Angela Brown Department of Chemical and Biomolecular Engineering Lehigh University Biography Publications Institution JoVE Articles Angela Brown Dr. Brown received her B.S. in Chemical Engineering from Penn State University. After receiving her Ph.D. in Chemical Engineering from Drexel University, she completed postdoctoral work at the University of Pennsylvania. Dr. Brown's research focuses on the development of novel therapeutics for the treatment of bacterial infections. Publications Aggregatibacter Actinomycetemcomitans Leukotoxin: From Mechanism to Targeted Anti-toxin Therapeutics Molecular Oral Microbiology. 06, 2020 | Pubmed ID: 32061022 Epigallocatechin Gallate Inhibits Leukotoxin Release by Aggregatibacter Actinomycetemcomitans by Promoting Association with the Bacterial Membrane Molecular Oral Microbiology. 01, 2020 | Pubmed ID: 31816197 Cholera Toxin Encapsulated Within Several O1 Serotype Inaba Outer Membrane Vesicles Lacks a Functional B-Subunit Toxins. 04, 2019 | Pubmed ID: 30959895 Inhibition of Bacterial Toxin Recognition of Membrane Components As an Anti-virulence Strategy Journal of Biological Engineering. Month, 2019 | Pubmed ID: 30820243 Catechin-mediated Restructuring of a Bacterial Toxin Inhibits Activity Biochimica Et Biophysica Acta. General Subjects. 01, 2019 | Pubmed ID: 30342156 Cytotoxic Activity of Kingella Kingae RtxA Toxin Depends on Post-translational Acylation of Lysine Residues and Cholesterol Binding Emerging Microbes & Infections. Nov, 2018 | Pubmed ID: 30405113 Leukotoxin Is Delivered to Host Cells in an LFA-1-Indepdendent Manner When Associated with Outer Membrane Vesicles Toxins. 10, 2018 | Pubmed ID: 30322160 Generation of a Recombinant Aggregatibacter Actinomycetemcomitans RTX Toxin in Escherichia Coli Gene. Sep, 2018 | Pubmed ID: 29879499 Receptor-Based Peptides for Inhibition of Leukotoxin Activity ACS Infectious Diseases. 07, 2018 | Pubmed ID: 29742342 Association of Vibrio Cholerae 569B Outer Membrane Vesicles with Host Cells Occurs in a GM1-independent Manner Cellular Microbiology. 06, 2018 | Pubmed ID: 29377560 Use of a Cholesterol Recognition Amino Acid Consensus Peptide To Inhibit Binding of a Bacterial Toxin to Cholesterol Biochemistry. 08, 2016 | Pubmed ID: 27504950 Inhibition of Bacterial Toxin Activity by the Nuclear Stain, DRAQ5™ The Journal of Membrane Biology. 08, 2016 | Pubmed ID: 27039399 Inhibition of LtxA Toxicity by Blocking Cholesterol Binding with Peptides Molecular Oral Microbiology. Feb, 2016 | Pubmed ID: 26352738 Disorder in Cholesterol-binding Functionality of CRAC Peptides: a Molecular Dynamics Study The Journal of Physical Chemistry. B. Nov, 2014 | Pubmed ID: 25347282 Size Exclusion Chromatography to Analyze Bacterial Outer Membrane Vesicle Heterogeneity Shannon M. Collins1, Justin B. Nice1, En Hyung Chang1, Angela C. Brown1 1Department of Chemical and Biomolecular Engineering, Lehigh University JoVE 62429 Bioengineering
Size Exclusion Chromatography to Analyze Bacterial Outer Membrane Vesicle Heterogeneity Shannon M. Collins1, Justin B. Nice1, En Hyung Chang1, Angela C. Brown1 1Department of Chemical and Biomolecular Engineering, Lehigh University JoVE 62429 Bioengineering
