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Find video protocols related to scientific articles indexed in Pubmed.
Downregulated expression of PTK6 is correlated with poor survival in esophageal squamous cell carcinoma.
Med. Oncol.
PUBLISHED: 11-07-2014
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To investigate the clinical prognostic value of protein tyrosine kinase 6 (PTK6) in patients with esophageal squamous cell carcinoma (ESCC), quantitative RT-PCR and Western blotting were utilized to measure the mRNA and protein expression levels of PTK6 in 29 and eight pairs of ESCC and peritumoral normal esophageal tissues, respectively. Furthermore, the expression of PTK6 protein in 210 ESCCs was examined with immunohistochemistry (IHC), and its clinical value was analyzed using Kaplan-Meier plots and the Cox proportional hazards regression model. The results found that the expression levels of both PTK6 mRNA and protein in ESCC tissues were significantly lower than those in peritumoral normal esophageal tissues. Regarding the IHC analysis of ESCC, the cytoplasmic expression of PTK6 was significantly correlated with tumor grade (P < 0.001). Compared with patients with low PTK6 expression, ESCC patients with overexpression of PTK6 displayed preferable disease-free survival (DFS) and overall survival (OS) (P < 0.001 and P = 0.001, respectively), especially in stage II disease (P = 0.002 and P = 0.021, respectively). PTK6 was evaluated as an independent prognostic factor for ESCC using multivariate Cox regression analysis. All data demonstrated that the expression level of PTK6 is an independent prognostic factor in ESCCs. Low expression of PTK6 is correlated with poor DFS and OS in ESCCs.
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Advanced hyperspectral video imaging system using Amici prism.
Opt Express
PUBLISHED: 10-17-2014
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In this paper, we propose an advanced hyperspectral video imaging system (AHVIS), which consists of an objective lens, an occlusion mask, a relay lens, an Amici prism and two cameras. An RGB camera is used for spatial reading and a gray scale camera is used for measuring the scene with spectral information. The objective lens collects more light energy from the observed scene and images the scene on an occlusion mask, which subsamples the image of the observed scene. Then, the subsampled image is sent to the gray scale camera through the relay lens and the Amici prism. The Amici prism that is used to realize spectral dispersion along the optical path reduces optical distortions and offers direct view of the scene. The main advantages of the proposed system are improved light throughput and less optical distortion. Furthermore, the presented configuration is more compact, robust and practicable.
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In vitro and in vivo anti-hepatitis B virus activities of the lignan niranthin isolated from Phyllanthus niruri L.
J Ethnopharmacol
PUBLISHED: 05-26-2014
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Niranthin is a lignan isolated from Phyllanthus niruri L. This plant has long been used in folk medicine for liver protection and antihepatitis B in many Asian countries. This study was designed to evaluate the anti-hepatitis B virus activity of niranthin using HepG2.2.15 cells and duck hepatitis B virus (DHBV) infected ducks as in vitro and in vivo models.
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In vitro and in vivo anti-hepatitis B virus activities of the lignan nirtetralin B isolated from Phyllanthus niruri L.
J Ethnopharmacol
PUBLISHED: 05-07-2014
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Nirtetralin B, a new lignan first reported by our team, is isolated from Phyllanthus niruri L. This plant has long been used in folk medicine for liver protection and antihepatitis B in many Asian countries. This study was designed to evaluate the anti-hepatitis B virus activity of nirtetralin B using HepG2.2.15 cells and duck hepatitis B virus (DHBV) infected ducks as in vitro and in vivo models.
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Content-adaptive high-resolution hyperspectral video acquisition with a hybrid camera system.
Opt Lett
PUBLISHED: 02-25-2014
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We present a hybrid camera system that combines optical designs with computational processing to achieve content-adaptive high-resolution hyperspectral video acquisition. In particular, we record two video streams: one high-spatial resolution RGB video and one low-spatial resolution hyperspectral video in which the recorded points are dynamically selected using a spatial light modulator (SLM). Then through video-frame registration and a spatio-temporal spreading of the co-located spectral/RGB information, video with high spatial and spectral resolution is produced. The sampling patterns on the SLM are generated on-the-fly according to the scene content, which fully exploits the self-adaptivity of the hybrid camera system. With an experimental prototype, we demonstrate significantly improved accuracy and efficiency as compared to the state-of-the-art.
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Nanoporous thermochromic VO? (M) thin films: controlled porosity, largely enhanced luminous transmittance and solar modulating ability.
Langmuir
PUBLISHED: 02-04-2014
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Vanadium dioxide is the most widely researched thermochromic material with a phase transition temperature (?(c)) of around 68 °C, and its thermochromic performance can be enhanced by adding nanoporosity. Freeze-drying has been employed to fabricate nanostructures with different porosities from 16 to 45% by varying the prefreezing temperature and precursor concentration. The luminous transmittance (Tlum) and solar modulating ability (?Tsol) are greatly enhanced as a result of increasing pore size and pore density. The freeze-dried sample with 7.5 mL of H2O2 precursor dip-coated at 300 mm/min gives the best combination of thermochromic properties (Tlum ? 50%, ?Tsol = 14.7%), which surpasses the best combined thermochromic performance reported to date that we are aware of (Tlum ? 41%, ?Tsol = 14.1%).
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O2, pH, and redox potential microprofiles around Potamogeton malaianus measured using microsensors.
PLoS ONE
PUBLISHED: 01-01-2014
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This study aimed to elucidate the effects of periphyton on the microprofiles of oxygen (O2), pH, and oxidation-reduction potential around the stems and leaves of a submerged macrophyte Potamogeton malaianus and on the plant growth in the eutrophic shallow Taihu Lake, China. The microprofiles were measured using a motorized microprofiling system equipped with microsensors. The leaf age of the macrophyte and periphyton exerted significant effects on the microprofiles of O2, pH, and oxidation-reduction potential. O2 concentration and pH increased whereas the oxidation-reduction potential decreased with decreasing distance to the stem/leaf surface. The fluctuation amplitudes of O2, pH, and oxidation-reduction potential were the largest in the microprofiles of mature leaves and the lowest in senescent leaves. The periphyton increased the thickness of the broad diffusive boundary layer and fluctuation amplitudes of O2, pH, and oxidation-reduction potential. When the periphyton was removed, the thickness of the broad diffusive boundary layer in the microprofiles of stems, senescent leaves, and mature leaves reduced by 29.0%, 49.72%, and 70.34%, and the O2, pH, and oxidation-reduction potential fluctuation amplitudes also declined accordingly. Our results suggest that a thick periphyton exerted negative effects on the growth of macrophytes by providing extensive shading and creating a barrier that hindered the transport of dissolved substances such as O2, and led to premature decline in macrophytes in the eutrophic Taihu Lake. The consequent implications can help to elucidate the control mechanism of the broad diffusive boundary layer around macrophytes on nutrient cycling in eutrophic waters and to better understand the role of this layer in the Taihu Lake and other similar eutrophic waters.
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Recognition of Objects in Simulated Irregular Phosphene Maps for an Epiretinal Prosthesis.
Artif Organs
PUBLISHED: 10-01-2013
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Visual prostheses offer a possibility of restoring vision to the blind. It is necessary to determine minimum requirements for daily visual tasks. To investigate the recognition of common objects in daily life based on the simulated irregular phosphene maps, the effect of four parameters (resolution, distortion, dropout percentage, and gray scale) on object recognition was investigated. The results showed that object recognition accuracy significantly increased with an increase of resolution. Distortion and dropout percentage had significant impact on the object recognition; with the increase of distortion level and dropout percentage, the recognition decreased considerably. The accuracy decreased significantly only at gray level 2, whereas the other three gray levels showed no obvious difference. The two image processing methods (merging pixels to lower the resolution and edge extraction before lowering resolution) showed significant difference on the object recognition when there was a high degree of distortion level or dot dropout.
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[Influence of Vallisneria spiralis on the physicochemical properties of black-odor sediment in urban sluggish river].
Huan Jing Ke Xue
PUBLISHED: 09-14-2013
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Using Indoor simulation method, the effect of Vallisneria spiralis on the physicochemical propertise of black and stink sediment was investigated. The surface sediment of urban sluggish river which had been heavily polluted was used as material in the study. The results showed that the redox environment of the sediment was significantly improved by Vallisneria spiralis. During the experiment, the Eh of surface sediment rose from -70 mV to 90 mV. The ferrous content was reduced by 25% in the experiment group while increased by 38% in the control group; the organic matter was decomposed effectively, prevented from natural decomposition to the smelly substances. There was a 3 mm thick greyish yellow oxide layer after 7 days in the experimental group, and the oxide layer gradually thickened over time. The thickness of the oxide layer reached 11 mm at the end of the experiment, and no significant odor was detected. On the contrary, the oxide layer in the control group was only 1 mm thick and the thickness remained unchanged. Meanwhile, an obnoxious odor existed during the whole experiment. The roots of Vallisneria spiralis had significant influence on the porosity of sediment. On one hand, the densification of sediment could be improved by Vallisneria spiralis. On the other hand, Vallisneria spiralis was able to change the state of the surface sediment flows, reduce the erosion of river sediment and inhibit the transfer of black-odor substances, which has a positive ecological meaning.
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Recent progress in research on the distribution and function of NUCB2/Nesfatin-1 in peripheral tissues.
Endocr. J.
PUBLISHED: 08-14-2013
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Nesfatin-1 is a polypeptide derived from the posttranslational processing of the N-terminal fragment of nucleobindin 2 (NUCB2), that was originally identified as an anorexigenic hypothalamic neuropeptide. A number of reports have recently shown that NUCB2/Nesfatin-1 is widely expressed in various peripheral tissues, including those of the gastrointestinal tract where it may participate in various pathophysiological processes. One of its roles may be regulation of energy homeostasis. As a result, Nesfatin-1 may be a novel target for exploring the underlying mechanisms and the treatment of metabolic syndromes.
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Prognostic value of preoperative mean corpuscular volume in esophageal squamous cell carcinoma.
World J. Gastroenterol.
PUBLISHED: 03-01-2013
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To evaluate whether preoperative mean corpuscular volume (MCV) is a prognostic indicator in patients with resectable esophageal squamous cell carcinoma (ESCC).
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Overexpression of hTERT in potentially malignant colorectal laterally spreading tumors.
Mol Med Rep
PUBLISHED: 02-27-2013
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Human telomerase reverse transcriptase (hTERT) is the main subunit of the core enzyme telomerase, which consists of three subunits. Telomeres are essential for chromosomal stability and integrity, protecting the ends of chromosomes from degradation and preventing chromosomal end fusions and recombination. A loss of telomere function is a major mechanism for the generation of chromosomal abnormalities. Telomere shortening leads to mutations, chromosome rearrangements and translocations. Colorectal laterally spreading tumors (LSTs) are a special type of superficial colorectal tumor. They are considered to have a high malignancy potential. The aim of the present study was to characterize the expression of hTERT in an LST cell line and paraffin sections. Immunohistochemistry was utilized to examine the protein expression of hTERT in the LST cell line, 48 resected LSTs, 48 protruded-type colorectal adenomas (PAs) and 48 normal mucosa samples. Statistical analyses were applied to test the associations between hTERT expression and clinicopathological parameters. The present study demonstrated that the positive expression levels of hTERT in LSTs, PAs and normal mucosa were 60.4, 22.9 and 10%, respectively. Compared with polypi and normal mucosa, the expression levels of hTERT were significantly increased in LSTs. The expression of hTERT was also observed in the LST cell line. The expression of hTERT was significantly higher in LSTs, which may indicate a potential for malignancy.
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Overexpression of cystatin SN positively affects survival of patients with surgically resected esophageal squamous cell carcinoma.
BMC Surg
PUBLISHED: 01-05-2013
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Cystatin SN is a secreted protein and a cysteine proteinase inhibitor. It has been considered to be a tumor marker for gastrointestinal tract cancer in several functional researches. However, the clinicopathological and prognostic significance of Cystatin SN expression in esophageal squamous cell carcinoma (ESCC) has not been elucidated.
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[Comparison of sentinel lymph node detection by methylene blue and carbon nanoparticle suspension injection in early breast cancer].
Zhonghua Zhong Liu Za Zhi
PUBLISHED: 05-18-2011
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To compare the efficacy of methylene blue versus carbon nanopartIcles suspension injection as a tracer for sentinel lymph node detection in breast cancer and the factors associated with the definition of sentinel lymph node biopsy.
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A Prism-Mask System for Multispectral Video Acquisition.
IEEE Trans Pattern Anal Mach Intell
PUBLISHED: 04-27-2011
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This paper presents a prism-mask system for capturing multispectral videos. The system is composed of a triangular prism, a monochrome camera, and an occlusion mask. Incoming light beams from the scene are sampled by the occlusion mask, dispersed into their constituent spectra by the triangular prism, and then captured by the monochrome camera. Our system is capable of capturing frames with high spectral resolution at video rates. It also allows for different tradeoffs between spectral and spatial resolution by adjusting the focal length of the camera. We demonstrate multispectral video acquisition with various spectral resolutions and spatial resolutions, as well as different frame rates. The effectiveness of our system is further evaluated with several applications, including human skin detection, physical material recognition, video segmentation, RGB video generation and illumination detection.
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Risk subset of the survival for nasopharyngeal carcinoma patients with bone metastases: who will benefit from combined treatment?
Oral Oncol.
PUBLISHED: 04-25-2011
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Bone metastasis from nasopharyngeal carcinoma (NPC) is the most frequent type of distant metastasis (DM). The purpose of this study was to elucidate survival, prognostic factors, and significant of treatment in NPC patients with bone metastasis. A total of 221 patients who developed single type of DM from NPC at the first failure after primary treatment were retrospectively recruited from January 1998 to October 2000. The correlation between disease-free interval (DFI) and clinicopathologic features was assessed by the Chi-square test. Univariate and multivariate analyses of clinicopathologic variables were performed using Cox proportional hazards regression models. Actuarial survival rates were plotted against time using the Kaplan-Meier method, and log-rank testing was used to compare the differences between the curves. The median overall survival (OS) of the whole cohort and bone metastatic NPC patients were 38.5 and 33.3months, respectively. After univariate and multivariate analyses of clinicopathologic variables, age, local recurrence, subsequent metastasis, DFI and treatment modality were independently significant prognostic factors. The outcomes of bone metastatic NPC patients in low- and high-risk subset were significantly different (49.5 vs. 19.4months, P<0.001). In stratified survival analysis, compared to chemotherapy alone, chemoradiotherapy (CRT) could benefit the patients in low-risk subset (P<0.001), but not those in high-risk subset (P=0.135). Our findings indicated that clinicopathologic variables could provide easily available prognostic factors for survival in NPC patients with bone metastasis. A subset of bone metastatic NPC patients would benefit from aggressive combined treatment and receive a long-term survival.
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Prognosticators and risk grouping in patients with lung metastasis from nasopharyngeal carcinoma: a more accurate and appropriate assessment of prognosis.
Radiat Oncol
PUBLISHED: 04-13-2011
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Lung metastases arising from nasopharyngeal carcinomas (NPC) have a relatively favourable prognosis. The purpose of this study was to identify the prognostic factors and to establish a risk grouping in patients with lung metastases from NPC.
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Factors determining the survival of nasopharyngeal carcinoma with lung metastasis alone: does combined modality treatment benefit?
BMC Cancer
PUBLISHED: 04-12-2011
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Nasopharyngeal carcinoma (NPC) with lung metastasis alone has been reported as a relatively favorable prognostic group, and combined modality treatment might be indicated for selected cases. However, the prognostic factors determining survival of this group and the indication of combined therapy have not been thoroughly studied.
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Managing esophageal fistulae by endoscopic transluminal drainage in esophageal cancer patients with superior mediastinal sepsis after esophagectomy.
Chin J Cancer
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The management of postoperative leaks into the mediastinum after esophagectomy remains a challenge. We describe our clinical management of this complication through endoscopic transluminal drainage. Between 2008 and 2011, 4 patients with esophageal squamous cell carcinoma (ESCC) who underwent McKeown-type esophagectomy with two-field lymphadenectomy experienced complicated anastomotic fistulae in the presence of superior mediastinal sepsis. All 4 patients underwent endoscopic transluminal drainage, and all survived. The mean healing period was 50 days (range, 31 to 58 days), the mean stay in the intensive care unit was 7.3 days (range, 1 to 18 days), and the mean hospital stay was 64.5 days (range, 49 to 70 days). Endoscopically guided transluminal drainage should be considered for ESCC patients with superior mediastinal fistulae after esophagectomy.
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Comparison between different reconstruction routes in esophageal squamous cell carcinoma.
World J. Gastroenterol.
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To compare postoperative complications and prognosis of esophageal squamous cell carcinoma patients treated with different routes of reconstruction.
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Preoperative Cyfra21-1 and SCC-Ag serum titers predict survival in patients with stage II esophageal squamous cell carcinoma.
J Transl Med
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The purpose of this study is to evaluate the predictive significance of preoperative serum level of cytokeratin 19 fragments (Cyfra21-1) and squamous cell carcinoma antigen (SCC-Ag) after complete resection in patients with stage II esophageal squamous cell carcinoma (ESCC).
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Tyrosine-protein phosphatase nonreceptor type 12 is a novel prognostic biomarker for esophageal squamous cell carcinoma.
Ann. Thorac. Surg.
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Tyrosine-protein phosphatase nonreceptor type 12 (PTPN12) is considered to be a tumor suppressor. It plays a significant role in human cancer, but its clinicopathologic and prognostic significance in esophageal squamous cell carcinoma (ESCC) has not yet been elucidated.
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What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

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We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.