JoVE Visualize What is visualize?
Stop Reading. Start Watching.
Advanced Search
Stop Reading. Start Watching.
Regular Search
Find video protocols related to scientific articles indexed in Pubmed.
[The effects of lifestyle factors on the incidence of central obesity in Chinese adults aged 35-74 years].
Zhonghua Yu Fang Yi Xue Za Zhi
PUBLISHED: 10-15-2014
Show Abstract
Hide Abstract
To understand the incidence of central obesity and its characteristics, and explore the effects of lifestyle factors on incidence of central obesity in Chinese adults aged 35-74 years.
Related JoVE Video
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
Hum. Mol. Genet.
PUBLISHED: 09-23-2014
Show Abstract
Hide Abstract
Hypertension is a common disorder and the leading risk factor for cardiovascular disease and premature deaths worldwide. Genome-wide association studies (GWASs) in the European population have identified multiple chromosomal regions associated with blood pressure, and the identified loci altogether explain only a small fraction of the variance for blood pressure. The differences in environmental exposures and genetic background between Chinese and European populations might suggest potential different pathways of blood pressure regulation. To identify novel genetic variants affecting blood pressure variation, we conducted a meta-analysis of GWASs of blood pressure and hypertension in 11 816 subjects followed by replication studies including 69 146 additional individuals. We identified genome-wide significant (P < 5.0 × 10(-8)) associations with blood pressure, which included variants at three new loci (CACNA1D, CYP21A2, and MED13L) and a newly discovered variant near SLC4A7. We also replicated 14 previously reported loci, 8 (CASZ1, MOV10, FGF5, CYP17A1, SOX6, ATP2B1, ALDH2, and JAG1) at genome-wide significance, and 6 (FIGN, ULK4, GUCY1A3, HFE, TBX3-TBX5, and TBX3) at a suggestive level of P = 1.81 × 10(-3) to 5.16 × 10(-8). These findings provide new mechanistic insights into the regulation of blood pressure and potential targets for treatments.
Related JoVE Video
Physical Activity Level and Incident Type 2 Diabetes among Chinese Adults.
Med Sci Sports Exerc
PUBLISHED: 08-10-2014
Show Abstract
Hide Abstract
To examine the association between physical activity level (PAL) and incident type 2 diabetes among middle-aged and older Chinese men and women in urban China.
Related JoVE Video
A Highly Selective Turn-on Fluorescent Chemodosimeter for Cu(2+) Through a Cu (2+)-Promoted Redox Reaction.
J Fluoresc
PUBLISHED: 07-23-2014
Show Abstract
Hide Abstract
A highly sensitive and selective photoinduced electron transfer (PET) fluorescence chemodosimeter L for Cu(2+) detection has been synthesized and characterized. This PET chemosensor composed of a butano-tethered electron-riched phenothiazine (Ptz) donor and acridine orange (AO) signalling element. Based on the Cu(2+)-promoted oxidation of Ptz donor, the signalling element AO showed a unique fluorescent turn-on properties, which led to a highly Cu(2+)-specific fluorescent chemodosimeter. A fluorescent enhancement factor over 8-fold can be reached by fully blocking the PET channel with a detection limit down to the 10(-7) M range. Meanwhile, the reversibility of the chemodosimeter L can be realized by the addition of L-cysteine.
Related JoVE Video
[Incidence of obesity and its modifiable risk factors in Chinese adults aged 35-74 years: a prospective cohort study].
Zhonghua Liu Xing Bing Xue Za Zhi
PUBLISHED: 07-11-2014
Show Abstract
Hide Abstract
To examine the incidence of obesity and its modifiable risk factors in Chinese adults aged 35-74 years.
Related JoVE Video
A highly sensitive and selective turn-on fluorescent chemosensor for palladium based on a phosphine-rhodamine conjugate.
Chem. Commun. (Camb.)
PUBLISHED: 05-29-2013
Show Abstract
Hide Abstract
A fluorescent chemosensor with high sensitivity and selectivity for palladium species based on a conjugate of phosphine and rhodamine B has been developed. The chemosensor showed an excellent palladium selectivity with a detection limit down to the 10(-9) M range, which is lower than the WHO limit for palladium content in drug chemicals.
Related JoVE Video
Efficient fluorescent chemosensors for HSO4(-) based on a strategy of anion-induced rotation-displaced H-aggregates.
Chem. Commun. (Camb.)
PUBLISHED: 05-24-2013
Show Abstract
Hide Abstract
A novel fluorometric sensing strategy based on the anion-induced rotation-displaced H-aggregates of styrylindolium dyes was employed to enhance the selectivity of fluorescent chemosensors for HSO4(-) detection. The marvelous anion-induced H-aggregate strategy opens new routes to simple synthesis of receptors for tetrahedral anionic species.
Related JoVE Video
Dietary glycine and blood pressure: the International Study on Macro/Micronutrients and Blood Pressure.
Am. J. Clin. Nutr.
PUBLISHED: 05-08-2013
Show Abstract
Hide Abstract
Available data have indicated independent direct relations of dietary animal protein and meat to the blood pressure (BP) of individuals.
Related JoVE Video
Relationship of dietary monounsaturated fatty acids to blood pressure: the international study of macro/micronutrients and blood pressure.
J. Hypertens.
PUBLISHED: 04-11-2013
Show Abstract
Hide Abstract
In short-term feeding trials, replacement of other macronutrients with monounsaturated fatty acid reduces blood pressure. However, observational studies have not clearly demonstrated a relationship between monounsaturated fatty acid intake and blood pressure. We report associations of monounsaturated fatty acid intake of individuals with blood pressure in a cross-sectional study.
Related JoVE Video
Association of raw fruit and fruit juice consumption with blood pressure: the INTERMAP Study.
Am. J. Clin. Nutr.
PUBLISHED: 04-03-2013
Show Abstract
Hide Abstract
Epidemiologic evidence suggests that fruit consumption may lower the risk of cardiovascular diseases through blood pressure (BP)-lowering effects; little is known on the independent effect of raw fruit and fruit juice on BP.
Related JoVE Video
Genome-wide association study in Han Chinese identifies three novel loci for human height.
Hum. Genet.
PUBLISHED: 02-18-2013
Show Abstract
Hide Abstract
Human height is a complex genetic trait with high heritability but discovery efforts in Asian populations are limited. We carried out a meta-analysis of genome-wide association studies (GWAS) for height in 6,534 subjects with in silico replication of 1,881 subjects in Han Chinese. We identified three novel loci reaching the genome-wide significance threshold (P < 5 × 10(-8)), which mapped in or near ZNF638 (rs12612930, P = 2.02 × 10(-10)), MAML2 (rs11021504, P = 7.81 × 10(-9)), and C18orf12 (rs11082671, P = 1.87 × 10(-8)). We also confirmed two loci previously reported in European populations including CS (rs3816804, P = 2.63 × 10(-9)) and CYP19A1 (rs3751599, P = 4.80 × 10(-10)). In addition, we provided evidence supporting 35 SNPs identified by previous GWAS (P < 0.05). Our study provides new insights into the genetic determination of biological regulation of human height.
Related JoVE Video
Common variants at 12q24 are associated with drinking behavior in Han Chinese.
Am. J. Clin. Nutr.
PUBLISHED: 01-30-2013
Show Abstract
Hide Abstract
Alcohol consumption is heritable, but genetic susceptibility to drinking behavior has not been investigated widely in genome-wide association studies.
Related JoVE Video
Association between alanine aminotransferase and intracerebral hemorrhage in East Asian populations.
Neuroepidemiology
PUBLISHED: 01-25-2013
Show Abstract
Hide Abstract
Intracerebral hemorrhage (ICH) and chronic liver disease are relatively common in East Asian countries. However, the relationship between the two diseases is unclear. Thus, we investigated the association between serum alanine aminotransferase (ALT) levels and ICH risk in East Asian populations.
Related JoVE Video
Relationship of serum interleukin-10 and its genetic variations with ischemic stroke in a Chinese general population.
PLoS ONE
PUBLISHED: 01-01-2013
Show Abstract
Hide Abstract
Anti-inflammatory cytokine and its genetic variations may play an important role in the process of atherosclerosis. We assessed whether serum interleukin-10 (IL-10) and its genetic variations are associated with ischemic stroke in a Chinese general population.
Related JoVE Video
Characterization of ultrathin InSb nanocrystals film deposited on SiO2/Si substrate.
Nanoscale Res Lett
PUBLISHED: 09-20-2011
Show Abstract
Hide Abstract
Recently, solid-phase recrystallization of ultrathin indium antimonide nanocrystals (InSb NCs (films grown on SiO2/Si substrate is very attractive, because of the rapid development of thermal annealing technique. In this study, the recrystallization behavior of 35 nm indium antimonide film was studied. Through X-ray diffraction (XRD) analysis, it is demonstrated that the InSb film is composed of nanocrystals after high temperature rapid thermal annealing. Scanning electron microscopy shows that the film has a smooth surface and is composed of tightly packed spherical grains, the average grain size is about 12.3 nm according to XRD results. The optical bandgap of the InSb NCs film analyzed by Fourier Transform infrared spectroscopy measurement is around 0.26 eV. According to the current-voltage characteristics of the InSb NCs/SiO2/p-Si heterojunction, the film has the rectifying behavior and the turn-on voltage value is near 1 V.
Related JoVE Video
Highly selective and sensitive fluorescent turn-on chemosensor for Al3+ based on a novel photoinduced electron transfer approach.
Org. Lett.
PUBLISHED: 09-14-2011
Show Abstract
Hide Abstract
A photoinduced electron transfer (PET)-based chemosensor possessing dual PET processes by simultaneously introducing both nitrogen and sulfur donors was achieved. The fluorescence signal of the free chemosensor is in a normal-off state due to the sulfur donor being insensitive to environmental pH stimuli. As a result, the device can be used over a wide pH span of 3-11. Upon binding Al(3+), a significant fluorescence enhancement with a turn-on ratio over 110-fold was triggered by the inhibition of PET processes from both the sulfur and the nitrogen donors to the fluorophore.
Related JoVE Video
Nutrient and food intakes of middle-aged adults at low risk of cardiovascular disease: the international study of macro-/micronutrients and blood pressure (INTERMAP).
Eur J Nutr
PUBLISHED: 07-19-2011
Show Abstract
Hide Abstract
Individuals with favorable levels of readily measured cardiovascular disease (CVD) risk factors (low risk, LR) experience low long-term rates of CVD mortality and greater longevity. The purpose of the current study was to compare nutrient/food intakes of LR participants with participants not LR in the INTERMAP study.
Related JoVE Video
Combination of carotid intima-media thickness and plaque for better predicting risk of ischaemic cardiovascular events.
Heart
PUBLISHED: 06-07-2011
Show Abstract
Hide Abstract
Several indices of carotid atherosclerosis have been studied to investigate their associations with the risk of cardiovascular disease. However, the best index of carotid atherosclerosis that predicts the risk of cardiovascular disease remains unclear.
Related JoVE Video
Relation of urinary calcium and magnesium excretion to blood pressure: The International Study Of Macro- And Micro-nutrients And Blood Pressure and The International Cooperative Study On Salt, Other Factors, And Blood Pressure.
Am. J. Epidemiol.
PUBLISHED: 05-30-2011
Show Abstract
Hide Abstract
Data indicate an inverse association between dietary calcium and magnesium intakes and blood pressure (BP); however, much less is known about associations between urinary calcium and magnesium excretion and BP in general populations. The authors assessed the relation of BP to 24-hour excretion of calcium and magnesium in 2 cross-sectional studies. The International Study of Macro- and Micro-Nutrients and Blood Pressure (INTERMAP) comprised 4,679 persons aged 40-59 years from 17 population samples in China, Japan, the United Kingdom, and the United States, and the International Cooperative Study on Salt, Other Factors, and Blood Pressure (INTERSALT) comprised 10,067 persons aged 20-59 years from 52 samples around the world. Timed 24-hour urine collections, BP measurements, and nutrient data from four 24-hour dietary recalls (INTERMAP) were collected. In multiple linear regression analyses, urinary calcium excretion was directly associated with BP. After adjustment for multiple confounders (including weight, height, alcohol intake, calcium intake, urinary sodium level, and urinary potassium intake), systolic BP was 1.9 mm Hg higher per each 4.1 mmol per 24 hours (2 standard deviations) of higher urinary calcium excretion (associations were smaller for diastolic BP) in INTERMAP. Qualitatively similar associations were observed in INTERSALT analyses. Associations between magnesium excretion and BP were small and nonsignificant for most of the models examined. The present data suggest that altered calcium homoeostasis, as exhibited by increased calcium excretion, is associated with higher BP levels.
Related JoVE Video
Relationship of dietary cholesterol to blood pressure: the INTERMAP study.
J. Hypertens.
PUBLISHED: 05-05-2011
Show Abstract
Hide Abstract
A direct relationship of dietary cholesterol to blood pressure of men has been reported in a few observational studies from the USA. It is not clear whether this association prevails consistently, for example, in populations with varied dietary habits, across ethnic groups, and sexes. Cross-sectional data from the International Study of Macro/Micro-nutrients and Blood Pressure (INTERMAP) were used to assess relations of dietary cholesterol intake to blood pressure in men and women from four countries.
Related JoVE Video
Sugar-sweetened beverage, sugar intake of individuals, and their blood pressure: international study of macro/micronutrients and blood pressure.
Hypertension
PUBLISHED: 02-28-2011
Show Abstract
Hide Abstract
The obesity epidemic has focused attention on relationships of sugars and sugar-sweetened beverages (SSBs) to cardiovascular risk factors. Here we report cross-sectional associations of SSBs, diet beverages, and sugars with blood pressure (BP) for United Kingdom and US participants of the International Study of Macro/Micronutrients and Blood Pressure. Data collected include four 24-hour dietary recalls, two 24-hour urine collections, 8 BP readings, and questionnaire data for 2696 people ages 40 to 59 years of age from 10 US/United Kingdom population samples. Associations of SSBs, diet beverages, and sugars (fructose, glucose, and sucrose) with BP were assessed by multiple linear regression. SSB intake related directly to BP, with P values of 0.005 to <0.001 (systolic BP) and 0.14 to <0.001 (diastolic BP). SSB intake higher by 1 serving per day (355 mL/24 hours) was associated with systolic/diastolic BP differences of +1.6/+0.8 mm Hg (both P<0.001) and +1.1/+0.4 mm Hg (P<0.001/<0.05) with adjustment for weight and height. Diet beverage intake was inversely associated with BP (P 0.41 to 0.003). Fructose- and glucose-BP associations were direct, with significant sugar-sodium interactions: for individuals with above-median 24-hour urinary sodium excretion, fructose intake higher by 2 SD (5.6% kcal) was associated with systolic/diastolic BP differences of +3.4/+2.2 mm Hg (both P<0.001) and +2.5/+1.7 mm Hg (both P=0.002) with adjustment for weight and height. Observed independent, direct associations of SSB intake and BP are consistent with recent trial data. These findings, plus adverse nutrient intakes among SSB consumers, and greater sugar-BP differences for persons with higher sodium excretion lend support to recommendations that intake of SSBs, sugars, and salt be substantially reduced.
Related JoVE Video
Highly sensitive and selective fluorescent chemosensor for Ag+ based on a coumarin-Se2N chelating conjugate.
Chem. Commun. (Camb.)
PUBLISHED: 12-17-2010
Show Abstract
Hide Abstract
A highly sensitive and selective fluorescent chemosensor SC1 for Ag(+) based on a coumarin-Se(2)N chelating conjugate has been synthesized and characterized. Due to inhibiting a photoinduced electron transfer (PET) quenching pathway, a fluorescent enhancement factor of 4-fold is observed under the binding of the Ag(+) cation to the chemosensor SC1 with a detection limit down to the 10(-8) M range.
Related JoVE Video
Comparative study on InAs/InGaAs dots-in-a-well structure grown on GaAs(311) B and (100) substrates.
J Nanosci Nanotechnol
PUBLISHED: 12-09-2010
Show Abstract
Hide Abstract
The InAs/InGaAs dots-in-a-well (DWELL) structures were grown on both GaAs(311) B and (100) substrates by molecular beam epitaxy. Quantum dots (QDs) grown on GaAs(311) B substrate are of higher density and more uniform size distribution, yet QDs grown on GaAs(100) substrate demonstrate a bimodal size distribution. The growth mechanism of these surface morphologies was briefly discussed. We found that the photoluminescence (PL) linewidth of DWELL grown on GaAs(311) B substrate was much narrower than the linewidth of DWELL grown on GaAs(100), which suggests a promising advantage in many QD based devices. We also found the temperature had a stronger impact on the PL intensity of DWELL grown on GaAs(311) B, which was explained by the lower thermal active energy and higher density of interfacial point defects of DWELL grown on GaAs(311) B. These results provide people a rather comprehensive insight into the advantages and disadvantages of DWELL grown on GaAs(311) B substrates.
Related JoVE Video
Metabolome-wide association study identifies multiple biomarkers that discriminate north and south Chinese populations at differing risks of cardiovascular disease: INTERMAP study.
J. Proteome Res.
PUBLISHED: 11-02-2010
Show Abstract
Hide Abstract
Rates of heart disease and stroke vary markedly between north and south China. A (1)H NMR spectroscopy-based metabolome-wide association approach was used to identify urinary metabolites that discriminate between southern and northern Chinese population samples, to investigate population biomarkers that might relate to the difference in cardiovascular disease risk. NMR spectra were acquired from two 24-h urine specimens per person for 523 northern and 244 southern Chinese participants in the INTERMAP Study of macro/micronutrients and blood pressure. Discriminating metabolites were identified using orthogonal partial least squares discriminant analysis and assessed for statistical significance with conservative family wise error rate < 0.01 to minimize false positive findings. Urinary metabolites significantly (P < 1.2 × 10(-16) to 2.9 × 10(-69)) higher in northern than southern Chinese populations included dimethylglycine, alanine, lactate, branched-chain amino acids (isoleucine, leucine, valine), N-acetyls of glycoprotein fragments (including uromodulin), N-acetyl neuraminic acid, pentanoic/heptanoic acid, and methylguanidine; metabolites significantly (P < 1.1 × 10(-12) to 2 × 10(-127)) higher in the south were gut microbial cometabolites (hippurate, 4-cresyl sulfate, phenylacetylglutamine, 2-hydroxyisobutyrate), succinate, creatine, scyllo-inositol, prolinebetaine, and trans-aconitate. These findings indicate the importance of environmental influences (e.g., diet), endogenous metabolism, and mammalian-gut microbial cometabolism, which may help explain north-south China differences in cardiovascular disease risk.
Related JoVE Video
Metabolic profiling and the metabolome-wide association study: significance level for biomarker identification.
J. Proteome Res.
PUBLISHED: 08-13-2010
Show Abstract
Hide Abstract
High throughput metabolic profiling via the metabolome-wide association study (MWAS) is a powerful new approach to identify biomarkers of disease risk, but there are methodological challenges: high dimensionality, high level of collinearity, the existence of peak overlap within metabolic spectral data, multiple testing, and selection of a suitable significance threshold. We define the metabolome-wide significance level (MWSL) as the threshold required to control the family wise error rate through a permutation approach. We used 1H NMR spectroscopic profiles of 24 h urinary collections from the INTERMAP study. Our results show that the MWSL primarily depends on sample size and spectral resolution. The MWSL estimates can be used to guide selection of discriminatory biomarkers in MWA studies. In a simulation study, we compare statistical performance of the MWSL approach to two variants of orthogonal partial least-squares (OPLS) method with respect to statistical power, false positive rate and correspondence of ranking of the most significant spectral variables. Our results show that the MWSL approach as estimated by the univariate t test is not outperformed by OPLS and offers a fast and simple method to detect disease-related discriminatory features in human NMR urinary metabolic profiles.
Related JoVE Video
Dietary sources of sodium in China, Japan, the United Kingdom, and the United States, women and men aged 40 to 59 years: the INTERMAP study.
J Am Diet Assoc
PUBLISHED: 05-01-2010
Show Abstract
Hide Abstract
Public health campaigns in several countries encourage population-wide reduced sodium (salt) intake, but excessive intake remains a major problem. Excessive sodium intake is independently related to adverse blood pressure and is a key factor in the epidemic of prehypertension/hypertension. Identification of food sources of sodium in modern diets is critical to effective reduction of sodium intake worldwide. We used data from the INTERMAP Study to define major food sources of sodium in diverse East Asian and Western population samples. INTERMAP is an international, cross-sectional, epidemiologic study of 4, 680 individuals ages 40 to 59 years from Japan (four samples), Peoples Republic of China (three rural samples), the United Kingdom (two samples), and the United States (eight samples); four in-depth, multipass 24-hour dietary recalls/person were used to identify foods accounting for most dietary sodium intake. In the Peoples Republic of China sample, most (76%) dietary sodium was from salt added in home cooking, about 50% less in southern than northern samples. In Japan, most (63%) dietary sodium came from soy sauce (20%), commercially processed fish/seafood (15%), salted soups (15%), and preserved vegetables (13%). Processed foods, including breads/cereals/grains, contributed heavily to sodium intake in the United Kingdom (95%) and the United States (for methodological reasons, underestimated at 71%). To prevent and control prehypertension/hypertension and improve health, efforts to remove excess sodium from diets in rural China should focus on reducing salt in home cooking. To avoid excess sodium intake in Japan, the United Kingdom, and the United States, salt must be reduced in commercially processed foods.
Related JoVE Video
Glutamic acid, the main dietary amino acid, and blood pressure: the INTERMAP Study (International Collaborative Study of Macronutrients, Micronutrients and Blood Pressure).
Circulation
PUBLISHED: 07-06-2009
Show Abstract
Hide Abstract
Data are available that indicate an independent inverse relationship of dietary vegetable protein to the blood pressure (BP) of individuals. Here, we assess whether BP is associated with glutamic acid intake (the predominant dietary amino acid, especially in vegetable protein) and with each of 4 other amino acids that are relatively higher in vegetable than animal protein (proline, phenylalanine, serine, and cystine).
Related JoVE Video
The effects of a reduced-sodium, high-potassium salt substitute on food taste and acceptability in rural northern China.
Br. J. Nutr.
PUBLISHED: 06-20-2009
Show Abstract
Hide Abstract
A potassium chloride-containing salt substitute lowers blood pressure levels, but its overall acceptability has been of concern due to its potential adverse effects on food taste. In a large-scale, blinded randomised trial evaluating the comparative effects of a salt substitute (65 % sodium chloride, 25 % potassium chloride and 10 % magnesium sulphate) and a normal salt (100 % sodium chloride) on blood pressure, we collected data on the saltiness, flavour and overall acceptability of food. We performed this at baseline, 1, 6 and 12 months post-randomisation using 100 mm visual analogue scales for assessments of both home-cooked foods and a standard salty soup. The mean age of the 608 participants from rural northern China was 60 years and 56 % of them were females. In the primary analyses, the changes in the saltiness, flavour and overall acceptability of both home-cooked foods and a standard salty soup were not different between the randomised groups (all P>0.08). In the secondary analyses, weighting each of the data points according to the lengths of the respective follow-up intervals, the flavour of both home-cooked foods (mean difference = - 1.8 mm, P = 0.045) and a standard salty soup (mean difference = - 1.9 mm, P = 0.03) was slightly weaker in the salt substitute group. We conclude that salt substitution is both an effective and an acceptable means of blood pressure control. Possible small differences in flavour did not importantly deter the use of the salt substitute in this study group, although the acceptability of the salt substitute by a more general population group would need to be confirmed.
Related JoVE Video
Improvement of awareness, treatment and control of hypertension among chronic kidney disease patients in China from 1999 to 2005.
Hypertens. Res.
PUBLISHED: 06-05-2009
Show Abstract
Hide Abstract
Controlling hypertension is important to protect renal function and prevent cardiovascular disease in chronic kidney disease (CKD) patients. However, data on hypertension awareness, treatment and control among CKD patients are limited. Two nationwide surveys were conducted in China in 1999-2000 and 2004-2005 among, respectively, 1328 and 1244 adult, non-dialysis, hypertensive CKD patients, to assess the status of hypertension awareness, treatment and control and associated factors. A standard questionnaire was adopted, and blood pressure (BP) was measured by trained staff according to a standard protocol in both surveys. Compared with the data from 1999-2000, the data from 2004-2005 showed increased awareness (87.2 vs. 75.7%, P<0.001), treatment (85.9 vs. 80.4%, P=0.001) and control (30.0 vs. 21.1%, P<0.001, by the general threshold of BP<140/90 mm Hg; 7.7 vs. 5.9%, P=0.075, by an optimal threshold of BP<130/80 mm Hg) of hypertension. The odds ratios for general BP control were 1.4 (95% confidence index (CI), 1.1-1.7) for female gender, 1.1 (95% CI, 1.0-1.1) for high estimated glomerular filtration rate, 1.3 (95% CI, 1.1-1.6) for treatment in a local hospital, 2.8 (95% CI, 2.0-3.9) for hypertension awareness and 1.7 (95% CI, 1.4-1.9) for combined treatment. General physicians from local hospitals made greater contributions to the total improvement. Lack of treatment was mainly due to patients not recognizing the necessity for it. This is the first report of hypertension awareness, treatment and control among hypertensive CKD patients from a developing country. Improvement of awareness and general control of hypertension were demonstrated. Education of both physicians and patients regarding optimal BP control should be reinforced in the future.
Related JoVE Video
Effect of Interfacial Bonds on the Morphology of InAs QDs Grown on GaAs (311) B and (100) Substrates.
Nanoscale Res Lett
PUBLISHED: 03-24-2009
Show Abstract
Hide Abstract
The morphology and transition thickness (t(c)) for InAs quantum dots (QDs) grown on GaAs (311) B and (100) substrates were investigated. The morphology varies with the composition of buffer layer and substrate orientation. And t(c) decreased when the thin InGaAs was used as a buffer layer instead of the GaAs layer on (311) B substrates. For InAs/(In)GaAs QDs grown on high miller index surfaces, both the morphology and t(c) can be influenced by the interfacial bonds configuration. This indicates that buffer layer design with appropriate interfacial bonds provides an approach to adjust the morphologies of QDs grown on high miller surfaces.
Related JoVE Video
Effects of salt substitute on pulse wave analysis among individuals at high cardiovascular risk in rural China: a randomized controlled trial.
Hypertens. Res.
PUBLISHED: 02-27-2009
Show Abstract
Hide Abstract
Reduced-sodium, increased-potassium salt substitutes lower blood pressure but may also have direct effects on vascular structure and arterial function. This study aimed to test the effects of long-term salt substitution on indices of these outcomes. The China Salt Substitute Study was a randomized, controlled trial designed to establish the effects of salt substitute (65% sodium chloride, 25% potassium chloride, 10% magnesium sulfate) compared with regular salt (100% sodium chloride) on blood pressure among 600 high-risk individuals living in six rural areas in northern China over a 12-month intervention period. Data on central aortic blood pressure, aortic pressure augmentation (AUG), augmentation index (AIx), the differences of the peak of first and baseline waves (P(1)-P(0)) and pulse wave reflection time (RT) were collected at randomization and at the completion of follow-up in 187 participants using the Sphygmocor pulse wave analysis system. Mean baseline blood pressure was 150.1/91.4 mm Hg, mean age was 58.4 years, 41% were male and three quarters had a history of vascular disease. After 12 months of intervention, there were significant net reductions in peripheral (7.4 mm Hg, P=0.009) and central (6.9 mm Hg, P=0.011) systolic blood pressure levels and central pulse pressure (4.5 mm Hg, P=0.012) and correspondingly there was a significant net reduction in P(1)-P(0) (3.0 mm Hg, P=0.007), borderline significant net reduction in AUG (1.5 mm Hg, P=0.074) and significant net increase in RT (2.59 ms, P=0.001). There were no detectable reductions in peripheral (2.8 mm Hg, P=0.14) or central (2.4 mm Hg, P=0.13) diastolic blood pressure levels or AIx (0.06%, P=0.96). In conclusion, over the 12-month study period the salt substitute significantly reduced not only peripheral and central systolic blood pressure but also reduced arterial stiffness.
Related JoVE Video
Dietary starch intake of individuals and their blood pressure: the International Study of Macronutrients and Micronutrients and Blood Pressure.
J. Hypertens.
PUBLISHED: 01-22-2009
Show Abstract
Hide Abstract
Data from the Multiple Risk Factor Intervention Trial show an independent direct association between starch intake and blood pressure in American men at higher risk of coronary heart disease. Cross-sectional data from the International Study of Macronutrients and Micronutrients and Blood Pressure (INTERMAP) were used to assess relations of dietary starch intake to blood pressure in men and women from four countries.
Related JoVE Video
A nutrient-wide association study on blood pressure.
Circulation
Show Abstract
Hide Abstract
A nutrient-wide approach may be useful to comprehensively test and validate associations between nutrients (derived from foods and supplements) and blood pressure (BP) in an unbiased manner.
Related JoVE Video
Food and nutrient intakes and their associations with lower BMI in middle-aged US adults: the International Study of Macro-/Micronutrients and Blood Pressure (INTERMAP).
Am. J. Clin. Nutr.
Show Abstract
Hide Abstract
Clinical trial data show that reduction in total energy intake enhances weight loss regardless of the macronutrient composition of the diet. Few studies have documented dietary patterns or nutrient intakes that favor leanness [BMI (in kg/m²) ?25] in free-living populations.
Related JoVE Video
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.
Nat. Genet.
Show Abstract
Hide Abstract
We performed a meta-analysis of 2 genome-wide association studies of coronary artery disease comprising 1,515 cases and 5,019 controls followed by replication studies in 15,460 cases and 11,472 controls, all of Chinese Han ancestry. We identify four new loci for coronary artery disease that reached the threshold of genome-wide significance (P < 5 × 10(-8)). These loci mapped in or near TTC32-WDR35, GUCY1A3, C6orf10-BTNL2 and ATP2B1. We also replicated four loci previously identified in European populations (in or near PHACTR1, TCF21, CDKN2A-CDKN2B and C12orf51). These findings provide new insights into pathways contributing to the susceptibility for coronary artery disease in the Chinese Han population.
Related JoVE Video
Selective and sensitive fluorescence chemosensor for the hypochlorite anion in water.
J Fluoresc
Show Abstract
Hide Abstract
Based on an oxidized irreversible ring-opening process of the spirolactam of rhodamine 6G to turn on the fluorescence pathway, a highly sensitive, selective fluorescent and easy accessible chemosensor for ClO(-) has been reported. Upon reaction of the chemosensor with ClO(-) ions, a fluorescent enhancement factor over 60-fold is observed. The chemosensor shows a remarkably high selectivity to discriminate between ClO(-) and other ROS, such as H(2)O(2), TBHP etc., and a wide range of the environmentally and biologically relevant anions and metal ions. The oxidized irreversible ring-opening process of the chemosensor also triggers a visible colorimetric change from colorless to pink, leading to production of both "naked-eye" and fluorimetric detection of ClO(-) anion. The detection limit is estimated to be 2 × 10(-8) M based on a signal-to-noise ratio of 3:1 method. The chemosensor can be used within a pH span of 6-11.5. The chemosensor also shows excellent performance in natural water samples.
Related JoVE Video
Factors explaining the gender disparity in lipid-lowering treatment goal attainment rate in Chinese patients with statin therapy.
Lipids Health Dis
Show Abstract
Hide Abstract
The lipid-lowering treatment goal attainment rate is lower for women than for men among Chinese patients, but the reasons for this disparity have not been fully explored yet.
Related JoVE Video
Factors associated with compliance to lipid-lowering treatment in China.
Eur J Prev Cardiol
Show Abstract
Hide Abstract
There are an estimated 200 million people in China with dyslipidaemia. We sought to explore factors that influence compliance to treatment of dyslipidaemia, using a multi-centre sample in China.
Related JoVE Video
The structural and optical properties of GaSb/InGaAs type-II quantum dots grown on InP (100) substrate.
Nanoscale Res Lett
Show Abstract
Hide Abstract
We have investigated the structural and optical properties of type-II GaSb/InGaAs quantum dots [QDs] grown on InP (100) substrate by molecular beam epitaxy. Rectangular-shaped GaSb QDs were well developed and no nanodash-like structures which could be easily found in the InAs/InP QD system were formed. Low-temperature photoluminescence spectra show there are two peaks centered at 0.75eV and 0.76ev. The low-energy peak blueshifted with increasing excitation power is identified as the indirect transition from the InGaAs conduction band to the GaSb hole level (type-II), and the high-energy peak is identified as the direct transition (type-I) of GaSb QDs. This material system shows a promising application on quantum-dot infrared detectors and quantum-dot field-effect transistor.
Related JoVE Video

What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.