Articles by Andrea J. Vernengo in JoVE
Synthesis of Thermogelling Poly(N-isopropylacrylamide)-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering Thomas R. Christiani1, Katelynn Toomer2, Joseph Sheehan2, Angelika Nitzl2, Amanda Branda2, Elizabeth England2, Pamela Graney3, Cristina Iftode2, Andrea J. Vernengo1 1Department of Chemical Engineering, Rowan University, 2Department of Biological Sciences, Rowan University, 3Department of Biomedical Engineering, Drexel University An injectable tissue engineering scaffold composed of poly(N-isopropylacrylamide)-graft-chondroitin sulfate (PNIPAAm-g-CS)-containing alginate microparticles was prepared. The adhesive strength, swelling properties and in vitro biocompatibility are analyzed in this study. The characterization techniques developed here may be applicable to other thermogelling systems.
Other articles by Andrea J. Vernengo on PubMed
Disc Height Loss and Restoration Via Injectable Hydrogel Influences Adjacent Segment Mechanics In-vitro Clinical Biomechanics (Bristol, Avon). Jul, 2016 | Pubmed ID: 27186646 Height loss can have a profound influence on the local mechanical environment of the disc. While disc height loss is incorporated into scales of degeneration, its direct influence on spine kinematics is unclear. Further, there is a need for minimally invasive techniques to restore disc height; injectable hydrogels are a potential solution. Tandem investigation of disc height loss and subsequent restoration will enhance understanding of spine dysfunction and aberrant movement.
Evaluation of an Injectable Hydrogel and Polymethyl Methacrylate in Restoring Mechanics to Compressively Fractured Spine Motion Segments The Spine Journal : Official Journal of the North American Spine Society. Jun, 2016 | Pubmed ID: 27374112 Compressive fracture can produce profound changes to the mechanical profile of a spine segment. Minimally invasive repair has the potential to restore both function and structural integrity to an injured spine. Use of both hydrogels to address changes to the disc, combined with polymethyl methacrylate (PMMA) to address changes to the vertebral body, has the potential to facilitate repair.