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Find video protocols related to scientific articles indexed in Pubmed.
Serum CRP and urinary trypsin inhibitor implicate postoperative cognitive dysfunction especially in elderly patients.
Int. J. Neurosci.
PUBLISHED: 09-17-2014
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Purpose: Postoperative cognitive dysfunction (POCD) characterized as the decline of memory and executive function after major surgery is not well illustrated. The aim of this study is to discover whether inflammatory cytokines and urinary trypsin inhibitor (uTi) contribute to the development of POCD. Method: Sixty-three patients undergoing lumber discectomy and 47 age-matched control volunteers were involved in this study. The level of C-reaction protein (CRP) and uTi/urine creatinine (Ucr) was measured by immunoturbidimetry and enzyme-inhibition assay, respectively. Meanwhile, ELISA was involved to detect the level of IL-6, IL-10, MMP-9 in serum. Montreal Cognitive Assessment (MoCA) test was used to determine the cognitive decline of the patients and age-matched controls. Result: In POCD group, the level of IL-6, IL-10, CRP, MMP-9 in serum and uTi /Ucr in urine was significantly higher than that in the group without POCD. The POCD was more frequently observed in elderly group than in the middle-aged group (43.75% versus 19.35%, p = 0.038). After logistic regression analysis adjusted by the age, only serum CRP at 72 h postoperation and urinary uTi /Ucr at 24 h postoperation were the independent risk factors of POCD. Conclusion: Age-related increasing proinflammatory postoperation may result in higher occurrence of POCD in the elderly. Additionally, patients with extremely high concentrations of CRP in serum at 72 h postoperation and uTi /Ucr in urine at 24 h postoperation are more likely to experience POCD, especially in the elderly.
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Prolonged neuroinflammation after lipopolysaccharide exposure in aged rats.
PLoS ONE
PUBLISHED: 08-29-2014
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Inflammation is a hallmark of several disease states ranging from neurodegeneration to sepsis but is also implicated in physiological processes like ageing. Non-resolving inflammation and prolonged neuroinflammation are unclear processes implicated in several conditions, including ageing. In this study we studied the long-term effects of endotoxemia, as systemic lipopolysaccharide (LPS) injection, focusing on the role of astrocyte activation and cytokine release in the brain of aged rats. A single dose of LPS (2 mg/kg) or 0.9% saline was injected intraperitoneally in aged rats. Levels of pro-inflammatory cytokines (TNF? and IL-1?) and NF-?B p65 activation were measured systemically and in hippocampal tissue. Astrocytes and cytokines release in the CNS were detected via double immunofluorescence staining at different time-points up to day 30. Serum levels of TNF? and IL-1? were significantly increased acutely after 30 minutes (p<0.001) and up to 6 hours (p<0.001) following LPS-injection. Centrally, LPS-treated rats showed up-regulated mRNA expression and protein levels of pro-inflammatory cytokines in the hippocampus. These changes associated with astrogliosis in the hippocampus dentate gyrus (DG), IL-1? immunoreactivity and elevated NF-?B p65 expression up to day 30 post LPS exposure. Overall, these data demonstrate that LPS induces prolonged neuroinflammation and astrocyte activation in the hippocampus of aged rats. Hippocampal NF-?B p65 and excessive astrocytes-derived IL-1? release may play a pivotal role in regulating long-lasting neuroinflammation.
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[Application of dexmedetomidine for brain nuclei lesion of patients with Parkinsons disease].
Zhonghua Yi Xue Za Zhi
PUBLISHED: 12-24-2013
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To observe the sedative and analgesic effects of dexmedetomidine (Dex) and its influence on respiration and blood pressure, evaluate electrophysiological monitoring and explore the optimal dose of Dex for brain nuclei lesion in Parkinsons disease (PD) patients.
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[Comparison of blockage effect of axillary brachial plexus block between ultrasound guidance alone and ultrasound guidance plus neurostimulation].
Zhonghua Yi Xue Za Zhi
PUBLISHED: 10-16-2013
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To compare the blockage effect of multiple injection axillary brachial plexus blockage between ultrasound guidance alone and ultrasound guidance plus neurostimulation.
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Ischemic Stroke Predicts Myocardial Injury After Carotid Endarterectomy for Symptomatic Severe Carotid Artery Stenosis.
Clin. Appl. Thromb. Hemost.
PUBLISHED: 04-23-2013
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Myocardial injury following carotid endarterectomy (CEA) is a common cause of morbidity and mortality, and its risk varies depending on the severity and extent of disease. However, when patients with sympotomatic severe carotid stenosis undergo CEA, the frequency and potential predictors of myocardial injury remain unknown. A total of 40 patients (32 men and 8 women) who underwent successful standard CEA were observed. Cardiac troponin I (cTnI) concentrations were assessed before surgery and on postoperative days 1, 2, and 3 in all patients. Myocardial injury was defined as the peak cTnI concentration > 0.04 ng/mL. In all, 42.5% patients had postoperative myocardial injury. Previous ischemic stroke and abnormal ST-segment changes were the preoperative predictors of myocardial injury after CEA, with odds ratios of 4.1 (95% confidence interval, 1.1-16.1; P = .04) and 5.9 (95% confidence interval, 1.3-27.7; P = .04), respectively. Sympotomatic patients with those conditions should receive more attention to myocardial injury, when presented for CEA.
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Glioma in the third trimester of pregnancy: Two cases and a review of the literature.
Oncol Lett
PUBLISHED: 01-04-2013
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We present two cases of glioma (WHO grade III) in pregnant females presenting in the third trimester. Gliomas during pregnancy are rare. At present, the association between gliomas and pregnancy is poorly understood and little has been reported with regard to the management of patients with gliomas in pregnancy. Management of these cases presents a medical dilemma. Gliomas during pregnancy pose a risk to maternal and fetal life. The benefit-to-risk ratio should be carefully evaluated and discussed prior to surgery. In the present cases, caesarean section (CS) followed by craniotomy was performed under the same general anesthesia at 34 weeks gestation. The mothers received radiotherapy and chemotherapy following surgery. They have been followed up to the present date and remain in good health. These two cases indicate that early CS followed by craniotomy is an effective choice in pregnant patients with gliomas at ?34 weeks gestation. In the present study, we describe these two cases and review the literature with regard to gliomas during pregnancy.
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[Application of sedation with a low dose of dexmedetomidine during intrathecal anesthesia in elderly patients].
Zhonghua Yi Xue Za Zhi
PUBLISHED: 11-19-2011
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To explore the feasibility and safety of sedation with a low dose of dexmedetomidine (DEX) during intrathecal anesthesia in the elderly patients.
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[Modelling of cerebral hyper-perfusion after chronic forebrain ischemia in rats].
Zhonghua Yi Xue Za Zhi
PUBLISHED: 09-06-2011
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To establish the cerebral hyper-perfusion model after chronic forebrain ischemia in rats.
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[Feasibility analysis of wavelet index for monitoring the depth of anesthesia in patients undergoing general anesthesia].
Zhonghua Yi Xue Za Zhi
PUBLISHED: 06-29-2011
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To evaluate the value of wavelet index (WLI) in general anesthesia through a comparison of WLI with bispectral index (BIS).
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Minocycline may be useful to prevent/treat postoperative cognitive decline in elderly patients.
Med. Hypotheses
PUBLISHED: 02-04-2011
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Postoperative cognitive dysfunction (POCD) is reported to occur frequently after all types especially cardiac surgery in elderly patients. It can be short-term or long-term and some cases even develop into Alzheimers disease (AD). Although multi-risk factors associated with POCD have been identified, the etiology and pathophysiological mechanisms of this surgical complication remain elusive. Therefore, developing strategies for preventing or treating POCD is still challenging. However, increasing evidence suggests that central and systemic inflammation triggered by surgery likely plays a fundamental role in POCD developing and progression. Minocycline, a tetracycline derivative with anti-inflammatory properties, has been shown to be effective in treating neuroinflammatory related conditions or neurodegenerative diseases such as AD, Parkinsons disease, Huntingtons disease. Considering that inflammation may be a potential factor of POCD and minocycline is effective in improving cognitive dysfunction induced by inflammation, we hypothesize that minocycline may be useful to treat/prevent the POCD development after surgery in elderly patients.
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[Investigation and analysis of status in simulation education of anesthesiology of China].
Zhonghua Yi Xue Za Zhi
PUBLISHED: 05-11-2010
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To investigate the status of simulation education of anesthesiology in China.
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[Exploration and application by combining human patient simulator drivers of critical and emergency events with micro-division teaching during training primary residents].
Zhonghua Yi Xue Za Zhi
PUBLISHED: 06-20-2009
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To explore the feasibility of combining human patient simulator (HPS) drivers with micro-division teaching during primary resident training by George Miller medical education step-wised principle of goal and competence.
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[A case report of perioperative management for liver transplantation in a patient with multiple old myocardial infarction].
Beijing Da Xue Xue Bao
PUBLISHED: 04-21-2009
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A 60-years-old (85 kg, 178 cm) coronary arterial disease patient having had acute myocardial infarction for several times received liver transplantation successfully. He had a previous episode of acute myocardial infarction associated with entire obstruction of right coronary 6 years ago, and was inserted a bracket then. One year ago the patient got chest pain again, and was diagnosed as inferior wall myocardial infarction. Then he received expectant treatment in internal medical department for several days. A 774HF75 PAC catheter (Edwards Lifescience, USA) was inserted into an internal jugular vein, and cardiac output, right ventricular end diastolic volume index, right ventricular ejection fraction, stroke volume index, system vascular resistance, pulmonary vascular resistance, left ventricular-stroke work index and right ventricular-stroke work index were calculated. During the operation, cardiovascular medications such as dopamine, norepinephrine, dobutamine were infused and adjusted by steps carefully. Electrolytes and acid-base balance were maintained normal. With these hemodynamic parameters, BGA and systemic management, the anesthesia was managed safely and successfully.
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[Clinical study on monitoring right ventricular end-diastolic volume in volume management during orthotopic liver transplantation].
Beijing Da Xue Xue Bao
PUBLISHED: 04-21-2009
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To explore the feasibility of guiding the volume management during orthotopic liver transplantation by right ventricular end-diastolic volume index(RVEDVI).
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Ultrasound facilitates identification of combined spinal-epidural puncture in obese parturients.
Chin. Med. J.
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The palpation method is widely used in clinical practice to identify the puncture site of combined spinal-epidural (CSE) blocks, but it is usually difficult to accurately locate the puncture site in obese parturients. Accurate identification of the puncture site is crucial for successful CSE block. The objective of this study was to evaluate the impact of ultrasound imaging on the success rate of CSE puncture in obese parturients.
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Evaluation of entropy for monitoring the depth of anesthesia compared with bispectral index: a multicenter clinical trial.
Chin. Med. J.
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As a new electroencephalogram (EEG) signal processing technique for monitoring the depth of anesthesia, entropy consists of two indices: reaction entropy (RE) and state entropy (SE). Our study compared entropy with classical bispectral index (BIS) in reduction of myoelectrical interference and noxious stimuli with EEG signals.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.