tolesa Bekele, Michelle L Bell, Eduardo Bernabé, Tariku J Beyene, Zulfiqar Bhutta, Aref Bin Abdulhak, Jed D Blore, Berrak Bora Basara, Dipan Bose, Nicholas Breitborde, Rosario Cárdenas, Carlos A Castañeda-Orjuela, Ruben Estanislao Castro, Ferrán Catalá-López, Alanur Cavlin, Jung-Chen Chang, Xuan Che, Costas A Christophi, Sumeet S Chugh, Massimo Cirillo, Samantha M Colquhoun, Leslie Trumbull Cooper, Cyrus Cooper, Iuri da Costa Leite, Lalit Dandona, Rakhi Dandona, Adrian Davis, Anand Dayama, Louisa Degenhardt, Diego De Leo, Borja del Pozo-Cruz, Kebede Deribe, Muluken Dessalegn, Gabrielle A deVeber, Samath D Dharmaratne, Ugur Dilmen, Eric L Ding, Rob E Dorrington, Tim R Driscoll, Sergei Petrovich Ermakov, Alireza Esteghamati, Emerito Jose A Faraon, Farshad Farzadfar, Manuela Mendonca Felicio, Seyed-Mohammad Fereshtehnejad, Graça Maria Ferreira De Lima, Mohammad H Forouzanfar, Elisabeth B França, Lynne Gaffikin, Ketevan Gambashidze, Fortuné Gbètoho Gankpé, Ana C Garcia, Johanna M Geleijnse, Katherine B Gibney, Maurice Giroud, Elizabeth L Glaser, Ketevan Goginashvili, Philimon Gona, Dinorah González-Castell, Atsushi Goto, Hebe N Gouda, Harish Chander Gugnani, Rahul Gupta, Rajeev Gupta, Nima Hafezi-Nejad, Randah Ribhi Hamadeh, Mouhanad Hammami, Graeme J Hankey, Hilda L Harb, Rasmus Havmoeller, Simon I Hay, Ileana B Heredia Pi, Hans W Hoek, H Dean Hosgood, Damian G Hoy, Abdullatif Husseini, Bulat T Idrisov, Kaire Innos, Manami Inoue, Kathryn H Jacobsen, Eiman Jahangir, Sun Ha Jee, Paul N Jensen, Vivekanand Jha, Guohong Jiang, Jost B Jonas, Knud Juel, Edmond Kato Kabagambe, Haidong Kan, Nadim E Karam, André Karch, Corine Kakizi Karema, Anil Kaul, Norito Kawakami, Konstantin Kazanjan, Dhruv S Kazi, Andrew H Kemp, André Pascal Kengne, Maia Kereselidze, Yousef Saleh Khader, Shams Eldin Ali Hassan Khalifa, Ejaz Ahmed Khan, Young-Ho Khang, Luke Knibbs, Yoshihiro Kokubo, Soewarta Kosen, Barthélemy Kuate Defo, Chanda Kulkarni, Veena S Kulkarni, G Anil Kumar, Kaushalendra Kumar, Ravi B Kumar, Gene Kwan, Taavi Lai, Ratilal Lalloo, Hilton Lam, Van C Lansingh, Anders Larsson, Jong-Tae Lee, James Leigh, Mall Leinsalu, Ricky Leung, Xiaohong Li, Yichong Li, Yongmei Li, Juan Liang, Xiaofeng Liang, Stephen S Lim, Hsien-Ho Lin, Steven E Lipshultz, Shiwei Liu, Yang Liu, Belinda K Lloyd, Stephanie J London, Paulo A Lotufo, Jixiang Ma, Stefan Ma, Vasco Manuel Pedro Machado, Nana Kwaku Mainoo, Marek Majdan, Christopher Chabila Mapoma, Wagner Marcenes, Melvin Barrientos Marzan, Amanda J Mason-Jones, Man Mohan Mehndiratta, Fabiola Mejia-Rodriguez, Ziad A Memish, Walter Mendoza, Ted R Miller, Edward J Mills, Ali H Mokdad, Glen Liddell Mola, Lorenzo Monasta, Jonathan de la Cruz Monis, Julio Cesar Montañez Hernandez, Ami R Moore, Maziar Moradi-Lakeh, Rintaro Mori, Ulrich O Mueller, Mitsuru Mukaigawara, Aliya Naheed, Kovin S Naidoo, Devina Nand, Vinay Nangia, Denis Nash, Chakib Nejjari, Robert G Nelson, Sudan Prasad Neupane, Charles R Newton, Marie Ng, Mark J Nieuwenhuijsen, Muhammad Imran Nisar, Sandra Nolte, Ole F Norheim, Luke Nyakarahuka, In-Hwan Oh, Takayoshi Ohkubo, Bolajoko O Olusanya, Saad B Omer, John Nelson Opio, Orish Ebere Orisakwe, Jeyaraj D Pandian, Christina Papachristou, Jae-Hyun Park, Angel J Paternina Caicedo, Scott B Patten, Vinod K Paul, Boris Igor Pavlin, Neil Pearce, David M Pereira, Konrad Pesudovs, Max Petzold, Dan Poenaru, Guilherme V Polanczyk, Suzanne Polinder, Dan Pope, Farshad Pourmalek, Dima Qato, D Alex Quistberg, Anwar Rafay, Kazem Rahimi, Vafa Rahimi-Movaghar, Sajjad Ur Rahman, Murugesan Raju, Saleem M Rana, Amany Refaat, Luca Ronfani, Nobhojit Roy, Tania Georgina Sánchez Pimienta, Mohammad Ali Sahraian, Joshua A Salomon, Uchechukwu Sampson, Itamar S Santos, Monika Sawhney, Felix Sayinzoga, Ione J C Schneider, Austin Schumacher, David C Schwebel, Soraya Seedat, Sadaf G Sepanlou, Edson E Servan-Mori, Marina Shakh-Nazarova, Sara Sheikhbahaei, Kenji Shibuya, Hwashin Hyun Shin, Ivy Shiue, Inga Dora Sigfusdottir, Donald H Silberberg, Andrea P Silva, Jasvinder A Singh, Vegard Skirbekk, Karen Sliwa, Sergey S Soshnikov, Luciano A Sposato, Chandrashekhar T Sreeramareddy, Konstantinos Stroumpoulis, Lela Sturua, Bryan L Sykes, Karen M Tabb, Roberto Tchio Talongwa, Feng Tan, Carolina Maria Teixeira, Eric Yeboah Tenkorang, Abdullah Sulieman Terkawi, Andrew L Thorne-Lyman, David L Tirschwell, Jeffrey A Towbin, Bach X Tran, Miltiadis Tsilimbaris, Uche S Uchendu, Kingsley N Ukwaja, Eduardo A Undurraga, Selen Begüm Uzun, Andrew J Vallely, Coen H van Gool, Tommi J Vasankari, Monica S Vavilala, N Venketasubramanian, Salvador Villalpando, Francesco S Violante, Vasiliy Victorovich Vlassov, Theo Vos, Stephen Waller, Haidong Wang, Linhong Wang, Xiaorong Wang, Yanping Wang, Scott Weichenthal, Elisabete Weiderpass, Robert G Weintraub, Ronny Westerman, James D Wilkinson, Solomon Meseret Woldeyohannes, John Q Wong, Muluemebet Abera Wordofa, Gelin Xu, Yang C Yang, Yuichiro Yano, Gokalp Kadri Yentur, Paul Yip, Naohiro Yonemoto, Seok-Jun Yoon, Mustafa Z Younis, Chuanhua Yu, Kim Yun Jin, Maysaa El Sayed Zaki, Yong Zhao, Yingfeng Zheng, Maigeng Zhou, Jun Zhu, Xiao Nong Zou, Alan D Lopez, Mohsen Naghavi, Christopher J L Murray, Rafael Lozano.
Lancet
PUBLISHED: 05-02-2014
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The fifth Millennium Development Goal (MDG 5) established the goal of a 75% reduction in the maternal mortality ratio (MMR; number of maternal deaths per 100,000 livebirths) between 1990 and 2015. We aimed to measure levels and track trends in maternal mortality, the key causes contributing to maternal death, and timing of maternal death with respect to delivery.
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Global, regional, and national levels of neonatal, infant, and under-5 mortality during 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.
Haidong Wang, Chelsea A Liddell, Matthew M Coates, Meghan D Mooney, Carly E Levitz, Austin E Schumacher, Henry Apfel, Marissa Iannarone, Bryan Phillips, Katherine T Lofgren, Logan Sandar, Rob E Dorrington, Ivo Rakovac, Troy A Jacobs, Xiaofeng Liang, Maigeng Zhou, Jun Zhu, Gonghuan Yang, Yanping Wang, Shiwei Liu, Yichong Li, Ayse Abbasoglu Ozgoren, Semaw Ferede Abera, Ibrahim Abubakar, Tom Achoki, Ademola Adelekan, Zanfina Ademi, Zewdie Aderaw Alemu, Peter J Allen, Mohammad AbdulAziz AlMazroa, Elena Alvarez, Adansi A Amankwaa, Azmeraw T Amare, Walid Ammar, Palwasha Anwari, Solveig Argeseanu Cunningham, Majed Masoud Asad, Reza Assadi, Amitava Banerjee, Sanjay Basu, Neeraj Bedi, Tolesa Bekele, Michelle L Bell, Zulfiqar Bhutta, Jed D Blore, Berrak Bora Basara, Soufiane Boufous, Nicholas Breitborde, Nigel G Bruce, Linh Ngoc Bui, Jonathan R Carapetis, Rosario Cárdenas, David O Carpenter, Valeria Caso, Ruben Estanislao Castro, Ferrán Catalá-López, Alanur Cavlin, Xuan Che, Peggy Pei-Chia Chiang, Rajiv Chowdhury, Costas A Christophi, Ting-Wu Chuang, Massimo Cirillo, Iuri da Costa Leite, Karen J Courville, Lalit Dandona, Rakhi Dandona, Adrian Davis, Anand Dayama, Kebede Deribe, Samath D Dharmaratne, Mukesh K Dherani, Ugur Dilmen, Eric L Ding, Karen M Edmond, Sergei Petrovich Ermakov, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Daniel Obadare Fijabi, Nataliya Foigt, Mohammad H Forouzanfar, Ana C Garcia, Johanna M Geleijnse, Bradford D Gessner, Ketevan Goginashvili, Philimon Gona, Atsushi Goto, Hebe N Gouda, Mark A Green, Karen Fern Greenwell, Harish Chander Gugnani, Rahul Gupta, Randah Ribhi Hamadeh, Mouhanad Hammami, Hilda L Harb, Simon Hay, Mohammad T Hedayati, H Dean Hosgood, Damian G Hoy, Bulat T Idrisov, Farhad Islami, Samaya Ismayilova, Vivekanand Jha, Guohong Jiang, Jost B Jonas, Knud Juel, Edmond Kato Kabagambe, Dhruv S Kazi, André Pascal Kengne, Maia Kereselidze, Yousef Saleh Khader, Shams Eldin Ali Hassan Khalifa, Young-Ho Khang, Daniel Kim, Yohannes Kinfu, Jonas M Kinge, Yoshihiro Kokubo, Soewarta Kosen, Barthélemy Kuate Defo, G Anil Kumar, Kaushalendra Kumar, Ravi B Kumar, Taavi Lai, Qing Lan, Anders Larsson, Jong-Tae Lee, Mall Leinsalu, Stephen S Lim, Steven E Lipshultz, Giancarlo Logroscino, Paulo A Lotufo, Raimundas Lunevicius, Ronan Anthony Lyons, Stefan Ma, Abbas Ali Mahdi, Melvin Barrientos Marzan, Mohammad Taufiq Mashal, Tasara T Mazorodze, John J McGrath, Ziad A Memish, Walter Mendoza, George A Mensah, Atte Meretoja, Ted R Miller, Edward J Mills, Karzan Abdulmuhsin Mohammad, Ali H Mokdad, Lorenzo Monasta, Marcella Montico, Ami R Moore, Joanna Moschandreas, William T Msemburi, Ulrich O Mueller, Magdalena M Muszyńska, Mohsen Naghavi, Kovin S Naidoo, K M Venkat Narayan, Chakib Nejjari, Marie Ng, Jean de Dieu Ngirabega, Mark J Nieuwenhuijsen, Luke Nyakarahuka, Takayoshi Ohkubo, Saad B Omer, Angel J Paternina Caicedo, Victoria Pillay-van Wyk, Dan Pope, Farshad Pourmalek, Dorairaj Prabhakaran, Sajjad U R Rahman, Saleem M Rana, Robert Quentin Reilly, David Rojas-Rueda, Luca Ronfani, Lesley Rushton, Mohammad Yahya Saeedi, Joshua A Salomon, Uchechukwu Sampson, Itamar S Santos, Monika Sawhney, Jürgen C Schmidt, Marina Shakh-Nazarova, Jun She, Sara Sheikhbahaei, Kenji Shibuya, Hwashin Hyun Shin, Kawkab Shishani, Ivy Shiue, Inga Dora Sigfusdottir, Jasvinder A Singh, Vegard Skirbekk, Karen Sliwa, Sergey S Soshnikov, Luciano A Sposato, Vasiliki Kalliopi Stathopoulou, Konstantinos Stroumpoulis, Karen M Tabb, Roberto Tchio Talongwa, Carolina Maria Teixeira, Abdullah Sulieman Terkawi, Alan J Thomson, Andrew L Thorne-Lyman, Hideaki Toyoshima, Zacharie Tsala Dimbuene, Parfait Uwaliraye, Selen Begüm Uzun, Tommi J Vasankari, Ana Maria Nogales Vasconcelos, Vasiliy Victorovich Vlassov, Stein Emil Vollset, Stephen Waller, Xia Wan, Scott Weichenthal, Elisabete Weiderpass, Robert G Weintraub, Ronny Westerman, James D Wilkinson, Hywel C Williams, Yang C Yang, Gokalp Kadri Yentur, Paul Yip, Naohiro Yonemoto, Mustafa Younis, Chuanhua Yu, Kim Yun Jin, Maysaa El Sayed Zaki, Shankuan Zhu, Theo Vos, Alan D Lopez, Christopher J L Murray.
Lancet
PUBLISHED: 05-02-2014
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Remarkable financial and political efforts have been focused on the reduction of child mortality during the past few decades. Timely measurements of levels and trends in under-5 mortality are important to assess progress towards the Millennium Development Goal 4 (MDG 4) target of reduction of child mortality by two thirds from 1990 to 2015, and to identify models of success.
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Optic neuropathy induced by experimentally reduced cerebrospinal fluid pressure in monkeys.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 04-17-2014
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To examine the influence of experimentally reduced cerebrospinal fluid pressure (CSFP) on retinal nerve fiber layer (RNFL) thickness and neuroretinal rim area of the optic nerve head.
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Localized retinal nerve fiber layer defects and stroke.
Stroke
PUBLISHED: 04-15-2014
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Because the blood circulation system of retina and brain are closely related to each other, we examined whether stroke is associated with localized retinal nerve fiber layer defects (RNFLDs).
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Genome-wide association study for refractive astigmatism reveals genetic co-determination with spherical equivalent refractive error: the CREAM consortium.
Hum. Genet.
PUBLISHED: 04-14-2014
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To identify genetic variants associated with refractive astigmatism in the general population, meta-analyses of genome-wide association studies were performed for: White Europeans aged at least 25 years (20 cohorts, N = 31,968); Asian subjects aged at least 25 years (7 cohorts, N = 9,295); White Europeans aged <25 years (4 cohorts, N = 5,640); and all independent individuals from the above three samples combined with a sample of Chinese subjects aged <25 years (N = 45,931). Participants were classified as cases with refractive astigmatism if the average cylinder power in their two eyes was at least 1.00 diopter and as controls otherwise. Genome-wide association analysis was carried out for each cohort separately using logistic regression. Meta-analysis was conducted using a fixed effects model. In the older European group the most strongly associated marker was downstream of the neurexin-1 (NRXN1) gene (rs1401327, P = 3.92E-8). No other region reached genome-wide significance, and association signals were lower for the younger European group and Asian group. In the meta-analysis of all cohorts, no marker reached genome-wide significance: The most strongly associated regions were, NRXN1 (rs1401327, P = 2.93E-07), TOX (rs7823467, P = 3.47E-07) and LINC00340 (rs12212674, P = 1.49E-06). For 34 markers identified in prior GWAS for spherical equivalent refractive error, the beta coefficients for genotype versus spherical equivalent, and genotype versus refractive astigmatism, were highly correlated (r = -0.59, P = 2.10E-04). This work revealed no consistent or strong genetic signals for refractive astigmatism; however, the TOX gene region previously identified in GWAS for spherical equivalent refractive error was the second most strongly associated region. Analysis of additional markers provided evidence supporting widespread genetic co-susceptibility for spherical and astigmatic refractive errors.
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Subfoveal choroidal thickness change after intravitreal ranibizumab for idiopathic choroidal neovascularization.
Retina (Philadelphia, Pa.)
PUBLISHED: 03-27-2014
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To investigate changes in subfoveal choroidal thickness (SFCT) after intravitreal injections of ranibizumab for idiopathic subfoveal choroidal neovascularization (ISCNV).
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Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe: 1990-2010.
Br J Ophthalmol
PUBLISHED: 03-24-2014
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To assess prevalence and causes of blindness and vision impairment in high-income regions and in Central/Eastern Europe in 1990 and 2010.
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Retinal vessel diameter and estimated cerebrospinal fluid pressure in arterial hypertension: the Beijing Eye Study.
Am. J. Hypertens.
PUBLISHED: 03-15-2014
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Hypertensive retinal microvascular abnormalities include an increased retinal vein-to-artery diameter ratio. Because central retinal vein pressure depends on cerebrospinal fluid pressure (CSFP), we examined whether the retinal vein-to-artery diameter ratio and other retinal hypertensive signs are associated with CSFP.
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Choroidal thickness in idiopathic subfoveal choroidal neovascularization.
Ophthalmologica
PUBLISHED: 03-05-2014
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To evaluate choroidal thickness in patients with idiopathic choroidal neovascularization.
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ABCC5, a gene that influences the anterior chamber depth, is associated with primary angle closure glaucoma.
PLoS Genet.
PUBLISHED: 03-01-2014
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Anterior chamber depth (ACD) is a key anatomical risk factor for primary angle closure glaucoma (PACG). We conducted a genome-wide association study (GWAS) on ACD to discover novel genes for PACG on a total of 5,308 population-based individuals of Asian descent. Genome-wide significant association was observed at a sequence variant within ABCC5 (rs1401999; per-allele effect size =? -0.045 mm, P = 8.17 × 10(-9)). This locus was associated with an increase in risk of PACG in a separate case-control study of 4,276 PACG cases and 18,801 controls (per-allele OR = 1.13 [95% CI: 1.06-1.22], P = 0.00046). The association was strengthened when a sub-group of controls with open angles were included in the analysis (per-allele OR = 1.30, P = 7.45 × 10(-9); 3,458 cases vs. 3,831 controls). Our findings suggest that the increase in PACG risk could in part be mediated by genetic sequence variants influencing anterior chamber dimensions.
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Visual impairment and blindness due to macular diseases globally: a systematic review and meta-analysis.
Am. J. Ophthalmol.
PUBLISHED: 02-11-2014
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To estimate the number of people visually impaired or blind due to macular diseases except those caused by diabetic maculopathy.
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Visual acuity and subfoveal choroidal thickness: the Beijing Eye Study.
Am. J. Ophthalmol.
PUBLISHED: 01-30-2014
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To examine the association between best corrected visual acuity (BCVA) and subfoveal choroidal thickness.
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Bruch's membrane thickness in high myopia.
Acta Ophthalmol
PUBLISHED: 01-29-2014
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To measure the thickness of Bruch's membrane (BM) and assess its associations with axial length.
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Ocular diseases and 10-year mortality: the Beijing Eye Study 2001/2011.
Acta Ophthalmol
PUBLISHED: 01-21-2014
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To examine the relationship between major ocular diseases and mortality.
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Prevalence of Depression, Suicidal Ideation, Alcohol Intake and Nicotine Consumption in Rural Central India. The Central India Eye and Medical Study.
PLoS ONE
PUBLISHED: 01-01-2014
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To investigate the prevalence of depression, suicidal ideations, alcohol and nicotine consumption in adults in an agrarian society mostly unchanged by the effects of urbanization.
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Ten-year cumulative incidence of diabetic retinopathy. The beijing eye study 2001/2011.
PLoS ONE
PUBLISHED: 01-01-2014
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To assess the cumulative 10-year incidence of diabetic retinopathy (DR) and its associated factors in a population living in Greater Beijing.
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Intraocular pressure and associations in children. The gobi desert children eye study.
PLoS ONE
PUBLISHED: 01-01-2014
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To assess the intraocular pressure (IOP) and its association in children in a population living in an oasis in the Gobi Desert.
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Oncogenic GNAQ and GNA11 mutations in uveal melanoma in Chinese.
PLoS ONE
PUBLISHED: 01-01-2014
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To examine whether GNAQ and GNA11 somatic mutations previously identified in uveal melanomas of Caucasians are associated with uveal melanomas in Chinese patients.
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The product of resting heart rate times blood pressure is associated with high brachial-ankle pulse wave velocity.
PLoS ONE
PUBLISHED: 01-01-2014
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To investigate potential associations between resting heart rate, blood pressure and the product of both, and the brachial-ankle pulse wave velocity (baPWV) as a maker of arterial stiffness.
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Subfoveal choroidal thickness and glaucoma. The Beijing Eye Study 2011.
PLoS ONE
PUBLISHED: 01-01-2014
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To examine subfoveal choroidal thickness (SFCT) in eyes with glaucoma, using enhanced depth imaging spectral domain optical coherence tomography.
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Ocular hypertension: general characteristics and estimated cerebrospinal fluid pressure. The Beijing Eye Study 2011.
PLoS ONE
PUBLISHED: 01-01-2014
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To examine characteristics of ocular hypertensive subjects and potential associations with estimated cerebrospinal fluid pressure (estCSFP).
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Diabetic retinopathy and estimated cerebrospinal fluid pressure. The Beijing Eye Study 2011.
PLoS ONE
PUBLISHED: 01-01-2014
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The cerebrospinal fluid pressure (CSFP) is a major determinant of central retinal vein pressure and thus of retinal capillary pressure. We tested the hypothesis whether prevalence and severity of diabetic retinopathy are associated with CSFP.
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Scleral cross section area and volume and axial length.
PLoS ONE
PUBLISHED: 01-01-2014
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To examine whether the scleral cross sectional area and estimated scleral volume are associated with a longer axial length in human eyes.
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Target refraction for best uncorrected distance and near vision in cataract surgery.
Eur J Ophthalmol
PUBLISHED: 12-16-2013
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Purpose: To assess the target refractive error after cataract surgery to achieve best uncorrected visual acuity for both distance vision and reading vision.

Methods: The study included patients consecutively undergoing routine phacoemulsification with clear corneal incisions and implantation of a foldable monofocal intraocular lens (IOL). Uncorrected distance visual acuity (UCDVA), best-corrected distance visual acuity (BCDVA), uncorrected near visual acuity (UCNVA,) and best-corrected near visual acuity were measured at 93 ± 47 days (minimum 4 weeks) after surgery. Inclusion criteria were a postoperative cylindrical refractive error ?1.5 D and an unremarkable postoperative status.

Results: The study included 493 eyes of 493 patients with a mean age of 74.2 ± 8.7 years and mean axial length 23.4 ± 1.1 mm. The UCDVA significantly (p<0.001) increased with decreasing myopic refractive error (spherical equivalent) towards emmetropia and then significantly (p<0.001) decreased with increasing hyperopic refractive error. The UCNVA significantly (p<0.001) decreased with decreasing myopic and increasing hyperopic refractive error. The ascending UCDVA line and the descending UCNVA line intersected in the refractive error range (spherical equivalent) of -1.00 D to -1.50 D. For patients with a BCDVA of ?20/25, the lines of UCDVA and UCNVA intersected at a UCDVA range between 20/40 (logMAR 0.30; -1.5 D) and 20/32 (logMAR 0.26; -1.0 D) and at a UCNVA range between Jaeger 3 (logMAR 0.26) and Jaeger 4 (logMAR 0.32).

Conclusions: For routine unilateral cataract surgery with implantation of monofocal IOLs, target refractive error to achieve best uncorrected distance and near vision was in the range of -1.00 D to -1.50 D (spherical equivalent).

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Parapapillary gamma zone hole.
J. Glaucoma
PUBLISHED: 12-05-2013
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To describe the appearance of a defect in the parapapillary region of a highly myopic eye.
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Peripapillary ring: histology and correlations.
Acta Ophthalmol
PUBLISHED: 10-09-2013
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To assess the histologic correlate of the peripapillary ring (PPR) as the optic disc boundary, to measure it histomorphometrically and to assess its associations with glaucoma and axial length.
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Dry eye disease, dry eye symptoms and depression: the Beijing Eye Study.
Br J Ophthalmol
PUBLISHED: 09-07-2013
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To investigate the association between dry eye symptoms and depression in an adult population.
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Cytomegalovirus retinitis in patients with AIDS before and after introduction of HAART in China.
Eur J Ophthalmol
PUBLISHED: 09-05-2013
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Purpose: To determine the prevalence of cytomegalovirus retinitis (CMVR) and other fundus lesions in subjects with acquired immunodeficiency syndrome (AIDS) before and after the introduction of highly active antiretroviral therapy (HAART) in China.

Methods: The retrospective study included subjects with AIDS who consecutively attended a third referral center in Beijing before and after HAART was introduced. Comprehensive systemic and ophthalmic examinations, including CD4+ T-cell count, ophthalmoscopy, and fundus photography, were carried out.

Results: A total of 173 HIV-infected, HAART-naive individuals and 267 people undergoing HAART were included in the study. The HAART-naive group as compared with the HAART group was significantly older (39.5 ± 11.5 years versus 36.7 ± 11.2 years; p = 0.02) and included significantly more men (p = 0.045). Prevalence of CMVR, microvascular retinopathy, and optic neuropathy in the HAART group (9.0 ± 1.8%, 7.9 ± 1.7%, and 4.9 ± 1.3%, respectively) were significantly (all p?0.001) lower than in the HAART-naive group (20.2 ± 3.1%, 31.2 ± 3.5%, and 13.9 ± 2.6%, respectively). Microvascular retinopathy was significantly associated with HAART-naive status (p<0.001; odds ratio [OR] 0.20; 95% confidence interval [CI] 0.12, 0.36) and higher age (p = 0.002; OR 1.04; 95% CI 1.10, 1.06). Cytomegalovirus retinitis was significantly associated with CD4+ cell count <50 cells/?L (p = 0.001; OR 5.50; 95% CI 1.95, 15.5), HAART-naive status (p = 0.02; OR 0.23; 95% CI 0.07, 0.79), and lower best-corrected visual acuity (p<0.001; OR 5.44; 95% CI 2.11, 14.0).

Conclusions: As in Western countries, prevalence of CMVR and microvascular retinopathy in Chinese subjects with AIDS were significantly associated with a low CD4+ cell count and a HAART-naive status as the 2 major risk factors.

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Meta-analysis of the effect of intravitreal bevacizumab versus intravitreal triamcinolone acetonide in central retinal vein occlusion.
J Ocul Pharmacol Ther
PUBLISHED: 08-24-2013
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To further evaluate the effect of intravitreal bevacizumab (IVB) for the treatment of central retinal vein occlusion (CRVO) by meta-analysis.
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Lack of association between primary angle-closure glaucoma susceptibility loci and the ocular biometric parameters anterior chamber depth and axial length.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 08-08-2013
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Three susceptibility loci for primary angle-closure glaucoma (PACG) were recently identified: PLEKHA7 rs11024102, COL11A1 rs3753841, and rs1015213 located in the intergenic region between PCMTD1 and ST18. The purpose of this study was to investigate the associations of these loci with the ocular biometric parameters anterior chamber depth (ACD) and axial length (AL).
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Visual impairment and spectacle use in schoolchildren in rural and urban regions in Beijing.
Eur J Ophthalmol
PUBLISHED: 08-07-2013
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Purpose: To determine prevalence and associations of visual impairment and frequency of spectacle use among grade 1 and grade 4 students in Beijing.

Methods: This school-based, cross-sectional study included 382 grade 1 children (age 6.3 ± 0.5 years) and 299 grade 4 children (age 9.4 ± 0.7 years) who underwent a comprehensive eye examination including visual acuity, noncycloplegic refractometry, and ocular biometry.

Results: Presenting visual acuity (mean 0.04 ± 0.17 logMAR) was associated with younger age (p = 0.002), hyperopic refractive error (p<0.001), and male sex (p = 0.03). Presenting visual impairment (presenting visual acuity ?20/40 in the better eye) was found in 44 children (prevalence 6.64 ± 1.0% [95% confidence interval (CI) 4.74, 8.54]). Mean best-corrected visual acuity (right eyes -0.02 ± 0.04 logMAR) was associated with more hyperopic refractive error (p = 0.03) and rural region of habitation (p<0.001). The prevalence of best-corrected visual impairment (best-corrected visual acuity ?20/40 in the better eye) was 2/652 (0.30 ± 0.21% [95% CI 0.00, 0.72]). Undercorrection of refractive error was present in 53 children (7.99 ± 1.05%) and was associated with older age (p = 0.003; B 0.53; OR 1.71 [95% CI 1.20, 2.42]), myopic refractive error (p = 0.001; B -0.72; OR 0.49 [95% CI 0.35, 0.68]), and longer axial length (p = 0.002; B 0.74; OR 2.10 [95% CI 1.32, 3.32]). Spectacle use was reported for 54 children (8.14 ± 1.06%). Mean refractive error of the worse eyes of these children was -2.09 ± 2.88 D (range -7.38 to +7.25 D).

Conclusions: Factors associated with presenting visual impairment were older age, myopic refractive error, and higher maternal education level. Despite a prevalence of myopia of 33% in young schoolchildren in Greater Beijing, prevalence of best-corrected visual impairment (0.30% ± 0.21%), presenting visual impairment (6.64% ± 1.0%), and undercorrection of refractive error (7.99% ± 1.05%) were relatively low.

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Prevalence of myelinated retinal nerve fibres in adult Indians: the Central India Eye and Medical Study.
Acta Ophthalmol
PUBLISHED: 07-09-2013
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Purpose:? To determine the prevalence of myelinated retinal nerve fibers in the adult Indian population. Methods:? The Central India Eye and Medical Study performed in rural Central India included 4711 participants aged 30+ years. The participants underwent a detailed ophthalmic and medical examination. Results:? Readable fundus photographs were available for 8645 eyes of 4485 (95.2%) subjects. Myelinated retinal nerve fibers were detected in 52 eyes (46 subjects) with a prevalence rate of 0.58?±?0.08 per 100 eyes [95% confidence interval (CI): 0.42, 0.74] and 1.03?±?0.15 per 100 subjects (95%CI: 0.73, 1.32). Prevalence of myelinated retinal nerve fibers was significantly associated hyperopic refractive error (p?=?0.008; OR: 1.31; 95%CI: 1.07, 1.59). It was not significantly associated with age (p?=?0.11), best corrected visual acuity (logMAR; p?=?0.33), intraocular pressure (p?=?0.09), amount of nuclear cataract (p?=?0.93), optic disc area (p?=?0.60), presence of glaucomatous optic nerve atrophy (p?=?0.62), and early age-related macular degeneration (p?=?0.53). Conclusions:? Myelinated retinal nerve fibers are present in about 10 out of 1000 adult Indians in rural Central India, with a higher prevalence in hyperopic eyes. Prevalence of myelinated retinal nerve fibers was not associated with age, visual acuity, glaucoma and macular degeneration.
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Vascular endothelial growth factor in Coats disease.
Acta Ophthalmol
PUBLISHED: 06-13-2013
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Purpose:? To examine whether vascular endothelial growth factor (VEGF) as one of the most important intraocular cytokines for angiogenesis and increased vascular permeability is associated with Coats disease. Methods:? The clinical interventional study included 28 patients with Coats disease and seven control patients with congenital cataract. During intraocular surgery, we obtained aqueous humour samples in which the VEGF concentration was measured by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Coats disease was graded into four stages. Results:? The mean aqueous VEGF level was significantly higher in the Coats study group than in the control group (158?±?88 versus 97?±?21?pg/ml; p?=?0.002). The VEGF concentrations increased significantly (p?
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Optical coherence tomography-assisted enhanced depth imaging of central serous chorioretinopathy.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 06-06-2013
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To describe characteristics of central serous chorioretinopathy (CSC) imaged by optical coherence tomography-assisted enhanced depth imaging (EDI-OCT).
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The microglial system in the eye and brain in response to stimuli in vivo.
J. Glaucoma
PUBLISHED: 06-05-2013
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Microglial cells function as first responders to signal inflammation, react to injuries by creating a wall to block invaders, and clear debris from the site. To better understand the modulation of microglia in inflammation and injury of eye and brain, we developed a morphological and orienting classification system of each stage of microglia, calling it the Spider Effect. We transected the olfactory bulb of rats and examined the activation of the microglial system histologically. Six stages of bidirectional microglial activation (A) and deactivation (R) were observed. Our findings support a morphologically defined stepwise activation and deactivation of microglia cells. This relates to inflammation in the eye due to noxious stimuli, injury, or increase in pressure. Future studies may address the reported modulation of the microglial system in retina and optic nerve head in acute and chronic glaucoma.
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Intracranial pressure and glaucoma.
J. Glaucoma
PUBLISHED: 06-05-2013
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Eyes with normal-tension and high-tension glaucoma can have a similar optic nerve head appearance, which differs markedly from the optic disc appearance in vascular optic neuropathies. Factors in addition to intraocular pressure (IOP) may play a role in the pathogenesis of glaucomatous optic neuropathy. Clinical and experimental studies have shown (1) physiologic associations between cerebrospinal fluid pressure (CSFP), systemic arterial blood pressure, IOP, and body mass index; (2) that a low CSFP was associated with the development of glaucomatous optic nerve damage in cats; and (3) that patients with normal-tension glaucoma had significantly lower CSFP and a higher trans-lamina cribrosa pressure difference when compared to normal subjects. Due to anatomic reasons, the orbital CSFP and the optic nerve tissue pressure (and not the atmospheric pressure) form the retro-laminar counter-pressure against the IOP and are thus part of the trans-lamina cribrosa pressure difference and gradient. Assuming that an elevated trans-lamina cribrosa pressure difference and a steeper trans-lamina cribrosa pressure gradient are important for glaucomatous optic nerve damage, a low orbital CSFP would therefore play a role in the pathogenesis of normal-tension glaucoma. Due to the association between CSFP and blood pressure, a low blood pressure would also be indirectly involved.
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Low cerebrospinal fluid pressure in the pathogenesis of primary open-angle glaucoma: epiphenomenon or causal relationship? The Beijing Intracranial and Intraocular Pressure (iCOP) study.
J. Glaucoma
PUBLISHED: 06-05-2013
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Previous experimental and clinical investigations have suggested that some patients with primary open-angle glaucoma may have an abnormally low orbital cerebrospinal fluid pressure (CSFP). A meta-analysis of available clinical data showed a marked overlap in lumbar CSFP measurements between patients with normal-tension glaucoma and healthy subjects, so that the question arises as to which additional factors play a role in the pathogenesis of glaucomatous optic neuropathy.
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Accuracy of matching optic discs with visual fields: the European Structure and Function Assessment Trial (ESAFAT).
Ophthalmology
PUBLISHED: 05-21-2013
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To determine the ability of ophthalmologists across Europe to match stereoscopic optic disc photographs to visual fields of varying severity.
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Cerebrospinal Fluid Pressure and Glaucoma.
J Ophthalmic Vis Res
PUBLISHED: 05-19-2013
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Eyes with normal-pressure glaucoma and those with high-pressure glaucoma can show a similar optic nerve head appearance, while eyes with vascular optic neuropathies show a markedly different optic disc appearance. Factors in addition to intraocular pressure (IOP) may thus play a role in the pathogenesis of glaucomatous optic neuropathy. Clinical and experimental studies showed that (1) physiologic associations between cerebrospinal fluid (CSF) pressure, systemic arterial blood pressure, IOP and body mass index exist; (2) a low CSF pressure was associated with the development of glaucomatous optic nerve damage in cats; (3) patients with normal (intraocular) pressure glaucoma had significantly lower CSF pressure and a higher trans lamina cribrosa pressure difference when compared to normal subjects; and (4) patients with normal- pressure glaucoma as compared with patients with high-pressure glaucoma have a significantly narrower orbital CSF space. A shallow orbital CSF space has been shown to be associated with a low CSF pressure. Due to anatomic reasons, the orbital CSF pressure and the optic nerve tissue pressure (and not the atmospheric pressure) form the retro-laminar counter-pressure against the IOP and are thus part of the trans-lamina cribrosa pressure difference and gradient. Assuming that an elevated trans-lamina cribrosa pressure difference and a steeper trans-lamina cribrosa pressure gradient are important for glaucomatous optic nerve damage, a low orbital CSF pressure would therefore play a role in the pathogenesis of normal-(intraocular) pressure glaucoma. Due to the association between CSF pressure and blood pressure, a low blood pressure could be indirectly involved.
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Retinal nerve fibre layer cross-sectional area, neuroretinal rim area and body mass index.
Acta Ophthalmol
PUBLISHED: 05-04-2013
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To examine associations between body mass index, neuroretinal rim area and retinal nerve fibre layer cross-sectional area (RNFLCRA) in a population-based setting.
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Valsalva manoeuver, intra-ocular pressure, cerebrospinal fluid pressure, optic disc topography: Beijing intracranial and intra-ocular pressure study.
Acta Ophthalmol
PUBLISHED: 05-04-2013
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To assess whether a Valsalva manoeuver influences intra-ocular pressure (IOP), cerebrospinal fluid pressure (CSF-P) and, by a change in the trans-laminar cribrosa pressure difference, optic nerve head morphology.
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Noninvasive intracranial pressure estimation by orbital subarachnoid space measurement: the Beijing Intracranial and Intraocular Pressure (iCOP) study.
Crit Care
PUBLISHED: 04-21-2013
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The orbital subarachnoid space surrounding the optic nerve is continuous with the circulation system for cerebrospinal fluid (CSF) and can be visualized by using magnetic resonance imaging (MRI). We hypothesized that the orbital subarachnoid space width (OSASW) is correlated with and can serve as a surrogate for intracranial pressure (ICP). Our aim was to develop a method for a noninvasive measurement of the intracranial CSF-pressure (CSF-P) based on MRI-assisted OSASW.
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Myopic Maculopathy Imaged by Optical Coherence Tomography: The Beijing Eye Study.
Ophthalmology
PUBLISHED: 02-26-2013
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To examine the features of myopia-related optical coherence tomography (OCT) findings in a population-based setting.
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Retinal nerve fibre layer thickness measured by Spectralis spectral-domain optical coherence tomography: The Beijing Eye Study.
Acta Ophthalmol
PUBLISHED: 01-31-2013
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The aim of this study was to measure retinal nerve fibre layer thickness (RNFLT) and its associated factors in a population-based setting.
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Intravitreal low-dosage bevacizumab for retinopathy of prematurity.
Acta Ophthalmol
PUBLISHED: 01-29-2013
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To report on the therapeutic effect of intravitreal low-dose bevacizumab for treatment for retinopathy of prematurity (ROP).
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Global prevalence of vision impairment and blindness: magnitude and temporal trends, 1990-2010.
Ophthalmology
PUBLISHED: 01-11-2013
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Vision impairment is a leading and largely preventable cause of disability worldwide. However, no study of global and regional trends in the prevalence of vision impairment has been carried out. We estimated the prevalence of vision impairment and its changes worldwide for the past 20 years.
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Asymptomatic Polyvascular Abnormalities in Community (APAC) Study in China: Objectives, Design and Baseline Characteristics.
PLoS ONE
PUBLISHED: 01-01-2013
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The population-based "Asymptomatic Polyvascular Abnormalities in Community (APAC) Study was designed to examine prevalence and associations of asymptomatic polyvascular abnormalities (APA) in a general population. In this report, the objectives, design and baseline data of the APAC study are described.
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Refractive error, visual acuity and causes of vision loss in children in shandong, china. The shandong children eye study.
PLoS ONE
PUBLISHED: 01-01-2013
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To examine the prevalence of refractive errors and prevalence and causes of vision loss among preschool and school children in East China.
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Prevalence and associated factors for pterygium in rural agrarian central India. The central India eye and medical study.
PLoS ONE
PUBLISHED: 01-01-2013
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To evaluate the prevalence of pterygia and associated factors in a rural population in a mostly undeveloped agrarian region.
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Trans-lamina cribrosa pressure difference and open-angle glaucoma. The central India eye and medical study.
PLoS ONE
PUBLISHED: 01-01-2013
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To assess associations of the trans-lamina cribrosa pressure difference (TLCPD) with glaucomatous optic neuropathy.
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Peripapillary intrachoroidal cavitations. The Beijing eye study.
PLoS ONE
PUBLISHED: 01-01-2013
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To assess prevalence, size and location of peripapillary intrachoroidal cavitations (PICCs) and their associations in a population-based sample. .
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Peripapillary arterial circle of zinn-haller: location and spatial relationships with myopia.
PLoS ONE
PUBLISHED: 01-01-2013
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To measure histomorphometrically the location of the peripapillary arterial circle of Zinn-Haller (ZHAC) and assess its associations with axial length.
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Pseudoexfoliation: normative data and associations. The central India eye and medical study.
PLoS ONE
PUBLISHED: 01-01-2013
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To assess the prevalence of pseudoexfoliation (PEX) and its associations in a population-based setting.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.