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Find video protocols related to scientific articles indexed in Pubmed.
Relative hypo- and hypercortisolism are both associated with depression and lower quality of life in bipolar disorder: a cross-sectional study.
PLoS ONE
PUBLISHED: 01-01-2014
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Depression in unipolar and bipolar disorders is associated with hypothalamic-pituitary-adrenal-axis (HPA-axis) hyperactivity. Also, unipolar disorder has recently been shown to exhibit HPA-axis hypoactivity. We studied for the first time how HPA-axis hypo- and hyperactivity relate to depression and disease burden in bipolar disorder. We were interested in studying hypocortisolism; characterized by increased HPA-axis negative feedback sensitivity and lower basal cortisol levels together with the opposite HPA-axis regulatory pattern of hypercortisolism.
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Shorter telomere length is linked to brain atrophy and white matter hyperintensities.
Age Ageing
PUBLISHED: 11-14-2013
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leukocyte telomere length (TL) is considered a marker of biological aging. Several studies have investigated the link between leukocyte TL and aging-associated functional attributes of the brain, but no prior study has investigated whether TL can be linked to brain atrophy and white matter hyperintensities (WMHs); two prominent structural manifestations of brain aging.
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Short telomeres in depression and the general population are associated with a hypocortisolemic state.
Biol. Psychiatry
PUBLISHED: 07-09-2011
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The hypothalamic-pituitary-adrenal (HPA) axis plays a central role in stress regulation, and leukocyte telomere length (TL) has been suggested to represent a cumulative measure of stress. Depression is intimately related with stress and frequently exhibits a dysregulated HPA axis. We aimed to study the relationships between TL and biological and psychological facets of stress in recurrent major depressive disorder and controls.
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The relationship between the val158met catechol-O-methyltransferase (COMT) polymorphism and irritable bowel syndrome.
PLoS ONE
PUBLISHED: 02-22-2011
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The catechol-O-methyltransferase (COMT) enzyme has a key function in the degradation of catecholamines and a functional polymorphism is val158met. The val/val genotype results in a three to fourfold higher enzymatic activity compared with the met/met genotype, with the val/met genotype exhibiting intermediate activity. Since pain syndromes as well as anxiety and depression are associated to low and high COMT activity respectively and these conditions are all associated with irritable bowel syndrome (IBS) we wanted for the first time to explore the relationship between the polymorphism and IBS.
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APOE ?4 is associated with longer telomeres, and longer telomeres among ?4 carriers predicts worse episodic memory.
Neurobiol. Aging
PUBLISHED: 02-05-2010
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Both leukocyte telomere length and the apolipoprotein ?4 allele have been associated with mortality, cardiovascular disease, cognition, and dementia. The authors investigated whether leukocyte telomere length was associated with APOE genotype or cognitive abilities in the context of APOE genotype. The setting for this cross-sectional study was 427 nondemented individuals aged 41-81 yr. The authors found that ?4 carriers overall exhibited significantly longer telomeres compared with non-carriers (difference of 268 bp, p = 0.001). This difference was greatest at the lower limit of the age span and nonsignificant at the upper limit, which translated into a significantly higher telomere attrition rate (p = 0.049) among ?4 carriers (37 bp/years) compared with non-carriers (21 bp/year). Further, longer telomeres among ?4 carriers significantly predicted worse performance on episodic memory tasks. No significant associations were found on tasks tapping semantic and visuospatial ability, or among ?3/?3 carriers. In conclusion, APOE ?4 carriers had longer telomeres compared with non-carriers, but higher rate of attrition. Among them, longer telomeres predicted worse performance on episodic memory tasks. These observations suggest that the ?4 allele is associated with abnormal cell turnover of functional and possibly clinical significance.
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Longer leukocyte telomere length is associated with smaller hippocampal volume among non-demented APOE ?3/?3 subjects.
PLoS ONE
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Telomere length shortens with cellular division, and leukocyte telomere length is used as a marker for systemic telomere length. The hippocampus hosts adult neurogenesis and is an important structure for episodic memory, and carriers of the apolipoprotein E ?4 allele exhibit higher hippocampal atrophy rates and differing telomere dynamics compared with non-carriers. The authors investigated whether leukocyte telomere length was associated with hippocampal volume in 57 cognitively intact subjects (29 ?3/?3 carriers; 28 ?4 carriers) aged 49-79 yr. Leukocyte telomere length correlated inversely with left (r(s)?=?-0.465; p?=?0.011), right (r(s)?=?-0.414; p?=?0.025), and total hippocampus volume (r(s)?=?-0.519; p?=?0.004) among APOE ?3/?3 carriers, but not among ?4 carriers. However, the ?4 carriers fit with the general correlation pattern exhibited by the ?3/?3 carriers, as ?4 carriers on average had longer telomeres and smaller hippocampi compared with ?3/?3 carriers. The relationship observed can be interpreted as long telomeres representing a history of relatively low cellular proliferation, reflected in smaller hippocampal volumes. The results support the potential of leukocyte telomere length being used as a biomarker for tapping functional and structural processes of the aging brain.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.