JoVE Visualize What is visualize?
Stop Reading. Start Watching.
Advanced Search
Stop Reading. Start Watching.
Regular Search
Find video protocols related to scientific articles indexed in Pubmed.
Immunotherapy for high-grade glioma.
Future Oncol
PUBLISHED: 06-20-2014
Show Abstract
Hide Abstract
4th Quadrennial Meeting of the World Federation of Neuro-Oncology in conjunction with the 18th Annual Meeting of the Society for Neuro-Oncology, San Francisco, CA, USA, 21-24 November 2013. Aside from temozolomide, there has been no major breakthrough for decades to improve outcome for high-grade glioma. Bevacizumab failed to show a survival advantage in two large studies - AVaglio and RTOG-0825 - and no other novel chemotherapy agents seem to be appearing on the horizon for this universally fatal disease. Consequently, the neuro-oncology fraternity is turning to immunotherapy. This became apparent in this meeting, considering a number of delegates focused their attention to presentations on immunotherapy. The ReACT study demonstrated the safety and efficacy of the combination of a promising peptide vaccine, rindopepimut, and bevacizumab with longer survival seen in patients with a higher antibody titer. Several presentations reassured that dendritic cell-based immunotherapy is safe and can generate a lasting immune response. Employing gene therapy, increased intratumor 5-fluorouracil chemotherapy concentration can be achieved using TOCA 511, and temozolomide-resistant transgenic lymphocytes could be produced through retroviral coding. Blocking immune checkpoints PDL-01, CTLA-4 and indoleamine 2,3-dioxygenase through monoclonal antibodies appears promising.
Related JoVE Video
Voltage mapping for delineating inexcitable dense scar in patients undergoing atrial fibrillation ablation: A new end point for enhancing pulmonary vein isolation.
Heart Rhythm
PUBLISHED: 05-26-2014
Show Abstract
Hide Abstract
Characterization of left atrial scar using bipolar voltage (BiV) mapping is not well defined. We have previously shown that the BiV range of 0.2-0.45 mV can identify chronic scar from prior pulmonary vein isolation (PVI).
Related JoVE Video
Use of a Novel Fragmentation Map to Identify the Substrate for Ventricular Tachycardia in Post Infarction Cardiomyopathy.
Heart Rhythm
PUBLISHED: 04-28-2014
Show Abstract
Hide Abstract
Substrate ablation is commonly performed in patients with post-infarction cardiomyopathy and ventricular tachycardia (VT). Recognition of fragmented and late potentials during sinus rhythm is a tedious process subject to operator fatigue.
Related JoVE Video
Related JoVE Video
Contact electroanatomic mapping derived voltage criteria for characterizing left atrial scar in patients undergoing ablation for atrial fibrillation.
J. Cardiovasc. Electrophysiol.
PUBLISHED: 02-02-2014
Show Abstract
Hide Abstract
Criteria have not been established for identifying LA scar using electroanatomic mapping (EAM). It is also unclear if voltage criteria using EAM may assist in identifying areas of pulmonary vein (PV) reconnection in patients undergoing repeat AF ablation.
Related JoVE Video
Appropriateness of primary prevention implantable cardioverter-defibrillators at the time of generator replacement: are indications still met?
J. Am. Coll. Cardiol.
PUBLISHED: 01-14-2014
Show Abstract
Hide Abstract
This study sought to determine how often patients with primary prevention implantable cardioverter-defibrillators (ICDs) meet guideline-derived indications at the time of generator replacement.
Related JoVE Video
Sudden cardiac death in patients with nonischemic cardiomyopathy.
Indian Heart J
PUBLISHED: 01-06-2014
Show Abstract
Hide Abstract
Sudden cardiac death (SCD) is an important cause of mortality worldwide. Although SCD is most often associated with coronary heart disease, the risk of SCD in patients without ischemic heart disease is well-established. Nonischemic cardiomyopathies, including idiopathic dilated cardiomyopathy, hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy represent three unique disease entities that have been shown to be highly associated with SCD and ventricular arrhythmias. A variety of risk stratification tools have been investigated, although the optimal strategy remains unknown. Identification of the arrhythmogenic substrate and treatment of ventricular arrhythmias in these subgroups can be challenging. Herein, we aim to discuss the current understanding of the anatomic and electrophysiologic substrate underlying ventricular arrhythmias and highlight features that may be associated with a higher risk of SCD in these 3 conditions.
Related JoVE Video
Catheter ablation of ventricular fibrillation: importance of left ventricular outflow tract and papillary muscle triggers.
Heart Rhythm
PUBLISHED: 01-04-2014
Show Abstract
Hide Abstract
Monomorphic ventricular premature depolarizations (VPDs) have been found to initiate ventricular fibrillation (VF) or polymorphic ventricular tachycardia (PMVT) in patients with and without structural heart disease.
Related JoVE Video
Characterization of Trans-septal Activation During Septal Pacing: Criteria for Identification of Intramural Ventricular Tachycardia Substrate in Nonischemic Cardiomyopathy.
Circ Arrhythm Electrophysiol
PUBLISHED: 10-08-2013
Show Abstract
Hide Abstract
Background- Identification of intramural basal-septal ventricular tachycardia (VT) substrate is challenging in nonischemic cardiomyopathy. We sought to (1) characterize normal/abnormal trans-septal right ventricular (RV) to left ventricular activation; (2) assess the effect of opposite RV pacing on left ventricular septal bipolar electrograms (EGMs); and (3) establish criteria for the identification of intramural septal VT substrate. Methods and Results- Endocardial activation mapping and local EGM assessment of the left interventricular septum was performed during RV basal septal pacing in 40 patients undergoing VT ablation with no evidence of septal scar (group 1, n=14) and with septal scar (group 2, n=26) defined by low septal unipolar voltage (<8.3 mV) and delayed enhancement on cardiac MRI with/without abnormal bipolar voltage (<1.5 mV) in sinus rhythm. Left ventricular trans-septal activation time was prolonged in Group 2 compared with Group 1 (55.3±33.0 versus 25.7±8.8 ms; P=0.003). In 6 group 2 patients, left ventricular septal breakthrough was displaced to the scar border. During RV pacing, group 2 had fractionated (8.8%), late (2.8%), and split (5.7%) EGMs not seen in group 1. Trans-septal activation >40 ms (sensitivity 60%, specificity 100%; P<0.001) and EGM duration >95 ms during pacing (sensitivity 22%, specificity 91%; P<0.001) identified septal scar (13/26 pts). Conclusions- In patients with nonischemic cardiomyopathy, VT and septal scar, delayed transmural conduction time (>40 ms) and fractionated, late, split, and wide (>95 ms) bipolar EGMs during RV basal pacing identify intramural VT substrate. In select cases, the basal septum appears compartmentalized as the stimulated wavefront is rerouted to the scar border.
Related JoVE Video
Unipolar Voltage Abnormality is Associated with Greater Left Ventricular Dysfunction in Ischemic Cardiomyopathy.
J. Cardiovasc. Electrophysiol.
PUBLISHED: 09-04-2013
Show Abstract
Hide Abstract
Following myocardial infarction (MI), left ventricular function is determined by cardiac remodeling occurring in both infarcted and noninfarcted myocardium (NIM). Unipolar voltage mapping may detect remodeling changes in NIM that are associated with the left ventricular ejection fraction (LVEF). We aimed to identify (1) unipolar voltage characteristics in patients with chronic MI, and (2) association of voltage abnormalities with degree of left ventricular dysfunction (LVD).
Related JoVE Video
Nonischemic cardiomyopathy substrate and ventricular tachycardia in the setting of coronary artery disease.
Heart Rhythm
PUBLISHED: 06-24-2013
Show Abstract
Hide Abstract
Patients with coronary artery disease (CAD) may have ventricular tachycardia (VT) from a separate nonischemic process. Catheter ablation in these patients can be misguided by abnormalities of coronary arteries.
Related JoVE Video
Inducibility of atrial fibrillation and flutter following pulmonary vein ablation.
J. Cardiovasc. Electrophysiol.
PUBLISHED: 02-06-2013
Show Abstract
Hide Abstract
Prior reports demonstrate prognostic value in noninducibility of atrial arrhythmias after atrial fibrillation (AF) ablation and suggest their utility in guiding additional ablation lesion sets. The type and mechanism of induced atrial arrhythmias, their relationship to the underlying atrial substrate, and prognostic significance of induced organized atrial arrhythmias are unknown.
Related JoVE Video
Assessing arrhythmia burden after catheter ablation of atrial fibrillation using an implantable loop recorder: the ABACUS study.
J. Cardiovasc. Electrophysiol.
PUBLISHED: 01-29-2013
Show Abstract
Hide Abstract
Arrhythmia monitoring in patients undergoing atrial fibrillation (AF) ablation is challenging. Transtelephonic monitors (TTMs) are cumbersome to use and provide limited temporal assessment. Implantable loop recorders (ILRs) may overcome these limitations. We sought to evaluate the utility of ILRs versus conventional monitoring (CM) in patients undergoing AF ablation.
Related JoVE Video
Relationship between voltage map "channels" and the location of critical isthmus sites in patients with post-infarction cardiomyopathy and ventricular tachycardia.
J. Am. Coll. Cardiol.
PUBLISHED: 01-08-2013
Show Abstract
Hide Abstract
The goal of this study was to determine the relationship of the ventricular tachycardia (VT) isthmus to channels of preserved voltage on an electroanatomic voltage map in postinfarction cardiomyopathy.
Related JoVE Video
Temozolomide induced liver injury.
Acta Neurol Belg
PUBLISHED: 12-07-2011
Show Abstract
Hide Abstract
A 62-year female received radiotherapy over six weeks with daily 75 mg/m2 Temozolomide (TMZ) for Glioblastoma (GB). At the last week of radiotherapy, her liver enzymes and serum bilirubin started deteriorating. TMZ was discontinued. The histopathology demonstrated the features of acute cholestasis and focal parenchymal inflammation. A range of investigations failed to show any other contributory cause of hepatitis. She required in-hospital care for a prolonged period for a grade three hepatic failure. The liver functions very slowly recovered over 40 weeks, but her general condition continues to deteriorate. TMZ may cause a mild temporary rise in the liver enzymes and has been reported to reactivate hepatitis B. In few other cases concomitant medications were the possible causes of hepatitis. However, searching the Medline and other bibliographic database, we have not come across any case of TMZ-induced liver injury (TMZ-DILI). Histopathology and pattern of liver enzyme elevation suggest that unlike Dacarbazine, which causes veno-occlusive type liver damage, TMZ in this patient caused mainly cholestasis type liver injury. On Naranjo Adverse Drug Reaction (ADR) probability scale, this case falls in probable grade (Scale 7).
Related JoVE Video
Randomized ablation strategies for the treatment of persistent atrial fibrillation: RASTA study.
Circ Arrhythm Electrophysiol
PUBLISHED: 12-02-2011
Show Abstract
Hide Abstract
The single-procedure efficacy of pulmonary vein isolation (PVI) is less than optimal in patients with persistent atrial fibrillation (AF). Adjunctive techniques have been developed to enhance single-procedure efficacy in these patients. We conducted a study to compare 3 ablation strategies in patients with persistent AF.
Related JoVE Video
Effect of electrocardiographic lead placement on localization of outflow tract tachycardias.
Heart Rhythm
PUBLISHED: 11-06-2011
Show Abstract
Hide Abstract
The origin of outflow tract ventricular tachycardia (OTVT) can be predicted from a surface electrocardiogram: indexes of R-wave amplitudes in leads V(1) and V(2) are used to differentiate a right origin from a left origin, while the axis of lead I differentiates an anterior origin from a posterior origin. Incorrect electrode placement is clinically common and may alter predictability of OTVTs.
Related JoVE Video
Assessing epicardial substrate using intracardiac echocardiography during VT ablation.
Circ Arrhythm Electrophysiol
PUBLISHED: 08-31-2011
Show Abstract
Hide Abstract
Intracardiac echocardiography (ICE) has played a limited role in defining the substrate for ventricular tachycardia (VT). The purpose of this study was to assess whether ICE could identify abnormal epicardial substrate in patients with nonischemic cardiomyopathy (NICM) and VT.
Related JoVE Video
Sinus rhythm ECG criteria associated with basal-lateral ventricular tachycardia substrate in patients with nonischemic cardiomyopathy.
J. Cardiovasc. Electrophysiol.
PUBLISHED: 07-07-2011
Show Abstract
Hide Abstract
Patients with nonischemic cardiomyopathy (NICM) and ventricular tachycardia (VT) usually have basal-lateral scar in the left ventricle (LV). We sought to determine electrocardiogram (ECG) characteristics that may help identify NICM patients with basal-lateral scar and VT.
Related JoVE Video
Surgical ablation of refractory ventricular tachycardia in patients with nonischemic cardiomyopathy.
Circ Arrhythm Electrophysiol
PUBLISHED: 06-14-2011
Show Abstract
Hide Abstract
The surgical approach for the treatment of ventricular tachycardia (VT) has been largely replaced by percutaneous, catheter-based techniques. However, some VT circuits, particularly in patients with nonischemic cardiomyopathy, remain inaccessible to percutaneous ablation. Surgical therapy of these VTs is an alternative approach; however, its methodology has not been well defined. The purpose of this study was to evaluate the efficacy of preoperative electroanatomic and electrophysiological characterization of the VT substrate and circuit to guide surgical ablation.
Related JoVE Video
Reversal of outflow tract ventricular premature depolarization-induced cardiomyopathy with ablation: effect of residual arrhythmia burden and preexisting cardiomyopathy on outcome.
Heart Rhythm
PUBLISHED: 04-04-2011
Show Abstract
Hide Abstract
Outflow tract ventricular premature depolarizations (VPDs) can be associated with reversible left ventricular cardiomyopathy (LVCM). Limited data exist regarding the outcome after ablation of outflow tract VPDs from the LV and the impact of residual VPDs or preexisting LVCM prior to the diagnosis of VPDs on recovery of LV function.
Related JoVE Video
Is there a relationship between complex fractionated atrial electrograms recorded during atrial fibrillation and sinus rhythm fractionation?
Heart Rhythm
PUBLISHED: 03-06-2011
Show Abstract
Hide Abstract
Ablation of persistent atrial fibrillation (AF) may require adjunctive methods of substrate modification. Both ablation-targeting complex fractionated atrial electrograms (CFAEs) recorded during AF and fractionated electrograms recorded during sinus rhythm (sinus rhythm fractionation [SRF]) have been described. However, the relationship of CFAEs with SRF is unclear.
Related JoVE Video
The sequential use of carmustine wafers (Gliadel®) and post-operative radiotherapy with concomitant temozolomide followed by adjuvant temozolomide: a clinical review.
Br J Neurosurg
PUBLISHED: 02-23-2011
Show Abstract
Hide Abstract
In patients with glioblastoma multiforme (GBM), there is no consensus on the sequential use of two existing regimens: post-operative Gliadel implantation into the surgical cavity and concomitant temozolomide with radiotherapy followed by adjuvant temozolomide (Stupp protocol). NICE in the guideline TA121 (July 2007) could not pass any judgement on the sequential use of both the regimens due to lack of evidence at the time of consultation. Since then, few prospective studies and retrospective series have been reported using these two regimens sequentially. Except in one study, results were indicative of an incremental gain of 2-3 months in median survival in comparison to the published results using Gliadel or Stupp Protocol alone. Post-surgical complications were manageable and within an acceptable range, when the sequential regimen was managed under defined guidelines and surgery was performed in a high volume centre. Moderate degree of increased myelosuppression has been reported in few series, however. In the absence of a phase III trial and the small number of patients in each series, the reported trend of toxicities and efficacy could only be substantiated by setting up a national database. Contributing to such a national database and toxicity recording could be made mandatory through peer review programme for the neurooncological services. Based on the preclinical and albeit lower level of clinical evidence, demonstrating temporal and spatial co-operation between two regimens (Gliadel and Stupp Protocol), resulting in incremental 2-3 months median survival gain, should enable NICE in its next review to issue a favourable guidance. Depending on the number of patients eligible for such a sequential regimen, which could be 15%-25% of Glioblastoma patients diagnosed in England per annum, the additional annual cost of concomitant temozolomide would be approximately £640,000 to £1 million.
Related JoVE Video
Feasibility of catheter ablation of mitral annular flutter in patients with prior mitral valve surgery.
Heart Rhythm
PUBLISHED: 01-07-2011
Show Abstract
Hide Abstract
Mitral annular flutter (MAF) may occur after ablation of atrial fibrillation in patients with prior mitral valve (MV) replacement or repair. Percutaneous catheter ablation may be challenging owing to the presence of surgical scar and a prosthetic MV.
Related JoVE Video
Isolated septal substrate for ventricular tachycardia in nonischemic dilated cardiomyopathy: incidence, characterization, and implications.
Heart Rhythm
PUBLISHED: 01-04-2011
Show Abstract
Hide Abstract
The substrate for ventricular tachycardia (VT) in nonischemic cardiomyopathy (NICM) has a predilection for the basolateral left ventricle with right bundle branch block VT morphology.
Related JoVE Video
The V(2) transition ratio: a new electrocardiographic criterion for distinguishing left from right ventricular outflow tract tachycardia origin.
J. Am. Coll. Cardiol.
PUBLISHED: 01-02-2011
Show Abstract
Hide Abstract
We sought to develop electrocardiography (ECG) criteria for distinguishing left ventricular outflow tract (LVOT) from right ventricular outflow tract (RVOT) origin in patients with idiopathic outflow tract ventricular tachycardia (OTVT) and lead V(3) R/S transition.
Related JoVE Video
Endocardial unipolar voltage mapping to detect epicardial ventricular tachycardia substrate in patients with nonischemic left ventricular cardiomyopathy.
Circ Arrhythm Electrophysiol
PUBLISHED: 12-03-2010
Show Abstract
Hide Abstract
Patients with nonischemic left ventricular cardiomyopathy (LVCM) and ventricular tachycardia (Vt) have complex 3-dimensional substrate with variable involvement of the endocardium (ENDO) and epicardium (EPI). The purpose of this study was to determine whether ENDO unipolar (UNI) mapping with a larger electric field of view could identify EPI low bipolar (BIP) voltage regions in patients with LVCM undergoing Vt ablation.
Related JoVE Video
Antiarrhythmics after ablation of atrial fibrillation (5A Study): six-month follow-up study.
Circ Arrhythm Electrophysiol
PUBLISHED: 11-13-2010
Show Abstract
Hide Abstract
We previously demonstrated that treatment with antiarrhythmic drugs (AADs) during the first 6 weeks after atrial fibrillation (AF) ablation reduces the incidence of clinically significant atrial arrhythmias and need for cardioversion or hospitalization for arrhythmia management. Whether early rhythm suppression decreases longer-term arrhythmia recurrence is unknown. We now report the 6-month follow-up data from this study.
Related JoVE Video
Noncontact electroanatomic mapping to characterize typical atrial flutter: participation of right atrial posterior wall in the reentrant circuit.
J. Cardiovasc. Electrophysiol.
PUBLISHED: 10-11-2010
Show Abstract
Hide Abstract
Reentry utilizing cavotricuspid isthmus (CTI) is accepted as the mechanism underlying typical atrial flutter (AFLT). However, it is unclear how the right atrial (RA) posterior wall (PW) participates in AFLT circuit. We sought to investigate this by using noncontact electroanatomic mapping.
Related JoVE Video
Related JoVE Video
Efficacy and risk of atrial fibrillation ablation before 45 years of age.
Circ Arrhythm Electrophysiol
PUBLISHED: 09-21-2010
Show Abstract
Hide Abstract
Young patients with atrial fibrillation (AF) tend to be more symptomatic and less willing to take long-term medications, yet catheter ablation remains recommended as second-line therapy for AF regardless of age. This study seeks to characterize the effectiveness and risk of AF ablation in the young.
Related JoVE Video
Lack of uniform progression of endocardial scar in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy and ventricular tachycardia.
Circ Arrhythm Electrophysiol
PUBLISHED: 06-17-2010
Show Abstract
Hide Abstract
The endocardial substrate for ventricular arrhythmias in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) is thought to be caused by a progressive degenerative process. Many clinical decisions and treatment plans are guided by this pathophysiologic assumption, but the extent of progression of macroscopic endocardial scar and right ventricular (RV) dilatation have not been assessed.
Related JoVE Video
Long-term outcome after successful catheter ablation of atrial fibrillation.
Circ Arrhythm Electrophysiol
PUBLISHED: 03-24-2010
Show Abstract
Hide Abstract
Pulmonary vein isolation (PVI) is increasingly used for treatment of atrial fibrillation (AF), but few reports exist regarding long-term success. We determined 5-year outcomes of PVI among patients with freedom from AF off antiarrhythmic drugs (AAD) for 1 year after PVI.
Related JoVE Video
Antiarrhythmics After Ablation of Atrial Fibrillation (5A Study).
Circulation
PUBLISHED: 09-08-2009
Show Abstract
Hide Abstract
Atrial arrhythmias are common early after atrial fibrillation (AF) ablation. We hypothesized that empirical antiarrhythmic drug (AAD) therapy for 6 weeks after AF ablation would reduce the occurrence of atrial arrhythmias.
Related JoVE Video
Arrhythmogenic potential of pulmonary venous tissue: triggers for atrial fibrillation identified within the remnant of a vein.
J. Cardiovasc. Electrophysiol.
PUBLISHED: 06-26-2009
Show Abstract
Hide Abstract
Pulmonary veins (PVs) have frequently been identified as triggers for atrial fibrillation (AF), and higher arrhythmogenic potential of superior PVs has been attributed to their larger size, which can more rigorously support abnormalities of impulse formation and/or conduction.
Related JoVE Video
Electroanatomic substrate and ablation outcome for suspected epicardial ventricular tachycardia in left ventricular nonischemic cardiomyopathy.
J. Am. Coll. Cardiol.
PUBLISHED: 02-09-2009
Show Abstract
Hide Abstract
The aim of the study was to define the epicardial substrate and ablation outcome in patients with left ventricular nonischemic cardiomyopathy (NICM) and suspected epicardial ventricular tachycardia (VT).
Related JoVE Video
Effect of pulmonary vein isolation on the distribution of complex fractionated electrograms in humans.
Heart Rhythm
PUBLISHED: 02-04-2009
Show Abstract
Hide Abstract
Targeting of complex fractionated electrograms (CFEs) has been used as an adjunctive strategy to pulmonary vein isolation (PVI) in patients with persistent atrial fibrillation (AF). However, it is unclear whether CFEs should be targeted before or after PVI.
Related JoVE Video
Characterization of the phrenic nerve course within the epicardial substrate of patients with nonischemic cardiomyopathy and ventricular tachycardia.
Heart Rhythm
PUBLISHED: 01-06-2009
Show Abstract
Hide Abstract
Patients with nonischemic cardiomyopathy and ventricular tachycardia (VT) often have low-voltage areas in the lateral left ventricular (LV) epicardium that serve as the VT substrate. The course of the left phrenic nerve in this region may pose a challenge to successful and safe ablation.
Related JoVE Video
Apical ventricular tachycardia morphology in left ventricular nonischemic cardiomyopathy predicts poor transplant-free survival.
Heart Rhythm
Show Abstract
Hide Abstract
The scar of patients with left ventricular (LV) nonischemic cardiomyopathy (NICM) and ventricular tachycardia (VT) typically originates at or near the mitral annulus and extends a variable distance toward the apex.
Related JoVE Video
An electrocardiographic scoring system for distinguishing right ventricular outflow tract arrhythmias in patients with arrhythmogenic right ventricular cardiomyopathy from idiopathic ventricular tachycardia.
Heart Rhythm
Show Abstract
Hide Abstract
Ventricular arrhythmias in patients with arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C) and idiopathic ventricular tachycardia (VT) can share a left bundle branch block/inferior axis morphology. We previously reported electrocardiogram characteristics during outflow tract ventricular arrhythmias that helped distinguish VT related to ARVD/C from idiopathic VT.
Related JoVE Video
Efforts to enhance catheter stability improve atrial fibrillation ablation outcome.
Heart Rhythm
Show Abstract
Hide Abstract
Contemporary techniques to enhance anatomical detail and catheter contact during atrial fibrillation (AF) ablation include (1) the integration of preacquired tomographic reconstructions with electroanatomical mapping (3-dimensional image integration [I-EAM]), (2) the use of steerable introducers (SIs), and (3) high-frequency jet ventilation (HFJV).
Related JoVE Video
Small cell cancer of the prostate.
Urology
Show Abstract
Hide Abstract
De novo small cell cancer of the prostate is a rare tumor and has different presentation, behavior, and outcome compared with adenocarcinoma. A 66-year-old man presented with symptoms masquerading as a rectal tumor. Primary symptoms were intermittent constipation and diarrhea without any urinary symptoms. Initial staging showed only 2 large pelvic nodes. Prostate-specific antigen was 4.8 ng/L. A transrectal prostate biopsy confirmed small cell histology. After having no response to hormones and carboplatin-etoposide, a course of palliative radiotherapy, docetaxel chemotherapy, and defunctioning colostomy offered palliation. Liver and lytic bone metastases developed later; the patient died 9 months after the presentation.
Related JoVE Video
New unipolar electrogram criteria to identify irreversibility of nonischemic left ventricular cardiomyopathy.
J. Am. Coll. Cardiol.
Show Abstract
Hide Abstract
This study sought to assess the value of left ventricular (LV) endocardial unipolar electroanatomical mapping (EAM) in identifying irreversibility of LV systolic dysfunction in patients with left ventricular nonischemic cardiomyopathy (LVCM).
Related JoVE Video
Percutaneous epicardial ventricular tachycardia ablation after noncoronary cardiac surgery or pericarditis.
Heart Rhythm
Show Abstract
Hide Abstract
Patients with previous noncoronary cardiac surgery or pericarditis may require epicardial access to facilitate successful ventricular tachycardia (VT) ablation. Percutaneous pericardial access is known to be difficult in these patients owing to the presence of pericardial adhesions.
Related JoVE Video
ECG criteria for accurate localization of left anterolateral and posterolateral accessory pathways.
Pacing Clin Electrophysiol
Show Abstract
Hide Abstract
BACKGround : Left lateral accessory pathway (AP) location along the mitral annulus (MA) can influence ablation strategy, including choice of a transseptal or retrograde aortic approach and the use of deflectable sheaths and/or bidirectional catheters. We aimed to develop electrocardiographic (ECG) criteria to accurately localize a left lateral AP, hypothesizing that the relationship of QRS amplitudes in limb leads II and III could be used to differentiate left anterolateral (LAL) from left posterolateral (LPL) AP locations.
Related JoVE Video
Chronic kidney disease and cardiac remodelling in patients with mild heart failure: results from the REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE) study.
Eur. J. Heart Fail.
Show Abstract
Hide Abstract
Chronic kidney disease (CKD) is a risk factor for left ventricular hypertrophy (LVH) and heart failure. We evaluated the effect of CKD on left ventricular (LV) remodelling among patients with mild heart failure.
Related JoVE Video
Temozolomide-related idiosyncratic and other uncommon toxicities: a systematic review.
Anticancer Drugs
Show Abstract
Hide Abstract
Temozolomide (TMZ)-related idiosyncratic and other uncommon toxicities have been reported. To better characterize these toxicities and to identify any associated risk factors, we performed a systematic review. We searched the PubMed database, limited to the English language, published between 1999 and December 2011. We selected only those articles in which TMZ was temporally related and was the sole or main contributing chemotherapeutic drug to idiosyncratic drug reactions (IDRs) and other uncommon toxicities. Hematological IDRs are biopsy-proven aplastic anemia or grade V toxicity or grade IV toxicity with slow and incomplete hematological recovery. Seventy-three cases were identified, including 21 hematological IDRs, 31 nonhematological IDRs and uncommon infections, and 21 second primary cancers. With a caveat of publication and reporting bias, the following observations could be made. The hematological IDRs predominantly occurred in female patients (exact binomial two-tailed, P=0.0041) and most patients were receiving TMZ concomitantly with radiotherapy for glioma. The median duration of exposure to TMZ was 30 days and the median cumulative TMZ exposure was 2250 mg/m (range, 500-6900 mg/m). The sex predilection was not evident in nonhematological IDRs and other uncommon toxicities. TMZ-induced pneumonitis and cholestatic hepatitis are emerging as a nonhematological hypersensitive reaction and IDR, respectively. For TMZ-related myelodysplasia or leukemia, the cumulative dose of TMZ ranged from 1400 to 30 000 mg/m. The cumulative dose of TMZ was lower and latency was shorter with a previous exposure to other leukemogenic drugs, suggesting that TMZ may have augmented the leukemogenic potential of other drugs. Early appearance of profound myelosuppression during the course of TMZ and concurrent radiotherapy could be a hematological IDR, which warrants prompt investigations to exclude aplastic anemia. Myelodysplasia or leukemia developed after a median TMZ exposure of 15 g/m.
Related JoVE Video
Risk of stroke and atrial fibrillation after radiofrequency catheter ablation of typical atrial flutter.
Heart Rhythm
Show Abstract
Hide Abstract
Studies suggest that 18%-50% of the patients develop atrial fibrillation (AF) after typical atrial flutter (AFL) ablation. However, little data exist about the incidence of and risk factors for stroke and AF after successful ablation of typical AFL.
Related JoVE Video
A study to evaluate the effect of nutritional intervention measures on admitted children in selected nutrition rehabilitation centers of indore and ujjain divisions of the state of madhya pradesh (India).
Indian J Community Med
Show Abstract
Hide Abstract
The state of Madhya Pradesh has 1.3 million severely malnourished children. Nutrition rehabilitation centers (NRCs) were started in the state to control severe malnutrition and decrease the prevalence of severe malnourished children to less than 1% among children aged 1-5 years.
Related JoVE Video
Predictors of recovery of left ventricular dysfunction after ablation of frequent ventricular premature depolarizations.
Heart Rhythm
Show Abstract
Hide Abstract
Frequent ventricular premature depolarizations (VPDs) can cause reversible left ventricular (LV) dysfunction. However, not all patients normalize their LV function after VPD elimination.
Related JoVE Video
A study to assess the needs of people living with HIV/AIDS reporting to an ART Center of Central India.
AIDS Care
Show Abstract
Hide Abstract
Effectively addressing the needs of people living with HIV/AIDS (PLHA) and providing them with adequate care and support services are an essential intervention necessary to address the problem of HIV. The current study analyzed the needs of PLHA, the support received and the support required, to help frame comprehensive and focused programs for HIV infected individuals. The study was cross-sectional in design, incorporating quantitative analysis techniques and was conducted at the Anti Retroviral Therapy (ART) Center of MGM Medical College Indore, India, from February 2009 to January 2010. A semistructured interview schedule was used to interview 420 respondents currently on ART and the data was analyzed using SPSS software. Males and females constituted 69 and 31% of the study participants, respectively. The major support received by the respondents was care and help from families and friends, free ART, medicines for opportunistic infections (OI) and monthly health check-up at the ART Center. Other support received included nutritional supplements, traveling allowance to travel to the ART Center for availing the monthly dose of ART and educational help for children. The major support required was regular availability of medicines for various OI and associated diseases at ART centers, free laboratory investigations at hospitals, educational help for children, employment opportunities, development of a vaccine, facility of households, availability of second line ART drugs at ART centers, decentralization of ART centers, strengthening of existing PLHA networks and support groups, and better and effective counseling services. Coordinated efforts by governmental, non-governmental sources and PLHA themselves will result in the development of a comprehensive package of care and support for PLHA, to cater to their needs and requirements.
Related JoVE Video
Radiotherapy-induced hypopituitarism: a review.
Expert Rev Anticancer Ther
Show Abstract
Hide Abstract
Hypopituitarism is a disorder caused by impaired hormonal secretions from the hypothalamic-pituitary axis. Radiotherapy is the most common cause of iatrogenic hypopituitarism. The hypothalamic-pituitary axis inadvertently gets irradiated in patients receiving prophylactic cranial radiotherapy for leukemia, total body irradiation and radiotherapy for intracranial, base skull, sinonasal and nasopharyngeal tumors. Radiation-induced hypopituitarism (RIH) is insidious, progressive and largely nonreversible. Mostly, RIH involves one hypothalamic-pituitary axis; however, multiple hormonal axes deficiency starts developing at higher doses. Although the clinical effects of the hypopituitarism are more profound in children and young adults, its implications in older adults are being increasingly recognized. The risk continues to persist or increase up to 10 years following radiation exposure. The clinical management of hypopituitarism is challenging both for the patients and healthcare providers. Here we have reviewed the scale of the problem, the risk factors and the management of RIH.
Related JoVE Video
Nearly uniform failure of atrial flutter ablation and continuation of antiarrhythmic agents (hybrid therapy) for the long-term control of atrial fibrillation.
J Interv Card Electrophysiol
Show Abstract
Hide Abstract
Ablation for atrial flutter and continued pharmacologic therapy (hybrid therapy) is a management strategy when treatment with class I antiarrhythmic drugs organize atrial fibrillation (AF) into flutter. Previous studies with 2-3-year follow-up have reported satisfactory control of AF burden.
Related JoVE Video
Related JoVE Video
Pulmonary vein antral isolation and nonpulmonary vein trigger ablation without additional substrate modification for treating longstanding persistent atrial fibrillation.
J. Cardiovasc. Electrophysiol.
Show Abstract
Hide Abstract
Effectiveness of antral pulmonary vein isolation (PVAI) and ablation of non-PV triggers (non-PVTA) in controlling longstanding persistent atrial fibrillation (AF) has not been reported. We sought to describe clinical outcomes with this ablation strategy in patients (pts) followed for at least 1 year.
Related JoVE Video
Frequent additional tachyarrhythmias in patients with inappropriate sinus tachycardia undergoing sinus node modification: an important cause of symptom recurrence.
J. Cardiovasc. Electrophysiol.
Show Abstract
Hide Abstract
Symptom recurrence following sinus node modification (SNM) for inappropriate sinus tachycardia (IST) remains significant despite achieving acute procedural success. The impact of non-IST tachyarrhythmias on symptom recurrence remains poorly characterized.
Related JoVE Video
Anesthetic management of patients undergoing pulmonary vein isolation for treatment of atrial fibrillation using high-frequency jet ventilation.
J. Cardiothorac. Vasc. Anesth.
Show Abstract
Hide Abstract
The aim of this study was to describe anesthetic management and perioperative complications in patients undergoing pulmonary vein isolation for the treatment of atrial fibrillation under general anesthesia using high-frequency jet ventilation. The authors also identified variables associated with longer ablation times in this patient cohort.
Related JoVE Video

What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.