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Find video protocols related to scientific articles indexed in Pubmed.
Bilateral macular detachments, venous stasis retinopathy, and retinal hemorrhages as initial presentation of multiple myeloma: a case report.
Retin Cases Brief Rep
PUBLISHED: 11-06-2014
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To present the case of a patient with bilateral macular detachments, venous stasis retinopathy, and retinal hemorrhages as the initial manifestation of multiple myeloma.
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The utility of a non-verbal prospective memory measure as a sensitive marker for early-stage Alzheimer's disease in Hong Kong.
Int Psychogeriatr
PUBLISHED: 09-24-2014
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ABSTRACT Background: With the proportion of older adults in Hong Kong projected to double in size in the next 30 years, it is important to develop measures for detecting individuals in the earliest stage of Alzheimer's disease (AD, 0.5 in Clinical Dementia Rating, CDR). We tested the utility of a non-verbal prospective memory task (PM, ability to remember what one has to do when a specific event occurs in the future) as an early marker for AD in Hong Kong Chinese. Methods: A large community dwelling sample of older adults who are healthy controls (CDR 0, N = 125), in the earliest stage of AD (CDR 0.5, N = 125), or with mild AD (CDR 1, N = 30) participated in this study. Their reaction time/accuracy data were analyzed by mixed-factor analyses of variance to compare the performance of the three CDR groups. Logistic regression analyses were performed to test the discriminative power of these measures for CDR 0 versus 0.5 participants. Results: Prospective memory performance declined as a function of AD severity: CDR 0 > CDR 0.5 > CDR 1, suggesting the effects of early-stage AD and AD progression on PM. After partialling out the variance explained by psychometric measures (e.g., ADAS-Cog), reaction time/accuracy measures that reflected the PM still significantly discriminated between CDR 0 versus 0.5 participants in most of the cases. Conclusion: The effectiveness of PM measures in discriminating individuals in the earliest stage of AD from healthy older adults suggests that these measures should be further developed as tools for early-stage AD discrimination.
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Dimensionality of burden in Alzheimer caregivers: confirmatory factor analysis and correlates of the Zarit Burden interview.
Int Psychogeriatr
PUBLISHED: 06-04-2014
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ABSTRACT Background: To investigate dimensions of caregiver burden through factor analysis of the Zarit Burden Interview (ZBI), and to examine predictors of different dimensions of burden. Methods: Confirmatory factor analyses were performed on 395 Hong Kong Chinese Alzheimer caregivers to examine whether several proposed factor structures fit the data well. Subsequently, participants were split into two roughly equal subsamples, for the purpose of identifying the most optimal factor structure through exploratory factor analysis in Sample A (n = 183) and an independent verification through confirmatory factor analysis in Sample B (n = 212). ZBI subscales representing the established factors were correlated with caregiver and care-recipient variables known to be associated with burden. Results: Confirmatory factor analyses showed that factor models reported elsewhere did not fit the data well. Subsequently, exploratory factor analysis in Sample A suggested a 4-factor structure. After dropping three items due to poor factor loadings, the 4-factor structure was found to fit the data moderately well in Sample B. The four factors tapped personal strain, captivity, self-criticism, and loss of control. However, self-criticism was basically unrelated to the other three factors and showed a rather different pattern of correlations with caregiver and care-recipient variables. Self-criticism was more common among child caregivers and those who did not live with the care-recipient and was less involved in day-to-day care, yet feeling obligated and close to the care-recipient. Conclusions: The dimensions of caregiver burden may be culturally specific. More research is needed to examine cultural considerations in measuring caregiver burden.
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Characteristics of Alzheimer's disease among patients in Taiwan, Hong Kong, and Beijing.
J. Alzheimers Dis.
PUBLISHED: 05-21-2014
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In order to obtain data from patients with Alzheimer's disease dementia and their informants in a uniform manner and to foster further research among the Chinese and other races, we have conducted an international study to recruit patients diagnosed with Alzheimer's disease (AD) from Taiwan, Hong Kong, and Beijing. The Uniform Data Set was translated into Chinese and administrated to AD patients and their informants. A total of 1,107 AD dementia patients were recruited, including 691 from Taiwan, 244 from Beijing, and 172 from Hong Kong. There were differences in the AD patients: gender (p = 0.099), education (p < 0.001), age (p < 0.001), and handedness (p = 0.007). For informants, age (p = 0.679), gender (p = 0.117), education (p < 0.001), and living together or not (p < 0.001) differed in the three samples. Although three areas across the Taiwan Strait are ethnic Chinese, the clinical picture for patients and informants are very different. Further study is needed to clarify the significance of clinical characteristics in Chinese societies.
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Generation of the probabilistic template of default mode network derived from resting-state fMRI.
IEEE Trans Biomed Eng
PUBLISHED: 05-16-2014
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Default-mode network (DMN) has become a prominent network among all large-scale brain networks which can be derived from the resting-state fMRI (rs-fMRI) data. Statistical template labeling the common location of hubs in DMN is favorable in the identification of DMN from tens of components resulted from the independent component analysis (ICA). This paper proposed a novel iterative framework to generate a probabilistic DMN template from a coherent group of 40 healthy subjects. An initial template was visually selected from the independent components derived from group ICA analysis of the concatenated rs-fMRI data of all subjects. An effective similarity measure was designed to choose the best-fit component from all independent components of each subject computed given different component numbers. The selected DMN components for all subjects were averaged to generate an updated DMN template and then used to select the DMN for each subject in the next iteration. This process iterated until the convergence was reached, i.e., the overlapping region between the DMN areas of the current template and the one generated from the previous stage is more than 95%. By validating the constructed DMN template on the rs-fMRI data from another 40 subjects, the generated probabilistic DMN template and the proposed similarity matching mechanism were demonstrated to be effective in automatic selection of independent components from the ICA analysis results.
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Differential cellular responses induced by dorsomorphin and LDN-193189 in chemotherapy-sensitive and chemotherapy-resistant human epithelial ovarian cancer cells.
Int. J. Cancer
PUBLISHED: 05-15-2014
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Inherent or acquired drug resistance is a major contributor to epithelial ovarian cancer (EOC) mortality. Novel drugs or drug combinations that produce EOC cell death or resensitize drug resistant cells to standard chemotherapy may improve patient treatment. After conducting drug tolerability studies for the multikinase inhibitors dorsomorphin (DM) and it is structural analogue LDN-193189 (LDN), these drugs were tested in a mouse intraperitoneal xenograft model of EOC. DM significantly increased survival, whereas LDN showed a trend toward increased survival. In vitro experiments using cisplatin (CP)-resistant EOC cell lines, A2780-cp or SKOV3, we determined that pretreatment or cotreatment with DM or LDN resensitized cells to the killing effect of CP or carboplatin (CB). DM was capable of blocking EOC cell cycle and migration, whereas LDN produced a less pronounced effect on cell cycle and no effect on migration. Subsequent analyses using primary human EOC cell samples or additional established EOC cells lines showed that DM or LDN induced a dose-dependent autophagic or cell death response, respectively. DM induced a characteristic morphological change with the appearance of numerous LC3B-containing acidic vacuoles and an increase in LC3BII levels. This was coincident with a decrease in cell growth and the altered cell cycle consistent with DM-induced cytostasis. By contrast, LDN produced a caspase 3-independent, reactive oxygen species-dependent cell death. Overall, DM and LDN possess drug characteristics suitable for adjuvant agents used to treat chemotherapy-sensitive and -resistant EOC.
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Benefit-Finding Intervention for Alzheimer Caregivers: Conceptual Framework, Implementation Issues, and Preliminary Efficacy.
Gerontologist
PUBLISHED: 03-31-2014
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To describe an intervention promoting benefit-finding in Alzheimer caregivers, to discuss key issues in implementation and ways to resolve them, and to examine whether the intervention reduced burden and depression in a small randomized trial.
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Efficacy of Physical Exercise in Preventing Falls in Older Adults With Cognitive Impairment: A Systematic Review and Meta-Analysis.
J Am Med Dir Assoc
PUBLISHED: 03-19-2014
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Numerous studies have reported the prevention of falls through exercise among cognitively healthy older people. This study aimed to determine whether the current evidence supports that physical exercise is also efficacious in preventing falls in older adults with cognitive impairment.
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Bias in discriminating very mild dementia for older adults with different levels of education in Hong Kong.
Int Psychogeriatr
PUBLISHED: 02-26-2014
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Education has a profound effect on older adults' cognitive performance. In Hong Kong, some dementia screening tasks were originally designed for developed population with, on average, higher education.
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The principle of assessing mental capacity for enduring power of attorney.
Hong Kong Med J
PUBLISHED: 01-30-2014
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With Hong Kong's rapidly ageing population, increasing numbers of people now have some form of cognitive impairment. Enduring power of attorney is a legal instrument that can allow individuals to manage their financial matters if they subsequently become mentally incapacitated. The law requires that the mental capacity of the individual making an enduring power of attorney should be certified by a registered medical practitioner and a solicitor. This paper discusses the principles involved in the assessment of mental capacity for making an enduring power of attorney and uses this example to illustrate various important considerations in the formal assessment of mental capacity.
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A multidimensional risk factor model for suicide attempts in later life.
Neuropsychiatr Dis Treat
PUBLISHED: 01-01-2014
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Elderly suicide is a public health problem worldwide, and the risk factors are multidimensional. Chronic mental health problems, personality traits, stressful life events, comorbid medical conditions, social isolation, unemployment, and poverty are associated with higher risk for suicide in later life. There was a relative paucity of data on the neurobiological markers of elderly suicide.
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COSMIC (Cohort Studies of Memory in an International Consortium): An international consortium to identify risk and protective factors and biomarkers of cognitive ageing and dementia in diverse ethnic and sociocultural groups.
BMC Neurol
PUBLISHED: 10-10-2013
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A large number of longitudinal studies of population-based ageing cohorts are in progress internationally, but the insights from these studies into the risk and protective factors for cognitive ageing and conditions like mild cognitive impairment and dementia have been inconsistent. Some of the problems confounding this research can be reduced by harmonising and pooling data across studies. COSMIC (Cohort Studies of Memory in an International Consortium) aims to harmonise data from international cohort studies of cognitive ageing, in order to better understand the determinants of cognitive ageing and neurocognitive disorders.Methods/design: Longitudinal studies of cognitive ageing and dementia with at least 500 individuals aged 60 years or over are eligible and invited to be members of COSMIC. There are currently 17 member studies, from regions that include Asia, Australia, Europe, and North America. A Research Steering Committee has been established, two meetings of study leaders held, and a website developed. The initial attempts at harmonising key variables like neuropsychological test scores are in progress.
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Neurocognitive profiles of people with borderline personality disorder.
Curr Opin Psychiatry
PUBLISHED: 05-15-2013
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This review summarizes recent neurocognitive research to better delineate the nosology, prognostication and cause underlying borderline personality disorder (BPD).
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Cognitive predictors for five-year conversion to dementia in community-dwelling Chinese older adults.
Int Psychogeriatr
PUBLISHED: 04-02-2013
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This study evaluates which cognitive measure is best for predicting incident dementia in a population-based random sample of Chinese older adults without dementia over a five-year period.
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Hong Kong: embracing a fast aging society with limited welfare.
Gerontologist
PUBLISHED: 03-25-2013
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With a noninterventionist government and an ideology emphasizing family self-reliance, yet one of the oldest populations around the world, Hong Kong faces many unresolved policy issues in aging, including public financial support, long-term care, and the lack of health or mental health care policies for older people. Despite funding limitations, research is vibrant and population aging is drawing more researchers into the field. Following a review of some of the major research activities, we conclude with some observations on a few key issues for the field of gerontology to move forward with in Hong Kong.
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Telomere length and cognitive function in southern Chinese community-dwelling male elders.
Age Ageing
PUBLISHED: 03-21-2013
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telomere attrition has been associated with an increased risk of different age-related diseases and is widely accepted as a marker of cellular ageing. On the other hand, it is well known that cognitive function declines with age. The telomere length may therefore act as a marker for the pathway associated with cognitive function.
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Structured assessment of mental capacity to make financial decisions in Chinese older persons with mild cognitive impairment and mild Alzheimer disease.
J Geriatr Psychiatry Neurol
PUBLISHED: 03-15-2013
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Previous studies suggested that patients with mild cognitive impairment (MCI) or dementia can have impaired and declining financial skills and abilities. The purpose of this study is to test a clinically applicable method, based on the contemporary legal standard, to examine directly the mental capacity to make financial decisions and its component decision-making abilities among patients with MCI and early dementia. A total of 90 patients with mild Alzheimer disease (AD), 92 participants with MCI, and 93 cognitively normal control participants were recruited for this study. Their mental capacity to make everyday financial decisions was assessed by clinician ratings and the Chinese version of the Assessment of Capacity for Everyday Decision-Making (ACED). Based on the clinician ratings, only 53.5% were found to be mentally competent in the AD group, compared with 94.6% in the MCI group. However, participants with MCI had mild but significant impairment in understanding, appreciating, and reasoning abilities as measured by the ACED. The ACED provided a reliable and clinically applicable structured framework for assessment of mental capacity to make financial decisions.
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Neuropsychiatric symptom clusters of Alzheimer disease in Hong Kong Chinese: correlates with caregiver burden and depression.
Am J Geriatr Psychiatry
PUBLISHED: 02-06-2013
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To investigate the relative effects of different neuropsychiatric syndromes of Alzheimer disease (AD) on caregiver burden and depression.
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The social networks of Hong Kong Chinese family caregivers of Alzheimers disease: correlates with positive gains and burden.
Gerontologist
PUBLISHED: 01-31-2013
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To examine the social networks of family caregivers of persons with Alzheimers disease and the degree to which network characteristics were associated with satisfaction with social support, burden, and positive gains.
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Estrogen Receptor ? Polymorphisms and the Risk of Cognitive Decline: A 2-Year Follow-Up Study.
Am J Geriatr Psychiatry
PUBLISHED: 01-11-2013
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OBJECTIVE: The neuroprotective role of estrogen is supported by biochemical studies, but the results from clinical trials of estrogen replacement therapy on cognitive decline are controversial. One possible missing link might be the interindividual difference in estrogen receptor expression. In this study, the association of estrogen receptor ? (ESR1) polymorphisms and cognitive decline was investigated. METHODS: Chinese older adults (n = 284) were recruited, and the cognitive profile was follow-up over 2-year period. Twenty ESR1 polymorphisms were investigated and correlated with the cognitive decline for the subjects. RESULTS: Significant association was found between ESR1 polymorphisms (rs9340799 [ESR1+351], rs1801132 [ESR1+975], rs6557171, rs9397456, and rs1884049) and subjects with no dementia (Clinical Dementia Rating, CDR 0) and very mild dementia (CDR 0.5). Several ESR1 polymorphisms were associated with cognitive decline as assessed by Chinese versions of Mini-Mental State Examination and Alzheimer Disease Association Scales-Cognitive Subscale. Different sets of ESR1 polymorphisms were associated with cognitive decline from CDR 0 to 0.5 and CDR 0.5 to 1. ESR1 polymorphisms (rs3853248, rs22334693 [ESR1+397], rs9340799 [ESR1+351], rs9397456, rs1801132 [ESR1+975], rs2179922, rs932477, and rs9341016) were associated with the deterioration of episodic memory among subjects with baseline CDR 0, indicating these polymorphisms might be markers for episodic memory decline at an earlier stage. CONCLUSION: This study showed association between ESR polymorphisms and cognitive decline or specific areas in cognitive profile. These findings might be useful in identifying individuals at risk for early intervention, and more research is required to elucidate the underlying mechanisms.
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Under-recognition of dementia in long-term care homes in Hong Kong.
Aging Ment Health
PUBLISHED: 11-30-2011
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To examine the extent to which dementia in nursing homes is recognized by staff.
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Classification of late-life leisure activities among elderly Chinese in Hong Kong.
East Asian Arch Psychiatry
PUBLISHED: 09-17-2011
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To develop a classification to describe leisure activities of elderly Hong Kong Chinese based on the functions fulfilled, namely: intellectual, physical, social, and recreational.
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Recent advances in pharmacological treatment of psychosis in late life.
Curr Opin Psychiatry
PUBLISHED: 07-30-2011
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Psychosis is among the most frequent psychiatric symptoms in late life. Treatment of late life psychosis is often challenging because of age-related changes, physical comorbidities and frailty of older adults. The present study aims at reviewing recent literature on pharmacological treatment of psychosis in the older population.
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Bevacizumab and ranibizumab tachyphylaxis in the treatment of choroidal neovascularisation.
Br J Ophthalmol
PUBLISHED: 07-26-2011
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To evaluate the effect of switching to bevacizumab or ranibizumab after developing tachyphylaxis during anti-vascular endothelial growth factor (VEGF) therapy for choroidal neovascularisation (CNV).
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The effects of exposure to scenarios about dementia on stigma and attitudes toward dementia care in a Chinese community.
Int Psychogeriatr
PUBLISHED: 05-17-2011
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This study investigated whether brief exposure to information has any effect on stigmatizing attitudes towards older people with dementia, and how people responded to this medical diagnosis.
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Examining the association between late-life leisure activity participation and global cognitive decline in community-dwelling elderly Chinese in Hong Kong.
Int J Geriatr Psychiatry
PUBLISHED: 04-28-2011
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This study examines the association between late-life leisure activity participation and global cognitive decline in community-dwelling elderly Chinese in Hong Kong.
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Panel of Genetic Variations as a Potential Non-invasive Biomarker for Early Diagnosis of Alzheimers Disease.
Clin Psychopharmacol Neurosci
PUBLISHED: 03-16-2011
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Alzheimers disease (AD) is the most prevalent form of dementia. Biomarkers such as levels of amyloid beta (A?) in cerebrospinal fluid and ApoE genotyping were suggested for the diagnosis of AD, however, the result is either non-conclusive or with invasive procedure. Genome-wide association studies (GWASs) for AD suggested single nucleotide polymorphisms (SNPs) in many genes are associated with the risk of AD, but each only contributed with small effect to the disease. By incorporating a panel of established genetic susceptibility factors, the risk of an individual in getting AD could be better estimated. Further research will be required to reveal if adding to the current well-developed clinical diagnosis protocol, the accuracy and specificity of diagnosis of AD would be greatly improved and if this might also be beneficial in identifying pre-symptomatic AD patients for early diagnosis and intervention of the disease.
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Neuropsychiatric symptoms are associated with increased risks of progression to dementia: a 2-year prospective study of 321 Chinese older persons with mild cognitive impairment.
Age Ageing
PUBLISHED: 11-23-2010
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studies have suggested that neuropsychiatric (NP) symptoms influence the development of dementia among older adults. But, the results are inconsistent and there is limited information about NP symptoms in population-based samples.
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Could hypothetical scenarios enhance understanding on decision for life-sustaining treatment in non-demented Chinese older persons?
Aging Ment Health
PUBLISHED: 11-12-2010
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With increasing longevity, there is an increasing need for medical professionals to face situations in which explanation for decision on life-sustaining treatment (LST) would be required.
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Prevalence of neuropsychiatric symptoms in chinese older persons with mild cognitive impairment-a population-based study.
Am J Geriatr Psychiatry
PUBLISHED: 09-03-2010
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To estimate the point prevalence and correlates of neuropsychiatric (NP) symptoms among older adults with mild cognitive impairment (MCI) and normal cognition (NC) in a Chinese community.
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Combined clinical and cognitive criteria to identify mild cognitive impairment in a southern chinese community.
Alzheimer Dis Assoc Disord
PUBLISHED: 08-10-2010
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Mild Cognitive Impairment (MCI) is a recognized risk condition for clinical dementia. This paper attempted to explore the applicability of a combined cognitive and clinical approach to identify older Chinese adults at-risk of cognitive decline. Seven hundred forty randomly recruited community dwelling participants (aged 60 or over) were assessed at baseline and 2 years with Clinical Dementia Rating (CDR) and a cognitive battery. Baseline MCI groups were categorized by CDR-MCI, cognitive function (Cog-MCI), and a combined CDR-Cog approach. The cognitive approach adopted the Mayo clinic criteria. For the combined approach, nonamnestic MCI combined CDR 0.5 plus nonmemory cognitive deficits. The overall concordance between CDR and Cognitive test ratings were 65.3% (? =256.4, P<0.001, ?=0.44). With a combined approach, 424(57%) participants were classified as normal. CDR-MCI group had higher cognitive scores compared with MCI groups by other criteria (1 way analysis of variance or ANOVA). At 2 years, the combined CDR-Cog MCI group identified all dementia (N=24) converters although group differences were not significant. Cognitive function and CDR identified participants potentially at-risk for furthermore decline, but exhibited some differences in detection profiles. A combined approach may be more practical in screening for MCI participants with diverse educational and cultural background.
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A PIN1 polymorphism that prevents its suppression by AP4 associates with delayed onset of Alzheimers disease.
Neurobiol. Aging
PUBLISHED: 05-12-2010
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Alzheimers disease (AD), the most common form of dementia, is characterized by the presence of neurofibrillary tangles composed of tau and senile plaques of amyloid-beta peptides (A?) derived from amyloid precursor protein (APP). Pin1 is a unique prolyl isomerase that has been shown to protect against age-dependent neurodegeneration by acting on phosphorylated tau and APP to suppress tangle formation and amyloidogenic APP processing. Here we report a functional polymorphism, rs2287839, in the Pin1 promoter that is significantly associated with a 3-year delay in the average age at onset (AAO) of late-onset AD in a Chinese population. More significantly, the Pin1 polymorphism rs2287839 is located within the consensus binding motif for the brain-selective transcription factor, AP4 (CAGCTG) and almost completely abolishes the ability of AP4 to bind and suppress the Pin1 promoter, as shown by chromatin immunoprecipitation, electrophoretic mobility shift assay, and promoter luciferase assay. Moreover, overexpression or knockdown of AP4 resulted in an 80% reduction or 2-fold increase in endogenous Pin1 levels, respectively. Thus, AP4 is a novel transcriptional repressor of Pin1 expression and the Pin1 promoter single nucleotide polymorphism (SNP) identified in this study that prevents such suppression is associated with delayed onset of AD. These results indicate that regulation of Pin1 by AP4 plays a critical role in determining age at onset of AD and might be a novel therapeutic target to delay the onset of AD.
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Neuropsychological profiles and short-term outcome in late-onset depression.
Int J Geriatr Psychiatry
PUBLISHED: 04-16-2010
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Neuropsychological impairments are common in older persons with late-onset depression. This study examined the relationship between neuropsychological profiles and short-term outcome in late-onset depression.
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Interim follow-up of a randomized controlled trial comparing Chinese style mind body (Tai Chi) and stretching exercises on cognitive function in subjects at risk of progressive cognitive decline.
Int J Geriatr Psychiatry
PUBLISHED: 02-21-2010
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We reported the interim findings of a randomized controlled trial (RCT) to examine the effects of a mind body physical exercise (Tai Chi) on cognitive function in Chinese subjects at risk of cognitive decline.
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Social support and well-being in dementia family caregivers: the mediating role of self-efficacy.
Aging Ment Health
PUBLISHED: 11-03-2009
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The study investigated self-efficacy as a possible mediator of the relationship between the social support and depressive symptoms of primarily informal caregivers, mainly family members, of patients with dementia in Hong Kong.
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Serum zinc is decreased in Alzheimers disease and serum arsenic correlates positively with cognitive ability.
Biometals
PUBLISHED: 10-15-2009
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Zinc, copper, and iron aggregate Abeta and accumulate in Alzheimers disease (AD) plaques. Some metals are increased in AD vs. control serum. The authors examined levels of 12 metals in serum of 44 AD and 41 control subjects. Zinc decreased from 12.3 to 10.9 micromol/L (means, p = 0.0007). Arsenic positively correlated with Mini-Mental State Examination score (p < 0.0001). Zinc deposition in brain amyloid might deplete zinc from other body compartments, such as serum. The arsenic correlation might be caused by the major contribution of seafood consumption to intake of both arsenic and docosahexaenoic acid, of which the latter may delay AD.
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Examining the association between participation in late-life leisure activities and cognitive function in community-dwelling elderly Chinese in Hong Kong.
Int Psychogeriatr
PUBLISHED: 09-29-2009
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Growing evidence suggests that participation in late-life leisure activity may have beneficial effects on cognitive function. The objective of the study was to evaluate the association between leisure activity participation and cognitive function in an elderly population of community-dwelling Hong Kong Chinese.
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Modality of physical exercise and cognitive function in Hong Kong older Chinese community.
Int J Geriatr Psychiatry
PUBLISHED: 08-07-2009
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We reported the association between modality of Physical Exercise and cognitive function in 782 older Chinese adults assessed in the second phase of a population survey for dementia in Hong Kong.
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Predicting changes in the health-related quality of life of Chinese depressed older people.
Int J Geriatr Psychiatry
PUBLISHED: 08-07-2009
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To identify predictors of change in Health Related Quality of Life (HRQoL) among community dwelling Chinese older people with depression.
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Subjective health-related quality of life of Chinese older persons with depression in Shanghai and Hong Kong: relationship to clinical factors, level of functioning and social support.
Int J Geriatr Psychiatry
PUBLISHED: 08-04-2009
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This study aimed to measure and compare the perceptions of HRQoL amongst Chinese older people with depression between Hong Kong and Shanghai and to explore the association of HRQoL with clinical factors, level of functioning and social support in the two sites.
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Polymorphisms of the estrogen receptor alpha (ESR1) gene and the risk of Alzheimers disease in a southern Chinese community.
Int Psychogeriatr
PUBLISHED: 07-09-2009
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Alzheimers disease (AD) is a neurodegenerative disease with a higher prevalence in women. Expression of estrogen receptor 1 (ESR1) gene has been identified throughout the brain. Owing to the putative neuroprotective effects of estrogen, estrogen receptor gene is a potential candidate modulating the development of AD. Preliminary associations between two polymorphisms of ESR1 (PvuII and XbaI) gene and AD have been reported.
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Capacity to make treatment decisions in Chinese older persons with very mild dementia and mild Alzheimer disease.
Am J Geriatr Psychiatry
PUBLISHED: 04-25-2009
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This study aims at assessing mental competence in Chinese patients with mild and very mild dementia with a semistructured assessment method and the impact of repeated presentations of information on patients mental competence.
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Interindividual and interethnic variation in genomewide gene expression: insights into the biological variation of gene expression and clinical implications.
Clin. Chem.
PUBLISHED: 02-20-2009
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Analysis of gene expression in peripheral blood samples is increasingly being applied in biomarker studies of disease diagnosis and prognosis. Although knowledge of interindividual and interethnic variation in gene expression is required to set ethnicity-specific reference intervals and to select reference genes and preferred markers from a list of candidate genes, few studies have attempted to characterize such biological variation on a genomewide scale.
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Cholesterol 24-hydroxylase (CYP46A1) polymorphisms are associated with faster cognitive deterioration in Chinese older persons: a two-year follow up study.
Int J Geriatr Psychiatry
PUBLISHED: 02-13-2009
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We previously found that the polymorphisms of cholesterol 24-hydroxylase (CYP46A1) gene were associated with the risk of Alzheimers disease (AD) in Chinese. However, its effect in predicting progression of cognitive decline remains unknown.
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Effects of education on very mild dementia among Chinese people in Hong Kong: potential mediators in the Cantonese Mini-Mental State Examination tasks.
Aging Ment Health
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In Hong Kong, older Chinese adults generally have a low level of education. This study examined the effect of education on very mild Alzheimers disease (AD), as quantified by Clinical Dementia Rating (CDR) scale (CDR 0.5 versus 0), in a Chinese community. The Cantonese version of the Mini-Mental State Examination (C-MMSE) was used to estimate cognitive abilities that were related to the level of education, and that in turn serve as protective factors for AD.
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The CEPHEUS Pan-Asian survey: high low-density lipoprotein cholesterol goal attainment rate among hypercholesterolaemic patients undergoing lipid-lowering treatment in a Hong Kong regional centre.
Hong Kong Med J
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OBJECTIVES. To evaluate attainment of low-density lipoprotein cholesterol goals among hypercholesterolaemic patients undergoing lipid-lowering drug treatment in Hong Kong and to identify potential determinants of treatment outcomes. DESIGN. Cross-sectional observational study. SETTING. A single site in Hong Kong, as part of the CEPHEUS Pan-Asian survey. PATIENTS. Subjects with hypercholesterolaemia aged 18 years or above, who had been on lipid-lowering drug treatment for at least 3 months with no dose adjustment for at least 6 weeks. RESULTS. A total of 561 such patients (mean age, 65.3; standard deviation, 9.7 years) were evaluated. Most had major cardiovascular risk factors; 534 (95.2%) of 561 patients had coronary heart disease and 534 (95.4%) of 560 patients had low-density lipoprotein cholesterol goals set at lower than 70 mg/dL. In all, 465 (82.9%) patients attained their respective low-density lipoprotein cholesterol goals. Among 75 patients who had coronary heart disease or equivalent risk, and multiple risk factors with a 10-year coronary heart disease risk of over 20%, 62 (82.7%) attained their respective low-density lipoprotein cholesterol goals. Significant predictors of low-density lipoprotein cholesterol goal attainment included the patients baseline lipid profile (total cholesterol and low-density lipoprotein cholesterol levels), blood pressure, and drugs (statin/non-statin) used for treatment. CONCLUSIONS. Hypercholesterolaemic patients undergoing lipid-lowering drug treatment in the present Hong Kong study were able to achieve a very high attainment rate for the low-density lipoprotein cholesterol goal, despite the fact that most of them had major cardiovascular risk factors.
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MxA polymorphisms are associated with risk and age-at-onset in Alzheimer disease and accelerated cognitive decline in Chinese elders.
Rejuvenation Res
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Alzheimer disease (AD) is the most common neurodegenerative disease, and inflammation has been associated with the pathogenesis of AD. The myxovirus resistance protein 1 (MxA) is an interferon-induced antiviral protein and is widely studied in virus-caused diseases. An immunohistochemical study has shown MxA expression in senile plaques of the AD brain, suggesting that MxA might be involved in the pathogenesis of AD. In this study, 10 tagged single-nucleotide polymorphisms (SNPs) and two commonly studied SNPs in the MxA gene were investigated in 220 AD patients and 316 age-matched healthy Chinese subjects to investigate the association to the predisposition and age of onset (AAO) of AD. Healthy subjects were followed up for 2 years to determine the association of MxA polymorphisms and the rate of cognitive deterioration. Our result showed rs17000900 (MxA-123) and rs461093 were significantly associated with the risk of AD. Six MxA SNPs, including MxA -123, were associated to AAO of AD. The carriers of minor alleles of five MxA SNPs, including rs457274, rs2071430 (MxA -88), rs461093, rs469083, and rs1557372, were associated with faster cognitive decline over 2 years. Furthermore, our functional assay showed significant association between increased MxA expression and the -123A/-88T haplotype, which is in line with our findings in genetic association. This is the first study showing the significant association of MxA SNPs and predisposition of AD, modulation of AAO in AD, and rate of cognitive decline.
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A benefit-finding intervention for family caregivers of persons with Alzheimer disease: study protocol of a randomized controlled trial.
Trials
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Caregivers of relatives with Alzheimers disease are highly stressed and at risk for physical and psychiatric conditions. Interventions are usually focused on providing caregivers with knowledge of dementia, skills, and/or support, to help them cope with the stress. This model, though true to a certain extent, ignores how caregiver stress is construed in the first place. Besides burden, caregivers also report rewards, uplifts, and gains, such as a sense of purpose and personal growth. Finding benefits through positive reappraisal may offset the effect of caregiving on caregiver outcomes.
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Neuropsychiatric symptom clusters of Alzheimers disease in Hong Kong Chinese: prevalence and confirmatory factor analysis of the Neuropsychiatric Inventory.
Int Psychogeriatr
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The aim of this study was to investigate the clustering of symptoms on the Neuropsychiatric Inventory (NPI) and the relative prevalence of symptom clusters in mild and moderate Alzheimers disease (AD).
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A 1-year randomized controlled trial comparing mind body exercise (Tai Chi) with stretching and toning exercise on cognitive function in older Chinese adults at risk of cognitive decline.
J Am Med Dir Assoc
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To compare the effectiveness of Chinese-style mind-body exercise (24 forms simplified Tai Chi) versus stretching and toning exercise in the maintenance of cognitive abilities in Chinese elders at risk of cognitive decline.
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Self-efficacy is associated with less burden and more gains from behavioral problems of Alzheimers disease in Hong Kong Chinese caregivers.
Gerontologist
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To test the effects of different self-efficacy beliefs on caregiver appraisals and depressive symptoms. We hypothesized that self-efficacy has a direct effect on depression while moderating the effects of behavioral problems on both negative (i.e., burden) and positive (i.e., uplifting) appraisals.
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Capacity to make decisions on medication management in Chinese older persons with mild cognitive impairment and mild Alzheimers disease.
Int Psychogeriatr
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This study aimed to assess if decisional capacity and the four decision-making abilities related to decisions concerning medication management were impaired among community-dwelling Chinese older persons in Hong Kong with amnestic mild cognitive impairment (MCI) and mild Alzheimers disease (AD), as compared with cognitively normal older adults.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.