Adam C. Resnick Center for Data Driven Discovery in Biomedicine Children’s Hospital of Philadelphia Biography Publications Institution JoVE Articles Adam C. Resnick has not added a biography. If you are Adam C. Resnick and would like to personalize this page please email our Author Liaison for assistance. Publications The Children's Brain Tumor Network (CBTN) - Accelerating Research in Pediatric Central Nervous System Tumors Through Collaboration and Open Science Neoplasia (New York, N.Y.). Jan, 2023 | Pubmed ID: 36335802 ALT in Pediatric High-Grade Gliomas Can Occur Without ATRX Mutation and is Enriched in Patients with Pathogenic Germline MMR Variants Neuro-oncology. Dec, 2022 | Pubmed ID: 36541551 Development of GPC2-directed Chimeric Antigen Receptors Using MRNA for Pediatric Brain Tumors Journal for Immunotherapy of Cancer. Sep, 2022 | Pubmed ID: 36167467 Neurotrophic Tyrosine Receptor Kinase Fusion in Pediatric Central Nervous System Tumors Cancer Genetics. Apr, 2022 | Pubmed ID: 35108662 Targeted Gene Expression Profiling of Inverted Papilloma and Squamous Cell Carcinoma International Forum of Allergy & Rhinology. Feb, 2022 | Pubmed ID: 34510780 MitoScape: A Big-data, Machine-learning Platform for Obtaining Mitochondrial DNA from Next-generation Sequencing Data PLoS Computational Biology. Nov, 2021 | Pubmed ID: 34762648 Cancer Informatics for Cancer Centers: Scientific Drivers for Informatics, Data Science, and Care in Pediatric, Adolescent, and Young Adult Cancer JCO Clinical Cancer Informatics. Aug, 2021 | Pubmed ID: 34428097 NTRK Fusions Identified in Pediatric Tumors: The Frequency, Fusion Partners, and Clinical Outcome JCO Precision Oncology. 2021 | Pubmed ID: 34036219 Integrated Molecular and Clinical Analysis of Low-grade Gliomas in Children with Neurofibromatosis Type 1 (NF1) Acta Neuropathologica. Apr, 2021 | Pubmed ID: 33585982 Proteogenomic and Metabolomic Characterization of Human Glioblastoma Cancer Cell. Apr, 2021 | Pubmed ID: 33577785 BRAF Fusions in Pediatric Histiocytic Neoplasms Define Distinct Therapeutic Responsiveness to RAF Paradox Breakers Pediatric Blood & Cancer. Jun, 2021 | Pubmed ID: 33565241 Genomic Characterization of a PPP1CB-ALK Fusion with Fusion Gene Amplification in a Congenital Glioblastoma Cancer Genetics. Apr, 2021 | Pubmed ID: 33341678 AnnoFuse: an R Package to Annotate, Prioritize, and Interactively Explore Putative Oncogenic RNA Fusions BMC Bioinformatics. Dec, 2020 | Pubmed ID: 33317447 Integrated Proteogenomic Characterization Across Major Histological Types of Pediatric Brain Cancer Cell. Dec, 2020 | Pubmed ID: 33242424 A Transcriptome-based Classifier to Determine Molecular Subtypes in Medulloblastoma PLoS Computational Biology. Oct, 2020 | Pubmed ID: 33119584 Harmonization of Postmortem Donations for Pediatric Brain Tumors and Molecular Characterization of Diffuse Midline Gliomas Scientific Reports. Jul, 2020 | Pubmed ID: 32616776 A Germline Pathogenic Variant Identified in a Pediatric High-grade Glioma Cold Spring Harbor Molecular Case Studies. Aug, 2020 | Pubmed ID: 32554798 Ancestry and Frequency of Genetic Variants in the General Population Are Confounders in the Characterization of Germline Variants Linked to Cancer BMC Medical Genetics. May, 2020 | Pubmed ID: 32375678 The InsP Phosphatase Siw14 Regulates Inositol Pyrophosphate Levels to Control Localization of the General Stress Response Transcription Factor Msn2 The Journal of Biological Chemistry. Feb, 2020 | Pubmed ID: 31848224 Comparative Tumor RNA Sequencing Analysis for Difficult-to-Treat Pediatric and Young Adult Patients With Cancer JAMA Network Open. Oct, 2019 | Pubmed ID: 31651965 Genomic Analysis of Dysembryoplastic Neuroepithelial Tumor Spectrum Reveals a Diversity of Molecular Alterations Dysregulating the MAPK and PI3K/mTOR Pathways Journal of Neuropathology and Experimental Neurology. Dec, 2019 | Pubmed ID: 31617914 Immunotherapy for Pediatric Brain Tumors: Past and Present Neuro-oncology. Oct, 2019 | Pubmed ID: 31504801 Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers The Journal of Molecular Diagnostics : JMD. Sep, 2019 | Pubmed ID: 31255796 Transcriptome Signatures Associated with Meningioma Progression Acta Neuropathologica Communications. Apr, 2019 | Pubmed ID: 31039818 Intratumoral Genetic and Functional Heterogeneity in Pediatric Glioblastoma Cancer Research. May, 2019 | Pubmed ID: 30877103 A Pilot Precision Medicine Trial for Children with Diffuse Intrinsic Pontine Glioma-PNOC003: A Report from the Pacific Pediatric Neuro-Oncology Consortium International Journal of Cancer. Mar, 2019 | Pubmed ID: 30861105 IPMK Mediates Activation of ULK Signaling and Transcriptional Regulation of Autophagy Linked to Liver Inflammation and Regeneration Cell Reports. Mar, 2019 | Pubmed ID: 30840891 Purification of MRNA Encoding Chimeric Antigen Receptor Is Critical for Generation of a Robust T-Cell Response Human Gene Therapy. Feb, 2019 | Pubmed ID: 30024272 Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2018 | Pubmed ID: 30322880 Author Correction: The Landscape of Genomic Alterations Across Childhood Cancers Nature. 07, 2018 | Pubmed ID: 29875405 Novel FGFR2-INA Fusion Identified in Two Low-grade Mixed Neuronal-glial Tumors Drives Oncogenesis Via MAPK and PI3K/mTOR Pathway Activation Acta Neuropathologica. Jul, 2018 | Pubmed ID: 29767381 Molecular, Pathological, Radiological, and Immune Profiling of Non-brainstem Pediatric High-Grade Glioma from the HERBY Phase II Randomized Trial Cancer Cell. May, 2018 | Pubmed ID: 29763623 Dual HDAC and PI3K Inhibition Abrogates NFκB- and FOXM1-Mediated DNA Damage Response to Radiosensitize Pediatric High-Grade Gliomas Cancer Research. Jul, 2018 | Pubmed ID: 29760046 Plain-language Medical Vocabulary for Precision Diagnosis Nature Genetics. Apr, 2018 | Pubmed ID: 29632381 The Landscape of Genomic Alterations Across Childhood Cancers Nature. Mar, 2018 | Pubmed ID: 29489754 Shared ACVR1 Mutations in FOP and DIPG: Opportunities and Challenges in Extending Biological and Clinical Implications Across Rare Diseases Bone. Apr, 2018 | Pubmed ID: 28780023 Overcoming Resistance to Single-agent Therapy for Oncogenic Gene Fusions Combinatorial Targeting of MAPK and PI3K/mTOR Signaling Pathways Oncotarget. Oct, 2017 | Pubmed ID: 29156677 MYB-QKI Drives Childhood Brain Tumors Via Tripartite Mechanism Cell Cycle (Georgetown, Tex.). Mar, 2017 | Pubmed ID: 27973981 Inositol Polyphosphates Intersect with Signaling and Metabolic Networks Via Two Distinct Mechanisms Proceedings of the National Academy of Sciences of the United States of America. Nov, 2016 | Pubmed ID: 27791083 The Biorepository Portal Toolkit: an Honest Brokered, Modular Service Oriented Software Tool Set for Biospecimen-driven Translational Research BMC Genomics. Aug, 2016 | Pubmed ID: 27535360 BRAF Status in Personalizing Treatment Approaches for Pediatric Gliomas Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Nov, 2016 | Pubmed ID: 27217440 MYB-QKI Rearrangements in Angiocentric Glioma Drive Tumorigenicity Through a Tripartite Mechanism Nature Genetics. Mar, 2016 | Pubmed ID: 26829751 A Novel Inositol Pyrophosphate Phosphatase in Saccharomyces Cerevisiae: Siw14 PROTEIN SELECTIVELY CLEAVES THE β-PHOSPHATE FROM 5-DIPHOSPHOINOSITOL PENTAKISPHOSPHATE (5PP-IP5) The Journal of Biological Chemistry. Mar, 2016 | Pubmed ID: 26828065 Phase II Study of Sorafenib in Children with Recurrent or Progressive Low-grade Astrocytomas Neuro-oncology. Oct, 2014 | Pubmed ID: 24803676 Exome Sequencing Identifies BRAF Mutations in Papillary Craniopharyngiomas Nature Genetics. Feb, 2014 | Pubmed ID: 24413733 Paradoxical Activation and RAF Inhibitor Resistance of BRAF Protein Kinase Fusions Characterizing Pediatric Astrocytomas Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23533272 Spinal Cord Ependymomas and Myxopapillary Ependymomas in the First 2 Decades of Life: a Clinicopathological and Immunohistochemical Characterization of 19 Cases Journal of Neurosurgery. Pediatrics. Jun, 2012 | Pubmed ID: 22656257 Inositol Polyphosphate Multikinase is a Physiologic PI3-kinase That Activates Akt/PKB Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21220345 The Genetic Landscape of the Childhood Cancer Medulloblastoma Science (New York, N.Y.). Jan, 2011 | Pubmed ID: 21163964 Activating Mutations in BRAF Characterize a Spectrum of Pediatric Low-grade Gliomas Neuro-oncology. Jul, 2010 | Pubmed ID: 20156809 Duplication of 7q34 in Pediatric Low-grade Astrocytomas Detected by High-density Single-nucleotide Polymorphism-based Genotype Arrays Results in a Novel BRAF Fusion Gene Brain Pathology (Zurich, Switzerland). Jul, 2009 | Pubmed ID: 19016743 Gene Deletion of Inositol Hexakisphosphate Kinase 1 Reveals Inositol Pyrophosphate Regulation of Insulin Secretion, Growth, and Spermiogenesis Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18268345 Inositol Polyphosphate Multikinase: Metabolic Architect of Nuclear Inositides Frontiers in Bioscience : a Journal and Virtual Library. 2008 | Pubmed ID: 17981594 Имплантация внутричерепных канюль для серийных локорегионарных инфузий Т-клеток химерного антигенного рецептора (CAR) у мышей Kyra Harvey1, Peter J. Madsen2,3, Tiffany Smith2, Crystal Griffin1,2, Luke Patterson1,2, Nicholas A. Vitanza4,5, Phillip B. Storm2,3, Adam C. Resnick2,3, Jessica B. Foster1,2 1Division of Oncology, Children’s Hospital of Philadelphia, 2Center for Data Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia, 3Division of Neurosurgery, Children’s Hospital of Philadelphia, 4Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, 5Department of Pediatrics, Seattle Children’s Hospital, University of Washington JoVE 64886 Cancer Research
Имплантация внутричерепных канюль для серийных локорегионарных инфузий Т-клеток химерного антигенного рецептора (CAR) у мышей Kyra Harvey1, Peter J. Madsen2,3, Tiffany Smith2, Crystal Griffin1,2, Luke Patterson1,2, Nicholas A. Vitanza4,5, Phillip B. Storm2,3, Adam C. Resnick2,3, Jessica B. Foster1,2 1Division of Oncology, Children’s Hospital of Philadelphia, 2Center for Data Driven Discovery in Biomedicine, Children’s Hospital of Philadelphia, 3Division of Neurosurgery, Children’s Hospital of Philadelphia, 4Ben Towne Center for Childhood Cancer Research, Seattle Children’s Research Institute, 5Department of Pediatrics, Seattle Children’s Hospital, University of Washington JoVE 64886 Cancer Research
