Alexander Metz Institute of Pharmaceutical Chemistry Philipps University of Marburg Biography Publications Institution JoVE Articles Alexander Metz Molecular scientist, computational and beyond. Publications F2X-Universal and F2X-Entry: Structurally Diverse Compound Libraries for Crystallographic Fragment Screening Structure (London, England : 1993). 06, 2020 | Pubmed ID: 32413289 Soaking Suggests "alternative Facts": Only Co-crystallization Discloses Major Ligand-induced Interface Rearrangements of a Homodimeric TRNA-binding Protein Indicating a Novel Mode-of-inhibition PloS One. Month, 2017 | Pubmed ID: 28419165 Structures of Endothiapepsin-fragment Complexes from Crystallographic Fragment Screening Using a Novel, Diverse and Affordable 96-compound Fragment Library Acta Crystallographica. Section F, Structural Biology Communications. 05, 2016 | Pubmed ID: 27139825 Six Biophysical Screening Methods Miss a Large Proportion of Crystallographically Discovered Fragment Hits: A Case Study ACS Chemical Biology. 06, 2016 | Pubmed ID: 27028906 Hot-spot Analysis to Dissect the Functional Protein-protein Interface of a TRNA-modifying Enzyme Proteins. Oct, 2014 | Pubmed ID: 24975703 Flusso di lavoro e strumenti per lo screening dei frammenti cristallografici presso l'Helmholtz-Zentrum di Berlino Jan Wollenhaupt1, Tatjana Barthel1,2, Gustavo M. A. Lima3, Alexander Metz4, Dirk Wallacher5, Elmir Jagudin3, Franziska U. Huschmann1,4, Thomas Hauß1, Christian G. Feiler1, Martin Gerlach1, Michael Hellmig1, Ronald Förster1, Michael Steffien1, Andreas Heine4, Gerhard Klebe4, Uwe Mueller1, Manfred S. Weiss1 1Macromolecular Crystallography, Helmholtz-Zentrum Berlin, 2Structural Biochemistry Group, Institute for Chemistry and Biochemistry, Freie Universität Berlin, 3BioMAX, MAX IV Laboratory, 4Drug Design Group, Institute of Pharmaceutical Chemistry, Philipps-Universität Marburg, 5Department Sample Environment, Helmholtz-Zentrum Berlin JoVE 62208 Biochemistry
Flusso di lavoro e strumenti per lo screening dei frammenti cristallografici presso l'Helmholtz-Zentrum di Berlino Jan Wollenhaupt1, Tatjana Barthel1,2, Gustavo M. A. Lima3, Alexander Metz4, Dirk Wallacher5, Elmir Jagudin3, Franziska U. Huschmann1,4, Thomas Hauß1, Christian G. Feiler1, Martin Gerlach1, Michael Hellmig1, Ronald Förster1, Michael Steffien1, Andreas Heine4, Gerhard Klebe4, Uwe Mueller1, Manfred S. Weiss1 1Macromolecular Crystallography, Helmholtz-Zentrum Berlin, 2Structural Biochemistry Group, Institute for Chemistry and Biochemistry, Freie Universität Berlin, 3BioMAX, MAX IV Laboratory, 4Drug Design Group, Institute of Pharmaceutical Chemistry, Philipps-Universität Marburg, 5Department Sample Environment, Helmholtz-Zentrum Berlin JoVE 62208 Biochemistry
