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Identifying changes in scores on the EORTC-QLQ-C30 representing a change in patients' supportive care needs.
Qual Life Res
PUBLISHED: 11-03-2014
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Using health-related quality-of-life measures for patient management requires knowing what changes in scores require clinical attention. We estimated changes on the European Organization for Research and Treatment of Cancer Quality-of-Life-Questionnaire-Core-30 (EORTC-QLQ-C30), representing important changes by comparing to patient-reported changes in supportive care needs.
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Nature of the Visual Loss in Observers With Leber's Congenital Amaurosis Caused by Specific Mutations in RPE65.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 09-27-2014
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To characterize visual losses associated with genetic mutations in the RPE65 gene that cause defects in the RPE-specific isomerase, RPE65. RPE65 is an important component of the retinoid cycle that restores 11-cis-retinal after its photoisomerization to its all-trans form. The defects investigated here cause Leber's congenital amaurosis (LCA2), an autosomal, recessively-inherited, severe, congenital-onset rod-cone dystrophy.
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Molecular Mechanisms of Alzheimer Disease Protection by the A673T Allele of Amyloid Precursor Protein.
J. Biol. Chem.
PUBLISHED: 09-24-2014
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Pathogenic mutations in the amyloid precursor protein (APP) gene have been described as causing early onset familial Alzheimer disease (AD). We recently identified a rare APP variant encoding an alanine-to-threonine substitution at residue 673 (A673T) that confers protection against development of AD (Jonsson, T., Atwal, J. K., Steinberg, S., Snaedal, J., Jonsson, P. V., Bjornsson, S., Stefansson, H., Sulem, P., Gudbjartsson, D., Maloney, J., Hoyte, K., Gustafson, A., Liu, Y., Lu, Y., Bhangale, T., Graham, R. R., Huttenlocher, J., Bjornsdottir, G., Andreassen, O. A., Jönsson, E. G., Palotie, A., Behrens, T. W., Magnusson, O. T., Kong, A., Thorsteinsdottir, U., Watts, R. J., and Stefansson, K. (2012) Nature 488, 96-99). The Ala-673 residue lies within the ?-secretase recognition sequence and is part of the amyloid-? (A?) peptide cleavage product (position 2 of A?). We previously demonstrated that the A673T substitution makes APP a less favorable substrate for cleavage by BACE1. In follow-up studies, we confirm that A673T APP shows reduced cleavage by BACE1 in transfected mouse primary neurons and in isogenic human induced pluripotent stem cell-derived neurons. Using a biochemical approach, we show that the A673T substitution modulates the catalytic turnover rate (Vmax) of APP by the BACE1 enzyme, without affecting the affinity (Km) of the APP substrate for BACE1. We also show a reduced level of A?(1-42) aggregation with A2T A? peptides, an observation not conserved in A?(1-40) peptides. When combined in a ratio of 1:9 A?(1-42)/A?(1-40) to mimic physiologically relevant mixtures, A2T retains a trend toward slowed aggregation kinetics. Microglial uptake of the mutant A?(1-42) peptides correlated with their aggregation level. Cytotoxicity of the mutant A? peptides was not dramatically altered. Taken together, our findings demonstrate that A673T, a protective allele of APP, reproducibly reduces amyloidogenic processing of APP and also mildly decreases A? aggregation. These effects could together have an additive or even synergistic impact on the risk of developing AD.
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The evolution of pregnancy.
Early Hum. Dev.
PUBLISHED: 09-23-2014
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Although viviparity has evolved many times in the animal kingdom, it remains relatively uncommon-scorpions and therian mammals being rare examples of entirely viviparous major taxa. Viviparity is a specialised form of intra-species parasitism which biases parental investment towards fertilised eggs, temporally spreads that investment, and also temporarily protects offspring from many selection pressures. Importantly, the mammalian viviparity appeared at a relatively late stage in the process of vertebrate evolution. Because of this, viviparity was 'superimposed' on complex pre-existing cardiovascular, respiratory, metabolic and immune systems, and has altered them dramatically. Also, pregnancy has exerted pervasive effects on gene expression in mammals, including genetic imprinting, X inactivation, sex determination, and the ectopic expression in the extra-embryonic membranes of many genes previously expressed in the gonads, brain, pituitary and immune system. Finally, although lactation probably pre-dated viviparity in mammalian evolution, the two have co-evolved as alternative strategies of offspring nutrition ever since.
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Evidence of b-Jet Quenching in PbPb Collisions at sqrt[s_{NN}]=2.76??TeV.
S Chatrchyan, V Khachatryan, A M Sirunyan, A Tumasyan, W Adam, T Bergauer, M Dragicevic, J Erö, C Fabjan, M Friedl, R Frühwirth, V M Ghete, C Hartl, N Hörmann, J Hrubec, M Jeitler, W Kiesenhofer, V Knünz, M Krammer, I Krätschmer, D Liko, I Mikulec, D Rabady, B Rahbaran, H Rohringer, R Schöfbeck, J Strauss, A Taurok, W Treberer-Treberspurg, W Waltenberger, C-E Wulz, V Mossolov, N Shumeiko, J Suarez Gonzalez, S Alderweireldt, M Bansal, S Bansal, T Cornelis, E A De Wolf, X Janssen, A Knutsson, S Luyckx, L Mucibello, S Ochesanu, B Roland, R Rougny, H Van Haevermaet, P Van Mechelen, N Van Remortel, A Van Spilbeeck, F Blekman, S Blyweert, J D'Hondt, N Heracleous, A Kalogeropoulos, J Keaveney, T J Kim, S Lowette, M Maes, A Olbrechts, D Strom, S Tavernier, W Van Doninck, P Van Mulders, G P Van Onsem, I Villella, C Caillol, B Clerbaux, G De Lentdecker, L Favart, A P R Gay, A Léonard, P E Marage, A Mohammadi, L Perniè, T Reis, T Seva, L Thomas, C Vander Velde, P Vanlaer, J Wang, V Adler, K Beernaert, L Benucci, A Cimmino, S Costantini, S Dildick, G Garcia, B Klein, J Lellouch, J Mccartin, A A Ocampo Rios, D Ryckbosch, S Salva Diblen, M Sigamani, N Strobbe, F Thyssen, M Tytgat, S Walsh, E Yazgan, N Zaganidis, S Basegmez, C Beluffi, G Bruno, R Castello, A Caudron, L Ceard, G G Da Silveira, C Delaere, T du Pree, D Favart, L Forthomme, A Giammanco, J Hollar, P Jez, M Komm, V Lemaitre, J Liao, O Militaru, C Nuttens, D Pagano, A Pin, K Piotrzkowski, A Popov, L Quertenmont, M Selvaggi, M Vidal Marono, J M Vizan Garcia, N Beliy, T Caebergs, E Daubie, G H Hammad, G A Alves, M Correa Martins Junior, T Martins, M E Pol, M H G Souza, W L Aldá Júnior, W Carvalho, J Chinellato, A Custódio, E M Da Costa, D De Jesus Damiao, C De Oliveira Martins, S Fonseca De Souza, H Malbouisson, M Malek, D Matos Figueiredo, L Mundim, H Nogima, W L Prado Da Silva, J Santaolalla, A Santoro, A Sznajder, E J Tonelli Manganote, A Vilela Pereira, C A Bernardes, F A Dias, T R Fernandez Perez Tomei, E M Gregores, C Lagana, P G Mercadante, S F Novaes, Sandra S Padula, V Genchev, P Iaydjiev, A Marinov, S Piperov, M Rodozov, G Sultanov, M Vutova, A Dimitrov, I Glushkov, R Hadjiiska, V Kozhuharov, L Litov, B Pavlov, P Petkov, J G Bian, G M Chen, H S Chen, M Chen, R Du, C H Jiang, D Liang, S Liang, X Meng, R Plestina, J Tao, X Wang, Z Wang, C Asawatangtrakuldee, Y Ban, Y Guo, W Li, S Liu, Y Mao, S J Qian, H Teng, D Wang, L Zhang, W Zou, C Avila, C A Carrillo Montoya, L F Chaparro Sierra, C Florez, J P Gomez, B Gomez Moreno, J C Sanabria, N Godinović, D Lelas, D Polic, I Puljak, Z Antunovic, M Kovac, V Brigljevic, K Kadija, J Luetic, D Mekterovic, S Morovic, L Tikvica, A Attikis, G Mavromanolakis, J Mousa, C Nicolaou, F Ptochos, P A Razis, M Finger, Y Assran, S Elgammal, T Elkafrawy, A Ellithi Kamel, M A Mahmoud, A Radi, M Kadastik, M Müntel, M Murumaa, M Raidal, L Rebane, A Tiko, P Eerola, G Fedi, M Voutilainen, J Härkönen, V Karimäki, R Kinnunen, M J Kortelainen, T Lampén, K Lassila-Perini, S Lehti, T Lindén, P Luukka, T Mäenpää, T Peltola, E Tuominen, J Tuominiemi, E Tuovinen, L Wendland, T Tuuva, M Besançon, F Couderc, M Dejardin, D Denegri, B Fabbro, J L Faure, F Ferri, S Ganjour, A Givernaud, P Gras, G Hamel de Monchenault, P Jarry, E Locci, J Malcles, A Nayak, J Rander, A Rosowsky, M Titov, S Baffioni, F Beaudette, P Busson, C Charlot, N Daci, T Dahms, M Dalchenko, L Dobrzynski, A Florent, R Granier de Cassagnac, P Miné, C Mironov, I N Naranjo, M Nguyen, C Ochando, P Paganini, D Sabes, R Salerno, Y Sirois, C Veelken, Y Yilmaz, A Zabi, J-L Agram, J Andrea, D Bloch, J-M Brom, E C Chabert, C Collard, E Conte, F Drouhin, J-C Fontaine, D Gelé, U Goerlach, C Goetzmann, P Juillot, A-C Le Bihan, P Van Hove, S Gadrat, S Beauceron, N Beaupere, G Boudoul, S Brochet, J Chasserat, R Chierici, D Contardo, P Depasse, H El Mamouni, J Fan, J Fay, S Gascon, M Gouzevitch, B Ille, T Kurča, M Lethuillier, L Mirabito, S Perries, J D Ruiz Alvarez, L Sgandurra, V Sordini, M Vander Donckt, P Verdier, S Viret, H Xiao, Z Tsamalaidze, C Autermann, S Beranek, M Bontenackels, B Calpas, M Edelhoff, L Feld, O Hindrichs, K Klein, A Ostapchuk, A Perieanu, F Raupach, J Sammet, S Schael, D Sprenger, H Weber, B Wittmer, V Zhukov, M Ata, J Caudron, E Dietz-Laursonn, D Duchardt, M Erdmann, R Fischer, A Güth, T Hebbeker, C Heidemann, K Hoepfner, D Klingebiel, S Knutzen, P Kreuzer, M Merschmeyer, A Meyer, M Olschewski, K Padeken, P Papacz, H Reithler, S A Schmitz, L Sonnenschein, D Teyssier, S Thüer, M Weber, V Cherepanov, Y Erdogan, G Flügge, H Geenen, M Geisler, W Haj Ahmad, F Hoehle, B Kargoll, T Kress, Y Kuessel, J Lingemann, A Nowack, I M Nugent, L Perchalla, O Pooth, A Stahl, I Asin, N Bartosik, J Behr, W Behrenhoff, U Behrens, A J Bell, M Bergholz, A Bethani, K Borras, A Burgmeier, A Cakir, L Calligaris, A Campbell, S Choudhury, F Costanza, C Diez Pardos, S Dooling, T Dorland, G Eckerlin, D Eckstein, T Eichhorn, G Flucke, A Geiser, A Grebenyuk, P Gunnellini, S Habib, J Hauk, G Hellwig, M Hempel, D Horton, H Jung, M Kasemann, P Katsas, J Kieseler, C Kleinwort, M Kramer, D Krücker, W Lange, J Leonard, K Lipka, W Lohmann, B Lutz, R Mankel, I Marfin, I-A Melzer-Pellmann, A B Meyer, J Mnich, A Mussgiller, S Naumann-Emme, O Novgorodova, F Nowak, H Perrey, A Petrukhin, D Pitzl, R Placakyte, A Raspereza, P M Ribeiro Cipriano, C Riedl, E Ron, M Ö Sahin, J Salfeld-Nebgen, P Saxena, R Schmidt, T Schoerner-Sadenius, M Schröder, M Stein, A D R Vargas Trevino, R Walsh, C Wissing, M Aldaya Martin, V Blobel, H Enderle, J Erfle, E Garutti, K Goebel, M Görner, M Gosselink, J Haller, R S Höing, H Kirschenmann, R Klanner, R Kogler, J Lange, I Marchesini, J Ott, T Peiffer, N Pietsch, D Rathjens, C Sander, H Schettler, P Schleper, E Schlieckau, A Schmidt, M Seidel, J Sibille, V Sola, H Stadie, G Steinbrück, D Troendle, E Usai, L Vanelderen, C Barth, C Baus, J Berger, C Böser, E Butz, T Chwalek, W De Boer, A Descroix, A Dierlamm, M Feindt, M Guthoff, F Hartmann, T Hauth, H Held, K H Hoffmann, U Husemann, I Katkov, A Kornmayer, E Kuznetsova, P Lobelle Pardo, D Martschei, M U Mozer, Th Müller, M Niegel, A Nürnberg, O Oberst, G Quast, K Rabbertz, F Ratnikov, S Röcker, F-P Schilling, G Schott, H J Simonis, F M Stober, R Ulrich, J Wagner-Kuhr, S Wayand, T Weiler, R Wolf, M Zeise, G Anagnostou, G Daskalakis, T Geralis, S Kesisoglou, A Kyriakis, D Loukas, A Markou, C Markou, E Ntomari, A Psallidas, I Topsis-Giotis, L Gouskos, A Panagiotou, N Saoulidou, E Stiliaris, X Aslanoglou, I Evangelou, G Flouris, C Foudas, P Kokkas, N Manthos, I Papadopoulos, E Paradas, G Bencze, C Hajdu, P Hidas, D Horvath, F Sikler, V Veszpremi, G Vesztergombi, A J Zsigmond, N Beni, S Czellar, J Molnár, J Palinkas, Z Szillasi, J Karancsi, P Raics, Z L Trocsanyi, B Ujvari, S K Swain, S B Beri, V Bhatnagar, N Dhingra, R Gupta, M Kaur, M Z Mehta, M Mittal, N Nishu, A Sharma, J B Singh, Ashok Kumar, Arun Kumar, S Ahuja, A Bhardwaj, B C Choudhary, A Kumar, S Malhotra, M Naimuddin, K Ranjan, V Sharma, R K Shivpuri, S Banerjee, S Bhattacharya, K Chatterjee, S Dutta, B Gomber, Sa Jain, Sh Jain, R Khurana, A Modak, S Mukherjee, D Roy, S Sarkar, M Sharan, A P Singh, A Abdulsalam, D Dutta, S Kailas, V Kumar, A K Mohanty, L M Pant, P Shukla, A Topkar, T Aziz, R M Chatterjee, S Ganguly, S Ghosh, M Guchait, A Gurtu, G Kole, S Kumar, M Maity, G Majumder, K Mazumdar, G B Mohanty, B Parida, K Sudhakar, N Wickramage, S Dugad, H Arfaei, H Bakhshiansohi, H Behnamian, S M Etesami, A Fahim, A Jafari, M Khakzad, M Mohammadi Najafabadi, M Naseri, S Paktinat Mehdiabadi, B Safarzadeh, M Zeinali, M Grunewald, M Abbrescia, L Barbone, C Calabria, S S Chhibra, A Colaleo, D Creanza, N De Filippis, M De Palma, L Fiore, G Iaselli, G Maggi, M Maggi, B Marangelli, S My, S Nuzzo, N Pacifico, A Pompili, G Pugliese, R Radogna, G Selvaggi, L Silvestris, G Singh, R Venditti, P Verwilligen, G Zito, G Abbiendi, A C Benvenuti, D Bonacorsi, S Braibant-Giacomelli, L Brigliadori, R Campanini, P Capiluppi, A Castro, F R Cavallo, G Codispoti, M Cuffiani, G M Dallavalle, F Fabbri, A Fanfani, D Fasanella, P Giacomelli, C Grandi, L Guiducci, S Marcellini, G Masetti, M Meneghelli, A Montanari, F L Navarria, F Odorici, A Perrotta, F Primavera, A M Rossi, T Rovelli, G P Siroli, N Tosi, R Travaglini, S Albergo, G Cappello, M Chiorboli, S Costa, F Giordano, R Potenza, A Tricomi, C Tuve, G Barbagli, V Ciulli, C Civinini, R D'Alessandro, E Focardi, E Gallo, S Gonzi, V Gori, P Lenzi, M Meschini, S Paoletti, G Sguazzoni, A Tropiano, L Benussi, S Bianco, D Piccolo, P Fabbricatore, R Ferretti, F Ferro, M Lo Vetere, R Musenich, E Robutti, S Tosi, A Benaglia, M E Dinardo, S Fiorendi, S Gennai, A Ghezzi, P Govoni, M T Lucchini, S Malvezzi, R A Manzoni, A Martelli, D Menasce, L Moroni, M Paganoni, D Pedrini, S Ragazzi, N Redaelli, T Tabarelli de Fatis, S Buontempo, N Cavallo, F Fabozzi, A O M Iorio, L Lista, S Meola, M Merola, P Paolucci, P Azzi, N Bacchetta, D Bisello, A Branca, R Carlin, P Checchia, T Dorigo, U Dosselli, M Galanti, F Gasparini, P Giubilato, A Gozzelino, K Kanishchev, S Lacaprara, I Lazzizzera, M Margoni, A T Meneguzzo, F Montecassiano, M Passaseo, J Pazzini, M Pegoraro, N Pozzobon, P Ronchese, F Simonetto, E Torassa, M Tosi, P Zotto, A Zucchetta, G Zumerle, M Gabusi, S P Ratti, C Riccardi, P Vitulo, M Biasini, G M Bilei, L Fanò, P Lariccia, G Mantovani, M Menichelli, F Romeo, A Saha, A Santocchia, A Spiezia, K Androsov, P Azzurri, G Bagliesi, J Bernardini, T Boccali, G Broccolo, R Castaldi, M A Ciocci, R Dell'Orso, F Fiori, L Foà, A Giassi, M T Grippo, A Kraan, F Ligabue, T Lomtadze, L Martini, A Messineo, C S Moon, F Palla, A Rizzi, A Savoy-Navarro, A T Serban, P Spagnolo, P Squillacioti, R Tenchini, G Tonelli, A Venturi, P G Verdini, C Vernieri, L Barone, F Cavallari, D Del Re, M Diemoz, M Grassi, C Jorda, E Longo, F Margaroli, P Meridiani, F Micheli, S Nourbakhsh, G Organtini, R Paramatti, S Rahatlou, C Rovelli, L Soffi, P Traczyk, N Amapane, R Arcidiacono, S Argiro, M Arneodo, R Bellan, C Biino, N Cartiglia, S Casasso, M Costa, A Degano, N Demaria, C Mariotti, S Maselli, E Migliore, V Monaco, M Musich, M M Obertino, G Ortona, L Pacher, N Pastrone, M Pelliccioni, A Potenza, A Romero, M Ruspa, R Sacchi, A Solano, A Staiano, U Tamponi, S Belforte, V Candelise, M Casarsa, F Cossutti, G Della Ricca, B Gobbo, C La Licata, M Marone, D Montanino, A Penzo, A Schizzi, T Umer, A Zanetti, S Chang, T Y Kim, S K Nam, D H Kim, G N Kim, J E Kim, M S Kim, D J Kong, S Lee, Y D Oh, H Park, D C Son, J Y Kim, Zero J Kim, S Song, S Choi, D Gyun, B Hong, M Jo, H Kim, Y Kim, K S Lee, S K Park, Y Roh, M Choi, J H Kim, C Park, I C Park, S Park, G Ryu, Y Choi, Y K Choi, J Goh, E Kwon, B Lee, J Lee, H Seo, I Yu, A Juodagalvis, J R Komaragiri, H Castilla-Valdez, E De La Cruz-Burelo, I Heredia-De La Cruz, R Lopez-Fernandez, J Martínez-Ortega, A Sánchez-Hernández, L M Villasenor-Cendejas, S Carrillo Moreno, F Vazquez Valencia, H A Salazar Ibarguen, E Casimiro Linares, A Morelos Pineda, D Krofcheck, P H Butler, R Doesburg, S Reucroft, H Silverwood, M Ahmad, M I Asghar, J Butt, H R Hoorani, S Khalid, W A Khan, T Khurshid, S Qazi, M A Shah, M Shoaib, H Bialkowska, M Bluj, B Boimska, T Frueboes, M Górski, M Kazana, K Nawrocki, K Romanowska-Rybinska, M Szleper, G Wrochna, P Zalewski, G Brona, K Bunkowski, M Cwiok, W Dominik, K Doroba, A Kalinowski, M Konecki, J Krolikowski, M Misiura, W Wolszczak, P Bargassa, C Beirão Da Cruz E Silva, P Faccioli, P G Ferreira Parracho, M Gallinaro, F Nguyen, J Rodrigues Antunes, J Seixas, J Varela, P Vischia, S Afanasiev, P Bunin, I Golutvin, I Gorbunov, A Kamenev, V Karjavin, V Konoplyanikov, G Kozlov, A Lanev, A Malakhov, V Matveev, P Moisenz, V Palichik, V Perelygin, S Shmatov, N Skatchkov, V Smirnov, A Zarubin, V Golovtsov, Y Ivanov, V Kim, P Levchenko, V Murzin, V Oreshkin, I Smirnov, V Sulimov, L Uvarov, S Vavilov, A Vorobyev, An Vorobyev, Yu Andreev, A Dermenev, S Gninenko, N Golubev, M Kirsanov, N Krasnikov, A Pashenkov, D Tlisov, A Toropin, V Epshteyn, V Gavrilov, N Lychkovskaya, V Popov, G Safronov, S Semenov, A Spiridonov, V Stolin, E Vlasov, A Zhokin, V Andreev, M Azarkin, I Dremin, M Kirakosyan, A Leonidov, G Mesyats, S V Rusakov, A Vinogradov, A Belyaev, E Boos, A Ershov, A Gribushin, V Klyukhin, O Kodolova, V Korotkikh, I Lokhtin, S Obraztsov, S Petrushanko, V Savrin, A Snigirev, I Vardanyan, I Azhgirey, I Bayshev, S Bitioukov, V Kachanov, A Kalinin, D Konstantinov, V Krychkine, V Petrov, R Ryutin, A Sobol, L Tourtchanovitch, S Troshin, N Tyurin, A Uzunian, A Volkov, P Adzic, M Djordjevic, M Ekmedzic, J Milosevic, M Aguilar-Benitez, J Alcaraz Maestre, C Battilana, E Calvo, M Cerrada, M Chamizo Llatas, N Colino, B De La Cruz, A Delgado Peris, D Domínguez Vázquez, C Fernandez Bedoya, J P Fernández Ramos, A Ferrando, J Flix, M C Fouz, P Garcia-Abia, O Gonzalez Lopez, S Goy Lopez, J M Hernandez, M I Josa, G Merino, E Navarro De Martino, J Puerta Pelayo, A Quintario Olmeda, I Redondo, L Romero, M S Soares, C Willmott, C Albajar, J F de Trocóniz, M Missiroli, H Brun, J Cuevas, J Fernandez Menendez, S Folgueras, I Gonzalez Caballero, L Lloret Iglesias, J A Brochero Cifuentes, I J Cabrillo, A Calderon, S H Chuang, J Duarte Campderros, M Fernandez, G Gomez, J Gonzalez Sanchez, A Graziano, A Lopez Virto, J Marco, R Marco, C Martinez Rivero, F Matorras, F J Munoz Sanchez, J Piedra Gomez, T Rodrigo, A Y Rodríguez-Marrero, A Ruiz-Jimeno, L Scodellaro, I Vila, R Vilar Cortabitarte, D Abbaneo, E Auffray, G Auzinger, M Bachtis, P Baillon, A H Ball, D Barney, J Bendavid, L Benhabib, J F Benitez, C Bernet, G Bianchi, P Bloch, A Bocci, A Bonato, O Bondu, C Botta, H Breuker, T Camporesi, G Cerminara, T Christiansen, J A Coarasa Perez, S Colafranceschi, M D'Alfonso, D d'Enterria, A Dabrowski, A David, F De Guio, A De Roeck, S De Visscher, S Di Guida, M Dobson, N Dupont-Sagorin, A Elliott-Peisert, J Eugster, G Franzoni, W Funk, M Giffels, D Gigi, K Gill, M Girone, M Giunta, F Glege, R Gomez-Reino Garrido, S Gowdy, R Guida, J Hammer, M Hansen, P Harris, V Innocente, P Janot, E Karavakis, K Kousouris, K Krajczar, P Lecoq, C Lourenço, N Magini, L Malgeri, M Mannelli, L Masetti, F Meijers, S Mersi, E Meschi, F Moortgat, M Mulders, P Musella, L Orsini, E Palencia Cortezon, E Perez, L Perrozzi, A Petrilli, G Petrucciani, A Pfeiffer, M Pierini, M Pimiä, D Piparo, M Plagge, A Racz, W Reece, G Rolandi, M Rovere, H Sakulin, F Santanastasio, C Schäfer, C Schwick, S Sekmen, P Siegrist, P Silva, M Simon, P Sphicas, J Steggemann, B Stieger, M Stoye, A Tsirou, G I Veres, J R Vlimant, H K Wöhri, W D Zeuner, W Bertl, K Deiters, W Erdmann, R Horisberger, Q Ingram, H C Kaestli, S König, D Kotlinski, U Langenegger, D Renker, T Rohe, F Bachmair, L Bäni, L Bianchini, P Bortignon, M A Buchmann, B Casal, N Chanon, A Deisher, G Dissertori, M Dittmar, M Donegà, M Dünser, P Eller, C Grab, D Hits, W Lustermann, B Mangano, A C Marini, P Martinez Ruiz Del Arbol, D Meister, N Mohr, C Nägeli, P Nef, F Nessi-Tedaldi, F Pandolfi, L Pape, F Pauss, M Peruzzi, M Quittnat, F J Ronga, M Rossini, A Starodumov, M Takahashi, L Tauscher, K Theofilatos, D Treille, R Wallny, H A Weber, C Amsler, V Chiochia, A De Cosa, C Favaro, A Hinzmann, T Hreus, M Ivova Rikova, B Kilminster, B Millan Mejias, J Ngadiuba, P Robmann, H Snoek, S Taroni, M Verzetti, Y Yang, M Cardaci, K H Chen, C Ferro, C M Kuo, S W Li, W Lin, Y J Lu, R Volpe, S S Yu, P Bartalini, P Chang, Y H Chang, Y W Chang, Y Chao, K F Chen, P H Chen, C Dietz, U Grundler, W-S Hou, Y Hsiung, K Y Kao, Y J Lei, Y F Liu, R-S Lu, D Majumder, E Petrakou, X Shi, J G Shiu, Y M Tzeng, M Wang, R Wilken, B Asavapibhop, N Suwonjandee, A Adiguzel, M N Bakirci, S Cerci, C Dozen, I Dumanoglu, E Eskut, S Girgis, G Gokbulut, E Gurpinar, I Hos, E E Kangal, A Kayis Topaksu, G Onengut, K Ozdemir, S Ozturk, A Polatoz, K Sogut, D Sunar Cerci, B Tali, H Topakli, M Vergili, I V Akin, T Aliev, B Bilin, S Bilmis, M Deniz, H Gamsizkan, A M Guler, G Karapinar, K Ocalan, A Ozpineci, M Serin, R Sever, U E Surat, M Yalvac, M Zeyrek, E Gülmez, B Isildak, M Kaya, O Kaya, S Ozkorucuklu, H Bahtiyar, E Barlas, K Cankocak, Y O Günaydin, F I Vardarlı, M Yücel, L Levchuk, P Sorokin, J J Brooke, E Clement, D Cussans, H Flacher, R Frazier, J Goldstein, M Grimes, G P Heath, H F Heath, J Jacob, L Kreczko, C Lucas, Z Meng, D M Newbold, S Paramesvaran, A Poll, S Senkin, V J Smith, T Williams, C Brew, R M Brown, D J A Cockerill, J A Coughlan, K Harder, S Harper, J Ilic, E Olaiya, D Petyt, C H Shepherd-Themistocleous, A Thea, I R Tomalin, W J Womersley, S D Worm, M Baber, R Bainbridge, O Buchmuller, D Burton, D Colling, N Cripps, M Cutajar, P Dauncey, G Davies, M Della Negra, W Ferguson, J Fulcher, D Futyan, A Gilbert, A Guneratne Bryer, G Hall, Z Hatherell, J Hays, G Iles, M Jarvis, G Karapostoli, M Kenzie, R Lane, R Lucas, L Lyons, A-M Magnan, J Marrouche, B Mathias, R Nandi, J Nash, A Nikitenko, J Pela, M Pesaresi, K Petridis, M Pioppi, D M Raymond, S Rogerson, A Rose, C Seez, P Sharp, A Sparrow, A Tapper, M Vazquez Acosta, T Virdee, S Wakefield, N Wardle, J E Cole, P R Hobson, A Khan, P Kyberd, D Leggat, D Leslie, W Martin, I D Reid, P Symonds, L Teodorescu, M Turner, J Dittmann, K Hatakeyama, A Kasmi, H Liu, T Scarborough, O Charaf, S I Cooper, C Henderson, P Rumerio, A Avetisyan, T Bose, C Fantasia, A Heister, P Lawson, D Lazic, J Rohlf, D Sperka, J St John, L Sulak, J Alimena, G Christopher, D Cutts, Z Demiragli, A Ferapontov, A Garabedian, U Heintz, S Jabeen, G Kukartsev, E Laird, G Landsberg, M Luk, M Narain, M Segala, T Sinthuprasith, T Speer, J Swanson, R Breedon, G Breto, M Calderón de la Barca Sánchez, S Chauhan, M Chertok, J Conway, R Conway, P T Cox, R Erbacher, M Gardner, W Ko, A Kopecky, R Lander, T Miceli, D Pellett, J Pilot, F Ricci-Tam, B Rutherford, M Searle, S Shalhout, J Smith, M Squires, M Tripathi, S Wilbur, R Yohay, D Cline, R Cousins, S Erhan, P Everaerts, C Farrell, M Felcini, J Hauser, M Ignatenko, C Jarvis, G Rakness, P Schlein, E Takasugi, V Valuev, J Babb, R Clare, J Ellison, J W Gary, G Hanson, J Heilman, P Jandir, F Lacroix, O R Long, A Luthra, M Malberti, H Nguyen, A Shrinivas, J Sturdy, S Sumowidagdo, S Wimpenny, W Andrews, J G Branson, G B Cerati, S Cittolin, R T D'Agnolo, D Evans, A Holzner, R Kelley, D Kovalskyi, M Lebourgeois, J Letts, I Macneill, S Padhi, C Palmer, M Pieri, M Sani, S Simon, E Sudano, M Tadel, Y Tu, A Vartak, S Wasserbaech, F Würthwein, A Yagil, J Yoo, D Barge, C Campagnari, T Danielson, K Flowers, P Geffert, C George, F Golf, J Incandela, C Justus, R Magaña Villalba, N Mccoll, V Pavlunin, J Richman, R Rossin, D Stuart, W To, C West, A Apresyan, A Bornheim, J Bunn, Y Chen, E Di Marco, J Duarte, D Kcira, A Mott, H B Newman, C Pena, C Rogan, M Spiropulu, V Timciuc, R Wilkinson, S Xie, R Y Zhu, V Azzolini, A Calamba, R Carroll, T Ferguson, Y Iiyama, D W Jang, M Paulini, J Russ, H Vogel, I Vorobiev, J P Cumalat, B R Drell, W T Ford, A Gaz, E Luiggi Lopez, U Nauenberg, J G Smith, K Stenson, K A Ulmer, S R Wagner, J Alexander, A Chatterjee, N Eggert, L K Gibbons, W Hopkins, A Khukhunaishvili, B Kreis, N Mirman, G Nicolas Kaufman, J R Patterson, A Ryd, E Salvati, W Sun, W D Teo, J Thom, J Thompson, J Tucker, Y Weng, L Winstrom, P Wittich, D Winn, S Abdullin, M Albrow, J Anderson, G Apollinari, L A T Bauerdick, A Beretvas, J Berryhill, P C Bhat, K Burkett, J N Butler, V Chetluru, H W K Cheung, F Chlebana, S Cihangir, V D Elvira, I Fisk, J Freeman, Y Gao, E Gottschalk, L Gray, D Green, S Grünendahl, O Gutsche, D Hare, R M Harris, J Hirschauer, B Hooberman, S Jindariani, M Johnson, U Joshi, K Kaadze, B Klima, S Kwan, J Linacre, D Lincoln, R Lipton, J Lykken, K Maeshima, J M Marraffino, V I Martinez Outschoorn, S Maruyama, D Mason, P McBride, K Mishra, S Mrenna, Y Musienko, S Nahn, C Newman-Holmes, V O'Dell, O Prokofyev, N Ratnikova, E Sexton-Kennedy, S Sharma, W J Spalding, L Spiegel, L Taylor, S Tkaczyk, N V Tran, L Uplegger, E W Vaandering, R Vidal, A Whitbeck, J Whitmore, W Wu, F Yang, J C Yun, D Acosta, P Avery, D Bourilkov, T Cheng, S Das, M De Gruttola, G P Di Giovanni, D Dobur, R D Field, M Fisher, Y Fu, I K Furic, J Hugon, B Kim, J Konigsberg, A Korytov, A Kropivnitskaya, T Kypreos, J F Low, K Matchev, P Milenovic, G Mitselmakher, L Muniz, A Rinkevicius, L Shchutska, N Skhirtladze, M Snowball, J Yelton, M Zakaria, V Gaultney, S Hewamanage, S Linn, P Markowitz, G Martinez, J L Rodriguez, T Adams, A Askew, J Bochenek, J Chen, B Diamond, J Haas, S Hagopian, V Hagopian, K F Johnson, H Prosper, V Veeraraghavan, M Weinberg, M M Baarmand, B Dorney, M Hohlmann, H Kalakhety, F Yumiceva, M R Adams, L Apanasevich, V E Bazterra, R R Betts, I Bucinskaite, R Cavanaugh, O Evdokimov, L Gauthier, C E Gerber, D J Hofman, S Khalatyan, P Kurt, D H Moon, C O'Brien, C Silkworth, P Turner, N Varelas, U Akgun, E A Albayrak, B Bilki, W Clarida, K Dilsiz, F Duru, M Haytmyradov, J-P Merlo, H Mermerkaya, A Mestvirishvili, A Moeller, J Nachtman, H Ogul, Y Onel, F Ozok, S Sen, P Tan, E Tiras, J Wetzel, T Yetkin, K Yi, B A Barnett, B Blumenfeld, S Bolognesi, D Fehling, A V Gritsan, P Maksimovic, C Martín, M Swartz, P Baringer, A Bean, G Benelli, R P Kenny, M Murray, D Noonan, S Sanders, J Sekaric, R Stringer, Q Wang, J S Wood, A F Barfuss, I Chakaberia, A Ivanov, S Khalil, M Makouski, Y Maravin, L K Saini, S Shrestha, I Svintradze, J Gronberg, D Lange, F Rebassoo, D Wright, A Baden, B Calvert, S C Eno, J A Gomez, N J Hadley, R G Kellogg, T Kolberg, Y Lu, M Marionneau, A C Mignerey, K Pedro, A Skuja, J Temple, M B Tonjes, S C Tonwar, A Apyan, R Barbieri, G Bauer, W Busza, I A Cali, M Chan, L Di Matteo, V Dutta, G Gomez Ceballos, M Goncharov, D Gulhan, M Klute, Y S Lai, Y-J Lee, A Levin, P D Luckey, T Ma, C Paus, D Ralph, C Roland, G Roland, G S F Stephans, F Stöckli, K Sumorok, D Velicanu, J Veverka, B Wyslouch, M Yang, A S Yoon, M Zanetti, V Zhukova, B Dahmes, A De Benedetti, A Gude, S C Kao, K Klapoetke, Y Kubota, J Mans, N Pastika, R Rusack, A Singovsky, N Tambe, J Turkewitz, J G Acosta, L M Cremaldi, R Kroeger, S Oliveros, L Perera, R Rahmat, D A Sanders, D Summers, E Avdeeva, K Bloom, S Bose, D R Claes, A Dominguez, R Gonzalez Suarez, J Keller, D Knowlton, I Kravchenko, J Lazo-Flores, S Malik, F Meier, G R Snow, J Dolen, A Godshalk, I Iashvili, S Jain, A Kharchilava, S Rappoccio, Z Wan, G Alverson, E Barberis, D Baumgartel, M Chasco, J Haley, A Massironi, D Nash, T Orimoto, D Trocino, D Wood, J Zhang, A Anastassov, K A Hahn, A Kubik, L Lusito, N Mucia, N Odell, B Pollack, A Pozdnyakov, M Schmitt, S Stoynev, K Sung, M Velasco, S Won, D Berry, A Brinkerhoff, K M Chan, A Drozdetskiy, M Hildreth, C Jessop, D J Karmgard, N Kellams, J Kolb, K Lannon, W Luo, S Lynch, N Marinelli, D M Morse, T Pearson, M Planer, R Ruchti, J Slaunwhite, N Valls, M Wayne, M Wolf, A Woodard, L Antonelli, B Bylsma, L S Durkin, S Flowers, C Hill, R Hughes, K Kotov, T Y Ling, D Puigh, M Rodenburg, G Smith, C Vuosalo, B L Winer, H Wolfe, H W Wulsin, E Berry, P Elmer, V Halyo, P Hebda, J Hegeman, A Hunt, P Jindal, S A Koay, P Lujan, D Marlow, T Medvedeva, M Mooney, J Olsen, P Piroué, X Quan, A Raval, H Saka, D Stickland, C Tully, J S Werner, S C Zenz, A Zuranski, E Brownson, A Lopez, H Mendez, J E Ramirez Vargas, E Alagoz, D Benedetti, G Bolla, D Bortoletto, M De Mattia, A Everett, Z Hu, M Jones, K Jung, M Kress, N Leonardo, D Lopes Pegna, V Maroussov, P Merkel, D H Miller, N Neumeister, B C Radburn-Smith, I Shipsey, D Silvers, A Svyatkovskiy, F Wang, W Xie, L Xu, H D Yoo, J Zablocki, Y Zheng, N Parashar, A Adair, B Akgun, K M Ecklund, F J M Geurts, B Michlin, B P Padley, R Redjimi, J Roberts, J Zabel, B Betchart, A Bodek, R Covarelli, P de Barbaro, R Demina, Y Eshaq, T Ferbel, A Garcia-Bellido, P Goldenzweig, J Han, A Harel, D C Miner, G Petrillo, D Vishnevskiy, M Zielinski, A Bhatti, R Ciesielski, L Demortier, K Goulianos, G Lungu, C Mesropian, S Arora, A Barker, J P Chou, C Contreras-Campana, E Contreras-Campana, D Duggan, D Ferencek, Y Gershtein, R Gray, E Halkiadakis, D Hidas, A Lath, S Panwalkar, M Park, R Patel, V Rekovic, J Robles, S Salur, S Schnetzer, C Seitz, S Somalwar, R Stone, S Thomas, P Thomassen, M Walker, K Rose, S Spanier, Z C Yang, A York, O Bouhali, R Eusebi, W Flanagan, J Gilmore, T Kamon, V Khotilovich, V Krutelyov, R Montalvo, I Osipenkov, Y Pakhotin, A Perloff, J Roe, A Safonov, T Sakuma, I Suarez, A Tatarinov, D Toback, N Akchurin, C Cowden, J Damgov, C Dragoiu, P R Dudero, K Kovitanggoon, S Kunori, S W Lee, T Libeiro, I Volobouev, E Appelt, A G Delannoy, S Greene, A Gurrola, W Johns, C Maguire, A Melo, M Sharma, P Sheldon, B Snook, S Tuo, J Velkovska, M W Arenton, S Boutle, B Cox, B Francis, J Goodell, R Hirosky, A Ledovskoy, C Lin, C Neu, J Wood, S Gollapinni, R Harr, P E Karchin, C Kottachchi Kankanamge Don, P Lamichhane, D A Belknap, L Borrello, D Carlsmith, M Cepeda, S Dasu, S Duric, E Friis, M Grothe, R Hall-Wilton, M Herndon, A Hervé, P Klabbers, J Klukas, A Lanaro, A Levine, R Loveless, A Mohapatra, I Ojalvo, T Perry, G A Pierro, G Polese, I Ross, A Sakharov, T Sarangi, A Savin, W H Smith, .
Phys. Rev. Lett.
PUBLISHED: 09-22-2014
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The production of jets associated to bottom quarks is measured for the first time in PbPb collisions at a center-of-mass energy of 2.76 TeV per nucleon pair. Jet spectra are reported in the transverse momentum (p_{T}) range of 80-250??GeV/c, and within pseudorapidity |?|<2. The nuclear modification factor (R_{AA}) calculated from these spectra shows a strong suppression in the b-jet yield in PbPb collisions relative to the yield observed in pp collisions at the same energy. The suppression persists to the largest values of p_{T} studied, and is centrality dependent. The R_{AA} is about 0.4 in the most central events, similar to previous observations for inclusive jets. This implies that jet quenching does not have a strong dependence on parton mass and flavor in the jet p_{T} range studied.
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Dark-adaptation functions in molecularly confirmed achromatopsia and the implications for assessment in retinal therapy trials.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 08-28-2014
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To describe the dark-adaptation (DA) functions in subjects with molecularly proven achromatopsia (ACHM) using refined testing conditions with a view to guiding assessment in forthcoming gene therapy trials.
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The severity of retinal pathology in homozygous Crb1rd8/rd8 mice is dependent on additional genetic factors.
Hum. Mol. Genet.
PUBLISHED: 08-21-2014
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Understanding phenotype-genotype correlations in retinal degeneration is a major challenge. Mutations in CRB1 lead to a spectrum of autosomal recessive retinal dystrophies with variable phenotypes suggesting the influence of modifying factors. To establish the contribution of the genetic background to phenotypic variability associated with the Crb1(rd8/rd8) mutation, we compared the retinal pathology of Crb1(rd8/rd8)/J inbred mice with that of two Crb1(rd8/rd8) lines backcrossed with C57BL/6JOlaHsd mice. Topical endoscopic fundal imaging and scanning laser ophthalmoscopy fundus images of all three Crb1(rd8/rd8) lines showed a significant increase in the number of inferior retinal lesions that was strikingly variable between the lines. Optical coherence tomography, semithin, ultrastructural morphology and assessment of inflammatory and vascular marker by immunohistochemistry and quantitative reverse transcriptase-polymerase chain reaction revealed that the lesions were associated with photoreceptor death, Müller and microglia activation and telangiectasia-like vascular remodelling-features that were stable in the inbred, variable in the second, but virtually absent in the third Crb1(rd8/rd8) line, even at 12 months of age. This suggests that the Crb1(rd8/rd8) mutation is necessary, but not sufficient for the development of these degenerative features. By whole-genome SNP analysis of the genotype-phenotype correlation, a candidate region on chromosome 15 was identified. This may carry one or more genetic modifiers for the manifestation of the retinal pathology associated with mutations in Crb1. This study also provides insight into the nature of the retinal vascular lesions that likely represent a clinical correlate for the formation of retinal telangiectasia or Coats-like vasculopathy in patients with CRB1 mutations that are thought to depend on such genetic modifiers.
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Development of our TAVI protocol for emergency initiation of cardiopulmonary bypass.
Perfusion
PUBLISHED: 08-20-2014
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All transcatheter aortic valve implantation (TAVI) cases are done in our hybrid operating room with a multidisciplinary team and a primed cardiopulmonary bypass (CPB) circuit on pump stand-by. We decided that we would resuscitate all patients undergoing a TAVI procedure via a transfemoral, transapical or transaortic approach, if required. Perfusion plays an essential role in providing rescue CPB for patient salvage when catastrophic complications occur. To coordinate the multidisciplinary effort, we have developed a written safety checklist that assigns a pre-determined role for team members for the rapid sequence initiation of CPB. Although many TAVI patients are not candidates for conventional aortic valve replacements, we feel strongly that rescue CPB should be offered to all TAVI patients to allow the correction of potentially reversible complications. This protocol is included in every surgical "Time Out" involving a TAVI procedure (Figure 1). The protocol has led to rapid and safe CPB initiation in less than five minutes of cardiac arrest. It has also led to a coordinated and consistent team, with pre-specified roles and improved communication. We discuss a case series of four TAVI patients who required emergent use of CPB. The first few cases did not have a written protocol. The experience from these cases led to the development of our protocol. We identified a lack of coordination, wasted movements, unnecessary delayed resuscitation and overall chaos, each of which was targeted for correction with the protocol. We will discuss the merits of the protocol in two recent TAVI cases which required emergent CPB.
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A prospective longitudinal study of retinal structure and function in achromatopsia.
Invest. Ophthalmol. Vis. Sci.
PUBLISHED: 08-07-2014
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To longitudinally characterize retinal structure and function in achromatopsia (ACHM) in preparation for clinical gene therapy trials.
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Aboriginal and Torres Strait Islander maternal and child health and wellbeing: a systematic search of programs and services in Australian primary health care settings.
BMC Pregnancy Childbirth
PUBLISHED: 06-27-2014
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Persistent disparities in pregnancy and birth outcomes between Aboriginal and Torres Strait Islander and other Australians evidence a need to prioritise responsive practice in Maternal Child Health (MCH). This study reviewed the existing knowledge output on Aboriginal and Torres Strait Islander MCH programs and services with the objective to advance understanding of the current evidence base and inform MCH service development, including the identification of new research priorities.
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Observation of the associated production of a single top quark and a W boson in pp collisions at sqrt[s] = 8 TeV.
S Chatrchyan, V Khachatryan, A M Sirunyan, A Tumasyan, W Adam, T Bergauer, M Dragicevic, J Erö, C Fabjan, M Friedl, R Frühwirth, V M Ghete, C Hartl, N Hörmann, J Hrubec, M Jeitler, W Kiesenhofer, V Knünz, M Krammer, I Krätschmer, D Liko, I Mikulec, D Rabady, B Rahbaran, H Rohringer, R Schöfbeck, J Strauss, A Taurok, W Treberer-Treberspurg, W Waltenberger, C-E Wulz, V Mossolov, N Shumeiko, J Suarez Gonzalez, S Alderweireldt, M Bansal, S Bansal, T Cornelis, E A De Wolf, X Janssen, A Knutsson, S Luyckx, L Mucibello, S Ochesanu, B Roland, R Rougny, H Van Haevermaet, P Van Mechelen, N Van Remortel, A Van Spilbeeck, F Blekman, S Blyweert, J D'Hondt, N Heracleous, A Kalogeropoulos, J Keaveney, T J Kim, S Lowette, M Maes, A Olbrechts, D Strom, S Tavernier, W Van Doninck, P Van Mulders, G P Van Onsem, I Van Parijs, I Villella, C Caillol, B Clerbaux, G De Lentdecker, L Favart, A P R Gay, A Léonard, P E Marage, A Mohammadi, L Perniè, T Reis, T Seva, L Thomas, C Vander Velde, P Vanlaer, J Wang, V 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R Loveless, A Mohapatra, I Ojalvo, T Perry, G A Pierro, G Polese, I Ross, A Sakharov, T Sarangi, A Savin, W H Smith, .
Phys. Rev. Lett.
PUBLISHED: 06-09-2014
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The first observation of the associated production of a single top quark and a W boson is presented. The analysis is based on a data set corresponding to an integrated luminosity of 12.2 fb(-1) of proton-proton collisions at sqrt[s] = 8 TeV recorded by the CMS experiment at the LHC. Events with two leptons and a jet originating from a b quark are selected. A multivariate analysis based on kinematic and topological properties is used to separate the signal from the dominant tt background. An excess consistent with the signal hypothesis is observed, with a significance which corresponds to 6.1 standard deviations above a background-only hypothesis. The measured production cross section is 23.4 ± 5.4 pb, in agreement with the standard model prediction.
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The Center for HIV/AIDS Vaccine Immunology (CHAVI) multi-site quality assurance program for cryopreserved human peripheral blood mononuclear cells.
J. Immunol. Methods
PUBLISHED: 05-23-2014
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The Center for HIV/AIDS Vaccine Immunology (CHAVI) consortium was established to determine the host and virus factors associated with HIV transmission, infection and containment of virus replication, with the goal of advancing the development of an HIV protective vaccine. Studies to meet this goal required the use of cryopreserved Peripheral Blood Mononuclear Cell (PBMC) specimens, and therefore it was imperative that a quality assurance (QA) oversight program be developed to monitor PBMC samples obtained from study participants at multiple international sites. Nine site-affiliated laboratories in Africa and the USA collected and processed PBMCs, and cryopreserved PBMC were shipped to CHAVI repositories in Africa and the USA for long-term storage. A three-stage program was designed, based on Good Clinical Laboratory Practices (GCLP), to monitor PBMC integrity at each step of this process. The first stage evaluated the integrity of fresh PBMCs for initial viability, overall yield, and processing time at the site-affiliated laboratories (Stage 1); for the second stage, the repositories determined post-thaw viability and cell recovery of cryopreserved PBMC, received from the site-affiliated laboratories (Stage 2); the third stage assessed the long-term specimen storage at each repository (Stage 3). Overall, the CHAVI PBMC QA oversight program results highlight the relative importance of each of these stages to the ultimate goal of preserving specimen integrity from peripheral blood collection to long-term repository storage.
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Measurement of inclusive W and Z boson production cross sections in pp collisions at sqrt[s] = 8 TeV.
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Phys. Rev. Lett.
PUBLISHED: 05-14-2014
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A measurement of total and fiducial inclusive W and Z boson production cross sections in pp collisions at sqrt[s] = 8 TeV is presented. Electron and muon final states are analyzed in a data sample collected with the CMS detector corresponding to an integrated luminosity of 18.2 ± 0.5 pb(-1). The measured total inclusive cross sections times branching fractions are ?(pp ? WX)×B(W ? ??) = 12.21 ± 0.03(stat) ± 0.24(syst) ± 0.32(lum) nb and ?(pp ? ZX) × B(Z ? ?+?-) = 1.15 ± 0.01(stat) ± 0.02(syst) ± 0.03(lum) nb for the dilepton mass in the range of 60-120 GeV. The measured values agree with next-to-next-to-leading-order QCD cross section calculations. Ratios of cross sections are reported with a precision of 2%. This is the first measurement of inclusive W and Z boson production in proton-proton collisions at sqrt[s] = 8 TeV.
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G Polese, I Ross, T Sarangi, A Savin, W H Smith, .
Phys. Rev. Lett.
PUBLISHED: 05-05-2014
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Spin correlations and polarization in the top quark-antiquark system are measured using dilepton final states produced in pp collisions at the LHC at sqrt[s]=7??TeV. The data correspond to an integrated luminosity of 5.0??fb(-1) collected with the CMS detector. The measurements are performed using events with two oppositely charged leptons (electrons or muons), a significant imbalance in transverse momentum, and two or more jets, where at least one of the jets is identified as originating from a b quark. The spin correlations and polarization are measured through asymmetries in angular distributions of the two selected leptons, unfolded to the parton level. All measurements are found to be in agreement with predictions of the standard model.
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G Polese, I Ross, T Sarangi, A Savin, W H Smith, .
Phys. Rev. Lett.
PUBLISHED: 05-02-2014
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A search for flavor-changing neutral currents in top-quark decays t ? Zq is performed in events produced from the decay chain tt ? Zq+Wb, where both vector bosons decay leptonically, producing a final state with three leptons (electrons or muons). A data set collected with the CMS detector at the LHC is used, corresponding to an integrated luminosity of 19.7 fb(-1) of proton-proton collisions at a center-of-mass energy of 8 TeV. No excess is seen in the observed number of events relative to the standard model prediction; thus, no evidence for flavor-changing neutral currents in top-quark decays is found. A combination with a previous search at 7 TeV excludes a t ? Zq branching fraction greater than 0.05% at the 95% confidence level.
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Search for top-quark partners with charge 5/3 in the same-sign dilepton final state.
S Chatrchyan, V Khachatryan, A M Sirunyan, A Tumasyan, W Adam, T Bergauer, M Dragicevic, J Erö, C Fabjan, M Friedl, R Frühwirth, V M Ghete, C Hartl, N Hörmann, J Hrubec, M Jeitler, W Kiesenhofer, V Knünz, M Krammer, I Krätschmer, D Liko, I Mikulec, D Rabady, B Rahbaran, H Rohringer, R Schöfbeck, J Strauss, A Taurok, W Treberer-Treberspurg, W Waltenberger, C-E Wulz, V Mossolov, N Shumeiko, J Suarez Gonzalez, S Alderweireldt, M Bansal, S Bansal, T Cornelis, E A De Wolf, X Janssen, A Knutsson, S Luyckx, L Mucibello, S Ochesanu, B Roland, R Rougny, H Van Haevermaet, P Van Mechelen, N Van Remortel, A Van Spilbeeck, F Blekman, S Blyweert, J D'Hondt, N Heracleous, A Kalogeropoulos, J Keaveney, T J Kim, S Lowette, M Maes, A Olbrechts, D Strom, S Tavernier, W Van Doninck, P Van Mulders, G P Van Onsem, I Villella, C Caillol, B Clerbaux, G De Lentdecker, L Favart, A P R Gay, T Hreus, A Léonard, P E Marage, A Mohammadi, L Perniè, T Reis, T Seva, L Thomas, C Vander Velde, P Vanlaer, J Wang, V Adler, K Beernaert, L Benucci, A Cimmino, S Costantini, S Dildick, G Garcia, B Klein, J Lellouch, J Mccartin, A A Ocampo Rios, D Ryckbosch, M Sigamani, N Strobbe, F Thyssen, M Tytgat, S Walsh, E Yazgan, N Zaganidis, S Basegmez, C Beluffi, G Bruno, R Castello, A Caudron, L Ceard, G G Da Silveira, C Delaere, T du Pree, D Favart, L Forthomme, A Giammanco, J Hollar, P Jez, M Komm, V Lemaitre, J Liao, O Militaru, C Nuttens, D Pagano, A Pin, K Piotrzkowski, A Popov, L Quertenmont, M Selvaggi, M Vidal Marono, J M Vizan Garcia, N Beliy, T Caebergs, E Daubie, G H Hammad, G A Alves, M Correa Martins Junior, T Martins, M E Pol, M H G Souza, W L Aldá Júnior, W Carvalho, J Chinellato, A Custódio, E M Da Costa, D De Jesus Damiao, C De Oliveira Martins, S Fonseca De Souza, H Malbouisson, M Malek, D Matos Figueiredo, L Mundim, H Nogima, W L Prado Da Silva, J Santaolalla, A Santoro, A Sznajder, E J Tonelli Manganote, A Vilela Pereira, C A Bernardes, F A Dias, T R Fernandez Perez Tomei, E M Gregores, C Lagana, P G Mercadante, S F Novaes, Sandra S Padula, V Genchev, P Iaydjiev, A Marinov, S Piperov, M Rodozov, G Sultanov, M Vutova, A Dimitrov, I Glushkov, R Hadjiiska, V Kozhuharov, L Litov, B Pavlov, P Petkov, J G Bian, G M Chen, H S Chen, M Chen, R Du, C H Jiang, D Liang, S Liang, X Meng, R Plestina, J Tao, X Wang, Z Wang, C Asawatangtrakuldee, Y Ban, Y Guo, Q Li, W Li, S Liu, Y Mao, S J Qian, D Wang, L Zhang, W Zou, C Avila, C A Carrillo Montoya, L F Chaparro Sierra, C Florez, J P Gomez, B Gomez Moreno, J C Sanabria, N Godinović, D Lelas, D Polic, I Puljak, Z Antunovic, M Kovac, V Brigljevic, K Kadija, J Luetic, D Mekterovic, S Morovic, L Tikvica, A Attikis, G Mavromanolakis, J Mousa, C Nicolaou, F Ptochos, P A Razis, M Finger, A A Abdelalim, Y Assran, S Elgammal, A Ellithi Kamel, M A Mahmoud, A Radi, M Kadastik, M Müntel, M Murumaa, M Raidal, L Rebane, A Tiko, P Eerola, G Fedi, M Voutilainen, J Härkönen, V Karimäki, R Kinnunen, M J Kortelainen, T Lampén, K Lassila-Perini, S Lehti, T Lindén, P Luukka, T Mäenpää, T Peltola, E Tuominen, J Tuominiemi, E Tuovinen, L Wendland, T Tuuva, M Besançon, F Couderc, M Dejardin, D Denegri, B Fabbro, J L Faure, F Ferri, S Ganjour, A Givernaud, P Gras, G Hamel de Monchenault, P Jarry, E Locci, J Malcles, A Nayak, J Rander, A Rosowsky, M Titov, S Baffioni, F Beaudette, P Busson, C Charlot, N Daci, T Dahms, M Dalchenko, L Dobrzynski, A Florent, R Granier de Cassagnac, M Haguenauer, P Miné, C Mironov, I N Naranjo, M Nguyen, C Ochando, P Paganini, D Sabes, R Salerno, Y Sirois, C Veelken, Y Yilmaz, A Zabi, J-L Agram, J Andrea, D Bloch, J-M Brom, E C Chabert, C Collard, E Conte, F Drouhin, J-C Fontaine, D Gelé, U Goerlach, C Goetzmann, P Juillot, A-C Le Bihan, P Van Hove, S Gadrat, S Beauceron, N Beaupere, G Boudoul, S Brochet, J Chasserat, R Chierici, D Contardo, P Depasse, H El Mamouni, J Fan, J Fay, S Gascon, M Gouzevitch, B Ille, T Kurča, M Lethuillier, L Mirabito, S Perries, J D Ruiz Alvarez, L Sgandurra, V Sordini, M Vander Donckt, P Verdier, S Viret, H Xiao, Z Tsamalaidze, C Autermann, S Beranek, M Bontenackels, B Calpas, M Edelhoff, L Feld, O Hindrichs, K Klein, A Ostapchuk, A Perieanu, F Raupach, J Sammet, S Schael, D Sprenger, H Weber, B Wittmer, V Zhukov, M Ata, J Caudron, E Dietz-Laursonn, D Duchardt, M Erdmann, R Fischer, A Güth, T Hebbeker, C Heidemann, K Hoepfner, D Klingebiel, S Knutzen, P Kreuzer, M Merschmeyer, A Meyer, M Olschewski, K Padeken, P Papacz, H Reithler, S A Schmitz, L Sonnenschein, D Teyssier, S Thüer, M Weber, V Cherepanov, Y Erdogan, G Flügge, H Geenen, M Geisler, W Haj Ahmad, F Hoehle, B Kargoll, T Kress, Y Kuessel, J Lingemann, A Nowack, I M Nugent, L Perchalla, O Pooth, A Stahl, I Asin, N Bartosik, J Behr, W Behrenhoff, U Behrens, A J Bell, M Bergholz, A Bethani, K Borras, A Burgmeier, A Cakir, L Calligaris, A Campbell, S Choudhury, F Costanza, C Diez Pardos, S Dooling, T Dorland, G Eckerlin, D Eckstein, T Eichhorn, G Flucke, A Geiser, A Grebenyuk, P Gunnellini, S Habib, J Hauk, G Hellwig, M Hempel, D Horton, H Jung, M Kasemann, P Katsas, C Kleinwort, M Kramer, D Krücker, W Lange, J Leonard, K Lipka, W Lohmann, B Lutz, R Mankel, I Marfin, I-A Melzer-Pellmann, A B Meyer, J Mnich, A Mussgiller, S Naumann-Emme, O Novgorodova, F Nowak, H Perrey, A Petrukhin, D Pitzl, R Placakyte, A Raspereza, P M Ribeiro Cipriano, C Riedl, E Ron, M Ö Sahin, J Salfeld-Nebgen, R Schmidt, T Schoerner-Sadenius, M Schröder, M Stein, A D R Vargas Trevino, R Walsh, C Wissing, M Aldaya Martin, V Blobel, H Enderle, J Erfle, E Garutti, M Görner, M Gosselink, J Haller, K Heine, R S Höing, H Kirschenmann, R Klanner, R Kogler, J Lange, I Marchesini, J Ott, T Peiffer, N Pietsch, D Rathjens, C Sander, H Schettler, P Schleper, E Schlieckau, A Schmidt, M Seidel, J Sibille, V Sola, H Stadie, G Steinbrück, D Troendle, E Usai, L Vanelderen, C Barth, C Baus, J Berger, C Böser, E Butz, T Chwalek, W De Boer, A Descroix, A Dierlamm, M Feindt, M Guthoff, F Hartmann, T Hauth, H Held, K H Hoffmann, U Husemann, I Katkov, A Kornmayer, E Kuznetsova, P Lobelle Pardo, D Martschei, M U Mozer, Th Müller, M Niegel, A Nürnberg, O Oberst, G Quast, K Rabbertz, F Ratnikov, S Röcker, F-P Schilling, G Schott, H J Simonis, F M Stober, R Ulrich, J Wagner-Kuhr, S Wayand, T Weiler, R Wolf, M Zeise, G Anagnostou, G Daskalakis, T Geralis, S Kesisoglou, A Kyriakis, D Loukas, A Markou, C Markou, E Ntomari, I Topsis-Giotis, L Gouskos, A Panagiotou, N Saoulidou, E Stiliaris, X Aslanoglou, I Evangelou, G Flouris, C Foudas, P Kokkas, N Manthos, I Papadopoulos, E Paradas, G Bencze, C Hajdu, P Hidas, D Horvath, F Sikler, V Veszpremi, G Vesztergombi, A J Zsigmond, N Beni, S Czellar, J Molnár, J Palinkas, Z Szillasi, J Karancsi, P Raics, Z L Trocsanyi, B Ujvari, S K Swain, S B Beri, V Bhatnagar, N Dhingra, R Gupta, M Kaur, M Z Mehta, M Mittal, N Nishu, A Sharma, J B Singh, Ashok Kumar, Arun Kumar, S Ahuja, A Bhardwaj, B C Choudhary, A Kumar, S Malhotra, M Naimuddin, K Ranjan, P Saxena, V Sharma, R K Shivpuri, S Banerjee, S Bhattacharya, K Chatterjee, S Dutta, B Gomber, Sa Jain, Sh Jain, R Khurana, A Modak, S Mukherjee, D Roy, S Sarkar, M Sharan, A P Singh, A Abdulsalam, D Dutta, S Kailas, V Kumar, A K Mohanty, L M Pant, P Shukla, A Topkar, T Aziz, R M Chatterjee, S Ganguly, S Ghosh, M Guchait, A Gurtu, G Kole, S Kumar, M Maity, G Majumder, K Mazumdar, G B Mohanty, B Parida, K Sudhakar, N Wickramage, S Dugad, H Arfaei, H Bakhshiansohi, H Behnamian, S M Etesami, A Fahim, A Jafari, M Khakzad, M Mohammadi Najafabadi, M Naseri, S Paktinat Mehdiabadi, B Safarzadeh, M Zeinali, M Grunewald, M Abbrescia, L Barbone, C Calabria, S S Chhibra, A Colaleo, D Creanza, N De Filippis, M De Palma, L Fiore, G Iaselli, G Maggi, M Maggi, B Marangelli, S My, S Nuzzo, N Pacifico, A Pompili, G Pugliese, R Radogna, G Selvaggi, L Silvestris, G Singh, R Venditti, P Verwilligen, G Zito, G Abbiendi, A C Benvenuti, D Bonacorsi, S Braibant-Giacomelli, L Brigliadori, R Campanini, P Capiluppi, A Castro, F R Cavallo, G Codispoti, M Cuffiani, G M Dallavalle, F Fabbri, A Fanfani, D Fasanella, P Giacomelli, C Grandi, L Guiducci, S Marcellini, G Masetti, M Meneghelli, A Montanari, F L Navarria, F Odorici, A Perrotta, F Primavera, A M Rossi, T Rovelli, G P Siroli, N Tosi, R Travaglini, S Albergo, G Cappello, M Chiorboli, S Costa, F Giordano, R Potenza, A Tricomi, C Tuve, G Barbagli, V Ciulli, C Civinini, R D'Alessandro, E Focardi, E Gallo, S Gonzi, V Gori, P Lenzi, M Meschini, S Paoletti, G Sguazzoni, A Tropiano, L Benussi, S Bianco, D Piccolo, P Fabbricatore, R Ferretti, F Ferro, M Lo Vetere, R Musenich, E Robutti, S Tosi, A Benaglia, M E Dinardo, S Fiorendi, S Gennai, A Ghezzi, P Govoni, M T Lucchini, S Malvezzi, R A Manzoni, A Martelli, D Menasce, L Moroni, M Paganoni, D Pedrini, S Ragazzi, N Redaelli, T Tabarelli de Fatis, S Buontempo, N Cavallo, F Fabozzi, A O M Iorio, L Lista, S Meola, M Merola, P Paolucci, P Azzi, N Bacchetta, D Bisello, A Branca, R Carlin, P Checchia, T Dorigo, U Dosselli, M Galanti, F Gasparini, U Gasparini, P Giubilato, A Gozzelino, K Kanishchev, S Lacaprara, I Lazzizzera, M Margoni, A T Meneguzzo, M Nespolo, M Passaseo, J Pazzini, M Pegoraro, N Pozzobon, P Ronchese, F Simonetto, E Torassa, M Tosi, P Zotto, A Zucchetta, G Zumerle, M Gabusi, S P Ratti, C Riccardi, P Vitulo, M Biasini, G M Bilei, L Fanò, P Lariccia, G Mantovani, M Menichelli, A Nappi, F Romeo, A Saha, A Santocchia, A Spiezia, K Androsov, P Azzurri, G Bagliesi, J Bernardini, T Boccali, G Broccolo, R Castaldi, M A Ciocci, R Dell'Orso, F Fiori, L Foà, A Giassi, M T Grippo, A Kraan, F Ligabue, T Lomtadze, L Martini, A Messineo, C S Moon, F Palla, A Rizzi, A Savoy-Navarro, A T Serban, P Spagnolo, P Squillacioti, R Tenchini, G Tonelli, A Venturi, P G Verdini, C Vernieri, L Barone, F Cavallari, D Del Re, M Diemoz, M Grassi, C Jorda, E Longo, F Margaroli, P Meridiani, F Micheli, S Nourbakhsh, G Organtini, R Paramatti, S Rahatlou, C Rovelli, L Soffi, P Traczyk, N Amapane, R Arcidiacono, S Argiro, M Arneodo, R Bellan, C Biino, N Cartiglia, S Casasso, M Costa, A Degano, N Demaria, C Mariotti, S Maselli, E Migliore, V Monaco, M Musich, M M Obertino, G Ortona, L Pacher, N Pastrone, M Pelliccioni, A Potenza, A Romero, M Ruspa, R Sacchi, A Solano, A Staiano, U Tamponi, S Belforte, V Candelise, M Casarsa, F Cossutti, G Della Ricca, B Gobbo, C La Licata, M Marone, D Montanino, A Penzo, A Schizzi, T Umer, A Zanetti, S Chang, T Y Kim, S K Nam, D H Kim, G N Kim, J E Kim, D J Kong, S Lee, Y D Oh, H Park, D C Son, J Y Kim, Zero J Kim, S Song, S Choi, D Gyun, B Hong, M Jo, H Kim, Y Kim, K S Lee, S K Park, Y Roh, M Choi, J H Kim, C Park, I C Park, S Park, G Ryu, Y Choi, Y K Choi, J Goh, M S Kim, E Kwon, B Lee, J Lee, H Seo, I Yu, A Juodagalvis, H Castilla-Valdez, E De La Cruz-Burelo, I Heredia-De La Cruz, R Lopez-Fernandez, J Martínez-Ortega, A Sánchez-Hernández, L M Villasenor-Cendejas, S Carrillo Moreno, F Vazquez Valencia, H A Salazar Ibarguen, E Casimiro Linares, A Morelos Pineda, D Krofcheck, P H Butler, R Doesburg, S Reucroft, H Silverwood, M Ahmad, M I Asghar, J Butt, H R Hoorani, S Khalid, W A Khan, T Khurshid, S Qazi, M A Shah, M Shoaib, H Bialkowska, M Bluj, B Boimska, T Frueboes, M Górski, M Kazana, K Nawrocki, K Romanowska-Rybinska, M Szleper, G Wrochna, P Zalewski, G Brona, K Bunkowski, M Cwiok, W Dominik, K Doroba, A Kalinowski, M Konecki, J Krolikowski, M Misiura, W Wolszczak, P Bargassa, C Beirão Da Cruz E Silva, P Faccioli, P G Ferreira Parracho, M Gallinaro, F Nguyen, J Rodrigues Antunes, J Seixas, J Varela, P Vischia, S Afanasiev, P Bunin, I Golutvin, I Gorbunov, V Karjavin, V Konoplyanikov, G Kozlov, A Lanev, A Malakhov, V Matveev, P Moisenz, V Palichik, V Perelygin, M Savina, S Shmatov, N Skatchkov, V Smirnov, A Zarubin, V Golovtsov, Y Ivanov, V Kim, P Levchenko, V Murzin, V Oreshkin, I Smirnov, V Sulimov, L Uvarov, S Vavilov, A Vorobyev, An Vorobyev, Yu Andreev, A Dermenev, S Gninenko, N Golubev, M Kirsanov, N Krasnikov, A Pashenkov, D Tlisov, A Toropin, V Epshteyn, V Gavrilov, N Lychkovskaya, V Popov, G Safronov, S Semenov, A Spiridonov, V Stolin, E Vlasov, A Zhokin, V Andreev, M Azarkin, I Dremin, M Kirakosyan, A Leonidov, G Mesyats, S V Rusakov, A Vinogradov, A Belyaev, E Boos, V Bunichev, M Dubinin, L Dudko, A Ershov, V Klyukhin, O Kodolova, I Lokhtin, A Markina, S Obraztsov, S Petrushanko, V Savrin, A Snigirev, I Azhgirey, I Bayshev, S Bitioukov, V Kachanov, A Kalinin, D Konstantinov, V Krychkine, V Petrov, R Ryutin, A Sobol, L Tourtchanovitch, S Troshin, N Tyurin, A Uzunian, A Volkov, P Adzic, M Djordjevic, M Ekmedzic, J Milosevic, M Aguilar-Benitez, J Alcaraz Maestre, C Battilana, E Calvo, M Cerrada, M Chamizo Llatas, N Colino, B De La Cruz, A Delgado Peris, D Domínguez Vázquez, C Fernandez Bedoya, J P Fernández Ramos, A Ferrando, J Flix, M C Fouz, P Garcia-Abia, O Gonzalez Lopez, S Goy Lopez, J M Hernandez, M I Josa, G Merino, E Navarro De Martino, J Puerta Pelayo, A Quintario Olmeda, I Redondo, L Romero, M S Soares, C Willmott, C Albajar, J F de Trocóniz, H Brun, J Cuevas, J Fernandez Menendez, S Folgueras, I Gonzalez Caballero, L Lloret Iglesias, J A Brochero Cifuentes, I J Cabrillo, A Calderon, S H Chuang, J Duarte Campderros, M Fernandez, G Gomez, J Gonzalez Sanchez, A Graziano, A Lopez Virto, J Marco, R Marco, C Martinez Rivero, F Matorras, F J Munoz Sanchez, J Piedra Gomez, T Rodrigo, A Y Rodríguez-Marrero, A Ruiz-Jimeno, L Scodellaro, I Vila, R Vilar Cortabitarte, D Abbaneo, E Auffray, G Auzinger, M Bachtis, P Baillon, A H Ball, D Barney, J Bendavid, L Benhabib, J F Benitez, C Bernet, G Bianchi, P Bloch, A Bocci, A Bonato, O Bondu, C Botta, H Breuker, T Camporesi, G Cerminara, T Christiansen, J A Coarasa Perez, S Colafranceschi, M D'Alfonso, D d'Enterria, A Dabrowski, A David, F De Guio, A De Roeck, S De Visscher, S Di Guida, M Dobson, N Dupont-Sagorin, A Elliott-Peisert, J Eugster, G Franzoni, W Funk, M Giffels, D Gigi, K Gill, M Girone, M Giunta, F Glege, R Gomez-Reino Garrido, S Gowdy, R Guida, J Hammer, M Hansen, P Harris, A Hinzmann, V Innocente, P Janot, E Karavakis, K Kousouris, K Krajczar, P Lecoq, C Lourenço, N Magini, L Malgeri, M Mannelli, L Masetti, F Meijers, S Mersi, E Meschi, F Moortgat, M Mulders, P Musella, L Orsini, E Palencia Cortezon, E Perez, L Perrozzi, A Petrilli, G Petrucciani, A Pfeiffer, M Pierini, M Pimiä, D Piparo, M Plagge, A Racz, W Reece, G Rolandi, M Rovere, H Sakulin, F Santanastasio, C Schäfer, C Schwick, S Sekmen, P Siegrist, P Silva, M Simon, P Sphicas, J Steggemann, B Stieger, M Stoye, A Tsirou, G I Veres, J R Vlimant, H K Wöhri, W D Zeuner, W Bertl, K Deiters, W Erdmann, K Gabathuler, R Horisberger, Q Ingram, H C Kaestli, S König, D Kotlinski, U Langenegger, D Renker, T Rohe, F Bachmair, L Bäni, L Bianchini, P Bortignon, M A Buchmann, B Casal, N Chanon, A Deisher, G Dissertori, M Dittmar, M Donegà, M Dünser, P Eller, C Grab, D Hits, W Lustermann, B Mangano, A C Marini, P Martinez Ruiz Del Arbol, D Meister, N Mohr, C Nägeli, P Nef, F Nessi-Tedaldi, F Pandolfi, L Pape, F Pauss, M Peruzzi, M Quittnat, F J Ronga, M Rossini, A Starodumov, M Takahashi, L Tauscher, K Theofilatos, D Treille, R Wallny, H A Weber, C Amsler, V Chiochia, A De Cosa, C Favaro, M Ivova Rikova, B Kilminster, B Millan Mejias, J Ngadiuba, P Robmann, H Snoek, S Taroni, M Verzetti, Y Yang, M Cardaci, K H Chen, C Ferro, C M Kuo, S W Li, W Lin, Y J Lu, R Volpe, S S Yu, P Bartalini, P Chang, Y H Chang, Y W Chang, Y Chao, K F Chen, P H Chen, C Dietz, U Grundler, W-S Hou, Y Hsiung, K Y Kao, Y J Lei, Y F Liu, R-S Lu, D Majumder, E Petrakou, X Shi, J G Shiu, Y M Tzeng, M Wang, R Wilken, B Asavapibhop, N Suwonjandee, A Adiguzel, M N Bakirci, S Cerci, C Dozen, I Dumanoglu, E Eskut, S Girgis, G Gokbulut, E Gurpinar, I Hos, E E Kangal, A Kayis Topaksu, G Onengut, K Ozdemir, S Ozturk, A Polatoz, K Sogut, D Sunar Cerci, B Tali, H Topakli, M Vergili, I V Akin, T Aliev, B Bilin, S Bilmis, M Deniz, H Gamsizkan, A M Guler, G Karapinar, K Ocalan, A Ozpineci, M Serin, R Sever, U E Surat, M Yalvac, M Zeyrek, E Gülmez, B Isildak, M Kaya, O Kaya, S Ozkorucuklu, N Sonmez, H Bahtiyar, E Barlas, K Cankocak, Y O Günaydin, F I Vardarlı, M Yücel, L Levchuk, P Sorokin, J J Brooke, E Clement, D Cussans, H Flacher, R Frazier, J Goldstein, M Grimes, G P Heath, H F Heath, J Jacob, L Kreczko, C Lucas, Z Meng, D M Newbold, S Paramesvaran, A Poll, S Senkin, V J Smith, T Williams, K W Bell, C Brew, R M Brown, D J A Cockerill, J A Coughlan, K Harder, S Harper, J Ilic, E Olaiya, D Petyt, C H Shepherd-Themistocleous, A Thea, I R Tomalin, W J Womersley, S D Worm, M Baber, R Bainbridge, O Buchmuller, D Burton, D Colling, N Cripps, M Cutajar, P Dauncey, G Davies, M Della Negra, W Ferguson, J Fulcher, D Futyan, A Gilbert, A Guneratne Bryer, G Hall, Z Hatherell, J Hays, G Iles, M Jarvis, G Karapostoli, M Kenzie, R Lane, R Lucas, L Lyons, A-M Magnan, J Marrouche, B Mathias, R Nandi, J Nash, A Nikitenko, J Pela, M Pesaresi, K Petridis, M Pioppi, D M Raymond, S Rogerson, A 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G Polese, I Ross, T Sarangi, A Savin, W H Smith, .
Phys. Rev. Lett.
PUBLISHED: 04-30-2014
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A search for the production of heavy partners of the top quark with charge 5/3 is performed in events with a pair of same-sign leptons. The data sample corresponds to an integrated luminosity of 19.5 fb(-1) and was collected at sqrt[s] = 8 TeV by the CMS experiment. No significant excess is observed in the data above the expected background, and the existence of top-quark partners with masses below 800 GeV is excluded at a 95% confidence level, assuming they decay exclusively to tW. This is the first limit on these particles from the LHC, and it is significantly more restrictive than previous limits.
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