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Find video protocols related to scientific articles indexed in Pubmed.
Variant histology: role in management and prognosis of nonmuscle invasive bladder cancer.
Curr Opin Urol
PUBLISHED: 06-13-2014
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The true clinical significance of variant histology is controversial and diagnosis is challenging, especially in the setting of nonmuscle invasive (NMI) disease. If the presence of variant architecture in NMI identifies a high-risk population with a worse prognosis and better suited for early aggressive intervention (i.e., radical cystectomy), then treatment recommendations should reflect this notion. This review outlines the current evidence and determines whether histologic variants should change management of patients with nonmuscle invasive bladder cancer.
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Neoadjuvant chemotherapy improves survival of patients with upper tract urothelial carcinoma.
Cancer
PUBLISHED: 02-05-2014
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High-grade upper tract urothelial carcinoma (UTUC) is frequently upstaged after surgery and is associated with uniformly poor survival. Neoadjuvant chemotherapy may offer a way to improve clinical outcomes. The authors compared the survival rates of patients with UTUC who received neoadjuvant chemotherapy before surgery with the rates among patients who did not.
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Identification of distinct basal and luminal subtypes of muscle-invasive bladder cancer with different sensitivities to frontline chemotherapy.
Cancer Cell
PUBLISHED: 01-13-2014
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Muscle-invasive bladder cancers (MIBCs) are biologically heterogeneous and have widely variable clinical outcomes and responses to conventional chemotherapy. We discovered three molecular subtypes of MIBC that resembled established molecular subtypes of breast cancer. Basal MIBCs shared biomarkers with basal breast cancers and were characterized by p63 activation, squamous differentiation, and more aggressive disease at presentation. Luminal MIBCs contained features of active PPAR? and estrogen receptor transcription and were enriched with activating FGFR3 mutations and potential FGFR inhibitor sensitivity. p53-like MIBCs were consistently resistant to neoadjuvant methotrexate, vinblastine, doxorubicin and cisplatin chemotherapy, and all chemoresistant tumors adopted a p53-like phenotype after therapy. Our observations have important implications for prognostication, the future clinical development of targeted agents, and disease management with conventional chemotherapy.
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Myths and Mysteries Surrounding Bacillus Calmette-Guérin Therapy for Bladder Cancer.
Eur. Urol.
PUBLISHED: 09-11-2013
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Intravesical therapy with bacillus Calmette-Guérin has proven effects for reducing recurrence, progression, and death from non-muscle-invasive bladder cancer. These advantages are seen mainly when appropriate maintenance therapy is used for 1-3 years, in the context of appropriate patient selection, tumor management, and symptom support for potential side effects.
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Xanthogranulomatous pyelonephritis presenting with a left flank mass.
Case Rep Med
PUBLISHED: 09-05-2013
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We present a case of a patient with xanthogranulomatous pyelonephritis (XGP) presenting with a large (18 × 12?cm) left-sided flank mass with worsening left flank pain. CT abdomen/pelvis demonstrated a left kidney with parenchyma replaced by multiple large hypodense collections containing fluid and gas, a left staghorn calculus, and a communication between the kidney and large flank collection. About 4.5 weeks after initial presentation, the patient underwent operative intervention. Pathology revealed an end-stage kidney with scar consistent with xanthogranulomatous pyelonephritis.
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Should histologic variants alter definitive treatment of bladder cancer?
Curr Opin Urol
PUBLISHED: 07-25-2013
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The clinical significance of variant histology is controversial and diagnosis is challenging. If variant architecture truly identifies high-risk patients, or those with a differential response to therapy, than treatment algorithms should be altered. This review outlines the current evidence and determines whether histologic variants should indeed alter definitive treatment.
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Refining Patient Selection for Neoadjuvant Chemotherapy before Radical Cystectomy.
J. Urol.
PUBLISHED: 07-22-2013
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We evaluated the survival of patients with muscle invasive bladder cancer undergoing radical cystectomy without neoadjuvant chemotherapy to confirm the utility of existing clinical tools to identify low risk patients who could be treated with radical cystectomy alone and a high risk group most likely to benefit from neoadjuvant chemotherapy.
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Gunshot wounds to the lower urinary tract: a single-institution experience.
J Trauma Acute Care Surg
PUBLISHED: 02-22-2013
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This study aimed to analyze characteristics and outcomes of gunshot wounds to the lower urinary tract at our Level I trauma center. Our hypothesis is that gunshot wounds to the lower urinary tract have characteristic bullet trajectories, injury patterns, and associated injuries.
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The role of active surveillance in the management of prostate cancer.
J Natl Compr Canc Netw
PUBLISHED: 02-16-2013
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In 2010, NCCN incorporated active surveillance (AS) into the NCCN Clinical Practice Guidelines in Oncology for Prostate Cancer, and the 2012 update serves as an excellent resource with the most current evidence regarding treatment options for men with all stages of disease. However, the lack of clinical trials that directly compare various treatment modalities or identify the best management, especially for men with low-risk prostate cancer, makes the decision-making process difficult for both patients and physicians. Although general agreement exists on definitions of candidates for AS-men with low-volume and low-grade disease thought to be at low risk for rapid progression-several key issues remain in establishing and supporting the role of AS in the management of prostate cancer, such as optimal timing and appropriate triggers for active treatment. The decision to initially pursue AS rather than active treatment after prostate cancer diagnosis is complex and involves myriad factors, including estimation of life expectancy, consideration of quality of life, and assessment of ultimate oncologic outcome.
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Changes in prostate cancer grade on serial biopsy in men undergoing active surveillance.
J. Clin. Oncol.
PUBLISHED: 05-31-2011
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Active surveillance is now considered a viable treatment option for men with low-risk prostate cancer. However, little is known regarding changes in Gleason grade on serial biopsies over an extended period of time.
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The relationship between prostate specific antigen change and biopsy progression in patients on active surveillance for prostate cancer.
J. Urol.
PUBLISHED: 03-21-2011
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We assessed whether an association exists between a change in prostate specific antigen and biopsy progression in men on active surveillance.
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Changes in cancer volume in serial biopsies of men on active surveillance for early stage prostate cancer.
J. Urol.
PUBLISHED: 02-25-2011
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We described changes in tumor volume on serial biopsies during an extended period in men on active surveillance.
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Factors associated with downgrading in patients with high grade prostate cancer.
Urol. Oncol.
PUBLISHED: 02-13-2011
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To determine the factors associated with downgrading between biopsy and prostatectomy in the contemporary era using extended-template biopsy techniques.
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The example of CaPSURE: lessons learned from a national disease registry.
World J Urol
PUBLISHED: 02-02-2011
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Although randomized controlled trials (RCTs) remain the gold standard for determining evidence-based clinical practices, large disease registries that enroll large numbers of patients have become paramount as a relatively cost-effective additional tool.
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The outcomes of perineal urethrostomy with preservation of the dorsal urethral plate and urethral blood supply.
Urology
PUBLISHED: 01-07-2011
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To describe the surgical technique and outcomes for perineal urethrostomy. We sought to identify factors that predicted surgery failure within our patient cohort and to describe key aspects of the operation aimed at preservation of the dorsal urethral plate and longitudinal blood supply within the urethra.
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Outcomes of active surveillance for men with intermediate-risk prostate cancer.
J. Clin. Oncol.
PUBLISHED: 11-29-2010
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Active surveillance (AS) is an option for the initial management of early-stage prostate cancer. Current risk stratification schema identify patients with low-risk disease who are presumed to be most suitable for AS. However, some men with higher risk disease also elect AS; outcomes for such men have not been widely reported.
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Diabetic kidney stone formers excrete more oxalate and have lower urine pH than nondiabetic stone formers.
J. Urol.
PUBLISHED: 04-18-2010
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The epidemiological relationship between nephrolithiasis and type 2 diabetes mellitus is well-known. Patients with diabetes mellitus are at increased risk for nephrolithiasis and those with nephrolithiasis are at risk for diabetes mellitus. We examined 24-hour urine composition in stone formers with and without diabetes mellitus.
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The role of race in determining 24-hour urine composition in white and Asian/Pacific Islander stone formers.
J. Urol.
PUBLISHED: 02-20-2010
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We examined differences in 24-hour urine composition between white and Asian/Pacific Islander stone formers.
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Disproportionate presentation of high risk prostate cancer in a safety net health system.
J. Urol.
PUBLISHED: 02-06-2010
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Most prostate cancer research is based on relatively homogenous cohorts of men, often with comparatively high socioeconomic status. We describe prostate cancer characteristics in men treated in a public health system and hypothesize a disproportionate burden of high risk disease in this population.
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The independent value of tumour volume in a contemporary cohort of men treated with radical prostatectomy for clinically localized disease.
BJU Int.
PUBLISHED: 08-13-2009
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To determine if prostate tumour volume is an independent prognostic factor in a contemporary cohort of men who had a radical prostatectomy (RP) for clinically localized disease, as the effect of tumour volume on prostate cancer outcomes has not been consistently shown in the era of widespread screening with prostate-specific antigen (PSA).
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Hypertension is associated with increased urinary calcium excretion in patients with nephrolithiasis.
J. Urol.
PUBLISHED: 06-09-2009
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The epidemiological relationship between nephrolithiasis and hypertension is well-known. Patients with hypertension are at increased risk for nephrolithiasis and those with nephrolithiasis are at risk for hypertension. Urine calcium or urine citrate may be related to hypertension status. We examined the relationship between hypertension and 24-hour urine composition in patients with nephrolithiasis.
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Prevalence and severity of undiagnosed urinary incontinence in women.
Am. J. Med.
PUBLISHED: 04-09-2009
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Urinary incontinence is a highly prevalent condition in aging women that results in significant morbidity. Less than half of women who suffer from urinary incontinence seek treatment, resulting in a significant proportion of clinically relevant urinary incontinence remaining undiagnosed. Therefore, the purpose of this study was to quantify the prevalence of urinary incontinence in undiagnosed women in a managed care population.
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High-risk nonmuscle invasive bladder cancer: definition and epidemiology.
Curr Opin Urol
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Nonmuscle invasive bladder cancer represents a large majority of patients diagnosed with this disease. Precise definition and risk stratification are paramount in this group as high-risk patients have higher rates of progression and mortality and may benefit from early identification and aggressive treatment.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.