JoVE Visualize What is visualize?
Stop Reading. Start Watching.
Advanced Search
Stop Reading. Start Watching.
Regular Search
Find video protocols related to scientific articles indexed in Pubmed.
Predictive factors associated with gefitinib response in patients with advanced non-small-cell lung cancer (NSCLC).
Chin. J. Cancer Res.
PUBLISHED: 07-02-2014
Show Abstract
Hide Abstract
A number of different clinical characteristics have been reported to singly correlate with therapeutic activity of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in advanced non-small-cell lung cancer (NSCLC). This study aimed to identify predictive factors associated with prognostic benefits of gefitinib.
Related JoVE Video
PKC? is activated in the liver of obese Zucker rats and mediates diet-induced whole body insulin resistance and hepatocyte cellular insulin resistance.
J. Nutr. Biochem.
PUBLISHED: 02-15-2014
Show Abstract
Hide Abstract
Insulin resistance can arise when pathological levels of free fatty acids (FFAs) and proinflammatory cytokines disrupt insulin signaling. Protein kinase C delta (PKC?) is a FFA- and a proinflammatory cytokine-regulated protein kinase that is associated with inhibition of insulin signaling and action. To gain insight into the role of PKC? in insulin resistance, PKC? activation was studied in a genetic model of obesity-linked insulin resistance. PKC? was found to be activated in the liver of obese insulin-resistant Zucker rats and in isolated cultured hepatocytes. PKC? was further studied in PKC?-null mice and their wild-type littermates fed a high-fat or control diet for 10 weeks. PKC?-null mice on a high-fat diet had improved insulin sensitivity and hepatic insulin signaling compared to wild-type littermates. Additionally, the deleterious effect of a high-fat diet on glucose tolerance in wild-type mice was completely blocked in PKC?-null mice. To directly test the role of PKC? in cellular insulin resistance, primary hepatocytes from the high-fat diet mice were isolated and stimulated with insulin. Primary hepatocytes from PKC?-null mice had improved insulin-stimulated Akt and FOXO phosphorylation compared to hepatocytes from wild-type littermates. Consistent with this result, tumor necrosis factor alpha-mediated inhibition of insulin signaling was blocked in PKC? knockdown primary hepatocytes. These results indicate that PKC? plays a role in insulin resistance and is consistent with the hypothesis that PKC? is a negative regulator of insulin signaling and thus may be a therapeutic target for the treatment of type 2 diabetes.
Related JoVE Video

What is Visualize?

JoVE Visualize is a tool created to match the last 5 years of PubMed publications to methods in JoVE's video library.

How does it work?

We use abstracts found on PubMed and match them to JoVE videos to create a list of 10 to 30 related methods videos.

Video X seems to be unrelated to Abstract Y...

In developing our video relationships, we compare around 5 million PubMed articles to our library of over 4,500 methods videos. In some cases the language used in the PubMed abstracts makes matching that content to a JoVE video difficult. In other cases, there happens not to be any content in our video library that is relevant to the topic of a given abstract. In these cases, our algorithms are trying their best to display videos with relevant content, which can sometimes result in matched videos with only a slight relation.