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Find video protocols related to scientific articles indexed in Pubmed.
[Efficiency and outcome of Boari bladder flap plasty surgery for the treatment of middle and lower ureteral carcinoma].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
PUBLISHED: 09-10-2014
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To study the effect and outcome of Boari bladder flap plasty surgery for the treatment of kidney-sparing strategy for patients with middle and lower ureteral carcinoma.
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Impact of metabolic syndrome on benign prostatic hyperplasia in elderly Chinese men.
Urol. Int.
PUBLISHED: 05-22-2014
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The aim of the present study was to evaluate the impact of metabolic syndrome (MetS) on benign prostatic hyperplasia (BPH) in elderly Chinese men.
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ImmunoCyt™ and cytology for diagnosis of bladder carcinoma: a meta analysis.
Chin. Med. J.
PUBLISHED: 02-19-2014
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Currently, cystoscopy and urine cytology are standard modalities in therapy monitoring and follow-up of bladder carcinoma (BC). Cystoscopy is an invasive and uncomfortable procedure while cytology has a limited value because it is operator-dependent and has low sensitivity. This study was to assess the accuracy of ImmunoCyt in detecting BC by comparing it with cytology using systemic analyses of studies published in both English and Chinese.
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RelB regulates Bcl-xl expression and the irradiation-induced apoptosis of murine prostate cancer cells.
Biomed Rep
PUBLISHED: 01-29-2014
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Apoptosis in prostate cancer (PCa) induced by ionizing radiation (IR) is believed to play a critical role in radioresistance. Bcl-xl, an important member of the anti-apoptotic Bcl-2 family, has critical roles in tumor progression and development. The aim of the present study was to investigate the association of Bcl-xl expression and radiosensitivity from murine PCa RM-1 cells. An adenovirus-mediated RNA interference technique was employed to inhibit the expression of the RelB gene. RelB proteins were detected upon irradiation following transfection with small interfering (si)RelB, as shown by western blot analysis. The radiosensitivity of the RM-1 cells was determined by clonogenic assays. The apoptosis of the RM-1 cells were detected by flow cytometry assay, then quantitative polymerase chain reaction assays were performed to determine the expression level of Bcl-xl mRNA in the RM-1 cells. Radiation treatment increased the RelB protein levels from the cytosol and nucleus in the RM-1 cells. The protein expression levels of RelB in the pLentilox-sh-RelB-transfected RM-1 cells were significantly lower than in the negative interference group following radiation treatment. The percentage of cells undergoing apoptosis in the siRelB-RM-1 group was significantly higher than that in the control group following radiation treatment. Finally, a positive link between Bcl-xl expression and RelB activity was established in the RM-1 cells. Inhibition of RelB correlates with a decrease in expression of Bcl-xl. In conclusion, adenovirus-mediated siRNA targeting RelB inhibits Bcl-xl expression, enhances radiosensitivity and regulates the irradiation-induced apoptosis of the murine PCa RM-1 cell line.
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Inflammatory myofibroblastic tumor of the urinary bladder in a patient with the left renal cell carcinoma: A case report.
Exp Ther Med
PUBLISHED: 01-27-2014
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This case report describes an inflammatory tumor of the urinary bladder along with left renal cell carcinoma which occurred in a 73-year-old male with a narrowed orificium urethrae internum and severe hyperplasia of the prostate gland. A biopsy was not obtained prior to surgery. An inflammatory myofibroblastic tumor (IMT) of the urinary bladder is a rare benign lesion, particularly in the elderly. To the best of our knowledge, there are no studies concerning IMTs of the urinary bladder in patients with unilateral renal cell carcinoma. A bladder lesion due to an IMT may be easily misdiagnosed as metastasis from left renal cell carcinoma due to the hypervascularity of the tumor. In this case, radical surgery of the cancer of the left kidney was performed by laparoscopy. Subsequently, after three weeks and according to the examination of the intraoperative frozen-sections, a partial cystectomy was performed. Thus, radical resection of the bladder and the associated complications were avoided.
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Overactive bladder symptom score to evaluate efficacy of solifenacin for the treatment of overactive bladder symptoms.
Chin. Med. J.
PUBLISHED: 01-21-2014
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Overactive bladder (OAB) is a series of symptoms with high prevalence in elderly people. This study was conducted using the overactive bladder symptom score (OABSS) to evaluate the efficacy of solifenacin succinate for the treatment of OAB.
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An extragastrointestinal stromal tumor originating from the seminal vesicles: A case report and review of the literature.
Oncol Lett
PUBLISHED: 06-14-2013
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The present study reports a case of an extragastrointestinal stromal tumor (EGIST) originating from the seminal vesicles. A 74-year-old male patient with a tumor in the seminal vesicles underwent a radical spermatocystectomy due to an increased defecation frequency and a huge mass in the seminal vesicles. Ultrasonography and computed tomography (CT) initially diagnosed the mass as a tumor originating from the prostate. However, the mass was ultimately confirmed as an EGIST from the seminal vesicles following a laparotomy. According to the size, mitotic activity, cellularity, necrotic situation and immunohistochemical data, the tumor belonged to a low-risk group. No recurrence or metastasis has been identified during six years of follow-up observations. To the best of our knowledge, this is the first study to report this particular pathological type of EGIST.
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[Renal transplantation with kidneys procured from cardiac deceased post-liver transplantation donor: 2 cases report and literature review].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
PUBLISHED: 02-15-2013
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To better understand the pre-operation evaluation of donor kidneys from extended criteria donation after cardiac death and to improve the management during and after renal transplantation.
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Influence and pathophysiological mechanisms of simvastatin on prostatic hyperplasia in spontaneously hypertensive rats.
Urol. Int.
PUBLISHED: 01-22-2013
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Objective: To explore the effects and mechanisms of simvastatin on prostate hyperplasia in spontaneously hypertensive rats (SHRs). Methods: Thirty-six male SHRs were randomly divided into three groups: the 10 and the 20 mg/kg/d simvastatin group and the control group. After 6 weeks the ultra-microscopic prostate structures were observed. The serum levels of interleukin-6 (IL-6), insulin-like growth factor (IGF-1) and angiotensin II (Ang-II) were measured by enzyme-linked immunosorbent assays. The endothelium-derived nitric oxide synthase (eNOS) expression was evaluated with immunohistochemistry. Results: Compared to the control group, the 20 mg/kg/d simvastatin group presented with lower absolute (p = 0.005) and relative prostate weight (p = 0.009). The basal cells and columnar cells presented with edema, condensed heterochromatin in interstitial fibroblast nuclei, widened nucleus gaps, and decreased mitochondria and endoplasmic reticulum in the 10 mg/kg/d simvastatin group, these changes were more pronounced in the 20 mg/kg/d simvastatin group. The IL-6 levels in the 10 and 20 mg/kg/d simvastatin groups were lower than those of the controls (p = 0.005 and p = 0.008). The IGF-1 levels of the 20 mg/kg/d simvastatin group were reduced compared to the control group (p = 0.016). Conclusions: Simvastatin can delay and inhibit prostatic hyperplasia and progression in SHR. These actions may be mediated through the suppression of inflammatory and growth factors.
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Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation.
Nat. Genet.
PUBLISHED: 01-15-2013
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Bladder cancer is one of the most common cancers worldwide, with transitional cell carcinoma (TCC) being the predominant form. Here we report a genomic analysis of TCC by both whole-genome and whole-exome sequencing of 99 individuals with TCC. Beyond confirming recurrent mutations in genes previously identified as being mutated in TCC, we identified additional altered genes and pathways that were implicated in TCC. Notably, we discovered frequent alterations in STAG2 and ESPL1, two genes involved in the sister chromatid cohesion and segregation (SCCS) process. Furthermore, we also detected a recurrent fusion involving FGFR3 and TACC3, another component of SCCS, by transcriptome sequencing of 42 DNA-sequenced tumors. Overall, 32 of the 99 tumors (32%) harbored genetic alterations in the SCCS process. Our analysis provides evidence that genetic alterations affecting the SCCS process may be involved in bladder tumorigenesis and identifies a new therapeutic possibility for bladder cancer.
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Decreased expression of miR-430 promotes the development of bladder cancer via the upregulation of CXCR7.
Mol Med Rep
PUBLISHED: 01-06-2013
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MicroRNAs (miRNAs) have been demonstrated to be involved in the development of numerous types of malignant tumor. However, the role of miRNA-430 (miR-430) in bladder cancer remains unclear. In the present study, we observed that the expression of miR-430 was significantly downregulated in bladder cancer. Furthermore, the overexpression of miR-430 in human bladder cancer 5637 cells significantly inhibited cell proliferation, migration and colony formation efficiency. These findings were contrary to those obtained following the overexpression of CXCR7, which was found to be a direct target of miR-430 in this study. Further analysis showed that cell proliferation- and migration-related genes, including ERK, matrix metalloproteinase-2 (MMP-2) and MMP-9, were significantly downregulated in miR-430 overexpressed 5637 cells, while they were markedly upregulated in CXCR7 overexpressed 5637 cells. In conclusion, our study reveals important roles of miR-430 and CXCR7 in bladder cancer, and suggests that the downregulation of miR-430 enhances the development of bladder cancer, partly via the upregulation of CXCR7.
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Extracorporeal shock wave lithotripsy for management of residual stones after ureterolithotripsy versus mini-percutaneous nephrolithotomy: a retrospective study.
PLoS ONE
PUBLISHED: 01-01-2013
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To compare the efficacy of extracorporeal shock wave lithotripsy in managing residual stones after ureterolithotripsy and mini-percutaneous nephrolithotomy.
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Benzalkonium bromide as a new potential instillation drug for bladder cancer: hypothesis and pilot study.
Med. Sci. Monit.
PUBLISHED: 12-02-2011
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Non-muscle-invasive urothelial carcinoma of the bladder has a high rate of recurrence, necessitating use of a variety of adjuvant treatments. A single, immediate post-operative administration of chemotherapy is an important measure for reducing the rate of recurrences, but the overall effect is not satisfactory and the treatment is a burden to the patient. Hence, there is a need for a new, more effective and cheaper agent for adjuvant treatment of non-muscle-invasive bladder carcinomas. Although cationic surfactants such as benzalkonium salts are used clinically and hygienically for the control of bacterial growth, there have been reports that cationic surfactants such as benzethonium chloride induce apoptosis in normal and in cancerous cells. We report our experience with benzalkonium bromide (BB) accidentally administered into a patients bladder as saline. It caused severe hematuria and pain, but after a week of persistent administration in the bladder, the patient was cured, as supported by evidence from cystoscopy, indicating that BB destroys bladder mucosa and suggesting that BB maybe a novel agent for use in a single, immediate post-operative administration. We present preliminary data to support this hypothesis and provide discussion we hope will be useful as the foundation for further experiments.
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[Retroperitoneoscopic ureterolithotomy for upper ureteral calculus: 69 cases].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
PUBLISHED: 09-23-2011
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To review the technical details of retroperitoneoscopic ureterolithotomy and evaluate the clinical effect.
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Frequent mutations of genes encoding ubiquitin-mediated proteolysis pathway components in clear cell renal cell carcinoma.
Nat. Genet.
PUBLISHED: 06-03-2011
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We sequenced whole exomes of ten clear cell renal cell carcinomas (ccRCCs) and performed a screen of ?1,100 genes in 88 additional ccRCCs, from which we discovered 12 previously unidentified genes mutated at elevated frequencies in ccRCC. Notably, we detected frequent mutations in the ubiquitin-mediated proteolysis pathway (UMPP), and alterations in the UMPP were significantly associated with overexpression of HIF1? and HIF2? in the tumors (P = 0.01 and 0.04, respectively). Our findings highlight the potential contribution of UMPP to ccRCC tumorigenesis through the activation of the hypoxia regulatory network.
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Frequent mutations of chromatin remodeling genes in transitional cell carcinoma of the bladder.
Nat. Genet.
PUBLISHED: 05-13-2011
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Transitional cell carcinoma (TCC) is the most common type of bladder cancer. Here we sequenced the exomes of nine individuals with TCC and screened all the somatically mutated genes in a prevalence set of 88 additional individuals with TCC with different tumor stages and grades. In our study, we discovered a variety of genes previously unknown to be mutated in TCC. Notably, we identified genetic aberrations of the chromatin remodeling genes (UTX, MLL-MLL3, CREBBP-EP300, NCOR1, ARID1A and CHD6) in 59% of our 97 subjects with TCC. Of these genes, we showed UTX to be altered substantially more frequently in tumors of low stages and grades, highlighting its potential role in the classification and diagnosis of bladder cancer. Our results provide an overview of the genetic basis of TCC and suggest that aberration of chromatin regulation might be a hallmark of bladder cancer.
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Comparative mRNA and microRNA expression profiling of three genitourinary cancers reveals common hallmarks and cancer-specific molecular events.
PLoS ONE
PUBLISHED: 04-07-2011
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Genome-wide gene expression profile using deep sequencing technologies can drive the discovery of cancer biomarkers and therapeutic targets. Such efforts are often limited to profiling the expression signature of either mRNA or microRNA (miRNA) in a single type of cancer.
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Effects of YC-1 on hypoxia-inducible factor 1 alpha in hypoxic human bladder transitional carcinoma cell line T24 cells.
Urol. Int.
PUBLISHED: 03-22-2011
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It was the aim of this study to explore the effects of 3-(5-hydroxymethyl-2-furyl)-l-benzyl indazole (YC-1) on transcription activity, cell proliferation and apoptosis of hypoxic human bladder transitional carcinoma cells (BTCC), mediated by hypoxia-inducible factor 1? (HIF-1?).
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[Diagnosis and treatment of mature adrenal teratoma].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
PUBLISHED: 03-04-2011
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To discuss the pathology, clinical manifestation, diagnosis, therapy and prognosis of mature teratoma in adrenal gland. We reported 2 cases of mature adrenal teratoma and summarized their characters. No local recurrence or metastasis was found in the close follow-up of the 2 patients after the radical resection. Teratomas are rare germ tumors with potential malignant character which usually occur in the testes and ovaries. Adrenal teratomas are extremely rare and the diagnosis relies on radiological examinations. Early diagnosis and early surgical resection are the key in the treatment. Whether the postoperative chemotherapy is needed depends on the pathological result. Close lifelong follow-up is recommended and the prognosis is unclear at present.
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Pd-catalyzed carbonylation of diazo compounds at atmospheric pressure: a catalytic approach to ketenes.
J. Am. Chem. Soc.
PUBLISHED: 03-03-2011
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The carbonylation of carbenes through catalytic cycles is highly desirable due to the importance of ketene-mediated reactions in organic synthesis. In this investigation, a highly efficient and mild catalytic approach toward ketene intermediates has been developed based on Pd-catalyzed carbonylation of diazo compounds with CO. When ?-diazocarbonyl compounds or N-tosylhydrazone salts are heated in the presence of a palladium catalyst under atmospheric pressure of CO, ketene intermediates are formed in situ, where they undergo further reactions with various nucleophiles such as alcohols, amines, or imines. The Pd-catalyzed tandem carbonylation-Staudinger cycloaddition gives ?-lactam derivatives in good yields with excellent trans diastereoselectivity. The results from DFT calculation on the reaction mechanism suggest that Pd is involved in the [2 + 2] cycloaddition process and affects the diastereoselectivity of the ?-lactam products by assisting isomerization of the addition intermediate. On the other hand, the acylketenes generated from the Pd-catalyzed carbonylation of ?-diazoketones react with imines in a formal [4 + 2] cycloaddition manner to afford 1,3-dioxin-4-one derivatives. This straightforward carbonylation provides a new approach toward highly efficient catalytic generation of ketene species under mild conditions.
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MicroRNA expression signatures of bladder cancer revealed by deep sequencing.
PLoS ONE
PUBLISHED: 03-02-2011
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MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate gene expression. They are aberrantly expressed in many types of cancers. In this study, we determined the genome-wide miRNA profiles in bladder urothelial carcinoma by deep sequencing.
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Primary mature teratoma presenting as an adrenal tumor in a child.
Urology
PUBLISHED: 02-12-2011
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Teratomas, rare germ tumors usually found in the ovaries and testes, are potentially malignant. Adrenal teratomas are extremely rare, and their diagnosis relies on the findings from radiologic examinations. Early diagnosis and surgical resection are important for effective treatment. The success of the treatment determines the need for postoperative chemotherapy. Because the prognosis is currently difficult to predict, close, lifelong follow-up is recommended. The present review discusses the character of mature teratomas of the adrenal gland. We report 1 case of a primary mature teratoma presenting as an adrenal tumor in a child and review the published data.
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Renal cavernous hemangioma in a child: case report and review of the literature.
Urology
PUBLISHED: 02-01-2011
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Renal cavernous hemangioma is rare, and most cases of renal hemangioma tend to be small, with a peak incidence between 30 and 40 years of age. We report a case of a large renal hemangioma in a 12-year-old child, which is extremely rare. The diagnosis and treatment of renal cavernous hemangiomas are discussed.
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Integrated profiling of microRNAs and mRNAs: microRNAs located on Xq27.3 associate with clear cell renal cell carcinoma.
PLoS ONE
PUBLISHED: 08-04-2010
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With the advent of second-generation sequencing, the expression of gene transcripts can be digitally measured with high accuracy. The purpose of this study was to systematically profile the expression of both mRNA and miRNA genes in clear cell renal cell carcinoma (ccRCC) using massively parallel sequencing technology.
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No advantage is gained by preoperative bowel preparation in radical cystectomy and ileal conduit: a randomized controlled trial of 86 patients.
Int Urol Nephrol
PUBLISHED: 02-19-2010
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Bowel preparation (BP) is performed routinely before intestinal surgery to reduce the risk of postoperative infectious complications. We studied the effect of BP on patients who underwent radical cystectomy and ileal conduit surgery. Our goal was to determine whether BP in these patients provided any benefits postoperatively.
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Nonbacterial prostatitis in Kunming mouse induced by long-term stimuli of passive sexual abstinence.
J. Androl.
PUBLISHED: 11-19-2009
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In this study, a state of sexual abstinence was imitated in Kunming male mice. Further assessment on the body and prostate weight and histomorphometric changes of the prostate showed that nonbacterial prostatitis in Kunming mice could be induced by long-term stimuli of passive sexual abstinence, and the normal physiological state of the mice could be kept in the process of induction. The analysis of the result suggests that copulation might be a protective factor in the process of nonbacterial prostatitis. The underlying mechanisms of this model may include immune response on prostate antigen, chronic pelvic congestion, disturbance of hormone regulation, and other mechanisms; this requires confirmation by further research.
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[Effect of extracorporeal shock-wave lithotripsy on residual stones after different methods of surgery].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
PUBLISHED: 08-04-2009
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To observe the effect of extracorporeal shock wave lithotripsy (ESWL) on residual stones after different methods of surgery.
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Meta-analysis of antibiotic prophylaxis use in transrectal prostatic biopsy.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
PUBLISHED: 03-10-2009
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To determine whether antibiotic prophylaxis can reduce the risk of postoperative infective complications in men undergoing transrectal prostatic biopsy (TPB) who had sterile preoperative urine.
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Large renal cavernous hemangioma with renal vein thrombosis: case report and review of literature.
Urology
PUBLISHED: 03-06-2009
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Kidney cavernous hemangiomas are rare. Renal cavernous hemangioma complicated by secondary chronic thrombosis of the renal vein has not been previously reported. A 17-year-old boy was initially diagnosed with a renal mass with tumor thrombosis. Radical nephrectomy was performed, and the pathologic examination revealed a renal cavernous hemangioma with chronic renal vein thrombosis. We also reviewed the previous diagnostic and treatment methods described in previous reports.
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Management of primary adenocarcinoma of the female urethra: Report of two cases and review of the literature.
Oncol Lett
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Primary adenocarcinoma of the female urethra is rare and only a few retrospective cases have been published. The origin of urethral adenocarcinomas remains unclear. Certain authors have suggested that urethral adenocarcinomas in females originate at the periurethral Skenes glands. We report one case of urethral adenocarcinoma of the proximal urethra in a 44-year-old female who presented with painless urethral bleeding. Abdominal and pelvic CT scan with contrast and chest radiology were unremarkable. Biopsy of the mass revealed adenocarcinoma of the urethra. The patient was treated with partial urethrectomy and was free of disease for more than 5 years. We also present another rare case of mucinous adenocarcinoma in a 52-year-old female who complained of an enlarged urethral mass. Pelvic MRI revealed a tumor surrounding the whole urethra and bilateral inguinal lymph nodes. A puncture biopsy later revealed that the tumor was mucinous adenocarcinoma. Anterior pelvic exenteration with pelvic and bilateral lymph node dissection was performed and chemotherapy was administered. The patient was followed up for 12 months and did not experience local recurrence or distant metastasis. In conclusion, for the diagnosis of urethral cancer, a biopsy is necessary for any suspicious urethral lesions. MRI is recommended for tumor staging. Small, superficial, distal urethral tumors may be treated with excision of the distal urethra. For advanced female urethral cancer, a combination of chemotherapy, radiation therapy and surgery is recommended for optimal local and distant disease control. Regular follow-up is required in these patients.
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[Percutaneous nephrolithotomy of staghorn calculi in patients by mini-tract and standard-tract].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
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To compare the outcome of mini-tract vs standard-tract percutaneous nephrolithotomy (PCNL) in staghorn calculi.
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[Application of tube gastrostomy in radical cystectomy with ileal conduit: a retrospective, comparative study].
Nan Fang Yi Ke Da Xue Xue Bao
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To evaluate the clinical results of tube gastrostomy in radical cystectomy and ileal conduit.
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Chinese minimally invasive percutaneous nephrolithotomy for intrarenal stones in patients with solitary kidney: a single-center experience.
PLoS ONE
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To report our experience with Chinese minimally invasive percutaneous nephrolithotomy (Chinese MPCNL) to manage patients with intrarenal stones in solitary kidney, and evaluate the safety, efficiency and feasibility of this technique.
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Primary testicular non-Hodgkins lymphoma associated with hemophagocytic syndrome: Case report and review of the literature.
Oncol Lett
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Primary testicular non-Hodgkins lymphoma (TNHL) was first described as a clinical entity in 1866. It is a rare disease which accounts for 1% of all non-Hodgkins lymphoma, 2% of all extranodal lymphomas and 5% of all testicular neoplasms. Hemophagocytic syndrome (HPS) is a rare but distinct condition caused by inappropriate and dysregulated activation of the immune system. We report a 47-year-old man with primary TNHL who developed HPS four months after occurrence of scrotal swelling. To the best of our knowledge, primary TNHL associated with HPS has not previously been reported.
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[Efficacy and safety of percutaneous nephrolithotomy for treatment of staghorn stones in solitary kidney].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
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To analyze efficacy and safety of percutaneous nephrolithotomy (PCNL) in the management of staghorn calculi with solitary kidney.
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Flexible ureteroscopy and laser lithotripsy for bilateral multiple intrarenal stones: is this a valuable choice?
Urology
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To demonstrate the safety and efficacy of flexible ureteroscopy (FURS) and holmium laser lithotripsy as a valuable treatment of bilateral multiple intrarenal stones and stratify the efficacy by stone burdens ? 20 and >20 mm.
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[Diagnosis and treatment of renal oncocytoma of 6 cases and literature review].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
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To improve the diagnosis and treatment of renal oncocytoma and avoid unnecessary radical nephrectomy. The clinical data of 6 cases of renal oncocytoma diagnosed at the Second Xiangya Hospital Central South University from March 2005 to November 2010, including symptoms, laboratory tests, imaging, style of operation, pathological examination, and follow-up were retrospectively analyzed.There were no special symptoms and obvious abnormal laboratory tests in the patients. Two patients had relatively special imaging. Partial nephrectomy was performed in 2 cases of renal oncocytoma with typical imaging, while radical nephrectomy was performed on other patients because of misdiagnosis. No relapse and metastasis were found in the following 1 to 5 years.Renal oncocytoma is an uncommon benign tumor. Partial nephrectomy or tumor excision can be performed on patients diagnosed with renal oncocytoma according to typical imaging and intraoperative frozen section biopsy. The final diagnosis depends on pathological examination and regular follow-up is imperative for patients with renal oncocytoma.
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microRNA-155 silencing inhibits proliferation and migration and induces apoptosis by upregulating BACH1 in renal cancer cells.
Mol Med Rep
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The purpose of this study was to explore the functional role and mechanism of miR-155 in the development of renal cell carcinoma (RCC). miR-155 expression was quantified in renal cancers, matched adjacent non?tumor tissues and renal cell lines using quantitative real-time PCR (RT-PCR). Cell proliferation, apoptosis and migratory activity were measured following suppression of miR-155 expression by antisense oligonucleotides. miR-155 targets were scanned using target prediction programs. Following the inhibition of miR-155, target gene expression was detected by western blotting. The expression of miR-155 was upregulated in clear cell RCC (ccRCC) tissue and renal cancer cell lines. The suppression of miR-155 inhibited cell proliferation and migratory activity and induced apoptosis in renal cancer cells. The suppressor gene suppressor of cytokine signaling (SOCS-1) and BACH1 were predicted as potential target genes by bioinformatics analysis. The suppression of miR-155 inhibited BACH1 protein expression. miR-155 may function as an oncogene by targeting BACH1. Thus, the inhibition of miR-155 may be an effective way to treat RCC.
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DNA repair gene XRCC3 T241M polymorphism and bladder cancer risk in a Chinese population.
Genet Test Mol Biomarkers
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The X-ray repair cross-complementing group 3 (XRCC3), one of the DNA repair genes, was suggested to play an imperative role in the development of carcinogenesis. The objective of this study was to evaluate the role of the XRCC3 T241M polymorphism in bladder cancer susceptibility in a Chinese population. We genotyped 150 bladder cancer cases and 150 healthy controls who had been frequency matched to cases by age and sex. Genotypes were determined by polymerase chain reaction-restriction fragment length polymorphism analysis. A significant association was found between smoker and bladder cancer [odds ratio (OR)=1.97, 95% confidence interval (CI)=1.24-3.13, p=0.004]. The XRCC3 241MM genotype was more frequent in the bladder cancer group than in the healthy controls group (OR=3.22, 95% CI=1.14-9.11, p=0.03). There were no significant associations between any genotypes and the stage, grade, and histological type of bladder cancer. Our study suggested an increased risk role of XRCC3 241MM genotype in bladder cancer susceptibility in a Chinese population.
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Prostate volume correlates with diabetes in elderly benign prostatic hyperplasia patients.
Int Urol Nephrol
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To evaluate the relationship between prostate volume (PV) and diabetes mellitus (DM) in geriatric benign prostatic hyperplasia (BPH) patients.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.