Preclinical Research Curcumin has been reported to be effective as a cancer therapy. However, the anti-metastatic effect and molecular mechanism(s) of curcumin in hepatocellular carcinoma (HCC) remain poorly understood. The purpose of this study was to test the effects of curcumin on HCC and its putative mechanism(s). Curcumin inhibited the proliferation of HCC cells and inhibited the migration and invasion of these cells at sub-cytotoxic concentrations. Curcumin also decreased the expression and activity of matrix metalloproteinases (MMP)-2 and MMP-9, and reduced p38 phosphorylation. Combination treatment of HCC cells with curcumin and SB203580 (a p38 signaling pathway inhibitor), generated a synergistic effect on the expression of MMP-2 and MMP-9, suggesting that the anti-metastatic effect of curcumin on HCC may involve a p38 signaling pathway.
Related JoVE Video
Journal of Visualized Experiments
What is Visualize?
JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.
How does it work?
We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.
Video X seems to be unrelated to Abstract Y...
In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.