Adolfo Saiardi Medical Research Council, Laboratory for Molecular Cell Biology University College London Biography Publications Institution JoVE Articles Adolfo Saiardi has not added a biography. If you are Adolfo Saiardi and would like to personalize this page please email our Author Liaison for assistance. Publications ITPK1 is an InsP/ADP Phosphotransferase That Controls Phosphate Signaling in Arabidopsis Molecular Plant. Jul, 2021 | Pubmed ID: 34274522 A Stable Immature Lattice Packages IP for HIV Capsid Maturation Science Advances. Mar, 2021 | Pubmed ID: 33692109 Cytoplasmic Cleavage of IMPA1 3' UTR is Necessary for Maintaining Axon Integrity Cell Reports. Feb, 2021 | Pubmed ID: 33626357 IP6K3 and IPMK Variations in LOAD and Longevity: Evidence for a Multifaceted Signaling Network at the Crossroad Between Neurodegeneration and Survival Mechanisms of Ageing and Development. 04, 2021 | Pubmed ID: 33497757 Inositol Phosphate Kinases in the Eukaryote Landscape Advances in Biological Regulation. 01, 2021 | Pubmed ID: 33422459 Phytocannabinoid-dependent MTORC1 Regulation is Dependent Upon Inositol Polyphosphate Multikinase Activity British Journal of Pharmacology. 03, 2021 | Pubmed ID: 33347604 MINPP1 Prevents Intracellular Accumulation of the Chelator Inositol Hexakisphosphate and is Mutated in Pontocerebellar Hypoplasia Nature Communications. 11, 2020 | Pubmed ID: 33257696 Analysis of Inositol Phosphate Metabolism by Capillary Electrophoresis Electrospray Ionization Mass Spectrometry Nature Communications. 11, 2020 | Pubmed ID: 33247133 IP-SPX Domain Interaction Controls Fungal Virulence by Stabilizing Phosphate Signaling Machinery MBio. 10, 2020 | Pubmed ID: 33082258 Effects of the Putative Lithium Mimetic Ebselen on Pilocarpine-induced Neural Activity European Journal of Pharmacology. Sep, 2020 | Pubmed ID: 32687920 Interplay Between Primary Familial Brain Calcification-associated SLC20A2 and XPR1 Phosphate Transporters Requires Inositol Polyphosphates for Control of Cellular Phosphate Homeostasis The Journal of Biological Chemistry. 07, 2020 | Pubmed ID: 32393577 Inorganic Polyphosphate in Mammals: Where's Wally? Biochemical Society Transactions. 02, 2020 | Pubmed ID: 32049314 Development of a Yeast Model to Study the Contribution of Vacuolar Polyphosphate Metabolism to Lysine Polyphosphorylation The Journal of Biological Chemistry. 02, 2020 | Pubmed ID: 31844018 Dictyostelium Discoideum As a Model to Study Inositol Polyphosphates and Inorganic Polyphosphate Methods in Molecular Biology (Clifton, N.J.). 2020 | Pubmed ID: 31773570 Cellular IP Levels Limit HIV Production While Viruses That Cannot Efficiently Package IP Are Attenuated for Infection and Replication Cell Reports. 12, 2019 | Pubmed ID: 31851928 ITPK1 Mediates the Lipid-independent Synthesis of Inositol Phosphates Controlled by Metabolism Proceedings of the National Academy of Sciences of the United States of America. 12, 2019 | Pubmed ID: 31754032 ITPK1 and ITPK2 Have an Evolutionarily Conserved Phytic Acid Kinase Activity ACS Chemical Biology. 10, 2019 | Pubmed ID: 31525024 Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity of Present Novel Drug Targeting Opportunities Frontiers in Cellular and Infection Microbiology. 2019 | Pubmed ID: 31380293 Harnessing C-labeled -inositol to Interrogate Inositol Phosphate Messengers by NMR Chemical Science. May, 2019 | Pubmed ID: 31191882 The Inositol Hexakisphosphate Kinases IP6K1 and -2 Regulate Human Cellular Phosphate Homeostasis, Including XPR1-mediated Phosphate Export The Journal of Biological Chemistry. 07, 2019 | Pubmed ID: 31186349 Inositol Polyphosphate Multikinase (), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity Genes. 02, 2019 | Pubmed ID: 30744060 Crosstalk Between Ras and Inositol Phosphate Signaling Revealed by Lithium Action on Inositol Monophosphatase in Schizophyllum Commune Advances in Biological Regulation. 05, 2019 | Pubmed ID: 30639095 Hydrophilic Interaction Liquid Chromatography-tandem Mass Spectrometry for the Quantitative Analysis of Mammalian-derived Inositol Poly/pyrophosphates Journal of Chromatography. A. Oct, 2018 | Pubmed ID: 30220429 Lithium and Fluoxetine Regulate the Rate of Phosphoinositide Synthesis in Neurons: a New View of Their Mechanisms of Action in Bipolar Disorder Translational Psychiatry. 08, 2018 | Pubmed ID: 30171184 Rab4A Organizes Endosomal Domains for Sorting Cargo to Lysosome-related Organelles Journal of Cell Science. 09, 2018 | Pubmed ID: 30154210 Inositol Phosphates Purification Using Titanium Dioxide Beads Bio-protocol. Aug, 2018 | Pubmed ID: 30148188 Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate To Define the Human PolyP-ome ACS Chemical Biology. 08, 2018 | Pubmed ID: 29924597 IP6 is an HIV Pocket Factor That Prevents Capsid Collapse and Promotes DNA Synthesis ELife. 05, 2018 | Pubmed ID: 29848441 Asp1 Bifunctional Activity Modulates Spindle Function Via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces Pombe Molecular and Cellular Biology. 05, 2018 | Pubmed ID: 29440310 Microbial Inositol Polyphosphate Metabolic Pathway As Drug Development Target Advances in Biological Regulation. 01, 2018 | Pubmed ID: 28964726 IP3-4 Kinase Arg1 Regulates Cell Wall Homeostasis and Surface Architecture to Promote Clearance of Cryptococcus Neoformans Infection in a Mouse Model Virulence. Oct, 2017 | Pubmed ID: 28976803 The Inositol Pyrophosphate Synthesis Pathway in Trypanosoma Brucei is Linked to Polyphosphate Synthesis in Acidocalcisomes Molecular Microbiology. Oct, 2017 | Pubmed ID: 28792096 Has Inositol Played Any Role in the Origin of Life? Life (Basel, Switzerland). Jun, 2017 | Pubmed ID: 28587245 Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling Topics in Current Chemistry (Cham). Feb, 2017 | Pubmed ID: 28101851 Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective Trends in Biochemical Sciences. 03, 2017 | Pubmed ID: 27876550 Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery Journal of Fungi (Basel, Switzerland). Sep, 2016 | Pubmed ID: 29376941 Protein Pyrophosphorylation: Moving Forward The Biochemical Journal. 11, 2016 | Pubmed ID: 27789744 Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels PloS One. 2016 | Pubmed ID: 27788189 Identification of a Major IP5 Kinase in Cryptococcus Neoformans Confirms That PP-IP5/IP7, Not IP6, is Essential for Virulence Scientific Reports. Apr, 2016 | Pubmed ID: 27033523 Phosphate, Inositol and Polyphosphates Biochemical Society Transactions. Feb, 2016 | Pubmed ID: 26862212 The New World of Inorganic Polyphosphates Biochemical Society Transactions. Feb, 2016 | Pubmed ID: 26862182 Developmental Accumulation of Inorganic Polyphosphate Affects Germination and Energetic Metabolism in Dictyostelium Discoideum Proceedings of the National Academy of Sciences of the United States of America. Jan, 2016 | Pubmed ID: 26755590 Why Always Lysine? The Ongoing Tale of One of the Most Modified Amino Acids Advances in Biological Regulation. Jan, 2016 | Pubmed ID: 26482291 There is No 'Conundrum' of InsP6 Open Biology. Nov, 2015 | Pubmed ID: 26581573 Fungal Inositol Pyrophosphate IP7 Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity MBio. Jun, 2015 | Pubmed ID: 26037119 Prometabolites of 5-Diphospho-myo-inositol Pentakisphosphate Angewandte Chemie (International Ed. in English). Aug, 2015 | Pubmed ID: 26014370 VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis The Plant Cell. Apr, 2015 | Pubmed ID: 25901085 A Novel Method for the Purification of Inositol Phosphates from Biological Samples Reveals That No Phytate is Present in Human Plasma or Urine Open Biology. Mar, 2015 | Pubmed ID: 25808508 Protein Polyphosphorylation of Lysine Residues by Inorganic Polyphosphate Molecular Cell. Apr, 2015 | Pubmed ID: 25773596 Raman Spectroscopy Detection of Phytic Acid in Plant Seeds Reveals the Absence of Inorganic Polyphosphate Molecular Plant. May, 2015 | Pubmed ID: 25620771 Inositol Phosphates Induce DAPI Fluorescence Shift The Biochemical Journal. Jun, 2014 | Pubmed ID: 24670057 Functions of Inorganic Polyphosphates in Eukaryotic Cells: a Coat of Many Colours Biochemical Society Transactions. Feb, 2014 | Pubmed ID: 24450634 Analysis of Dictyostelium Discoideum Inositol Pyrophosphate Metabolism by Gel Electrophoresis PloS One. 2014 | Pubmed ID: 24416420 Inositol Pyrophosphates Regulate JMJD2C-dependent Histone Demethylation Proceedings of the National Academy of Sciences of the United States of America. Nov, 2013 | Pubmed ID: 24191012 Modulation of Inositol Polyphosphate Levels Regulates Neuronal Differentiation Molecular Biology of the Cell. Sep, 2013 | Pubmed ID: 23864704 Inositol Pyrophosphates: Between Signalling and Metabolism The Biochemical Journal. Jun, 2013 | Pubmed ID: 23725456 Arginine Transcriptional Response Does Not Require Inositol Phosphate Synthesis The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 22992733 How Inositol Pyrophosphates Control Cellular Phosphate Homeostasis? Advances in Biological Regulation. May, 2012 | Pubmed ID: 22781748 Cell Signalling by Inositol Pyrophosphates Sub-cellular Biochemistry. 2012 | Pubmed ID: 22374099 Influenza Di Pirofosfati Inositolo Sulle Dinamiche Di Energia Cellulare Science (New York, N.Y.). Nov, 2011 | Pubmed ID: 22076377 Identificazione Di Una Famiglia Evolutivamente Conservata Di Inorganico Polifosfato Endopolyphosphatases The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21775424 Chinasi Di Inositolo Hexakisphosphate Inducono La Morte Delle Cellule Nella Malattia Di Huntington The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21652713 Identificazione Del Gene IP6K in Genomi Vegetali Da Tag Ricerca BMC Proceedings. 2011 | Pubmed ID: 21554757 Multikinase Di Inositolo Polifosfato è Una Fisiologica PI3-chinasi Che Attiva Akt/PKB Proceedings of the National Academy of Sciences of the United States of America. Jan, 2011 | Pubmed ID: 21220345 Il Ruolo Di Segnalazione Delle Chinasi Di Inositolo Hexakisphosphate (IP6Ks) Advances in Enzyme Regulation. 2011 | Pubmed ID: 21035498 Chinasi Hexakisphosphate Inositolo Promuovono Autophagy The International Journal of Biochemistry & Cell Biology. Dec, 2010 | Pubmed ID: 20883817 Sintesi Di InsP7 Dall'inositolo Hexakisphosphate Chinasi 1 (IP6K1) Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20645182 Un Elemento Reattivo NGF Obiettivi Myo-inositolo Monophosphatase-1 MRNA Di Assoni Neurone Simpatico Nature Neuroscience. Mar, 2010 | Pubmed ID: 20118926 Inositolo Pyrophosphorylation Pirofosfato Mediata Del AP3B1 Disciplina Rilascio Gag Di HIV-1 Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 19934039 Pirofosfati Inositolo Modulano La Segnalazione Di Perossido Di Idrogeno The Biochemical Journal. Oct, 2009 | Pubmed ID: 19614566 Pirofosfati Inositolo E Loro Complessità Unica Metabolica: Analisi Tramite Elettroforesi Del Gel PloS One. 2009 | Pubmed ID: 19440344 Sono Pirofosfati Inositolo Molecole Di Segnalazione? Journal of Cellular Physiology. Jul, 2009 | Pubmed ID: 19326391 Inositolo Hexakisphosphate Chinasi Prodotti Contengono Gruppi Difosfato E Trifosfato Chemistry & Biology. Mar, 2008 | Pubmed ID: 18355727 Il Valproato Di Stabilizzatore Dell'umore Inibisce Entrambi Percorsi Di Segnalazione Di Diacilglicerolo E Inositolo in Caenorhabditis Elegans Molecular Biology of the Cell. May, 2008 | Pubmed ID: 18287529 ITPK1 Umana: Una Reversibile Inositolo Fosfato Chinasi/fosfatasi Che Collega Dipendente Dal Recettore Fosfolipasi C Di Ca2 +-attivato Canali Di Cloruro Science Signaling. 2008 | Pubmed ID: 18272466 Acidi Grassi Polinsaturi Influenza Synaptojanin Localizzazione Per Regolamentare La Vescicola Sinaptica Di Riciclaggio Molecular Biology of the Cell. Mar, 2008 | Pubmed ID: 18094048 Multikinase Di Inositolo Polifosfato: Architetto Metabolica Di Inositides Nucleare Frontiers in Bioscience : a Journal and Virtual Library. 2008 | Pubmed ID: 17981594 Requisito Di Pirofosfati Di Inositolo Per Questo Piena Capacità Nelle Cellule Beta Del Pancreas Science (New York, N.Y.). Nov, 2007 | Pubmed ID: 18033884 Proteina Pyrophosphorylation Di Pirofosfati Di Inositolo è Un Evento Post Traduzionale Proceedings of the National Academy of Sciences of the United States of America. Sep, 2007 | Pubmed ID: 17873058 Pirofosfati Inositolo Ottenere Il Trattamento Vip1 Cell. May, 2007 | Pubmed ID: 17512396 Estrazione E Analisi Di Solubile Inositolo Polifosfati Da Lievito Nature Protocols. 2006 | Pubmed ID: 17406485 Inibizione Del Fosfatidilinositolo 3-chinasi/Akt Percorso Di Inositolo Pentakisphosphate Risultati in Effetti Antitumorali E Antiangiogenetica Cancer Research. Sep, 2005 | Pubmed ID: 16166311 Multikinase Di Inositolo Polifosfato è Una Nucleare PI3-chinasi Con Attività Transcriptional Normativo Proceedings of the National Academy of Sciences of the United States of America. Sep, 2005 | Pubmed ID: 16123124 Pirofosfati Inositolo Regolano Delle Cellule Morte E Telomeri Lunghezza Attraverso Le Chinasi Fosfoinositide 3-chinasi-related Protein Proceedings of the National Academy of Sciences of the United States of America. Feb, 2005 | Pubmed ID: 15665079 Inositolo Hexakisphosphate Chinasi-2, Un Mediatore Fisiologico Di Morte Cellulare The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15533939 Fosforilazione Delle Proteine Da Pirofosfati Di Inositolo Science (New York, N.Y.). Dec, 2004 | Pubmed ID: 15604408 Simultanea Assenza Di Dopamina D1 E D2 Recettore-mediata Segnalazione è Letale Nel Topo Proceedings of the National Academy of Sciences of the United States of America. Aug, 2004 | Pubmed ID: 15272078 Pirofosfati Inositolo Mediano Chemiotassi in Dictyostelium Tramite Interazioni Di P3 Settori Omologia Dominio-PtdIns (3, 4,5) Cell. Sep, 2003 | Pubmed ID: 13678580 Pirofosfati Inositolo Regolano Traffico Endocitico Proceedings of the National Academy of Sciences of the United States of America. Oct, 2002 | Pubmed ID: 12391334 Ruolo Dei Recettori Di Dopamina D2-like in Autosomministrazione Di Cocaina: Studi Con Romanzo Antagonisti Dei Recettori D2 E D2 Receptor Topi Mutanti The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2002 | Pubmed ID: 11923462 Pirofosfati Inositolo Sono Richiesti Per DNA Hyperrecombination in Lievito Mutante Di Proteina Chinasi C1 Biochemistry. Feb, 2002 | Pubmed ID: 11851397 Quantificazione assoluta di inositolo pirofosfati mediante elettroforesi capillare Elettrospray ionizzazione spettrometria di massa Danye Qiu1, Verena B. Eisenbeis1, Adolfo Saiardi2, Henning J. Jessen1 1Institute of Organic Chemistry, University of Freiburg, 2Medical Research Council, Laboratory for Molecular Cell Biology, University College London JoVE 62847 Biochemistry Preparazione di Qualità pirofosfati Inositolo Omar Loss1, Cristina Azevedo1, Zsolt Szijgyarto1, Daniel Bosch1, Adolfo Saiardi1 1Medical Research Council (MRC), Cell Biology Unit and Laboratory for Molecular Cell Biology, University College London JoVE 3027 Biology
Quantificazione assoluta di inositolo pirofosfati mediante elettroforesi capillare Elettrospray ionizzazione spettrometria di massa Danye Qiu1, Verena B. Eisenbeis1, Adolfo Saiardi2, Henning J. Jessen1 1Institute of Organic Chemistry, University of Freiburg, 2Medical Research Council, Laboratory for Molecular Cell Biology, University College London JoVE 62847 Biochemistry
Preparazione di Qualità pirofosfati Inositolo Omar Loss1, Cristina Azevedo1, Zsolt Szijgyarto1, Daniel Bosch1, Adolfo Saiardi1 1Medical Research Council (MRC), Cell Biology Unit and Laboratory for Molecular Cell Biology, University College London JoVE 3027 Biology