Alexei Protopopov Institute of Applied Cancer Science UT MD Anderson Cancer Center Biography Publications Institution JoVE Articles Alexei Protopopov has not added a biography. If you are Alexei Protopopov and would like to personalize this page please email our Author Liaison for assistance. Publications Co-clinical Assessment Identifies Patterns of BRAF Inhibitor Resistance in Melanoma The Journal of Clinical Investigation. Apr, 2015 | Pubmed ID: 25705882 Identification of a Novel Fusion Gene, IRF2BP2-RARA, in Acute Promyelocytic Leukemia Journal of the National Comprehensive Cancer Network : JNCCN. Jan, 2015 | Pubmed ID: 25583766 Telomere Dysfunction Suppresses Multiple Endocrine Neoplasia in Mice Genes & Cancer. Sep, 2014 | Pubmed ID: 25352948 Characterization of HPV and Host Genome Interactions in Primary Head and Neck Cancers Proceedings of the National Academy of Sciences of the United States of America. Oct, 2014 | Pubmed ID: 25313082 Intratumor Heterogeneity in Localized Lung Adenocarcinomas Delineated by Multiregion Sequencing Science (New York, N.Y.). Oct, 2014 | Pubmed ID: 25301631 Yap1 Activation Enables Bypass of Oncogenic Kras Addiction in Pancreatic Cancer Cell. Jul, 2014 | Pubmed ID: 24954535 Recurrent PTPRB and PLCG1 Mutations in Angiosarcoma Nature Genetics. Apr, 2014 | Pubmed ID: 24633157 Identification of Double-stranded Genomic DNA Spanning All Chromosomes with Mutated KRAS and P53 DNA in the Serum Exosomes of Patients with Pancreatic Cancer The Journal of Biological Chemistry. Feb, 2014 | Pubmed ID: 24398677 Role of Telomere Dysfunction in Cardiac Failure in Duchenne Muscular Dystrophy Nature Cell Biology. Aug, 2013 | Pubmed ID: 23831727 ZNF365 Promotes Stability of Fragile * Sites and Telomeres Cancer Discovery. Jun, 2013 | Pubmed ID: 23776040 Diverse Mechanisms of Somatic Structural Variations in Human Cancer Genomes Cell. May, 2013 | Pubmed ID: 23663786 TRIM13 (RFP2) Downregulation Decreases Tumour Cell Growth in Multiple Myeloma Through Inhibition of NF Kappa B Pathway and Proteasome Activity British Journal of Haematology. Jul, 2013 | Pubmed ID: 23647456 Quantitative Imaging of Haematopoietic Stem and Progenitor Cell Localization and Hypoxic Status in the Bone Marrow Microenvironment Nature Cell Biology. May, 2013 | Pubmed ID: 23624405 Spectrum of Somatic Mitochondrial Mutations in Five Cancers Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22891333 Melanoma Genome Sequencing Reveals Frequent PREX2 Mutations Nature. May, 2012 | Pubmed ID: 22622578 Telomerase Reactivation Following Telomere Dysfunction Yields Murine Prostate Tumors with Bone Metastases Cell. Mar, 2012 | Pubmed ID: 22341455 Antitelomerase Therapy Provokes ALT and Mitochondrial Adaptive Mechanisms in Cancer Cell. Feb, 2012 | Pubmed ID: 22341440 DNA Breaks and Chromosome Pulverization from Errors in Mitosis Nature. Feb, 2012 | Pubmed ID: 22258507 Genes with a Spike Expression Are Clustered in Chromosome (sub)bands and Spike (sub)bands Have a Powerful Prognostic Value in Patients with Multiple Myeloma Haematologica. Apr, 2012 | Pubmed ID: 22102711 Altered Antisense-to-sense Transcript Ratios in Breast Cancer Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 21098291 PTEN is a Major Tumor Suppressor in Pancreatic Ductal Adenocarcinoma and Regulates an NF-κB-cytokine Network Cancer Discovery. Jul, 2011 | Pubmed ID: 21984975 The BCL11B Tumor Suppressor is Mutated Across the Major Molecular Subtypes of T-cell Acute Lymphoblastic Leukemia Blood. Oct, 2011 | Pubmed ID: 21878675 Telomere Dysfunction Induces Metabolic and Mitochondrial Compromise Nature. Feb, 2011 | Pubmed ID: 21307849 Telomerase Reactivation Reverses Tissue Degeneration in Aged Telomerase-deficient Mice Nature. Jan, 2011 | Pubmed ID: 21113150 Glioma Oncoprotein Bcl2L12 Inhibits the P53 Tumor Suppressor Genes & Development. Oct, 2010 | Pubmed ID: 20837658 Absence of Biallelic TCRgamma Deletion Predicts Early Treatment Failure in Pediatric T-cell Acute Lymphoblastic Leukemia Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Aug, 2010 | Pubmed ID: 20644084 Inactivation of LEF1 in T-cell Acute Lymphoblastic Leukemia Blood. Apr, 2010 | Pubmed ID: 20124220 FoxOs Cooperatively Regulate Diverse Pathways Governing Neural Stem Cell Homeostasis Cell Stem Cell. Nov, 2009 | Pubmed ID: 19896444 GOLPH3 Modulates MTOR Signalling and Rapamycin Sensitivity in Cancer Nature. Jun, 2009 | Pubmed ID: 19553991 High Mutability of the Tumor Suppressor Genes RASSF1 and RBSP3 (CTDSPL) in Cancer PloS One. 2009 | Pubmed ID: 19478941 High Frequency of PTEN, PI3K, and AKT Abnormalities in T-cell Acute Lymphoblastic Leukemia Blood. Jul, 2009 | Pubmed ID: 19458356 Biologic Sequelae of I{kappa}B Kinase (IKK) Inhibition in Multiple Myeloma: Therapeutic Implications Blood. May, 2009 | Pubmed ID: 19270264 Genomic Alterations Link Rho Family of GTPases to the Highly Invasive Phenotype of Pancreas Cancer Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19050074 Oncogenesis of T-ALL and Nonmalignant Consequences of Overexpressing Intracellular NOTCH1 The Journal of Experimental Medicine. Nov, 2008 | Pubmed ID: 18981238 Bcl2L12-mediated Inhibition of Effector Caspase-3 and Caspase-7 Via Distinct Mechanisms in Glioblastoma Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008 | Pubmed ID: 18669646 Feedback Circuit Among INK4 Tumor Suppressors Constrains Human Glioblastoma Development Cancer Cell. Apr, 2008 | Pubmed ID: 18394558 Full Complexity Genomic Hybridization on 60-mer Oligonucleotide Microarrays for Array Comparative Genomic Hybridization (aCGH) Methods in Molecular Biology (Clifton, N.J.). 2008 | Pubmed ID: 18370097 Telomere Dysfunction Promotes Genome Instability and Metastatic Potential in a K-ras P53 Mouse Model of Lung Cancer Carcinogenesis. Apr, 2008 | Pubmed ID: 18283039 Common and Distinct Genomic Events in Sporadic Colorectal Cancer and Diverse Cancer Types Cancer Research. Nov, 2007 | Pubmed ID: 18006816 A Comparison of DNA Copy Number Profiling Platforms Cancer Research. Nov, 2007 | Pubmed ID: 17968032 Chromosomally Unstable Mouse Tumours Have Genomic Alterations Similar to Diverse Human Cancers Nature. Jun, 2007 | Pubmed ID: 17515920 The Differentiation and Stress Response Factor XBP-1 Drives Multiple Myeloma Pathogenesis Cancer Cell. Apr, 2007 | Pubmed ID: 17418411 Epidermal Growth Factor Receptor Variant III Mutations in Lung Tumorigenesis and Sensitivity to Tyrosine Kinase Inhibitors Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16672372 High-resolution Genomic Profiles Define Distinct Clinico-pathogenetic Subgroups of Multiple Myeloma Patients Cancer Cell. Apr, 2006 | Pubmed ID: 16616336 Block of T Cell Development in P53-deficient Mice Accelerates Development of Lymphomas with Characteristic RAG-dependent Cytogenetic Alterations Cancer Cell. Feb, 2006 | Pubmed ID: 16473278 Epigenetic Transdifferentiation of Normal Melanocytes by a Metastatic Melanoma Microenvironment Cancer Research. Nov, 2005 | Pubmed ID: 16288000 HUNC-93B1, a Novel Gene Mainly Expressed in the Heart, is Related to Left Ventricular Diastolic Function, Heart Failure Morbidity and Mortality in Elderly Men European Journal of Heart Failure. Oct, 2005 | Pubmed ID: 16111919 Telomerase Inhibition by SiRNA Causes Senescence and Apoptosis in Barrett's Adenocarcinoma Cells: Mechanism and Therapeutic Potential Molecular Cancer. 2005 | Pubmed ID: 16022731 High-resolution Genomic Profiles of Human Lung Cancer Proceedings of the National Academy of Sciences of the United States of America. Jul, 2005 | Pubmed ID: 15983384 High-resolution Global Profiling of Genomic Alterations with Long Oligonucleotide Microarray Cancer Research. Jul, 2004 | Pubmed ID: 15256441 MSin3-associated Protein, MSds3, is Essential for Pericentric Heterochromatin Formation and Chromosome Segregation in Mammalian Cells Genes & Development. Oct, 2003 | Pubmed ID: 14522945 Restriction Site Tagged (RST) Microarrays: a Novel Technique to Study the Species Composition of Complex Microbial Systems Nucleic Acids Research. Aug, 2003 | Pubmed ID: 12907747 Deletion Mapping Using Quantitative Real-time PCR Identifies Two Distinct 3p21.3 Regions Affected in Most Cervical Carcinomas Oncogene. May, 2003 | Pubmed ID: 12771950 An Integrated Physical and Gene Map of the 3.5-Mb Chromosome 3p21.3 (AP20) Region Implicated in Major Human Epithelial Malignancies Cancer Research. Jan, 2003 | Pubmed ID: 12543795 NotI Subtraction and NotI-specific Microarrays to Detect Copy Number and Methylation Changes in Whole Genomes Proceedings of the National Academy of Sciences of the United States of America. Aug, 2002 | Pubmed ID: 12149436 NotI Flanking Sequences: a Tool for Gene Discovery and Verification of the Human Genome Nucleic Acids Research. Jul, 2002 | Pubmed ID: 12136098 Human Cell Lines Engineered for Tetracycline-regulated Expression of Tumor Suppressor Candidate Genes from a Frequently Affected Chromosomal Region, 3p21 The Journal of Gene Medicine. Jul-Aug, 2002 | Pubmed ID: 12124982 The RASSF1A Tumor Suppressor Gene is Inactivated in Prostate Tumors and Suppresses Growth of Prostate Carcinoma Cells Cancer Research. Jun, 2002 | Pubmed ID: 12067994 HUNC93B1: a Novel Human Gene Representing a New Gene Family and Encoding an Unc-93-like Protein Gene. Jan, 2002 | Pubmed ID: 11867227 A New Approach to Genome Mapping and Sequencing: Slalom Libraries Nucleic Acids Research. Jan, 2002 | Pubmed ID: 11788732 Utnytte Murint induserbar Telomerase Alleler i Studier av Tissue Degenerasjon / Regeneration og kreft Takashi Shingu1, Mariela Jaskelioff2, Liang Yuan1, Zhihu Ding3, Alexei Protopopov4, Maria Kost-Alimova4, Jian Hu1 1Department of Cancer Biology, UT MD Anderson Cancer Center, 2Novartis Institutes for Biomedical Research, 3Sanofi US, 4Institute of Applied Cancer Science, UT MD Anderson Cancer Center Medicine
Utnytte Murint induserbar Telomerase Alleler i Studier av Tissue Degenerasjon / Regeneration og kreft Takashi Shingu1, Mariela Jaskelioff2, Liang Yuan1, Zhihu Ding3, Alexei Protopopov4, Maria Kost-Alimova4, Jian Hu1 1Department of Cancer Biology, UT MD Anderson Cancer Center, 2Novartis Institutes for Biomedical Research, 3Sanofi US, 4Institute of Applied Cancer Science, UT MD Anderson Cancer Center Medicine