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BH3 Mimetics Inhibit Growth of Chondrosarcoma - A Novel Targeted-therapy for Candidate Models.
Anticancer Res.
PUBLISHED: 11-05-2014
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Chondrosarcoma is refractory to conventional chemotherapy. BH-3 mimetics ABT-737 and ABT-263 are synthetic small-molecule inhibitors of anti-apoptotic proteins B-cell lymphoma-2 (Bcl2) and Bcl-xL, which play a critical role in survival of chondrosarcoma cells.
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Phys. Rev. Lett.
PUBLISHED: 10-20-2014
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A search for scalar particles decaying via narrow resonances into two photons in the mass range 65-600 GeV is performed using 20.3??fb^{-1} of sqrt[s]=8??TeV pp collision data collected with the ATLAS detector at the Large Hadron Collider. The recently discovered Higgs boson is treated as a background. No significant evidence for an additional signal is observed. The results are presented as limits at the 95% confidence level on the production cross section of a scalar boson times branching ratio into two photons, in a fiducial volume where the reconstruction efficiency is approximately independent of the event topology. The upper limits set extend over a considerably wider mass range than previous searches.
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Evidence for Electroweak Production of W^{±}W^{±}jj in pp Collisions at sqrt[s]=8??TeV with the ATLAS Detector.
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Phys. Rev. Lett.
PUBLISHED: 10-03-2014
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This Letter presents the first study of W^{±}W^{±}jj, same-electric-charge diboson production in association with two jets, using 20.3??fb^{-1} of proton-proton collision data at sqrt[s]=8??TeV recorded by the ATLAS detector at the Large Hadron Collider. Events with two reconstructed same-charge leptons (e^{±}e^{±}, e^{±}?^{±}, and ?^{±}?^{±}) and two or more jets are analyzed. Production cross sections are measured in two fiducial regions, with different sensitivities to the electroweak and strong production mechanisms. First evidence for W^{±}W^{±}jj production and electroweak-only W^{±}W^{±}jj production is observed with a significance of 4.5 and 3.6 standard deviations, respectively. The measured production cross sections are in agreement with standard model predictions. Limits at 95% confidence level are set on anomalous quartic gauge couplings.
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D-dimer levels in the differential diagnosis between lipoma and well-differentiated liposarcoma.
Anticancer Res.
PUBLISHED: 09-10-2014
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Lipoma and well-differentiated liposarcoma (WDLS) are two representative lipogenic soft tissue tumors that have similar clinical, radiological, and pathological characteristics. Accordingly, it is difficult to distinguish these tumors preoperatively. Plasma D-dimer levels are associated with the status of tumor progression, and we hypothesized that D-dimer levels could contribute to differential diagnosis. The D-dimer levels of these two entities have not yet been reported.
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[Correlation of PBX2/ELF2 expression with prognosis of non-small cell lung cancer].
Zhejiang Da Xue Xue Bao Yi Xue Ban
PUBLISHED: 09-05-2014
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To investigate the relationship between pre B cell leukemia transcription factor 2 (PBX2)/Ets domain transcription factor 2 (ELF2) expression with prognosis of non-small cell lung cancer (NSCLC).
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Embolic Effects of Transcatheter Mesenteric Arterial Embolization with Microspheres on the Small Bowel in a Dog Model.
J Vasc Interv Radiol
PUBLISHED: 08-06-2014
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To determine the arterial distribution and ischemic effects of various particle sizes after transcatheter embolization of the small bowel in a dog model.
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Clear cell adenocarcinoma of the peritoneum: a case report and literature review.
J Ovarian Res
PUBLISHED: 08-05-2014
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Clear cell adenocarcinoma (CCC) is generally thought to originate from ovarian, endometrial, or renal tissue. A CCC of the peritoneum (CCAP) is an extremely rare medical condition and is associated with a poor prognosis. To date, only 10 cases of CCAP have been reported, of which half resulted in death or recurrence within 6 months after initial treatment because CCAP is commonly resistant to multiple drugs. In this report, we present a case of CCAP of the pouch of Douglas coexisting with an endometriosis and we offer a review of the related literature.
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Evaluation of PSF1 as a prognostic biomarker for prostate cancer.
Prostate Cancer Prostatic Dis.
PUBLISHED: 08-03-2014
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Background:Partner of SLD5 1 (PSF1) is an evolutionarily conserved DNA replication factor. Previous studies have suggested that transcriptional activity of the PSF1 gene correlated with malignancy of cancer cells. The objective of the current study was to evaluate the relationship between PSF1 expression and the clinical features of prostate cancer.Methods:We determined the expression of PSF1 in 120 needle biopsy samples of prostate cancer by immunohistochemistry. We divided patients into PSF1-positive or -negative groups and analyzed the relationships between the expression of PSF1, the Gleason score, PSA level, TNM classification and prognosis.Results:Our results showed that the PSF1 expression correlated significantly with PSA values at diagnosis (P=0.0028), with tumor grade (P<0.0001), and with clinical stage (P=0.0005). Moreover, the PSF1 expression correlated significantly with overall survival (hazard ratio (HR) 5.5; 95% confidence interval (CI) 2.17-15.8; P=0.003) and progression-free survival in 99 consecutive patients with prostate cancer. Noteworthy, the prognosis of PSF1-positive cases was also worse in patients with a Gleason score of 8-10 (HR 3.7; 95% CI 1.28-13.43; P=0.0143). Limitations include that this study had a retrospective design, that patients in the study were heterogeneous and included those with early and advanced cancer, and that small tumor fragments may not be representative of the entire carcinoma.Conclusions:PSF1 is expressed in high-grade prostate cancer and may be a useful biomarker to identify patients with a poor prognosis at the time of diagnosis.Prostate Cancer and Prostatic Disease advance online publication, 18 November 2014; doi:10.1038/pcan.2014.46.
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V843I, a lung cancer predisposing EGFR mutation, is responsible for resistance to EGFR tyrosine kinase inhibitors.
J Thorac Oncol
PUBLISHED: 07-25-2014
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We previously demonstrated that a family predisposed to lung cancer harbored a V843I substitution in the epidermal growth factor receptor (EGFR) protein. We report here the further characterization of this mutant EGFR protein in the context of tumorigenicity and resistance to tyrosine kinase inhibitors (TKIs) of EGFR activity.
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Prospective multicenter surveillance and risk factor analysis of deep surgical site infection after posterior thoracic and/or lumbar spinal surgery in adults.
J Orthop Sci
PUBLISHED: 07-24-2014
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Surgical site infection is a serious and significant complication after spinal surgery and is associated with high morbidity rates, high healthcare costs and poor patient outcomes. Accurate identification of risk factors is essential for developing strategies to prevent devastating infections. The purpose of this study was to identify independent risk factors for surgical site infection among posterior thoracic and/or lumbar spinal surgery in adult patients using a prospective multicenter surveillance research method.
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Uterine cervical cancer displaying tumor-related leukocytosis: a distinct clinical entity with radioresistant feature.
J. Natl. Cancer Inst.
PUBLISHED: 07-01-2014
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Tumor-related leukocytosis (TRL) is occasionally found in patients with nonhematopoietic malignancies. We investigated the clinical implication of TRL and individualized treatment for TRL-positive cervical cancer, as well as the underlying biological mechanism.
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Measurements of four-lepton production at the Z resonance in pp collisions at sqrt[s] = 7 and 8 TeV with ATLAS.
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Nedden, G Zurzolo, V Zutshi, L Zwalinski, .
Phys. Rev. Lett.
PUBLISHED: 06-13-2014
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Measurements of four-lepton (4?, ?=e,?) production cross sections at the Z resonance in pp collisions at the LHC with the ATLAS detector are presented. For dilepton and four-lepton invariant mass regions m(?+?(-)) > 5 GeV and 80
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Evaluation of the new IASLC/ATS/ERS proposed classification of adenocarcinoma based on lepidic pattern in patients with pathological stage IA pulmonary adenocarcinoma.
Gen Thorac Cardiovasc Surg
PUBLISHED: 05-19-2014
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The International association for the study of cancer (IASLC)/American thoracic society (ATS)/European respiratory society (ERS) has established a new subclassification of lung adenocarcinoma, especially for the lepidic pattern component, formerly called bronchioloalveolar adenocarcinoma (BAC). According to the new classification, BAC has been classified into the following 4 main subtypes: adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), invasive adenocarcinoma (IA), and variants of invasive adenocarcinoma (VIA). An observational study was conducted to validate this classification in patients with pathological stage IA pulmonary adenocarcinoma.
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Endometrial adenocarcinoma arising in a Turner's syndrome patient with spontaneous menstruation: a case report.
J Reprod Med
PUBLISHED: 04-15-2014
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Women with Turner's syndrome exhibit anovulation, and the majority do not spontaneously menstruate. We present an unusual case of endometrial adenocarcinoma developing in a Turner's syndrome patient who was exhibiting spontaneous menstruation while not receiving regular hormone therapy.
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Prognostic importance of volumetric measurements in stage I lung adenocarcinoma.
Radiology
PUBLISHED: 04-06-2014
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To perform volumetric analysis of stage I lung adenocarcinomas by using an automated computer program and to determine value of volumetric computed tomographic (CT) measurements associated with prognostic factors and outcome.
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Esophageal early basaloid squamous carcinoma with unusual narrowband imaging magnified endoscopy findings.
World J. Gastroenterol.
PUBLISHED: 04-02-2014
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Basaloid squamous carcinoma (BSC) is a rare variant of esophageal cancer. There are very few reports of "early" BSC. Here we report a case of early BSC with unusual findings by narrowband imaging magnified endoscopy (NBI-ME). A 70-year-old man with a middle thoracic esophageal tumor was referred to our hospital. White-light endoscopy revealed a reddish depressed lesion 5 mm in diameter having a subepithelial tumor-like prominence with a gentle rising slope. NBI-ME revealed irregular loop-shaped microvessels coexistent with thick irregularly branched non-looped vessels. Iodine staining revealed a pale brown lesion. We performed endoscopic submucosal dissection for diagnostic treatment. Histologic examination showed the proliferation of basal cell-like hyperchromatic tumor cells in the lamina propria and with slight invasion into the submucosa at a depth of 320 ?m. The tumor cells formed solid nests and microcystic structures, containing an Alcian blue-positive mucoid matrix. The surface was covered with squamous epithelium without cellular atypia. Thin vessels were observed in the intra-epithelial papilla and thick vessels were observed around the solid nests beneath the epithelium. Based on these findings together, we diagnosed the lesion as BSC. In this case, the NBI-ME findings differed from those of typical squamous cell carcinoma in that both non-invasive cancer-like irregular loop-shaped microvessels coexisted with massively invasive cancer-like thick non-looped vessels. We speculate that the looped and non-looped vessels observed by NBI-ME histologically corresponded to thin vessels in the intra-epithelial papilla and thick vessels around the tumor nests, respectively. These NBI-ME findings might be a feature of early esophageal BSC.
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Esophageal adenocarcinoma with white opaque substance observed by magnifying endoscopy with narrow band imaging.
Dig Endosc
PUBLISHED: 03-31-2014
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White opaque substance (WOS) is observed in the gastric neoplasia of 0-IIa type using magnifying endoscopy with narrow band imaging (NBI-ME). Colonic and duodenal neoplasms with WOS have also been reported. Immunohistochemical examination with adipophilin reveals WOS in gastric neoplasms as lipid droplets, and WOS is specific for neoplasm with intestinal or gastrointestinal phenotype. We herein report a case of adenocarcinoma of the esophagogastric junction with WOS. A male patient in his sixties was found by esophagogastroduodenoscopy to have an esophageal elevated lesion. NBI-ME showed whitish deposits that looked similar to WOS in gastric neoplasms. The patient underwent endoscopic submucosal dissection and the lesion was resected in a single piece. This tumor had diffuse positivity for adipophilin and gastrointestinal phenotype.
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Intrahepatic cholangiocarcinoma in a worker at an offset color proof-printing company: An autopsy case report.
Hepatol. Res.
PUBLISHED: 03-20-2014
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A 40-year-old Japanese man visited our hospital after test results indicated elevated hepatobiliary enzymes. He had worked at a printing plant for 8 years and been exposed to organic solvents, including 1,2-dichloropropane (1,2-DCP) and dichloromethane (DCM). Abdominal computed tomography (CT) showed an intrahepatic tumor with dilation of the intrahepatic bile duct. He was diagnosed with intrahepatic cholangiocarcinoma. He had no known risk factors for cholangiocarcinoma. Extended left hepatectomy with lymph node dissection was performed and the tumor was histologically diagnosed as well-differentiated adenocarcinoma. A histological examination also showed biliary intraepithelial preneoplastic lesions in non-cancerous liver areas. Two years after surgery, the patient developed jaundice, esophageal varices and ascites. A CT examination showed liver cirrhosis without recurrence of the cholangiocarcinoma. Although a liver transplantation was planned as a therapeutic option for his liver cirrhosis, his liver failure progressed rapidly and he died before transplantation could be performed. At autopsy, fibrosis was found in the whole liver, especially in the wall of the bile duct and periductal area suggesting chronic bile duct injury due to exposure to organic solvents. Taken together, the current case may suggest that exposure to organic solvents, including 1,2-DCP and DCM, is a risk factor for cholangiocarcinoma. Identifying risk factors for cholangiocarcinoma will help identify the mechanism and help prevent development of the disease.
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Assessment of combination of contrast-enhanced magnetic resonance imaging and positron emission tomography/computed tomography for evaluation of ovarian masses.
Invest Radiol
PUBLISHED: 03-19-2014
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The objectives of this study were to correlate fluorodeoxyglucose uptake in ovarian masses on positron emission tomography/computed tomography (PET/CT) with pathological grades of malignancy and subtypes and to determine the appropriate approach for combining PET/CT and contrast-enhanced magnetic resonance imaging (CE-MRI) to characterize ovarian masses.
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In Vivo Evaluation of Irinotecan-Loaded QuadraSphere Microspheres for Use in Chemoembolization of VX2 Liver Tumors.
J Vasc Interv Radiol
PUBLISHED: 03-11-2014
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To investigate the pharmacokinetics and chemoembolization efficacy of irinotecan-loaded QuadraSphere microspheres (QSMs) in a rabbit VX2 liver tumor model.
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Search for quantum black hole production in high-invariant-mass lepton+jet final states using pp collisions at ?s=8? TeV and the ATLAS detector.
G Aad, T Abajyan, B Abbott, J Abdallah, S Abdel Khalek, O Abdinov, R Aben, B Abi, M Abolins, O S AbouZeid, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, L Adamczyk, D L Adams, T N Addy, J Adelman, S Adomeit, T Adye, S Aefsky, T Agatonovic-Jovin, J A Aguilar-Saavedra, M Agustoni, S P Ahlen, A Ahmad, F Ahmadov, G Aielli, T P A Akesson, G Akimoto, A V Akimov, M A Alam, J Albert, S Albrand, M J Alconada Verzini, M Aleksa, I N Aleksandrov, C Alexa, G Alexander, G Alexandre, T Alexopoulos, M Alhroob, G Alimonti, L Alio, J Alison, B M M Allbrooke, L J Allison, P P Allport, S E Allwood-Spiers, J Almond, A Aloisio, R Alon, A Alonso, F Alonso, A Altheimer, B Alvarez Gonzalez, M G Alviggi, K Amako, Y Amaral Coutinho, C Amelung, V V Ammosov, S P Amor Dos Santos, A Amorim, S Amoroso, N Amram, G Amundsen, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, G Anders, K J Anderson, A Andreazza, V Andrei, X S Anduaga, S Angelidakis, P Anger, A Angerami, F Anghinolfi, A V Anisenkov, N Anjos, A 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Catinaccio, J R Catmore, A Cattai, G Cattani, S Caughron, V Cavaliere, D Cavalli, M Cavalli-Sforza, V Cavasinni, F Ceradini, B Cerio, K Cerny, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, M Cerv, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, I Chalupkova, K Chan, P Chang, B Chapleau, J D Chapman, D Charfeddine, D G Charlton, V Chavda, C A Chavez Barajas, S Cheatham, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, H Chen, K Chen, L Chen, S Chen, X Chen, Y Chen, H C Cheng, Y Cheng, A Cheplakov, R Cherkaoui El Moursli, V Chernyatin, E Cheu, L Chevalier, V Chiarella, G Chiefari, J T Childers, A Chilingarov, G Chiodini, A S Chisholm, R T Chislett, A Chitan, M V Chizhov, S Chouridou, B K B Chow, I A Christidi, D Chromek-Burckhart, M L Chu, J Chudoba, G Ciapetti, A K Ciftci, R Ciftci, D Cinca, V Cindro, A Ciocio, P Cirkovic, Z H Citron, M Citterio, M Ciubancan, A Clark, P J Clark, R N Clarke, W Cleland, J C Clemens, B Clement, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, L Coffey, J G Cogan, J Coggeshall, B Cole, S Cole, A P Colijn, C Collins-Tooth, J Collot, T Colombo, G Colon, G Compostella, P Conde Muiño, E Coniavitis, M C Conidi, I A Connelly, S M Consonni, V Consorti, S Constantinescu, C Conta, G Conti, F Conventi, M Cooke, B D Cooper, A M Cooper-Sarkar, N J Cooper-Smith, K Copic, T Cornelissen, M Corradi, F Corriveau, A Corso-Radu, A Cortes-Gonzalez, G Cortiana, G Costa, M J Costa, R Costa Batalha Pedro, D Costanzo, D Côté, G Cottin, G Cowan, B E Cox, K Cranmer, G Cree, S Crépé-Renaudin, F Crescioli, M Crispin Ortuzar, M Cristinziani, G Crosetti, C-M Cuciuc, C Cuenca Almenar, T Cuhadar Donszelmann, J Cummings, M Curatolo, C Cuthbert, H Czirr, P Czodrowski, Z Czyczula, S D'Auria, M D'Onofrio, A D'Orazio, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, A Dafinca, T Dai, F Dallaire, C Dallapiccola, M Dam, A C Daniells, M Dano Hoffmann, V Dao, G Darbo, G L Darlea, S Darmora, J A Dassoulas, W Davey, C David, T Davidek, E Davies, M Davies, O Davignon, A R Davison, Y Davygora, E Dawe, I Dawson, R K Daya-Ishmukhametova, K De, R de Asmundis, S De Castro, S De Cecco, J de Graat, N De Groot, P de Jong, C De La Taille, H De la Torre, F De Lorenzi, L De Nooij, D De Pedis, A De Salvo, U De Sanctis, A De Santo, J B De Vivie De Regie, G De Zorzi, W J Dearnaley, R Debbe, C Debenedetti, B Dechenaux, D V Dedovich, J Degenhardt, I Deigaard, J Del Peso, T Del Prete, T Delemontex, F Deliot, M Deliyergiyev, A Dell'Acqua, L Dell'Asta, M Della Pietra, D Della Volpe, M Delmastro, P A Delsart, C Deluca, S Demers, M Demichev, A Demilly, B Demirkoz, S P Denisov, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, P O Deviveiros, A Dewhurst, S Dhaliwal, A Di Ciaccio, L Di Ciaccio, C Di Donato, A Di Girolamo, B Di Girolamo, A Di Mattia, B Di Micco, R Di Nardo, A Di Simone, R Di Sipio, D Di Valentino, M A Diaz, E B Diehl, J Dietrich, T A Dietzsch, S Diglio, A Dimitrievska, K Dindar Yagci, J Dingfelder, C Dionisi, P Dita, S Dita, F Dittus, F Djama, T Djobava, M A B do Vale, A Do Valle Wemans, T K O Doan, D Dobos, E Dobson, C Doglioni, T Doherty, T Dohmae, J Dolejsi, Z Dolezal, B A Dolgoshein, M Donadelli, S Donati, P Dondero, J Donini, J Dopke, A Doria, A Dos Anjos, A Dotti, M T Dova, A T Doyle, M Dris, J Dubbert, S Dube, E Dubreuil, E Duchovni, G Duckeck, O A Ducu, D Duda, A Dudarev, F Dudziak, L Duflot, L Duguid, M Dührssen, M Dunford, H Duran Yildiz, M Düren, M Dwuznik, J Ebke, W Edson, C A Edwards, N C Edwards, W Ehrenfeld, T Eifert, G Eigen, K Einsweiler, T Ekelof, M El Kacimi, M Ellert, S Elles, F Ellinghaus, K Ellis, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, O C Endner, M Endo, R Engelmann, J Erdmann, A Ereditato, D Eriksson, G Ernis, J Ernst, M Ernst, J Ernwein, D Errede, S Errede, E Ertel, M Escalier, H Esch, C Escobar, X Espinal Curull, B Esposito, F Etienne, A I Etienvre, E Etzion, D Evangelakou, H Evans, L Fabbri, G Facini, R M Fakhrutdinov, S Falciano, Y Fang, M Fanti, A Farbin, A Farilla, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, B Fatholahzadeh, A Favareto, L Fayard, P Federic, O L Fedin, W Fedorko, M Fehling-Kaschek, S Feigl, L Feligioni, C Feng, E J Feng, H Feng, A B Fenyuk, S Fernandez Perez, W Fernando, S Ferrag, J Ferrando, V Ferrara, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, A Ferretto Parodi, M Fiascaris, F Fiedler, A Filipčič, M Filipuzzi, F Filthaut, M Fincke-Keeler, K D Finelli, M C N Fiolhais, L Fiorini, A Firan, J Fischer, M J Fisher, E A Fitzgerald, M Flechl, I Fleck, P Fleischmann, S Fleischmann, G T Fletcher, G Fletcher, T Flick, A Floderus, L R Flores Castillo, A C Florez Bustos, M J Flowerdew, A Formica, A Forti, D Fortin, D Fournier, H Fox, P Francavilla, M Franchini, S Franchino, D Francis, M Franklin, S Franz, M Fraternali, S Fratina, S T French, C Friedrich, F Friedrich, D Froidevaux, J A Frost, C Fukunaga, E Fullana Torregrosa, B G Fulsom, J Fuster, C Gabaldon, O Gabizon, A Gabrielli, S Gadatsch, T Gadfort, S Gadomski, G Gagliardi, P Gagnon, C Galea, B Galhardo, E J Gallas, V Gallo, B J Gallop, P Gallus, G Galster, K K Gan, R P Gandrajula, J Gao, Y S Gao, F M Garay Walls, F Garberson, C García, J E García Navarro, M Garcia-Sciveres, R W Gardner, N Garelli, V Garonne, C Gatti, G Gaudio, B Gaur, L Gauthier, P Gauzzi, I L Gavrilenko, C Gay, G Gaycken, E N Gazis, P Ge, Z Gecse, C N P Gee, D A A Geerts, Ch Geich-Gimbel, K Gellerstedt, C Gemme, A Gemmell, M H Genest, S Gentile, M George, S George, D Gerbaudo, A Gershon, H Ghazlane, N Ghodbane, B Giacobbe, S Giagu, V Giangiobbe, P Giannetti, F Gianotti, B Gibbard, S M Gibson, M Gilchriese, T P S Gillam, D Gillberg, A R Gillman, D M Gingrich, N Giokaris, M P Giordani, R Giordano, F M Giorgi, P Giovannini, P F Giraud, D Giugni, C Giuliani, M Giunta, B K Gjelsten, I Gkialas, L K Gladilin, C Glasman, J Glatzer, A Glazov, G L Glonti, M Goblirsch-Kolb, J R Goddard, J Godfrey, J Godlewski, C Goeringer, S Goldfarb, T Golling, D Golubkov, A Gomes, L S Gomez Fajardo, R Gonçalo, J Goncalves Pinto Firmino Da Costa, L Gonella, S González de la Hoz, G Gonzalez Parra, M L Gonzalez Silva, S Gonzalez-Sevilla, L Goossens, P A Gorbounov, H A Gordon, I Gorelov, G Gorfine, B Gorini, E Gorini, A Gorišek, E Gornicki, A T Goshaw, C Gössling, M I Gostkin, M Gouighri, D Goujdami, M P Goulette, A G Goussiou, C Goy, S Gozpinar, H M X Grabas, L Graber, I Grabowska-Bold, P Grafström, K-J Grahn, J Gramling, E Gramstad, F Grancagnolo, S Grancagnolo, V Grassi, V Gratchev, H M Gray, J A Gray, E Graziani, O G Grebenyuk, Z D Greenwood, K Gregersen, I M Gregor, P Grenier, J Griffiths, N Grigalashvili, A A Grillo, K Grimm, S Grinstein, Ph Gris, Y V Grishkevich, J-F Grivaz, J P Grohs, A Grohsjean, E Gross, J Grosse-Knetter, G C Grossi, J Groth-Jensen, Z J Grout, K Grybel, L Guan, F Guescini, D Guest, O Gueta, C Guicheney, E Guido, T Guillemin, S Guindon, U Gul, C Gumpert, J Gunther, J Guo, S Gupta, P Gutierrez, N G Gutierrez Ortiz, C Gutschow, N Guttman, C Guyot, C Gwenlan, C B Gwilliam, A Haas, C Haber, H K Hadavand, P Haefner, S Hageboeck, Z Hajduk, H Hakobyan, M Haleem, D Hall, G Halladjian, K Hamacher, P Hamal, K Hamano, M Hamer, A Hamilton, S Hamilton, L Han, K Hanagaki, K Hanawa, M Hance, P Hanke, J R Hansen, J B Hansen, J D Hansen, P H Hansen, P Hansson, K Hara, A S Hard, T Harenberg, S Harkusha, D Harper, R D Harrington, O M Harris, P F Harrison, F Hartjes, A Harvey, S Hasegawa, Y Hasegawa, S Hassani, S Haug, M Hauschild, R Hauser, M Havranek, C M Hawkes, R J Hawkings, A D Hawkins, T Hayashi, D Hayden, C P Hays, H S Hayward, S J Haywood, S J Head, T Heck, V Hedberg, L Heelan, S Heim, T Heim, B Heinemann, L Heinrich, S Heisterkamp, J Hejbal, L Helary, C Heller, M Heller, S Hellman, D Hellmich, C Helsens, J Henderson, R C W Henderson, C Hengler, A Henrichs, A M Henriques Correia, S Henrot-Versille, C Hensel, G H Herbert, Y Hernández Jiménez, R Herrberg-Schubert, G 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Vogel, P Vokac, G Volpi, M Volpi, H von der Schmitt, H von Radziewski, E von Toerne, V Vorobel, M Vos, R Voss, J H Vossebeld, N Vranjes, M Vranjes Milosavljevic, V Vrba, M Vreeswijk, T Vu Anh, R Vuillermet, I Vukotic, Z Vykydal, W Wagner, P Wagner, S Wahrmund, J Wakabayashi, J Walder, R Walker, W Walkowiak, R Wall, P Waller, B Walsh, C Wang, H Wang, J Wang, K Wang, R Wang, S M Wang, T Wang, X Wang, A Warburton, C P Ward, D R Wardrope, M Warsinsky, A Washbrook, C Wasicki, I Watanabe, P M Watkins, A T Watson, I J Watson, M F Watson, G Watts, S Watts, A T Waugh, B M Waugh, S Webb, M S Weber, S W Weber, J S Webster, A R Weidberg, P Weigell, J Weingarten, C Weiser, H Weits, P S Wells, T Wenaus, D Wendland, Z Weng, T Wengler, S Wenig, N Wermes, M Werner, P Werner, M Wessels, J Wetter, K Whalen, A White, M J White, R White, S White, D Whiteson, D Whittington, D Wicke, F J Wickens, W Wiedenmann, M Wielers, P Wienemann, C Wiglesworth, L A M Wiik-Fuchs, P A Wijeratne, A Wildauer, M A Wildt, H G Wilkens, J Z Will, H H Williams, S Williams, S Willocq, J A Wilson, A Wilson, I Wingerter-Seez, S Winkelmann, F Winklmeier, M Wittgen, T Wittig, J Wittkowski, S J Wollstadt, M W Wolter, H Wolters, B K Wosiek, J Wotschack, M J Woudstra, K W Wozniak, K Wraight, M Wright, S L Wu, X Wu, Y Wu, E Wulf, T R Wyatt, B M Wynne, S Xella, M Xiao, D Xu, L Xu, B Yabsley, S Yacoob, M Yamada, H Yamaguchi, Y Yamaguchi, A Yamamoto, K Yamamoto, S Yamamoto, T Yamamura, T Yamanaka, K Yamauchi, Y Yamazaki, Z Yan, H Yang, U K Yang, Y Yang, S Yanush, L Yao, Y Yasu, E Yatsenko, K H Yau Wong, J Ye, S Ye, A L Yen, E Yildirim, M Yilmaz, R Yoosoofmiya, K Yorita, R Yoshida, K Yoshihara, C Young, C J S Young, S Youssef, D R Yu, J Yu, J M Yu, L Yuan, A Yurkewicz, B Zabinski, R Zaidan, A M Zaitsev, A Zaman, S Zambito, L Zanello, D Zanzi, A Zaytsev, C Zeitnitz, M Zeman, A Zemla, K Zengel, O Zenin, T Zeniš, D Zerwas, G Zevi Della Porta, D Zhang, H Zhang, J Zhang, L Zhang, X Zhang, Z Zhang, Z Zhao, A Zhemchugov, J Zhong, B Zhou, L Zhou, N Zhou, C G Zhu, H Zhu, J Zhu, Y Zhu, X Zhuang, A Zibell, D Zieminska, N I Zimin, C Zimmermann, R Zimmermann, S Zimmermann, Z Zinonos, M Ziolkowski, R Zitoun, L Zivkovic, G Zobernig, A Zoccoli, M Zur Nedden, G Zurzolo, V Zutshi, L Zwalinski, .
Phys. Rev. Lett.
PUBLISHED: 03-05-2014
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This Letter presents a search for quantum black-hole production using 20.3 fb-1 of data collected with the ATLAS detector in pp collisions at the LHC at ?s = 8 TeV. The quantum black holes are assumed to decay into a final state characterized by a lepton (electron or muon) and a jet. In either channel, no event with a lepton-jet invariant mass of 3.5 TeV or more is observed, consistent with the expected background. Limits are set on the product of cross sections and branching fractions for the lepton+jet final states of quantum black holes produced in a search region for invariant masses above 1 TeV. The combined 95% confidence level upper limit on this product for quantum black holes with threshold mass above 3.5 TeV is 0.18 fb. This limit constrains the threshold quantum black-hole mass to be above 5.3 TeV in the model considered.
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First results from the LUX dark matter experiment at the Sanford underground research facility.
Phys. Rev. Lett.
PUBLISHED: 03-04-2014
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The Large Underground Xenon (LUX) experiment is a dual-phase xenon time-projection chamber operating at the Sanford Underground Research Facility (Lead, South Dakota). The LUX cryostat was filled for the first time in the underground laboratory in February 2013. We report results of the first WIMP search data set, taken during the period from April to August 2013, presenting the analysis of 85.3 live days of data with a fiducial volume of 118 kg. A profile-likelihood analysis technique shows our data to be consistent with the background-only hypothesis, allowing 90% confidence limits to be set on spin-independent WIMP-nucleon elastic scattering with a minimum upper limit on the cross section of 7.6 × 10(-46) cm(2) at a WIMP mass of 33 GeV/c(2). We find that the LUX data are in disagreement with low-mass WIMP signal interpretations of the results from several recent direct detection experiments.
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The translation elongation factor eEF2 is a novel tumor?associated antigen overexpressed in various types of cancers.
Int. J. Oncol.
PUBLISHED: 03-04-2014
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Recent studies have shown that cancer immunotherapy could be a promising therapeutic approach for the treatment of cancer. In the present study, to identify novel tumor-associated antigens (TAAs), the proteins expressed in a panel of cancer cells were serologically screened by immunoblot analysis and the eukaryotic elongation factor 2 (eEF2) was identified as an antigen that was recognized by IgG autoantibody in sera from a group of patients with head and neck squamous cell carcinoma (HNSCC) or colon cancer. Enzyme-linked immunosorbent assay showed that serum eEF2 IgG Ab levels were significantly higher in colorectal and gastric cancer patients compared to healthy individuals. Immunohistochemistry experiments showed that the eEF2 protein was overexpressed in the majority of lung, esophageal, pancreatic, breast and prostate cancers, HNSCC, glioblastoma multiforme and non-Hodgkin's lymphoma (NHL). Knockdown of eEF2 by short hairpin RNA (shRNA) significantly inhibited the growth in four eEF2-expressing cell lines, PC14 lung cancer, PCI6 pancreatic cancer, HT1080 fibrosarcoma and A172 glioblastoma cells, but not in eEF2-undetectable MCF7 cells. Furthermore, eEF2-derived 9-mer peptides, EF786 (eEF2 786-794 aa) and EF292 (eEF2 292-300 aa), elicited cytotoxic T lymphocyte (CTL) responses in peripheral blood mononuclear cells (PBMCs) from an HLA-A*24:02- and an HLA-A*02:01-positive healthy donor, respectively, in an HLA-A-restricted manner. These results indicated that the eEF2 gene is overexpressed in the majority of several types of cancers and plays an oncogenic role in cancer cell growth. Moreover, the eEF2 gene product is immunogenic and a promising target molecule of cancer immunotherapy for several types of cancers.
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Clinical utility of 2-[(18)F] fluoro-2-deoxy-D-glucose positron emission tomography in predicting World Health Organization grade in pancreatic neuroendocrine tumors.
Surgery
PUBLISHED: 02-26-2014
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Pancreatic neuroendocrine tumors (PNETs) present various histologic stages, and their clinical behavior ranges from benign to highly aggressive. World Health Organization (WHO) grading categorizes PNETs into 3 groups (G1, G2, and G3) based on proliferative activity. The aim of this study was to assess the clinical utility of 2-[(18)F] fluoro-2-deoxy-D-glucose positron emission tomography (FDG-PET) in preoperative differential diagnosis for various histologic grades of PNETs and in predicting postoperative prognosis in PNET patients.
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Placenta percreta with a vaginal fistula after successful management by uterine transverse fundal incision and subsequent cesarean hysterectomy.
Obstet Gynecol Sci
PUBLISHED: 02-14-2014
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Placenta previa presents a highest risk to pregnancy, and placenta accreta is the most serious. Placenta accreta requires cesarean delivery and often results in massive obstetric hemorrhage and higher maternal morbidity. Challenges associated with cesarean delivery techniques may contribute to increased maternal blood loss and morbidity rates. Several recent obstetric studies reported the usefulness of transverse uterine fundal incision for managing placenta accreta. We present a case of placenta percreta that was treated by a transverse fundal incision. We successfully avoided cutting through the placenta and helped decrease maternal blood loss. After delivery, the patient underwent a cesarean hysterectomy. Postoperative day 48, she experienced watery discharge and was diagnosed with vaginal fistula. We present our case and review the literature.
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Search for dark matter in events with a hadronically decaying W or Z boson and missing transverse momentum in pp collisions at ?s=8??TeV with the ATLAS detector.
G Aad, T Abajyan, B Abbott, J Abdallah, S Abdel Khalek, O Abdinov, R Aben, B Abi, M Abolins, O S AbouZeid, H Abramowicz, H Abreu, Y Abulaiti, B S Acharya, L Adamczyk, D L Adams, T N Addy, J Adelman, S Adomeit, T Adye, S Aefsky, T Agatonovic-Jovin, J A Aguilar-Saavedra, M Agustoni, S P Ahlen, A Ahmad, F Ahmadov, M Ahsan, G Aielli, T P A Akesson, G Akimoto, A V Akimov, M A Alam, J Albert, S Albrand, M J Alconada Verzini, M Aleksa, I N Aleksandrov, F Alessandria, C Alexa, G Alexander, G Alexandre, T Alexopoulos, M Alhroob, M Aliev, G Alimonti, L Alio, J Alison, B M M Allbrooke, L J Allison, P P Allport, S E Allwood-Spiers, J Almond, A Aloisio, R Alon, A Alonso, F Alonso, A Altheimer, B Alvarez Gonzalez, M G Alviggi, K Amako, Y Amaral Coutinho, C Amelung, V V Ammosov, S P Amor Dos Santos, A Amorim, S Amoroso, N Amram, G Amundsen, C Anastopoulos, L S Ancu, N Andari, T Andeen, C F Anders, G Anders, K J Anderson, A Andreazza, V Andrei, X S Anduaga, S Angelidakis, P Anger, A Angerami, F 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Bartsch, A Bassalat, A Basye, R L Bates, L Batkova, J R Batley, M Battistin, F Bauer, H S Bawa, T Beau, P H Beauchemin, R Beccherle, P Bechtle, H P Beck, K Becker, S Becker, M Beckingham, A J Beddall, A Beddall, S Bedikian, V A Bednyakov, C P Bee, L J Beemster, T A Beermann, M Begel, K Behr, C Belanger-Champagne, P J Bell, W H Bell, G Bella, L Bellagamba, A Bellerive, M Bellomo, A Belloni, O L Beloborodova, K Belotskiy, O Beltramello, O Benary, D Benchekroun, K Bendtz, N Benekos, Y Benhammou, E Benhar Noccioli, J A Benitez Garcia, D P Benjamin, J R Bensinger, K Benslama, S Bentvelsen, D Berge, E Bergeaas Kuutmann, N Berger, F Berghaus, E Berglund, J Beringer, C Bernard, P Bernat, R Bernhard, C Bernius, F U Bernlochner, T Berry, P Berta, C Bertella, F Bertolucci, M I Besana, G J Besjes, O Bessidskaia, N Besson, S Bethke, W Bhimji, R M Bianchi, L Bianchini, M Bianco, O Biebel, S P Bieniek, K Bierwagen, J Biesiada, M Biglietti, J Bilbao De Mendizabal, H Bilokon, M Bindi, S Binet, A Bingul, C Bini, B Bittner, C W Black, J E Black, K M Black, D Blackburn, R E Blair, J-B Blanchard, T Blazek, I Bloch, C Blocker, J Blocki, W Blum, U Blumenschein, G J Bobbink, V S Bobrovnikov, S S Bocchetta, A Bocci, C R Boddy, M Boehler, J Boek, T T Boek, N Boelaert, J A Bogaerts, A G Bogdanchikov, A Bogouch, C Bohm, J Bohm, V Boisvert, T Bold, V Boldea, A S Boldyrev, N M Bolnet, M Bomben, M Bona, M Boonekamp, S Bordoni, C Borer, A Borisov, G Borissov, M Borri, S Borroni, J Bortfeldt, V Bortolotto, K Bos, D Boscherini, M Bosman, H Boterenbrood, J Bouchami, J Boudreau, E V Bouhova-Thacker, D Boumediene, C Bourdarios, N Bousson, S Boutouil, A Boveia, J Boyd, I R Boyko, I Bozovic-Jelisavcic, J Bracinik, P Branchini, A Brandt, G Brandt, O Brandt, U Bratzler, B Brau, J E Brau, H M Braun, S F Brazzale, B Brelier, K Brendlinger, R Brenner, S Bressler, T M Bristow, D Britton, F M Brochu, I Brock, R Brock, F Broggi, C Bromberg, J Bronner, G Brooijmans, T Brooks, W K Brooks, J Brosamer, E Brost, G Brown, J Brown, P A Bruckman de Renstrom, D Bruncko, R Bruneliere, S Brunet, A Bruni, G Bruni, M Bruschi, L Bryngemark, T Buanes, Q Buat, F Bucci, J Buchanan, P Buchholz, R M Buckingham, A G Buckley, S I Buda, I A Budagov, B Budick, F Buehrer, L Bugge, O Bulekov, A C Bundock, M Bunse, H Burckhart, S Burdin, T Burgess, S Burke, I Burmeister, E Busato, V Büscher, P Bussey, C P Buszello, B Butler, J M Butler, A I Butt, C M Buttar, J M Butterworth, W Buttinger, A Buzatu, M Byszewski, S Cabrera Urbán, D Caforio, O Cakir, P Calafiura, G Calderini, P Calfayan, R Calkins, L P Caloba, R Caloi, D Calvet, S Calvet, R Camacho Toro, P Camarri, D Cameron, L M Caminada, R Caminal Armadans, S Campana, M Campanelli, V Canale, F Canelli, A Canepa, J Cantero, R Cantrill, T Cao, M D M Capeans Garrido, I Caprini, M Caprini, M Capua, R Caputo, R Cardarelli, T Carli, G Carlino, L Carminati, S Caron, E Carquin, G D Carrillo-Montoya, A A Carter, J R Carter, J Carvalho, D Casadei, M P Casado, C Caso, E Castaneda-Miranda, A Castelli, V Castillo Gimenez, N F Castro, P Catastini, A Catinaccio, J R Catmore, A Cattai, G Cattani, S Caughron, V Cavaliere, D Cavalli, M Cavalli-Sforza, V Cavasinni, F Ceradini, B Cerio, K Cerny, A S Cerqueira, A Cerri, L Cerrito, F Cerutti, A Cervelli, S A Cetin, A Chafaq, D Chakraborty, I Chalupkova, K Chan, P Chang, B Chapleau, J D Chapman, J W Chapman, D Charfeddine, D G Charlton, V Chavda, C A Chavez Barajas, S Cheatham, S Chekanov, S V Chekulaev, G A Chelkov, M A Chelstowska, C Chen, H Chen, K Chen, S Chen, X Chen, Y Chen, Y Cheng, A Cheplakov, R Cherkaoui El Moursli, V Chernyatin, E Cheu, L Chevalier, V Chiarella, G Chiefari, J T Childers, A Chilingarov, G Chiodini, A S Chisholm, R T Chislett, A Chitan, M V Chizhov, G Choudalakis, S Chouridou, B K B Chow, I A Christidi, D Chromek-Burckhart, M L Chu, J Chudoba, G Ciapetti, A K Ciftci, R Ciftci, D Cinca, V Cindro, A Ciocio, M Cirilli, P Cirkovic, Z H Citron, M Citterio, M Ciubancan, A Clark, P J Clark, R N Clarke, J C Clemens, B Clement, C Clement, Y Coadou, M Cobal, A Coccaro, J Cochran, S Coelli, L Coffey, J G Cogan, J Coggeshall, J Colas, B Cole, S Cole, A P Colijn, C Collins-Tooth, J Collot, T Colombo, G Colon, G Compostella, P Conde Muiño, E Coniavitis, M C Conidi, S M Consonni, V Consorti, S Constantinescu, C Conta, G Conti, F Conventi, M Cooke, B D Cooper, A M Cooper-Sarkar, N J Cooper-Smith, K Copic, T Cornelissen, M Corradi, F Corriveau, A Corso-Radu, A Cortes-Gonzalez, G Cortiana, G Costa, M J Costa, D Costanzo, D Côté, G Cottin, L Courneyea, G Cowan, B E Cox, K Cranmer, G Cree, S Crépé-Renaudin, F Crescioli, M Cristinziani, G Crosetti, C-M Cuciuc, C Cuenca Almenar, T Cuhadar Donszelmann, J Cummings, M Curatolo, C Cuthbert, H Czirr, P Czodrowski, Z Czyczula, S D'Auria, M D'Onofrio, A D'Orazio, M J Da Cunha Sargedas De Sousa, C Da Via, W Dabrowski, A Dafinca, T Dai, F Dallaire, C Dallapiccola, M Dam, D S Damiani, A C Daniells, M Dano Hoffmann, V Dao, G Darbo, G L Darlea, S Darmora, J A Dassoulas, W Davey, C David, T Davidek, E Davies, M Davies, O Davignon, A R Davison, Y Davygora, E Dawe, I Dawson, R K Daya-Ishmukhametova, K De, R de Asmundis, S De Castro, S De Cecco, J de Graat, N De Groot, P de Jong, C De La Taille, H De la Torre, F De Lorenzi, L De Nooij, D De Pedis, A De Salvo, U De Sanctis, A De Santo, J B De Vivie De Regie, G De Zorzi, W J Dearnaley, R Debbe, C Debenedetti, B Dechenaux, D V Dedovich, J Degenhardt, J Del Peso, T Del Prete, T Delemontex, F Deliot, M Deliyergiyev, A Dell'Acqua, L Dell'Asta, M Della Pietra, D Della Volpe, M Delmastro, P A Delsart, C Deluca, S Demers, M Demichev, A Demilly, B Demirkoz, S P Denisov, D Derendarz, J E Derkaoui, F Derue, P Dervan, K Desch, P O Deviveiros, A Dewhurst, B DeWilde, S Dhaliwal, R Dhullipudi, A Di Ciaccio, L Di Ciaccio, C Di Donato, A Di Girolamo, B Di Girolamo, A Di Mattia, B Di Micco, R Di Nardo, A Di Simone, R Di Sipio, D Di Valentino, M A Diaz, E B Diehl, J Dietrich, T A Dietzsch, S Diglio, K Dindar Yagci, J Dingfelder, C Dionisi, P Dita, S Dita, F Dittus, F Djama, T Djobava, M A B do Vale, A Do Valle Wemans, T K O Doan, D Dobos, E Dobson, J Dodd, C Doglioni, T Doherty, T Dohmae, Y Doi, J Dolejsi, Z Dolezal, B A Dolgoshein, M Donadelli, S Donati, J Donini, J Dopke, A Doria, A Dos Anjos, A Dotti, M T Dova, A T Doyle, M Dris, J Dubbert, S Dube, E Dubreuil, E Duchovni, G Duckeck, O A Ducu, D Duda, A Dudarev, F Dudziak, L Duflot, L Duguid, M Dührssen, M Dunford, H Duran Yildiz, M Düren, M Dwuznik, J Ebke, W Edson, C A Edwards, N C Edwards, W Ehrenfeld, T Eifert, G Eigen, K Einsweiler, E Eisenhandler, T Ekelof, M El Kacimi, M Ellert, S Elles, F Ellinghaus, K Ellis, N Ellis, J Elmsheuser, M Elsing, D Emeliyanov, Y Enari, O C Endner, M Endo, R Engelmann, J Erdmann, A Ereditato, D Eriksson, G Ernis, J Ernst, M Ernst, J Ernwein, D Errede, S Errede, E Ertel, M Escalier, H Esch, C Escobar, X Espinal Curull, B Esposito, F Etienne, A I Etienvre, E Etzion, D Evangelakou, H Evans, L Fabbri, G Facini, R M Fakhrutdinov, S Falciano, Y Fang, M Fanti, A Farbin, A Farilla, T Farooque, S Farrell, S M Farrington, P Farthouat, F Fassi, P Fassnacht, D Fassouliotis, B Fatholahzadeh, A Favareto, L Fayard, P Federic, O L Fedin, W Fedorko, M Fehling-Kaschek, L Feligioni, C Feng, E J Feng, H Feng, A B Fenyuk, W Fernando, S Ferrag, J Ferrando, V Ferrara, A Ferrari, P Ferrari, R Ferrari, D E Ferreira de Lima, A Ferrer, D Ferrere, C Ferretti, A Ferretto Parodi, M Fiascaris, F Fiedler, A Filipčič, M Filipuzzi, F Filthaut, M Fincke-Keeler, K D Finelli, M C N Fiolhais, L Fiorini, A Firan, J Fischer, M J Fisher, E A Fitzgerald, M Flechl, I Fleck, P Fleischmann, S Fleischmann, G T Fletcher, G Fletcher, T Flick, A Floderus, L R Flores Castillo, A C Florez Bustos, M J Flowerdew, T Fonseca Martin, A Formica, A Forti, D Fortin, D Fournier, H Fox, P Francavilla, M Franchini, S Franchino, D Francis, M Franklin, S Franz, M Fraternali, S Fratina, S T French, C Friedrich, F Friedrich, D 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