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Find video protocols related to scientific articles indexed in Pubmed.
Off-Hours Admission and Acute Stroke Care Quality: A Nationwide Study of Performance Measures and Case-Fatality.
Stroke
PUBLISHED: 11-08-2014
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Studies have reported higher risks of death and other adverse outcomes in acute stroke patients admitted off-hours; however, little is known about the underlying mechanisms. According to time of admission, our aim was to examine compliance with performance measures for acute stroke care processes, including the effect of a systematic quality improvement program, and to examine 30 days case-fatality.
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Preadmission oral anticoagulant therapy and clinical outcome in patients hospitalised with acute stroke and atrial fibrillation.
Dan Med J
PUBLISHED: 09-05-2014
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Information about the effect of preadmission oral anticoagulant therapy (OAT) on stroke outcome in patients with atrial fibrillation (AF) is scarce. A systematic review was done of the existing data on the association between preadmission OAT and stroke outcome in patients with AF.
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Impact of prestroke selective serotonin reuptake inhibitor treatment on stroke severity and mortality.
Stroke
PUBLISHED: 06-03-2014
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Selective serotonin reuptake inhibitors (SSRIs) have been associated with an increased risk of bleeding but also a possible neuroprotective effect in stroke. We aimed to examine the implications of prestroke SSRI use in hemorrhagic and ischemic stroke.
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Health outcomes with and without use of inotropic therapy in cardiac surgery: results of a propensity score-matched analysis.
Anesthesiology
PUBLISHED: 03-12-2014
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Inotropes used to obtain short-term hemodynamic benefits in cardiac surgery may carry a risk of increased myocardial ischemia and adverse outcomes. This study investigated the association between intra- and postoperative use of inotropes and mortality and postoperative complications.
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Post-stroke mortality, stroke severity, and preadmission antipsychotic medicine use--a population-based cohort study.
PLoS ONE
PUBLISHED: 01-01-2014
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It has been suggested that antipsychotic medication may be neuroprotective and may reduce post-stroke mortality, but studies are few and ambiguous. We aimed to investigate the post-stroke effects of preadmission antipsychotic use.
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Registration of acute stroke: validity in the Danish Stroke Registry and the Danish National Registry of Patients.
Clin Epidemiol
PUBLISHED: 01-01-2014
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The validity of the registration of patients in stroke-specific registries has seldom been investigated, nor compared with administrative hospital discharge registries. The objective of this study was to examine the validity of the registration of patients in a stroke-specific registry (The Danish Stroke Registry [DSR]) and a hospital discharge registry (The Danish National Patient Registry [DNRP]).
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Preadmission oral anticoagulant treatment and clinical outcome among patients hospitalized with acute stroke and atrial fibrillation: a nationwide study.
Stroke
PUBLISHED: 11-26-2013
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Preadmission oral anticoagulant treatment (OAT) has been linked with less severe stroke and a better outcome in patients with atrial fibrillation. However, the existing studies have methodological limitations and have, with one exception, not included hemorrhagic strokes. We performed a nationwide historic follow-up study using data from population-based healthcare registries to assess the effect of preadmission OAT on stroke outcomes further.
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Processes of in-hospital psychiatric care and subsequent criminal behaviour among patients with schizophrenia: a national population-based, follow-up study.
Can J Psychiatry
PUBLISHED: 10-09-2013
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It is unknown whether evidence-based, in-hospital processes of care may influence the risk of criminal behaviour among patients with schizophrenia. Our study aimed to examine the association between guideline recommended in-hospital psychiatric care and criminal behaviour among patients with schizophrenia.
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Hospital-based versus community-based shared care cardiac rehabilitation after acute coronary syndrome: protocol for a randomized clinical trial.
Dan Med J
PUBLISHED: 09-05-2013
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Participation in cardiac rehabilitation (CR) is poor although CR reduces morbidity and mortality. One way in which attendance may potentially be improved is by involving municipal health-care centres (MHCC) and the patients general practitioner (GP) to a larger degree in a model of shared care cardiac rehabilitation (SC-CR). Our study tests the feasibility of SC-CR and compares the attendance and effects of SC-CR with the individually tailored hospital-based CR (H-CR) programme.
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Use of non-invasive ventilation is increasing in patients admitted with a chronic obstructive pulmonary disease exacerbation.
Dan Med J
PUBLISHED: 08-03-2013
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A nationwide chronic obstructive pulmonary disease (COPD) quality improvement programme--DrCOPD--was initiated in Denmark in 2008. We examined subsequent national and regional trends in the use of non-invasive ventilation (NIV) and trends in mortality following NIV and invasive mechanical ventilation among patients acutely admitted with a COPD exacerbation.
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Post-operative acute kidney injury and five-year risk of death, myocardial infarction, and stroke among elective cardiac surgical patients: a cohort study.
Crit Care
PUBLISHED: 08-02-2013
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The prognostic impact of acute kidney injury (AKI) on long-term clinical outcomes remains controversial. We examined the five-year risk of death, myocardial infarction, and stroke after elective cardiac surgery complicated by AKI.
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Trends in quality of care among patients with incident heart failure in Denmark 2003-2010: a nationwide cohort study.
BMC Health Serv Res
PUBLISHED: 03-28-2013
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The treatment of heart failure (HF) is complex and the prognosis remains serious. A range of strategies is used across health care systems to improve the quality of care for HF patients. We present results from a nationwide multidisciplinary initiative to monitor and improve the quality of care and clinical outcome of HF patients using indicator monitoring combined with systematic auditing.
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Implementing a nationwide criteria-based emergency medical dispatch system: A register-based follow-up study.
Scand J Trauma Resusc Emerg Med
PUBLISHED: 01-23-2013
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A criteria-based nationwide Emergency Medical Dispatch (EMD) system was recently implemented in Denmark. We described the system and studied its ability to triage patients according to the severity of their condition by analysing hospital admission and case-fatality risks.
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Improving quality of care among COPD outpatients in Denmark 2008-2011.
Clin Respir J
PUBLISHED: 01-22-2013
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To examine whether the quality of care among Danish patients with chronic obstructive pulmonary disease (COPD) has improved since the initiation of a national multidisciplinary quality improvement program.
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Post stroke use of selective serotonin reuptake inhibitors and clinical outcome among patients with ischemic stroke: a nationwide propensity score-matched follow-up study.
Stroke
PUBLISHED: 01-10-2013
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Selective serotonin reuptake inhibitors (SSRIs) are widely prescribed after stroke. We aimed to investigate whether potential antiplatelet or vasospastic effects have important clinical implications.
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Use of secondary medical prophylaxis and clinical outcome among patients with ischemic stroke: a nationwide follow-up study.
Stroke
PUBLISHED: 12-29-2011
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Although secondary medical prevention strategies in patients with stroke are well established, only sparse data exist regarding their effectiveness in routine care. We examined the effectiveness in a nationwide, population-based follow-up study.
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How do we define congenital heart defects for scientific studies?
Congenit Heart Dis
PUBLISHED: 10-20-2011
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Estimates of the prevalence of congenital heart defects (CHD) have been published over many years and from many regions. As they are based on different definitions of which cases to include in the CHD prevalence, published prevalence estimates vary substantially. With the increasing use of echocardiography in neonatal intensive care, a patent ductus arteriosus (PDA) or flow over the atrial septum will often be visible. These findings may be coded as CHD at discharge and in this way falsely increase the CHD prevalence in the population. There are several purposes for which population-based data on CHD may be used: etiology, planning of treatment, or obtain information on outcome, including mortality. For etiology studies, it is important to include terminations of pregnancy as well as all births with CHD. For mortality studies in live births, inclusion of preterm born infants with PDA will increase overall mortality of CHD. The Danish Register of Congenital Heart Disease is based on hospital discharge diagnoses and diagnoses from outpatient visits. To increase the validity of these data, extensive data cleaning has been carried out based on record review and knowledge on the discharge coding practice. We include PDA and atrial septal defects as CHD cases if these defects are still open 2?months after birth. International consensus on how to define CHD would improve the validity and comparability of epidemiological studies on CHD.
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Health care system delay and heart failure in patients with ST-segment elevation myocardial infarction treated with primary percutaneous coronary intervention: follow-up of population-based medical registry data.
Ann. Intern. Med.
PUBLISHED: 09-21-2011
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In patients with ST-segment elevation myocardial infarction (STEMI), delay between contact with the health care system and initiation of reperfusion therapy (system delay) is associated with mortality, but data on the associated risk for congestive heart failure (CHF) among survivors are limited.
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The Danish Register of Congenital Heart Disease.
Scand J Public Health
PUBLISHED: 09-08-2011
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Congenital heart defects (CHD) constitute the largest group of congenital defects with a prevalence at birth of 5-11 per 1000 live births, and the population of adults with CHD is increasing. However, few population-based long-term outcome data exist.
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Marine n-3 polyunsaturated fatty acids in adipose tissue and the risk of acute coronary syndrome.
Circulation
PUBLISHED: 08-22-2011
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Marine n-3 polyunsaturated fatty acids may reduce coronary mortality. Previous data in relation to nonfatal coronary disease, however, have been inconsistent, which may be explained by the use of heterogeneous methods to assess the intake of marine n-3 polyunsaturated fatty acids. We investigated the hypothesis that the content of total and individual marine n-3 polyunsaturated fatty acids in adipose tissue is negatively associated with the incidence of acute coronary syndrome (ACS), including both fatal and nonfatal coronary disease.
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The EuroSCORE in western Denmark: a population-based study.
J. Cardiothorac. Vasc. Anesth.
PUBLISHED: 08-10-2011
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The present study aimed to examine the predictive performance of the logistic European System for Cardiac Operative Risk Evaluation (EuroSCORE) in a large cohort of patients undergoing cardiac surgery from 1999 through 2010 because methodologic shortcomings have hampered many previous studies questioning its predictive performance.
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Quality of care and patient outcome in stroke units: is medical specialty of importance?
Med Care
PUBLISHED: 07-16-2011
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Specialized stroke unit care improves outcome in stroke patients. However, it is uncertain whether the units should be placed in a neurological or non-neurological (eg, internal medicine or geriatric) setting.
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Responsiveness and sensitivity of the Stroke Specific Quality of Life Scale Danish version.
Disabil Rehabil
PUBLISHED: 04-27-2011
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To test responsiveness and sensitivity to change of the Stroke Specific Quality of Life Scale Danish version (SSQOL-DK) scores in patients following stroke.
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Survival and morbidity following congenital heart surgery in a population-based cohort of children--up to 12 years of follow-up.
Congenit Heart Dis
PUBLISHED: 03-21-2011
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The Risk Adjusted Classification for Congenital Heart Surgery can predict early mortality. However, the relation to long-term outcome in terms of mortality and morbidity is unknown.
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Antidiabetic treatments and risk of hospitalisation with myocardial infarction: a nationwide case-control study.
Pharmacoepidemiol Drug Saf
PUBLISHED: 01-10-2011
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Data on cardiovascular risk associated with different types of antidiabetic treatments are sparse and conflicting. We examined the risk of hospitalisation with myocardial infarction (MI) among patients treated with sulfonylureas, metformin, insulin, any combination and no antidiabetic pharmacotherapy.
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Type of preadmission antidiabetic treatment and outcome among patients with ischemic stroke: a nationwide follow-up study.
J Stroke Cerebrovasc Dis
PUBLISHED: 01-05-2011
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We examined whether the preadmission use of sulfonylureas is associated with improved clinical outcome compared with other antidiabetic treatments after hospitalization with ischemic stroke.
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No excess surgical blood loss in patients with acquired type 2A von Willebrand disease.
Scand. Cardiovasc. J.
PUBLISHED: 12-29-2010
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Acquired type 2A von Willebrand disease may develop as a consequence of aortic valve stenosis and is associated with varying degrees of bleeding tendency. It remains unknown, whether it portends excess blood loss during aortic valve replacement.
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System delay and mortality among patients with STEMI treated with primary percutaneous coronary intervention.
JAMA
PUBLISHED: 08-19-2010
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Timely reperfusion therapy is recommended for patients with ST-segment elevation myocardial infarction (STEMI), and door-to-balloon delay has been proposed as a performance measure in triaging patients for primary percutaneous coronary intervention (PCI). However, focusing on the time from first contact with the health care system to the initiation of reperfusion therapy (system delay) may be more relevant, because it constitutes the total time to reperfusion modifiable by the health care system. No previous studies have focused on the association between system delay and outcome in patients with STEMI treated with primary PCI.
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Quality of cardiopulmonary resuscitation in out-of-hospital cardiac arrest is hampered by interruptions in chest compressions--a nationwide prospective feasibility study.
Resuscitation
PUBLISHED: 06-27-2010
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Quality of cardiopulmonary resuscitation (CPR) is a critical determinant of outcome following out-of-hospital cardiac arrest. The aim of our study was to evaluate the quality of CPR provided by emergency medical service providers (Basic Life Support (BLS) capability) and emergency medical service providers assisted by paramedics, nurse anesthetists or physician-manned ambulances (Advanced Life Support (ALS) capability) in a nationwide, unselected cohort of out-of-hospital cardiac arrest cases.
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Microalbuminuria is associated with high adverse event rate following cardiac surgery.
Eur J Cardiothorac Surg
PUBLISHED: 06-24-2010
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To examine if preoperative microalbuminuria is associated with an increased risk of long-term adverse outcomes following elective cardiac surgery and if it provides additional prognostic information beyond the European System for Cardiac Operative Risk Evaluation (EuroSCORE).
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Paclitaxel and sirolimus eluting stents versus bare metal stents: long-term risk of stent thrombosis and other outcomes. From the Western Denmark Heart Registry.
EuroIntervention
PUBLISHED: 06-15-2010
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Stent thrombosis is a serious complication of percutaneous coronary intervention (PCI). We examined the incidence of stent thrombosis and other outcomes in patients treated with PCI and paclitaxeleluting stents (PES), sirolimus-eluting stents (SES) or bare-metal stents (BMS).
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Medical prophylaxis following hospitalization for ischemic stroke: age- and sex-related differences and relation to mortality.
Cerebrovasc. Dis.
PUBLISHED: 04-19-2010
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The extent and implications of age- and sex-related differences in prophylaxis following ischemic stroke are unknown. We examined differences in the use of medical prophylaxis across age and sex groups in stroke patients after hospital discharge in Denmark and estimated the possible impact on age- and sex-related differences in mortality.
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Efficacy and safety of zotarolimus-eluting and sirolimus-eluting coronary stents in routine clinical care (SORT OUT III): a randomised controlled superiority trial.
Lancet
PUBLISHED: 03-16-2010
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In low-risk patients, the zotarolimus-eluting stent has been shown to reduce rates of restenosis without increasing the risk of stent thrombosis. We compared the efficacy and safety of the zotarolimus-eluting stent versus the sirolimus-eluting stent in patients with coronary artery disease who were receiving routine clinical care with no direct follow-up.
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Late mortality among Danish patients with congenital heart defect.
Am. J. Cardiol.
PUBLISHED: 03-04-2010
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To examine long-term mortality in Danish patients with congenital heart defect (CHD), we performed a population-based follow-up study using nationwide registries. We identified all children born in Denmark from January 1, 1977 to January 1, 2006 from the Danish Civil Registration System. Children with a primary diagnosis of CHD, diagnosed before 1 year of age, were then identified in the National Registry of Patients. We computed cumulative mortality of patients and the background population according to birth period (1977 to 1986, 1987 to 1996, and 1997 to 2005). We identified 6,646 patients with CHDs. Overall cumulative mortality estimates in patients with CHDs at 1 year and 10 and 25 years of age were 20% (95% confidence interval [CI] 19 to 21), 25% (95% CI 24 to 26), and 28% (95% CI 27 to 30). In Danes born in the same period equivalent mortality estimates were 0.6% (95% CI 0.6 to 0.6), 0.8% (95% CI 0.7 to 0.8), and 1.3% (95% CI 1.3 to 1.3). Mortality differed substantially according to heart defect type and mortality at 10 years of age ranged from 9% (95% CI 6 to 12) in patients with atrial septal defects (n = 361) to 55% (95% CI 45 to 66) in patients with common arterial trunk (n = 78). Mortality decreased during the study period; 1-year mortality was 28% (95% CI 26 to 31) for patients born from 1977 to 1986 (n = 2,907) compared to 13% (95% CI 12 to 15) for patients born from 1997 to 2005 (n = 2,741). Mortality decreased in all heart defect type categories. In conclusion, mortality in patients with CHD was high compared to the general population, especially in infancy, but also after 10 years of age, emphasizing the need for long-term medical follow up. Mortality at 1 year of age has decreased substantially during recent decades.
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Adhesion molecules and C-reactive protein are associated to adverse events in angina pectoris.
Scand. Cardiovasc. J.
PUBLISHED: 02-27-2010
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To examine the prognostic value of soluble cellular adhesion molecules (CAMs) and highly sensitive C reactive protein (hsCRP) on long-term outcome for patients with stable angina pectoris (SAP).
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Survival of primary total hip arthroplasty in rheumatoid arthritis patients.
Acta Orthop
PUBLISHED: 02-26-2010
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There has been a limited amount of research on survival of total hip arthroplasties (THAs) in rheumatoid arthritis (RA). We therefore performed a population-based, nationwide study to compare the survival of primary THAs in RA patients and in osteoarthritis (OA) patients. We also wanted to identify predictors of THA failure in RA patients.
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Long-term outcomes after percutaneous coronary intervention in patients with and without diabetes mellitus in Western Denmark.
Am. J. Cardiol.
PUBLISHED: 01-05-2010
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Patients with diabetes mellitus have worse outcomes after percutaneous coronary intervention than patients without diabetes mellitus. We compared the risk of stent thrombosis, myocardial infarction, death, and target lesion revascularization in diabetic and nondiabetic patients after implantation of drug-eluting stents or bare metal stents. In the Western Denmark Heart Registry, 12,347 consecutive patients (1,575 with and 10,772 without diabetes) were identified and followed up for 2 years. The 2-year risk of definite stent thrombosis was 0.52% in patients with diabetes mellitus and 0.71% in nondiabetic patients (adjusted relative risk [RR] 0.74, 95% confidence interval [CI] 0.41 to 1.34, p = 0.321). The 2-year risk of myocardial infarction was greater in the diabetic patients (6.9%) than in the nondiabetic patients (3.6%; adjusted RR 1.96, 95% CI 1.58 to 2.43; p <0.001). The all-cause 2-year mortality rate was almost twice as great for the diabetic patients compared to the nondiabetic patients (12.4% vs 6.7%; adjusted RR 1.91, 95% CI 1.63 to 2.23; p <0.001). The 2-year risk of target lesion revascularization was 8.5% in the diabetic patients and 6.8% in the nondiabetic patients (adjusted RR 1.28, 95% CI 1.10 to 1.49; p <0.001). In conclusion, 2 years after drug-eluting stent or bare metal stent implantation, diabetic patients had a greater risk than nondiabetic patients of myocardial infarction and death. Drug-eluting stent treatment reduced the risk of target lesion revascularization compared to bare metal stent treatment, regardless of diabetes status.
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Body height and sex-related differences in incidence of venous thromboembolism: a Danish follow-up study.
Eur. J. Intern. Med.
PUBLISHED: 01-04-2010
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Sex-related differences in incidence rate of venous thromboembolism (VTE) have been reported. It is unclear whether these differences reflect sex-related differences in the incidence of deep venous thrombosis (DVT), pulmonary embolism (PE) or both and to which extent the differences are mediated by known risk factors for VTE.
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Anthropometry, body fat, and venous thromboembolism: a Danish follow-up study.
Circulation
PUBLISHED: 10-26-2009
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Obesity, measured as body mass index, is associated with venous thromboembolism (VTE). Body mass index is a marker of excess weight and correlates well with body fat content in adults; however, it fails to consider the distribution of body fat. We assessed the association between anthropometric variables and VTE.
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Sulfonylureas and prognosis after myocardial infarction in patients with diabetes: a population-based follow-up study.
Diabetes Metab. Res. Rev.
PUBLISHED: 05-22-2009
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The cardiovascular safety, including risk of myocardial infarction (MI), of individual sulfonylureas (SUs) may differ. It remains uncertain whether treatment with individual SUs influences prognosis following MI.
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Use of statins and risk of hospitalization with dementia: a Danish population-based case-control study.
Alzheimer Dis Assoc Disord
PUBLISHED: 05-20-2009
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Several epidemiologic studies have indicated reduced risk of dementia among users of statins. We assessed the risk of hospitalization with dementia associated with use of statins in a population-based case-control study in 4 Northern Danish counties in the period 1991 to 2005. We identified 11,039 cases with dementia and 110,340 age- matched and sex-matched population controls using data from the National Patient Registry, the Danish Psychiatric Central Register, and the Civil Registration System. Prescriptions for statins filled before the admission for dementia were identified using population-based prescription databases. We used conditional logistic regression analysis to compute relative risk of hospitalization with dementia associated with use of statins using nonusers as reference group. We found an overall reduced risk of hospitalization with dementia among statin users (adjusted odds ratio: 0.67, 95% confidence intervals: 0.60-0.75). The reduced risk associated with statin use remained robust in various subanalyses, however, we found no clear dose-response pattern between the number of filled prescriptions for statin and the risk of hospitalization with dementia. In conclusion, we found a reduced risk of hospitalization with dementia among users of statins, however, whether this association is causal remains to be clarified.
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Atrial fibrillation in patients with ischemic stroke: A population-based study.
Clin Epidemiol
PUBLISHED: 05-06-2009
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Atrial fibrillation is a major risk factor for ischemic stroke. However, the prognostic impact of atrial fibrillation among patients with stroke is not fully clarified. We compared patient characteristics, including severity of stroke and comorbidity, quality of in-hospital care and outcomes in a cohort of first-time ischemic stroke patients with and without atrial fibrillation.
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Quality of care and length of hospital stay among patients with stroke.
Med Care
PUBLISHED: 04-15-2009
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The relationship between quality of care and economic outcome measures, including length of stay (LOS), among patients with stroke remains to be clarified.
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Moderate mitral regurgitation in patients undergoing CABG--the MoMIC trial.
Scand. Cardiovasc. J.
PUBLISHED: 03-14-2009
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The presence of mild to moderate ischemic mitral regurgitation (IMR) marks a significantly reduced long-term survival and increased hospitalizations due to heart-failure. However, it is common practice in many institutions to refrain from repairing the mitral valve in these patients. There are no available conclusive data to support this practice, and thus there is a need for an adequately powered randomized trial.
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2-year clinical outcomes after implantation of sirolimus-eluting, paclitaxel-eluting, and bare-metal coronary stents: results from the WDHR (Western Denmark Heart Registry).
J. Am. Coll. Cardiol.
PUBLISHED: 02-24-2009
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This registry study assessed the safety and efficacy of the 2 types of drug-eluting stents (DES), sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES), compared with bare-metal stents (BMS).
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The Danish Centre for Strategic Research in Type 2 Diabetes (DD2): organization of diabetes care in Denmark and supplementary data sources for data collection among DD2 study participants.
Clin Epidemiol
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This paper provides a short overview of the Danish health care system and the organization of care for type 2 diabetes patients in Denmark. It also describes the supplementary data sources that are used for collection of baseline data in the nationwide Danish Centre for Strategic Research in Type 2 Diabetes (DD2) Project. The Danish National Health Service provides tax-funded medical care for all 5.6 million Danish residents. The health care system is characterized by extensive individual-level registration of data used for planning, administration, quality improvement, and research. It is estimated that there are currently at least 250,000 individuals with known diabetes in Denmark (approximately 4.5% of the Danish population), of which an estimated 80% are followed and treated by their general practitioners and approximately 20% are followed at hospital specialist outpatient clinics. These health care providers form the basis for recruiting diabetes patients in the DD2 project, and the data sources that these providers use in clinical practice give access to important supplementary patient data. The DD2s patient-enrollment system is designed to be fast and simple, and thus only collects primary interview data that cannot be extracted from already existing data sources. Thus, in addition to an online DD2 questionnaire filled out by general practitioners and hospital physicians at the time of patient enrollment, supplementary data are obtained from the Danish Diabetes Database for Adults, a nationwide clinical quality improvement registry. Both hospital physicians and a growing number of general practitioners routinely report data to this database. For general practitioners, the Danish General Practice Database acts as an important feeder database for the Danish Diabetes Database for Adults and thereby also for the DD2 project.
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Higher stroke unit volume associated with improved quality of early stroke care and reduced length of stay.
Stroke
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Specialized stroke unit care improves outcome among patients with stroke, but it is unclear whether there are any scale advantages in costs and clinical outcome from treating a larger number of patients. We examined whether the case volume in stroke units was associated with quality of early stroke care, mortality, and hospital bed-day use.
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Challenges in validating quality of care data in a schizophrenia registry: experience from the Danish National Indicator Project.
Clin Epidemiol
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Improvement of quality of care for psychiatric patients is a key objective of health care systems worldwide. Consequently, there is an increasing interest in documenting quality of care; however, little is known about the validity of the available data on psychiatric care.
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The impact of statin use on pneumonia risk and outcome: a combined population-based case-control and cohort study.
Crit Care
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ABSTRACT: INTRODUCTION: The impact of statin use on pneumonia risk and outcome remains unclear. We therefore examined this risk in a population-based case-control study and did a 5-year update of our previous 30-day mortality analyses. METHODS: We identified 70,953 adults with a first-time hospitalization for pneumonia between 1997 and 2009 in Northern Denmark. Ten age- and sex-matched population controls were selected for each pneumonia patient. To control for potential confounders, we retrieved individual-level data on other medications, comorbidities, recent surgery, socioeconomic indicators, influenza vaccination, and other markers of frailty or health awareness from medical databases. We followed all pneumonia patients for 30 days after hospital admission. RESULTS: A total of 7,223 pneumonia cases (10.2%) and 64 523 controls (9.1%) were statin users before admission, corresponding to an age- and sex-matched odds ratio (OR) of 1.17 (95% confidence interval [CI]: 1.14-1.21). After controlling for higher comorbidity and a wide range of other potential confounders, the adjusted OR for pneumonia associated with current statin use dropped to 0.80 (95% CI: 0.77-0.83). Previous statin use was not associated with decreased pneumonia risk (adjusted OR = 0.97, 95% CI: 0.91-1.02). Decreased risk remained significant after further adjustment for frailty and health awareness markers.The prevalence of statin use among Danish pneumonia patients increased from 1% in 1997 to 24% in 2009. Thirty-day mortality following pneumonia hospitalization was 11.3% among statin users versus 15.1% among nonusers. This corresponded to a 27% reduced mortality rate (adjusted hazard ratio = 0.73, 95% CI: 0.67-0.79), corroborating our earlier findings. CONCLUSIONS: Current statin use was associated with both a decreased risk of hospitalization for pneumonia and lower 30-day mortality following pneumonia.
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[Use of clinical databases and central health registries for description of disease courses].
Ugeskr. Laeg.
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In Denmark, the linkage between national clinical databases and central health administrative and socio-demographic registries provides unique opportunities for describing and analysing disease courses in ways that can be applied for quality improvement purposes, in the evaluation of new organisational initiatives, and for research. This status article presents an overview of the possibilities and discusses the potentials and challenges.
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[Registries of in-hospital cardiac arrest are a challenge in daily clinical practice].
Ugeskr. Laeg.
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In-hospital cardiac arrest carries a poor prognosis. Registries of in-hospital cardiac arrest provide the opportunity to improve quality of care and conduct research of disease mechanisms and treatment. This paper describes the preliminary experience with systematic registration of in-hospital cardiac arrest at Aarhus University Hospital, Denmark. Data from 102 patients are presented and practical aspects and challenges of establishing a registry and implementing the collection of data in daily clinical practice are discussed.
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Infant, obstetrical and maternal characteristics associated with thromboembolism in infancy: a nationwide population-based case-control study.
Arch. Dis. Child. Fetal Neonatal Ed.
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To identify infant, obstetrical and maternal characteristics associated with arterial ischaemic stroke (AIS) and venous thromboembolism (VTE) in infancy (<1 year).
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Systematic Suicide Risk Assessment for Patients With Schizophrenia: A National Population-Based Study.
Psychiatr Serv
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OBJECTIVES Systematic suicide risk assessment is recommended for patients with schizophrenia; however, little is known about the implementation of suicide risk assessment in routine clinical practice. The study aimed to determine the use of systematic suicide risk assessment at discharge and predictors of suicide attempt among hospitalized patients with schizophrenia in Denmark. METHODS A one-year follow-up study was conducted of 9,745 patients with schizophrenia who were discharged from psychiatric wards and registered in a national population-based schizophrenia registry between 2005 and 2009. RESULTS The proportion of patients receiving suicide risk assessment at discharge from a psychiatric ward increased from 72% (95% confidence interval [CI]=71%-74%) in 2005, when the national monitoring began, to 89% (CI=89%-90%) in 2009. Within one year after discharge, 1% of all registered patients had died by suicide and 8% had attempted suicide. One out of three patients who died by suicide had no documented suicide risk assessment before discharge. CONCLUSIONS The use of systematic suicide risk assessment at discharge among patients with schizophrenia increased in Denmark between 2005 and 2009, in accordance with recommendations in national clinical guidelines and monitoring in a national clinical registry. Additional efforts are warranted to ensure a lower risk of suicidal behavior after hospital discharge.
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JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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