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Find video protocols related to scientific articles indexed in Pubmed.
A cage-based cationic body-centered tetragonal metal-organic framework: single-crystal to single-crystal transformation and selective uptake of organic dyes.
Chem. Commun. (Camb.)
PUBLISHED: 11-20-2014
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A cage-based cationic body-centered metal-organic framework was successfully synthesized using a custom-designed bifunctional triazolcarboxylate ligand. It shows interesting single-crystal-to-single-crystal transformation upon solvent exchange process and selective uptake of organic dyes.
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Change of Recipient Corneal Endothelial Cells After Non-Descemet's Stripping Automated Endothelial Keratoplasty in a Rabbit Model.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 11-20-2014
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Purpose:We used a rabbit model to evaluate the interface embedded between the recipient corneas and transplanted donor corneal discs after non-Descemet's stripping automated endothelial keratoplasty (nDSAEK). Methods:Six unilateral DSAEK and nDSAEK surgeries were performed on New Zealand white rabbits. In vivo confocal microscopy was performed to show: 1) the changes in corneal endothelial cells embedded between the recipient corneas and the transplanted donor corneal discs (CEEB); and 2) the interface opacity by z-profile. Immunohistochemistry were performed to evaluate the functional change of CEEB at post-nDSAEK 3 months. Transmission electron microscopy was performed to evaluate the morphology of CEEB after nDSAEK at post-nDSAEK six months. Results: In vivo confocal microscopy showed a time-dependent decrease in the density of CEEB at post-operative one, two or three months (p<0.01). Interface opacity was higher in the nDSAEK group than the DSAEK group at all examination points but the difference was statistically insignificant. At three months after surgery, the CEEB were negative for Na+/K+-ATPase staining. Terminal deoxynucleotidyl transferase dUTP nick end labelin (TUNEL) staining showed apoptotic changes in some areas. The CEEB showed a time dependent thickening and loss of uniform thickness of cellular morphology during a six month's observation. At post-nDSAEK three and six months, extensions of the cellular processes into the donor graft stroma combined with intracellular vacuoles containing collagen-like materials were also found. Conclusions:CEEB showed decreased density, loss of pump function, apoptosis and changed morphology after nDSAEK. However, the interface opacity was not significantly greater compared with DSAEK eyes.
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Novel permanent magnet linear motor with isolated movers: Analytical, numerical and experimental study.
Rev Sci Instrum
PUBLISHED: 11-03-2014
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This paper proposes a novel permanent magnet linear motor possessing two movers and one stator. The two movers are isolated and can interact with the stator poles to generate independent forces and motions. Compared with conventional multiple motor driving system, it helps to increase the system compactness, and thus improve the power density and working efficiency. The magnetic field distribution is obtained by using equivalent magnetic circuit method. Following that, the formulation of force output considering armature reaction is carried out. Then inductances are analyzed with finite element method to investigate the relationships of the two movers. It is found that the mutual-inductances are nearly equal to zero, and thus the interaction between the two movers is negligible. A research prototype of the linear motor and a measurement apparatus on thrust force have been developed. Both numerical computation and experiment measurement are conducted to validate the analytical model of thrust force. Comparison shows that the analytical model matches the numerical and experimental results well.
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Reference-free beam-sampling system for freeform surface measurements.
Appl Opt
PUBLISHED: 10-17-2014
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Freeform optical elements have wide applications in optics, manufacturing, and precision industries. Due to the diversity of the nonrotationally symmetrical nature of a surface profile, few noncontact measurement techniques have been proposed or reported. This paper proposes and develops a new reference-free beam-sampling (RFBS) methodology and system for this particular application. The RFBS system uses the beam itself as an optical probe to sample the surface. Through introducing lateral disturbance to the modulated beam, the curvature matrix of the sample is measured. Simulation and experiments have been conducted to investigate the method's capability and study the configuration, so as to optimize the system. It is shown that a tens of nanometers measurement accuracy is achieved, even for surfaces with a peak valley value of more than 1 mm. The feasibility and effectiveness of the RFBS methodology is proven.
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A mechanistic study on urine retention in d-amphetamine addicts.
Chin J Physiol
PUBLISHED: 09-24-2014
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Chronic amphetamine intake leads to neurogenic bladder and chronic urinary retention. The mechanism underlying persistent urinary retention is unclear. The pelvic-urethral reflex (PUR) is essential for the urethra to develop sufficient resistance to maintain urine continence, an important function of the urinary system. Recent studies on PUR activities have indicated that repetitive/tetanic stimulation of the pelvic afferent fibers induces spinal reflex potentiation (SRP) in PUR activities, which further increases urinary retention. In this study, results showed that test stimulation (TS, 1/30 Hz) evoked a baseline reflex activity, while repetitive stimulation (RS, 1 Hz) induced reflex potentiation in the external urethral sphincter. Intrathecal d-amphetamine (AMPH, 30 ?M) did not but higher AMPH concentration (100 ?M) induced SRP in TS-induced reflex activity. H89 (10 ?M, a protein kinase A inhibitor), but not chelerythrine chloride (CTC, 10 ?M, a protein kinase C inhibitor), prevented the 100 ?M AMPH-elicited SRP. At 30 ?M, forskolin, an activator of adenylyl cyclase, elicited SRP. The co-administration of 10 ?M forskolin and 30 ?M AMPH induced SRP in TS-induced reflex activity. These results implied that the repetitive/tetanic stimulation of the pelvic afferent fibers could induce SRP in PUR activities, so that the urethra can produce sufficient resistance and played a significant role in urinary retention. Findings in this study demonstrated that amphetamine could induce bladder dysfunction by triggering protein kinase A activation, and provide a practical basis for the development of treatment for amphetamine-associated urinary retention.
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The complete mitochondrial gemome of a medicinal insect Martianus dermestoides (Coleoptera, Tenebrionidae).
Mitochondrial DNA
PUBLISHED: 09-11-2014
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Abstract In this study, the complete mitogenome sequence of Martianus dermestoides (Coleoptera, Tenebrionidae) has been amplified and sequenced employing the long polymerase chain reaction method. The mitogenome, consisting of 15,434 base pairs (bp), had the typical invertebrate mitochondrial gene arrangement, including 13 protein-coding, 22 transfer RNAs, 2 ribosomal RNAs genes and a noncoding control region (CR). The CR of 798?bp length is rather compact and located between srRNA and tRNA(iLe). The overall base composition of M. dermestoides is 40.97% for A, 18.53% for C, 31.13% for T and 9.38% for G, with a high AT bias of 72.09%. The complete mitogenome may provide useful DNA molecular data for further phylogenetic analyses for higher taxa of Tenebrionidae.
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Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
N. Engl. J. Med.
PUBLISHED: 09-11-2014
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Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. The frequency and spectrum of genetic alterations in Ph-like ALL and its responsiveness to tyrosine kinase inhibition are undefined, especially in adolescents and adults.
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PROTEIN PROFILES OF CHINESE WHITE WAX SCALE, Ericerus pela, AT THE MALE PUPAL STAGE BY HIGH-THROUGHPUT PROTEOMICS.
Arch. Insect Biochem. Physiol.
PUBLISHED: 09-03-2014
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The Chinese white wax scale insect (Ericerus pela) is sexually dimorphic with holometabolous males and hemimetabolous females. Holometabolous insects were assumed to originate from hemimetabolous ancestors. Therefore, the male pupal stage is a major innovation compared with hemimetabolous female insects. Here, the protein profiles of the male pupae were obtained by high-throughput proteomics and analyzed using bioinformatics methods. A total of 1,437 peptides were identified and assigned to 677 protein groups. Most of the proteins had molecular weights below 40 kDa and isoelectric points from 4 to 7. Gene Ontology terms were assigned to 331 proteins, including metabolic process, developmental process, and cellular process. Kyoto Encyclopedia of Genes and Genomes annotations identified 142 pathways and most proteins were assigned to metabolism events. Pathways involved in cell growth and death, signal transduction, folding, and sorting and degradation were also identified. Six proteins that had undergone positive selection were classified into four groups, protein biosynthesis, protein degeneration, signal transduction, and detoxification. Many of the high-abundance proteins were enzymes involved in carbohydrate, lipid, and amino acid metabolism; signal transduction; degradation; and immunization, which indicated that metabolism, disruption, and development occurred intensely at the pupal stage. These processes are closely related to the physiological status of pupae. The results also suggested that these related proteins may be fundamental factors in the formation of pupae. This study describes pupal characterization at the molecular level and provides a basis for further physiological studies.
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Comparison the prognostic value of galectin-3 and serum markers of cardiac extracellular matrix turnover in patients with chronic systolic heart failure.
Int J Med Sci
PUBLISHED: 08-13-2014
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Galectin-3 (Gal-3) shows the ability of survival prediction in heart failure (HF) patients. However, Gal-3 is strongly associated with serum markers of cardiac extracellular matrix (ECM) turnover. The aim of this study is to compare the impact of Gal-3 and serum markers of cardiac ECM turnover on prognostic prediction of chronic systolic HF patients.
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Understanding the behavior of Thermomyces lanuginosus lipase in acylation of pyrimidine nucleosides possessing 2'-substituent.
Appl. Biochem. Biotechnol.
PUBLISHED: 08-02-2014
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The effect of 2'-differing substituent groups (such as the H, F, Cl, Br, OCH3) as well as various chain lengths of the acyl substrates (C6, C10, and C14) on the performance of Thermomyces lanuginosus lipase for the regioselective acylation of pyrimidine nucleoside analogs was investigated systematically for the first time. The results evidently demonstrated that changing substituents in nucleosides had a significant influence on the substrate specificity for the enzymatic reaction, possibly due to the differences in physicochemical properties of the substituents and the special shape of the substrate binding site in enzyme active region. With respect to the chain-length selectivity, the enzyme exhibited the highest 5'-regioselectivity toward the longer chain (C14) as compared to short (C6 and C10) ones. The reason might be attributed to the presence of the interaction between the acyl chain and the large hydrophobic substrate-binding pocket.
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A Heterometallic Fe(II) -Dy(III) Single-Molecule Magnet with a Record Anisotropy Barrier.
Angew. Chem. Int. Ed. Engl.
PUBLISHED: 07-31-2014
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A record anisotropy barrier (319?cm(-1) ) for all d-f complexes was observed for a unique Fe(II) -Dy(III) -Fe(II) single-molecule magnet (SMM), which possesses two asymmetric and distorted Fe(II) ions and one quasi-D5h Dy(III) ion. The frozen magnetization of the Dy(III) ion leads to the decreased Fe(II) relaxation rates evident in the Mössbauer spectrum. Ab initio calculations suggest that tunneling is interrupted effectively thanks to the exchange doublets.
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Anti-inflammatory and analgesic effects of the marine-derived compound comaparvin isolated from the crinoid Comanthus bennetti.
Molecules
PUBLISHED: 07-29-2014
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To date, no study has been conducted to explore the bioactivity of the crinoid Comanthus bennetti. Here we report the anti-inflammatory properties of comaparvin (5,8-dihydroxy-10-methoxy-2-propylbenzo[h]chromen-4-one) based on in vivo experiments. Our preliminary screening for anti-inflammatory activity revealed that the crude extract of Comanthus bennetti significantly inhibited the expression of pro-inflammatory proteins in lipopolysaccharide (LPS)-stimulated murine RAW 264.7 macrophage cells. Comaparvin isolated from crinoids significantly decreased the expression of inducible nitric oxide synthase (iNOS) protein and mRNA in LPS-stimulated macrophage cells. Moreover, our results showed that post-treatment with comaparvin significantly inhibited mechanical allodynia, thermal hyperalgesia and weight-bearing deficits in rats with carrageenan-induced inflammation. Comaparvin also attenuated leukocyte infiltration and iNOS protein expression in carrageenan-induced inflamed paws. These results suggest that comaparvin is a potential anti-inflammatory therapeutic agent against inflammatory pain.
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[Preparation and application of the quinonyl chloromethylation polystyrene in biological treatment of wastewater].
Huan Jing Ke Xue
PUBLISHED: 07-25-2014
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The technology of non-water-soluble mediator anaerobic biological catalysis has attracted more and more attention in the field of environment technology. In this study, five kinds of quinonly compounds were grafted on the chloromethylation polystyrene macromolecular carrier by Friedel-Crafts reaction. Reaction factors of temperature and molar ratio for the 1,4-naphthoquinone grafting carrier were optimized, and the optimal temperature was 78 degreesC while the optimal molar ratio of 1, 4-naphthoquinone and chloromethylation polystyrene was 2: 1. Fourier infrared spectrum analysis confirmed that the quinone groups were successfully grafted on the macromolecular backbone chloromethylation polystyrene. Catalysis using the five kinds of quinonly materials as non-water-soluble redox mediators enhanced the biological denitrification rate and the decoloration of azo dyes, meanwhile these materials showed good reusability in the biodegradation of azo dye. This study developed a new method for the preparation of quinonly materials and revealed a new field in the technology of mediator catalysis.
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Complexity of heart rate variability predicts outcome in intensive care unit admitted patients with acute stroke 
J. Neurol. Neurosurg. Psychiatr.
PUBLISHED: 07-24-2014
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Heart rate variability (HRV) has been proposed as a predictor of acute stroke outcome. This study aimed to evaluate the predictive value of a novel non-linear method for analysis of HRV, multiscale entropy (MSE) and outcome of patients with acute stroke who had been admitted to the intensive care unit (ICU).
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N-3 polyunsaturated fatty acids decrease levels of doxorubicin-induced reactive oxygen species in cardiomyocytes -- involvement of uncoupling protein UCP2.
J. Biomed. Sci.
PUBLISHED: 07-22-2014
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BackgroundUse of the chemotherapeutic drug doxorubicin (DOX) is associated with serious cardiotoxicity, as it increases levels of reactive oxygen species (ROS). N-3 polyunsaturated fatty acid dietary supplements can be of benefit to patients undergoing cancer therapy. The aims of this study were to determine whether DOX-induced cardiotoxicity is related to mitochondrial uncoupling proteins and whether eicosapentaenoic acid (EPA, C20:5 n-3) or docosahexaenoic acid (DHA, C22:6 n-3) affects DOX-induced cardiomyocyte toxicity.ResultsTreatment of H9C2 cells with DOX resulted in decreased cell viability and UCP2 expression. Treatment with 100 ¿M EPA or 50 ¿M DHA for 24 h resulted in a maximal mitochondria concentration of these fatty acids and increased UCP2 expression. Pretreatment with 100 ¿M EPA or 50 ¿M DHA prevented the DOX-induced decrease in UCP2 mRNA and protein levels, but these effects were not seen with EPA or DHA and DOX cotreatment. In addition, the DOX-induced increase in ROS production and subsequent mitochondrial membrane potential change (¿¿) were significantly attenuated by pretreatment with EPA or DHA.ConclusionEPA or DHA pre-treatment inhibits the DOX-induced decrease in UCP2 expression, increase in ROS production, and subsequent mitochondrial membrane potential change that contribute to the cardiotoxicity of DOX.
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The reduced autophagic response by oxidative stress in angiotensin II-induced hypertrophic H9C2 cells causes more apoptotic cell death.
Exp. Biol. Med. (Maywood)
PUBLISHED: 07-10-2014
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Autophagy is an important process in the pathogenesis of cardiovascular diseases, and angiotensin II (Ang II) plays a causative role in the induction of cardiomyocyte autophagy. The purpose of this study was to explore whether, under conditions of oxidative stress, levels and types of cell death were different in untreated and Ang II-treated cardiomyocytes (H9C2 cells). Treatment with 20?µM Ang II induced cardiac hypertrophy in H9C2 cells, with increased expression of the hypertrophic markers c-Fos, ß-myosin heavy chain, atrial natriuretic factor (ANF), and brain natriuretic factor (BNF). Under normal conditions, there was no difference in the levels of autophagic vacuoles and apoptotic bodies in untreated and Ang II-treated H9C2 cells. However, oxidative stress generated by 100?µM H2O2 triggered autophagy in untreated control cells, but had a reduced effect in Ang II-induced hypertrophic cells, resulting in more cell death, and this was associated with a decrease in connexin 43 expression. Blocking this autophagic response with 3-methyladenine resulted in a significant increase in cell death and apoptosis of H9C2 cells but did not significantly affect the response of Ang II-treated cells. The autophagic response to 100?µM H2O2 provides a survival advantage for cells and this is reduced by Ang II treatment.
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Single-crystal X-ray diffraction studies on structural transformations of porous coordination polymers.
Chem Soc Rev
PUBLISHED: 06-28-2014
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X-Ray single-crystal diffraction has been the most straightforward and important technique in structural determination of crystalline materials for understanding their structure-property relationships. This powerful tool can be used to directly visualize the precise and detailed structural information of porous coordination polymers or metal-organic frameworks at different states, which are unique for their flexible host frameworks compared with conventional adsorbents. With a series of selected recent examples, this review gives a brief overview of single-crystal X-ray diffraction studies and single-crystal to single-crystal transformations of porous coordination polymers under various chemical and physical stimuli such as solvent and gas sorption/desorption/exchange, chemical reaction and temperature change.
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An Orientation Measurement Method Based on Hall-effect Sensors for Permanent Magnet Spherical Actuators with 3D Magnet Array.
Sci Rep
PUBLISHED: 06-06-2014
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An orientation measurement method based on Hall-effect sensors is proposed for permanent magnet (PM) spherical actuators with three-dimensional (3D) magnet array. As there is no contact between the measurement system and the rotor, this method could effectively avoid friction torque and additional inertial moment existing in conventional approaches. Curved surface fitting method based on exponential approximation is proposed to formulate the magnetic field distribution in 3D space. The comparison with conventional modeling method shows that it helps to improve the model accuracy. The Hall-effect sensors are distributed around the rotor with PM poles to detect the flux density at different points, and thus the rotor orientation can be computed from the measured results and analytical models. Experiments have been conducted on the developed research prototype of the spherical actuator to validate the accuracy of the analytical equations relating the rotor orientation and the value of magnetic flux density. The experimental results show that the proposed method can measure the rotor orientation precisely, and the measurement accuracy could be improved by the novel 3D magnet array. The study result could be used for real-time motion control of PM spherical actuators.
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Safety and six-month durability of angioplasty for isolated penile artery stenoses in patients with erectile dysfunction: a first-in-man study.
EuroIntervention
PUBLISHED: 05-17-2014
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Obstructive pelvic arterial lesions are highly prevalent in patients with erectile dysfunction and commonly located in penile artery segments. In this first-in-man study, we intended to assess the safety and feasibility of balloon angioplasty for isolated penile artery stenoses in patients with erectile dysfunction.
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Subconjunctival Injection of Fluconazole in the Treatment of Fungal Alternaria Keratitis.
Ocul. Immunol. Inflamm.
PUBLISHED: 05-17-2014
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Abstract Purpose: We report two cases of Alternaria keratitis refractory to the conventional antifungal medical treatment successfully treated with subconjunctival fluconazole injection. Methods: Report of two cases. Results: After subconjunctival injection of fluconazole (2?mg/mL) 0.5?mL twice a day for 5 days then once a day till 14 days, two cases of Alternaria keratitis refractory to the conventional antifungal medical treatment were successfully treated. No severe local and systemic side effects were found in these two patients. Conclusions: Alternaria keratitis has a varied clinical presentation and suspicion must be maintained for unusual causes of infectious keratitis. Alternaria keratitis can be difficult to eradicate even with traditional antifungals such as amphotericin B and natamycin. Subconjunctival injection of fluconazole could be effective for Alternaria keratitis unresponsive to conventional antifungal medical treatment.
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Restraining the motion of a ligand for modulating the structural phase transition in two isomorphic polar coordination polymers.
Dalton Trans
PUBLISHED: 05-09-2014
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A structural phase transition induced by ligand motion was found in a new polar coordination polymer: [Cu(NCS)2(4-APy)2]n (4-APy = 4-aminopyridine). Restraining such motion in an isomorphic compound [Cu(NCS)2(4-MeAPy)2]n (4-MeAPy = 4-methylaminopyridine) results in distinct phase transition behaviour. These findings provide a new clue for modulating phase transition behaviour in known materials.
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Multi-scale symbolic entropy analysis provides prognostic prediction in patients receiving extracorporeal life support.
Crit Care
PUBLISHED: 05-08-2014
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IntroductionExtracorporeal life support (ECLS) can temporarily support cardiopulmonary function, and is occasionally used in resuscitation. Multi-scale entropy (MSE) derived from heart rate variability (HRV) is a powerful tool in outcome prediction of patients with cardiovascular diseases. Multi-scale symbolic entropy analysis (MSsE), a new method derived from MSE, mitigates the effect of arrhythmia on analysis. The objective is to evaluate the prognostic value of MSsE in patients receiving ECLS. The primary outcome is death or urgent transplantation during the index admission.MethodsFifty-seven patients receiving ECLS less than 24 hours and 23 control subjects were enrolled. Digital 24-hour Holter electrocardiograms were recorded and three MSsE parameters (slope 5, Area 6¿20, Area 6¿40) associated with the multiscale correlation and complexity of heart beat fluctuation were calculated.ResultsPatients receiving ECLS had significantly lower value of slope 5, area 6 to 20, and area 6 to 40 than control subjects. During the follow-up period, 29 patients met primary outcome. Age, slope 5, Area 6 to 20, Area 6 to 40, acute physiology and chronic health evaluation II score, multiple organ dysfunction score (MODS), logistic organ dysfunction score (LODS), and myocardial infarction history were significantly associated with primary outcome. Slope 5 showed the greatest discriminatory power. In a net reclassification improvement model, slope 5 significantly improved the predictive power of LODS; Area 6 to 20 and Area 6 to 40 significantly improved the predictive power in MODS. In an integrated discrimination improvement model, slope 5 added significantly to the prediction power of each clinical parameter. Area 6 to 20 and Area 6 to 40 significantly improved the predictive power in sequential organ failure assessment.ConclusionsMSsE provides additional prognostic information in patients receiving ECLS.
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[Protection effect and mechanism of hemin against ischemia/reperfusion injury in rat hearts].
Zhongguo Ying Yong Sheng Li Xue Za Zhi
PUBLISHED: 04-19-2014
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To investigate whether the cardioprotective effect of hemin against ischemia/reperfusion (I/R) injury is through the inhibition of calpain activity, and to explore its underlying mechanism.
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Drastic enhancement of catalytic activity via post-oxidation of a porous MnII triazolate framework.
Chemistry
PUBLISHED: 04-16-2014
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Mn(III) is a powerful active site for catalytic oxidation of alkyl aromatics, but it can be only stabilized by macrocyclic chelating ligands such porphyrinates. Herein, by using benzobistriazolate as a rigid bridging ligand, a porous Mn(II) azolate framework with a nitrogen-rich coordinated environment similar to that of metalloporphyrins was synthesized, in which the Mn(II) ions can be post-oxidized to Mn(III) to achieve drastic increase of catalytic (aerobic) oxidation performance.
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Anterior corneal buttons from DSAEK donor tissue can be stored in optisol GS for later use in tectonic lamellar patch grafting.
Cornea
PUBLISHED: 03-29-2014
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The aim of this study was to evaluate the feasibility of storing anterior corneal buttons split from donor Descemet stripping automated endothelial keratoplasty (DSAEK) tissue for later use in tectonic lamellar patch grafting.
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Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese population.
J Am Heart Assoc
PUBLISHED: 02-28-2014
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Fatty infiltration of the pancreas is an enigmatic manifestation of ectopic fat deposition in obesity. Studies have shown that pancreatic lipid accumulation interferes with insulin secretion in humans. However, the prevalence of fatty pancreas and its associated factors in the general population remain unclear. The aim of this study was to investigate the prevalence of fatty pancreas and its association with diabetes, nonalcoholic fatty liver disease (NAFLD), and cardiometabolic risk factors in a Chinese population.
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Intensified chemotherapy without SCT in infant ALL: Results from COG P9407 (Cohort 3).
Pediatr Blood Cancer
PUBLISHED: 02-24-2014
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Infants with acute lymphoblastic leukemia (ALL) present with aggressive disease and a poor prognosis. Early relapse within 6-9 months of diagnosis is common. Approximately 75% of infants have MLL-rearranged (MLL-R) ALL with event free survival (EFS) ranging from 20% to 30%. Children's Oncology Group (COG) P9407 used shortened (46 weeks), intensified therapy to address early relapse and poor EFS.
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Assessment of the cost-effectiveness and clinical outcomes of a fourth-generation synchronous telehealth program for the management of chronic cardiovascular disease.
J. Med. Internet Res.
PUBLISHED: 02-24-2014
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Telehealth programs are a growing field in the care of patients. The evolution of information technology has resulted in telehealth becoming a fourth-generation synchronous program. However, long-term outcomes and cost-effectiveness analysis of fourth-generation telehealth programs have not been reported in patients with chronic cardiovascular diseases.
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Effect of chitosan molecular weight on the functional properties of chitosan-maltose Maillard reaction products and their application to fresh-cut Typha latifolia L.
Carbohydr Polym
PUBLISHED: 02-11-2014
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The objective was to evaluate antimicrobial, antioxidant and copper-chelating activities of Maillard reaction products (MRP) prepared from maltose and different molecular weight chitosan, and their effects on preservation of fresh-cut Typha latifolia L. (TLL). LMRP (maltose and low molecular weight chitosan MRP) showed the highest browning and UV absorbance as well as fluorescence intensity. The DPPH radical scavenging activity, reducing power and copper-chelating activity of chitosan-maltose MRP varied depending on the chitosan molecular weight. HMRP (maltose-high molecular weight chitosan MRP) exhibited better effects on inhibiting PPO activity and discoloration, alleviating declines of total soluble solids and ascorbic acid content of fresh-cut TLL. LMRP and MMRP (maltose-medium molecular weight chitosan MRP) effectively decreased weight loss and maintained firmness of TLL, respectively. These results indicated that molecular weight of chitosan had a great impact on the functional properties of chitosan-maltose MRP and their application to be used as a preservative.
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Observation of allylic rearrangement in water-rich reaction.
Chem. Commun. (Camb.)
PUBLISHED: 02-04-2014
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Allylic rearrangement or the migration of a double bond from its original position in the carbon skeleton to an adjacent site was observed when 3,4,5,6-tetrahydrophthalate was hydrolyzed in a basic solution and in the presence of Co(ii) and Mn(ii) under hydrothermal conditions.
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Bidirectional adherence changes and associated factors in patients switched from free combinations to equivalent single-pill combinations of antihypertensive drugs.
Hypertension
PUBLISHED: 01-20-2014
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There are no reported studies assessing the effects of fixed-dose single-pill combinations (SPCs) of antihypertensive drugs on adherence in real-world patients with hypertension switched from free combinations to the corresponding SPCs. In this retrospective cohort study with a 1-year mirror-image design, a total of 896 patients who had been prescribed with an angiotensin-converting enzyme inhibitor or angiotensin receptor blocker and a thiazide-type diuretic within the preceding 12 months of the index (switching) date and the corresponding SPC within 12 months after the index date were included by using the Taiwan National Health Insurance database from January 2001 to December 2007. Adherence was measured by medication possession ratio (MPR). For patients switched to SPCs, the MPR increased significantly from 42% in the preindex period to 69% in the postindex period (relative difference, 75%; 95% confidence interval, 58%-100%; P<0.001). However, for switched patients with high adherence (MPR ?0.8) in the preindex period, the MPR unexpectedly decreased in the postindex period (absolute difference, -13%; 95% confidence interval, -17% to -9%; P<0.001). In multivariate analysis, MPR difference was inversely related to the preindex MPR, the number of other antihypertensive drugs, and congestive heart failure. In summary, despite of the dramatic effect of SPCs on improving adherence, this strategy is not effective or even worse in patients adequately adhering to their free-combined antihypertensive regimens. The inverse association between adherence improvement and number of concurrent antihypertensive drugs suggests early use of SPCs to curtail the nonadherence gap.
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Above-room-temperature ferroelastic phase transition in a perovskite-like compound [N(CH3)4][Cd(N3)3].
Chem. Commun. (Camb.)
PUBLISHED: 01-14-2014
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A new perovskite-like compound [N(CH3)4][Cd(N3)3] is reported here, which undergoes a series of reversible phase transitions including an above-room-temperature ferroelastic phase transition. An order-disorder mechanism is found in these structural transitions owing to the sway of the rod-like N3(-) bridges as well as the rotation of the tetrahedron-like [N(CH3)4](+) guests.
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Working hours, sleep duration and the risk of acute coronary heart disease: a case-control study of middle-aged men in Taiwan.
Int. J. Cardiol.
PUBLISHED: 01-14-2014
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This study aimed to examine whether long working hours and short sleep duration were associated with an increased risk of acute myocardial infarction (AMI) or severe coronary heart diseases (SCHD), independent of established psychosocial work-related factors.
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Systematic study of the effects of lowering low-density lipoprotein-cholesterol on regression of coronary atherosclerotic plaques using intravascular ultrasound.
BMC Cardiovasc Disord
PUBLISHED: 01-02-2014
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Conflicting results currently exist on the effects of LDL-C levels and statins therapy on coronary atherosclerotic plaque, and the target level of LDL-C resulting in the regression of the coronary atherosclerotic plaques has not been settled.
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Measurement of visceral fat: should we include retroperitoneal fat?
PLoS ONE
PUBLISHED: 01-01-2014
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Whether retroperitoneal fat should be included in the measurement of visceral fat remains controversial. We compared the relationships of fat areas in peritoneal, retroperitoneal, and subcutaneous compartments to metabolic syndrome, adipokines, and incident hypertension and diabetes.
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Evaluation of circulating adipokines and abdominal obesity as predictors of significant myocardial ischemia using gated single-photon emission computed tomography.
PLoS ONE
PUBLISHED: 01-01-2014
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Coronary artery disease (CAD) is associated with abdominal obesity and metabolic syndrome. Adipocytes secrete adipokines, including the newly discovered adipocyte fatty acid binding protein (A-FABP) and chemerin. Adipokines contribute to the pathogenesis of CAD. In patients with CAD, the presence of significant ischemia predicts adverse outcomes. It is unknown whether adipokines can be better predictors of the presence of significant myocardial ischemia than conventional risk factors. This study aimed to compare adipokines with clinical risk factors and abdominal obesity as predictive factors for significant myocardial ischemia.
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Mechanisms controlling the effects of bevacizumab (avastin) on the inhibition of early but not late formed corneal neovascularization.
PLoS ONE
PUBLISHED: 01-01-2014
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To evaluate the effects and underlying mechanisms of early and late subconjunctival injection of bevacizumab on the inhibition of corneal neovascularization (NV).
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[The clinical characteristics of 10 cases of adrenocorticotropic hormone- independent macronodular adrenal hyperplasia].
Zhonghua Nei Ke Za Zhi
PUBLISHED: 12-10-2013
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To evaluate the clinical characteristics of patients with adrenocorticotropin-independent macronodular adrenal hyperplasia (AIMAH).
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A flexible porous Cu(ii) bis-imidazolate framework with ultrahigh concentration of active sites for efficient and recyclable CO2 capture.
Chem. Commun. (Camb.)
PUBLISHED: 10-18-2013
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By virtue of planar Cu2(?-OH)2(2+) cluster units, a flexible porous metal azolate framework not only adsorbs large amounts of CO2 (19.6 wt% or 266 g L(-1) at 298 K and 1 atm) with a high zero-coverage adsorption enthalpy (-47 kJ mol(-1)), but also desorbs quickly at very low temperatures.
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GPS-based outdoor activity pattern recording and analysis system.
Conf Proc IEEE Eng Med Biol Soc
PUBLISHED: 10-11-2013
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In this paper, a recording and analysis system is designed and developed for outdoor activity patterns characterization. Some mental problems of aging, especially the occurrence of dementia, are not easily noticed in early stage. In this study, the proposed system is employed for outdoor activity patterns analysis. From the pattern analysis, the abnormal activity which is different from the usual patterns may be differentiated and warned. The proposed system integrates the tablet PC and GPS to track and to detect the occurrence of abnormal condition off-line. In the beginning, the sequence of GPS data is segmented in time frame, and represented in vector form for data reduction. Some filtering technique is also applied for noise reduction.
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Gall development and clone dynamics of the galling aphid Schlechtendalia chinensis (Hemiptera: Pemphigidae).
J. Econ. Entomol.
PUBLISHED: 09-12-2013
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The aphid Schlechtendalia chinensis (Bell) induces galls on its primary host, Rhus chinensis Mill. We studied temporal changes in gall and aphid clonal population size throughout the period of gall development. Gall-size changes occurred in four stages: a first slow growth period, a fast growth period, a second slow growth period, and a growth reduction period. Gall volume and surface area increased abruptly toward the end of July, peaking during October, in parallel with an increase in aphid clonal population size, from one individual to > 10,000 aphids per gall. Clear changes were seen in the clone dynamics of S. chinensis. Fundatrix began to produce first-generation apterous fundatrigenia during late May to early June. Second-generation apterous fundatrigenia appeared at the start of July. Alate fundatrigeniae with wing pads first appeared at the end of August, but accounted for < 1% of the individuals in the galls. Adult alate fundatrigeniae first appeared at the start of October. Abrupt changes in aphid density and crowding might trigger the induction of alate morphs in the galls. Of the eight gall properties that we recorded, gall volume was the most accurate measure of gall fitness.
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A noble-metal-free porous coordination framework with exceptional sensing efficiency for oxygen.
Angew. Chem. Int. Ed. Engl.
PUBLISHED: 08-16-2013
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Light material: By virtue of the unique framework structure and very high oxygen permeability, a noble-metal-free, highly fluorescent, porous coordination polymer demonstrates a rapid, reversible, efficient, stable, and selective fluorescence-quenching response toward oxygen.
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Establishment of a green fluorescent protein tracing murine model focused on the functions of host components in necrosis repair and the niche of subcutaneously implanted glioma.
Oncol. Rep.
PUBLISHED: 08-14-2013
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Due to progress in the research of glioma stem cells and the glioma niche, development of an animal model that facilitates the elucidation of the roles of the host tissue and cells is necessary. The aim of the present study was to develop a subcutaneous xenograft green fluorescent protein nude mouse model and use this model to analyze the roles of host cells in tumor necrosis repair. Tumors derived from the human glioma stem/progenitor cell line SU3 were subcutaneously implanted in green fluorescent protein nude mice. The implanted tumors were then passed from animal to animal for 10 generations. Finally, subcutaneous xenografts were assayed with traditional pathology, immunopathological techniques and fluorescence photography. For each generation, the tumorigenicity rate was 100%. Subcutaneous xenografts were rich in blood vessels, and necrotic and hemorrhagic foci, which highly expressed hypoxia-inducible factor-1?, tumor necrosis factor, Ki-67, CD68 and CD11b. In the interstitial tissue, particularly in old hemorrhagic foci, there were numerous cells expressing green fluorescent protein, CD68 and CD11b. Green fluorescent protein nude mouse subcutaneous xenografts not only consistently maintained the high invasiveness and tumorigenicity of glioma stem/progenitor cells, but also consisted of a high concentration of tumor blood vessels and necrotic and hemorrhagic foci. Subcutaneous xenografts also expressed high levels of tumor microenvironment-related proteins and host-derived tumor interstitial molecules. The model has significant potential for further research on tumor tissue remodeling and the tumor microenvironment.
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Complete coding region of the mitochondrial genome of Monochamus alternatus hope (Coleoptera: Cerambycidae).
Zool. Sci.
PUBLISHED: 07-09-2013
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The Japanese pine sawyer, Monochamus alternatus Hope, 1842, an important forest pest, mainly occurs in Far East. It is the main vector of pine wood nematode Bursaphelenchus xylophilus, which causes pine wilt disease. We determined the complete mitochondrial genome coding region of M. alternatus using long PCR and conserved primer walking. Our results show that the entire mitogenome coding region is 14,649 bp long, with 78.22% A+T content [deposited in GenBank (JX987292)]. Positions and arrangement of the 37 genes encoded by the coding region are identical to those of two other longhorn beetles (Psacothea hilaris and Anoplophora glabripennis) for which the complete gene content and arrangement are known. All protein-coding genes start with a typical initiation codon ATN in insects. All tRNAs show standard clover-leaf structure, except the tRNA(Ser) (AGN), which lacks dihydrouridine (DHU) arm. The most unusual feature found is the use of TCT as tRNA(Ser) (AGN) anticodon instead of GCT, which is used in most other arthropods. This provides further insights into the diversity and evolution of the Cerambycidae family of long-horned beetles.
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Phosphorescence doping in a flexible ultramicroporous framework for high and tunable oxygen sensing efficiency.
Chem. Commun. (Camb.)
PUBLISHED: 06-21-2013
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Doping very small amounts of Ru(II) into a flexible, ultramicroporous, fluorescent Zn(II) coordination polymer produced phosphorescent materials with very high and tunable oxygen quenching efficiency; and a simple color-changing ratiometric oxygen sensor has been constructed.
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Comparison of predictive performance of various fatty acids for the risk of cardiovascular disease events and all-cause deaths in a community-based cohort.
Atherosclerosis
PUBLISHED: 06-19-2013
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The issue of whether saturated fats and trans fats are superior predictors of all-cause death and cardiovascular disease than n-3 polyunsaturated fatty acids, such as eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), remains a matter of contention. Furthermore, few studies have examined the relationship between fatty acids and the outcomes of cardiovascular disease (CVD) in Asian populations. The aim of this study was to compare the effectiveness of various plasma fatty acids as predictors for all-cause death and CVD events in an ethnic Chinese population.
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Statin use and cataract surgery: a nationwide retrospective cohort study in elderly ethnic Chinese patients.
Drug Saf
PUBLISHED: 06-18-2013
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Since a report of lenticular opacities in dogs treated with high dosages of statins, the debate on the relationship between statin therapy and cataracts has not reached a conclusion.
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[Host glial cell canceration induced by glioma stem cells in GFP/RFP dual fluorescence orthotopic glioma models in nude mice].
Zhonghua Zhong Liu Za Zhi
PUBLISHED: 05-08-2013
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During the process of tissue remodeling in human tumor transplantation models, the roles of the inoculated tumor cells and host tissue in tumor progression is still largely unknown. The aim of this study was to investigate the relationships and interactions between these two sides using GFP-RFP double fluorescence tracing technique.
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Higher homocysteine and lower betaine increase the risk of microangiopathy in patients with diabetes mellitus carrying the GG genotype of PEMT G774C.
Diabetes Metab. Res. Rev.
PUBLISHED: 05-04-2013
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Diabetes represents one of the greatest medical and socioeconomic threats worldwide. The pathogenesis involved is complicated. The effect of methyl donors and genetic polymorphisms in metabolic enzymes on the risk of microangiopathy in patients with diabetes is not well understood. This study investigates the association of homocysteine, choline and betaine levels and phosphatidylethanolamine N-methyltransferase (PEMT) G774C (rs12325817) genotypes with the risk of diabetes and its related microangiopathic complications.
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Clinical outcome and cost-effectiveness of a synchronous telehealth service for seniors and nonseniors with cardiovascular diseases: quasi-experimental study.
J. Med. Internet Res.
PUBLISHED: 03-19-2013
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Telehealth based on advanced information technology is an emerging health care strategy for managing chronic diseases. However, the cost-effectiveness and clinical effect of synchronous telehealth services in older patients with cardiovascular diseases has not yet been studied. Since 2009, the Telehealth Center at the National Taiwan University Hospital has provided a range of telehealth services (led by a cardiologist and staffed by cardiovascular nursing specialists) for cardiovascular disease patients including (1) instant transmission of blood pressure, pulse rate, electrocardiography, oximetry, and glucometry for analysis, (2) mutual telephone communication and health promotion, and (3) continuous analytical and decision-making support.
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Direct visualization of a guest-triggered crystal deformation based on a flexible ultramicroporous framework.
Nat Commun
PUBLISHED: 03-18-2013
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Host-guest composites may exhibit abnormal and/or controllable physical properties that are unavailable for traditional solids. However, it is still very difficult to control or visualize the occupancy and motion of the guest. Here we report a flexible ultramicroporous coordination polymer showing exceptional guest-responsive thermal-expansion properties. The vacant crystal exhibits constant and huge thermal expansion over a wide temperature range not only in vacuum but also in air, as its ultramicroporous channel excludes air adsorption even at 77?K. More interestingly, as demonstrated by single-crystal X-ray crystallography, molecular dynamic simulations and solid-state nuclear magnetic resonance, it selectively responds to the molecular rearrangement of N,N-dimethylformamide, leading to conformation reversion of the flexible ligand, which transfers these actions to deform the whole crystal lattice. These results illustrate that combination of ultramicroporous channel and flexible pore surface could be an effective strategy for the utilization of external physical and chemical stimuli.
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Eicosapentaenoic acid attenuated oxidative stress-induced cardiomyoblast apoptosis by activating adaptive autophagy.
Eur J Nutr
PUBLISHED: 02-18-2013
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Recently, several large, randomized clinical trials have proven the benefits of eicosapentaenoic acid (EPA) in cardiovascular prevention. However, the precise protective mechanisms of EPA for heart disease are still controversial. In this study, we evaluate the possible protective effects of EPA, especially the role of autophagy, against cardiomyocyte apoptosis induced by oxidative stress.
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A Taiwanese food frequency questionnaire correlates with plasma docosahexaenoic acid but not with plasma eicosapentaenoic acid levels: questionnaires and plasma biomarkers.
BMC Med Res Methodol
PUBLISHED: 02-05-2013
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Little evidence is available for the validity of dietary fish and polyunsaturated fatty acid intake derived from interviewer-administered questionnaires and plasma docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) concentration.
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Inhibition of RhoA/Rho-kinase pathway suppresses the expression of extracellular matrix induced by CTGF or TGF-? in ARPE-19.
Int J Ophthalmol
PUBLISHED: 01-28-2013
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To investigate the role of Rho-associated protein kinase (ROCK) inhibitor, Y27632, in mediating the production of extracellular matrix (ECM) components including fibronectin, matrix metallo-proteinase-2 (MMP-2) and type I collagen as induced by connective tissue growth factor (CTGF) or transforming growth factor-? (TGF-?) in a human retinal pigment epithelial cell line, ARPE-19.
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Comparative assessment of the HAS-BLED score with other published bleeding risk scoring schemes, for intracranial haemorrhage risk in a non-atrial fibrillation population: the Chin-Shan Community Cohort Study.
Int. J. Cardiol.
PUBLISHED: 01-19-2013
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The HAS-BLED score is a validated bleeding risk model for predicting major bleeding events in anticoagulated individuals with atrial fibrillation (AF). It remains uncertain whether the HAS-BLED score could identify non-AF individuals at risk of developing intracranial haemorrhage (ICH), which is the most intractable and devastating major bleeding complication.
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Codelivery of mTERT siRNA and paclitaxel by chitosan-based nanoparticles promoted synergistic tumor suppression.
Biomaterials
PUBLISHED: 01-05-2013
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Clinical applications of siRNA are being hindered by poor intracellular uptake and enzymatic degradation. To address these problems, we devised an oral delivery system for telomerase reverse transcriptase siRNA using N-((2-hydroxy-3-trimethylammonium) propyl) chitosan chloride (HTCC) nanoparticles (HNP). Both the porous structure and the positive charge of HNP facilitated siRNA encapsulation. The outer coating of HTCC not only protected siRNA from enzymatic degradation, but also improved siRNA permeability in intestine tract. In vivo and in vitro experiments proved that HNP could effectively deliver siRNA to lesion site and further into tumor cells. On the basis of confirming the antitumor activity of HNP:siRNA, we continued to encapsulate a hydrophobic chemotherapeutic drug-paclitaxel (PTX) into HNP to form a "two-in-one" nano-complex (HNP:siRNA/PTX). We demonstrated that HNP:siRNA/PTX could simultaneously ferry siRNA and PTX into tumor cells and increase drug concentration, which, in particular, was much more effective in tumor suppression than that of traditional cocktail therapy. These results suggested that the HNP, as a powerful delivery system for both siRNA and chemotherapeutic drug, would have a far-reaching application in human cancer therapy.
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Total white blood cell count or neutrophil count predict ischemic stroke events among adult Taiwanese: report from a community-based cohort study.
BMC Neurol
PUBLISHED: 01-03-2013
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Evidence about whether white blood cell (WBC) or its subtypes can act as a biomarker to predict the ischemic stroke events in the general population is scanty, particularly in Asian populations. The aim of this study is to establish the predictive ability of total WBC count or subtypes for long-term ischemic stroke events in the cohort population in Taiwan.
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The association between nonalcoholic fatty pancreas disease and diabetes.
PLoS ONE
PUBLISHED: 01-01-2013
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Fatty infiltration of the pancreas has been shown to interfere with insulin secretion. Both insulin sensitivity and secretion are important in the pathogenesis of diabetes and prediabetes. However, the relationship between diabetes, prediabetes, and fatty pancreas remains unknown. We aim to investigate the relationships that fatty pancreas and nonalcoholic fatty liver disease (NAFLD) have with prediabetes and diabetes in a Chinese population.
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Association of the recovery of objective abnormal cerebral perfusion with neurocognitive improvement after carotid revascularization.
J. Am. Coll. Cardiol.
PUBLISHED: 01-01-2013
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This study sought to report the effect of carotid artery stenting (CS) on neurocognitive function (NCF) in patients with severe carotid artery occlusive disease, depending on baseline brain perfusion status.
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Layer-by-layer evolution and a hysteretic single-crystal to single-crystal transformation cycle of a flexible pillared-layer open framework.
Chem. Commun. (Camb.)
PUBLISHED: 11-09-2011
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Two hypothetical crystal-growth intermediates of a new pillared-layer framework have been isolated. The seemingly rigid pillared-layer framework also undergoes temperature-induced, time-dependent, hysteretic framework distortion.
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Lipid-related residual risk and renal function for occurrence and prognosis among patients with first-event acute coronary syndrome and normal LDL cholesterol.
Lipids Health Dis
PUBLISHED: 10-12-2011
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We investigated relationship of low levels of high density lipoprotein cholesterol (HDL-C), high levels of triglycerides, and renal function for the odds, prognosis and survival following acute coronary events among patients with a first event and normal low density lipoprotein cholesterol levels.
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Left atrial dimension and risk of stroke in women without atrial fibrillation: the Chin-Shan Community Cardiovascular Cohort study.
Echocardiography
PUBLISHED: 10-11-2011
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Evidence on the relationship between left atrial dimension and cardiovascular events is inconclusive. We explored the association between left atrial dimension and stroke and all-cause death in an ethnic Chinese population.
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The effects of 3-month atorvastatin therapy on arterial inflammation, calcification, abdominal adipose tissue and circulating biomarkers.
Eur. J. Nucl. Med. Mol. Imaging
PUBLISHED: 09-12-2011
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(18)F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT has the potential to track vascular inflammation and monitor therapeutic response. The purpose of this study was to determine the association between arterial inflammation, calcification and serological biomarkers in subjects with atherosclerosis, and to assess their therapeutic response to 12-week atorvastatin treatment.
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Arterial function of carotid and brachial arteries in postmenopausal vegetarians.
Vasc Health Risk Manag
PUBLISHED: 08-22-2011
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Vegetarianism is associated with a lower risk of cardiovascular disease. However, studies of arterial function in vegetarians are limited.
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A one-dimensional coordination polymer exhibiting simultaneous spin-crossover and semiconductor behaviour.
Chem. Commun. (Camb.)
PUBLISHED: 08-22-2011
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A rare organosulfur one-dimensional coordination polymer, [Co(C(9)H(6)NS)(2)], was synthesized by the reaction between the 8-mercaptoquinoline and cobalt acetate salts in EtOH, which shows strong magnetic coupling and the presence of spin-glassy and spin-crossover phenomena with simultaneous semiconductor behaviour.
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Neurocognitive improvement after carotid artery stenting in patients with chronic internal carotid artery occlusion and cerebral ischemia.
Stroke
PUBLISHED: 08-11-2011
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Chronic cerebral hypoperfusion may lead to impairment in neurocognitive performance in patients with chronic internal carotid artery occlusion, and the effects of carotid artery stenting on neurocognitive function have been unclear.
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Effects of immunosuppressants after penetrating keratoplasty: meta-analysis of randomized controlled trials.
Int J Ophthalmol
PUBLISHED: 07-29-2011
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To assess the effectiveness of immunosuppressants in the prophylaxis of corneal allograft rejection after high-risk keratoplasty and normal-risk keratoplasty.
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Flexible porous coordination polymers constructed from 1,2-bis(4-pyridyl)hydrazine via solvothermal in situ reduction of 4,4-azopyridine.
Dalton Trans
PUBLISHED: 07-26-2011
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Solvothermal reactions of Zn(NO(3))(2), 1,4-benzenedicarboxylic acid (H(2)bdc), and 4,4-azopyridine (azpy) in different conditions yielded [Zn(bdc)(bphy)]·DMF·H(2)O (1a, bphy = 1,2-bis(4-pyridyl)hydrazine, DMF = N,N-dimethylformamide) and [Zn(bdc)(bphy)]·EtOH·H(2)O (1b) with two-fold interpenetrated dmp topology and [Zn(2)(bdc)(2)(bphy)]·1.5EtOH·H(2)O (2a) and [Zn(2)(bdc)(2)(bphy)]·DMA·1.5H(2)O (2b, DMA = N,N-dimethylacetamide) with two-fold interpenetrated pcu topology. The in situ reduction of azpy to bphy was confirmed by single-crystal structures and LC-MS analyses of the acid-digested crystalline samples, as well as controlled solvothermal experiments. Removal of the guest molecules in 1a/1b and 2a/2b converts the materials to guest-free phases [Zn(bdc)(bphy)] (1) and [Zn(2)(bdc)(2)(bphy)] (2), respectively, which were identified by PXRD. CO(2) sorption experiments performed at 195 and 298 K showed low porosity for 1 and gated sorption behavior for 2. At 298 K, 2 exhibits high selectivity for adsorbing CO(2) over CH(4).
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JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.