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Find video protocols related to scientific articles indexed in Pubmed.
Modified bortezomib, adriamycin and dexamethasone (PAD) regimen in advanced multiple myeloma.
Pathol. Oncol. Res.
PUBLISHED: 04-20-2014
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The PAD regime, composed of bortezomib, adriamycin and dexamethasone, improves the outcomes of patients with advanced multiple myeloma (MM), but at the same time produces high frequency of serious toxic side effects. For the first time, we evaluated the efficacy and safety of a bortezomib-dose-reduced PAD regime in the treatment of relapsed/refractory MM in this clinical study. Forty-five patients were treated with two to six 21-day cycles of PAD, comprising bortezomib at 1.3 mg/m(2) (P1AD, n?=?21) or 1.0 mg/m(2) (P2AD, n?=?24) (days 1, 4, 8, 11), adriamycin at 9 mg/m(2) (days 1-4) and dexamethasone at 40 mg/day (days 1-4). Overall, 36 patients (80 %) showed at least partial remission (PR), in which 9 cases (20 %) showed complete remission (CR) and 10 cases (22 %) showed very good partial remission (VGPR). The efficacy of PAD regimen in advanced MM patients was not related to the traditional prognostic factors. There was no significant difference between P1AD and P2AD in the rates of PR, CR or VGPR, 1.5-year progression-free survival (PFS), and overall survival (OS) (81 % vs. 79 %, 48 % vs. 38 %, 64 % vs. 59 %, and 85 % vs. 73 %, respectively). However, the grade 3-4 toxic effects, including thrombocytopenia (13 % vs. 38 %), peripheral neuropathy (8 % vs. 33 %) and 3-4 grade gastrointestinal reaction (13 % vs. 43 %), were markedly inhibited after P2AD compared to P1AD (P?
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3T magnetic resonance diffusion tensor imaging in chronic kidney disease.
Abdom Imaging
PUBLISHED: 03-14-2014
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To investigate the relationship of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values with renal function on 3T diffusion tensor imaging (DTI) in chronic kidney disease.
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Novel CX?? halogen bonds in complexes of acetylene and its derivatives of Na and MPH3 (M=Cu, Ag, Au) with XCCF (X=Cl, Br, I).
Spectrochim Acta A Mol Biomol Spectrosc
PUBLISHED: 01-28-2014
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Ab initio calculations have been carried out for a variety of model systems with a T-shaped CX?? motif. The CX?? interaction of acetylene with the halogen donor molecule XCCF (X=Cl, Br, I) is invariably found to be weak with the interaction energy less than 11kJ/mol in magnitude. Substitution of the two protons in acetylene with more electron-donating sodium atoms increases the ? electron density in the CC bond and leads to a substantial enhancement in its interaction with the halogen donor. The calculated interaction energies increase to as much as 73kJ/mol in the case of C2Na2-ICCF. The interaction of XCCF with a model coinage metal ethynide, H3PMCCMPH3 (M=Cu, Ag, Au), is intermediate between these two extremes, and the interaction energy is related to the nature of coinage metals. The CX?? halogen bonds have been analyzed with natural bond orbital, atoms in molecules, and energy decomposition.
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A case report of acute myeloid leukemia after liver transplantation.
Acta Haematol.
PUBLISHED: 01-05-2013
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Acute myeloid leukemia (AML) is a rare complication observed after liver transplantation and only a handful of cases have been reported until now. We report a case of acute promyelocytic leukemia (APL) after liver transplantation in a 50-year-old man. The case presentation was postodontectomy bleeding with an associative abnormal coagulation test 85 months after liver transplantation. A routine blood test, bone marrow test, chromosome analysis and examination of PML/RAR? chimeric gene confirmed the diagnosis of APL and disseminated intravascular coagulation (DIC). Induction chemotherapy with all-trans retinoic acid, arsenic trioxide and daunorubicin was given to this patient and complete remission was achieved. The patient was subjected to DA (daunorubicin combined with cytarabine) and MA (mitoxantrone combined with cytarabine) regimens after remission induction to consolidate the chemotherapy for two courses of treatment, and subsequently subjected to arsenous acid chemotherapy on a periodic basis. Twenty-two months into the follow-up, sustained bone marrow remission was observed with the adapted treatment regimen.
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Proton magnetic resonance spectroscopy in prostate tuberculosis.
Urology
PUBLISHED: 04-29-2009
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Prostate tuberculosis is an uncommon disease of the prostate, which usually involves the upper urinary tract. In the elderly patients, it may be mistaken for prostate carcinoma, both clinically and by conventional radiology. However, magnetic resonance spectroscopy can provide more information to differentiate prostate tuberculosis from prostate cancer.
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Vindesine-induced neuropathy mimicking Guillain-Barré syndrome.
Leuk. Res.
PUBLISHED: 03-08-2009
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A 13-year-old girl with acute lymphoblastic leukaemia, who was being treated with chemotherapy (including vindesine), developed paraplegia without paresthesia, which mimic Guillain-Barré syndrome. Spinal fluid analysis showed a normal protein level, vindesine neuropathy seemed to be the cause of the patients neurological symptoms. The patient seemed to benefit from human normal immunoglobulin therapy and recovered 4 weeks later.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.