Antonis E. Koromilas

Publications

• An Integrated Stress Response Via PKR Suppresses HER2+ Cancers and Improves Trastuzumab Therapy
  Nature Communications. 05, 2019  |   Pubmed ID: 31086176
• M(en)TORship Lessons on Life and Death by the Integrated Stress Response
  Biochimica Et Biophysica Acta. General Subjects. 03, 2019  |   Pubmed ID: 30572003
• Downregulation of PERK Activity and EIF2α Serine 51 Phosphorylation by MTOR Complex 1 Elicits Pro-oxidant and Pro-death Effects in Tuberous Sclerosis-deficient Cells
  Cell Death & Disease. Feb, 2018  |   Pubmed ID: 29449538
• Regulation of ULK1 Expression and Autophagy by STAT1
  The Journal of Biological Chemistry. 02, 2017  |   Pubmed ID: 28011640
• STAT1 Promotes KRAS Colon Tumor Growth and Susceptibility to Pharmacological Inhibition of Translation Initiation Factor EIF4A
  Molecular Cancer Therapeutics. 12, 2016  |   Pubmed ID: 27913706
• Increased Phosphorylation of EIF2α in Chronic Myeloid Leukemia Cells Stimulates Secretion of Matrix Modifying Enzymes
  Oncotarget. Nov, 2016  |   Pubmed ID: 27802179
• The EIF2α Serine 51 Phosphorylation-ATF4 Arm Promotes HIPPO Signaling and Cell Death Under Oxidative Stress
  Oncotarget. 08, 2016  |   Pubmed ID: 27409837
• STAT1-mediated Translational Control in Tumor Suppression and Antitumor Therapies
  Molecular & Cellular Oncology. May, 2016  |   Pubmed ID: 27314074
• MTORC2 Balances AKT Activation and EIF2α Serine 51 Phosphorylation to Promote Survival Under Stress
  Molecular Cancer Research : MCR. Oct, 2015  |   Pubmed ID: 26130148
• Stat1 Stimulates Cap-independent MRNA Translation to Inhibit Cell Proliferation and Promote Survival in Response to Antitumor Drugs
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015  |   Pubmed ID: 25870277
• Roles of the Translation Initiation Factor EIF2α Serine 51 Phosphorylation in Cancer Formation and Treatment
  Biochimica Et Biophysica Acta. Jul, 2015  |   Pubmed ID: 25497381
• Translational Control During Endoplasmic Reticulum Stress Beyond Phosphorylation of the Translation Initiation Factor EIF2α
  The Journal of Biological Chemistry. May, 2014  |   Pubmed ID: 24648524
• Evidence for EIF2α Phosphorylation-independent Effects of GSK2656157, a Novel Catalytic Inhibitor of PERK with Clinical Implications
  Cell Cycle (Georgetown, Tex.). 2014  |   Pubmed ID: 24401334
• EIF2α Phosphorylation Bypasses Premature Senescence Caused by Oxidative Stress and Pro-oxidant Antitumor Therapies
  Aging. Dec, 2013  |   Pubmed ID: 24334569
• The Tumor Suppressor Function of STAT1 in Breast Cancer
  JAK-STAT. Apr, 2013  |   Pubmed ID: 24058806
• The PERK-eIF2α Phosphorylation Arm is a Pro-survival Pathway of BCR-ABL Signaling and Confers Resistance to Imatinib Treatment in Chronic Myeloid Leukemia Cells
  Cell Cycle (Georgetown, Tex.). Nov, 2012  |   Pubmed ID: 23095523
• Alternative Ferritin MRNA Translation Via Internal Initiation
  RNA (New York, N.Y.). Mar, 2012  |   Pubmed ID: 22271759
• Akt Determines Cell Fate Through Inhibition of the PERK-eIF2α Phosphorylation Pathway
  Science Signaling. Sep, 2011  |   Pubmed ID: 21954288
• Negative Regulation of MTORC2 by Glycogen Synthase Kinase-3β: an Adaptive Process to Stress with an Anticancer Therapeutic Potential?
  Future Oncology (London, England). Jul, 2011  |   Pubmed ID: 21732756
• Development of Transgenic Mice Expressing a Conditionally Active Form of the EIF2α Kinase PKR
  Genesis (New York, N.Y. : 2000). Sep, 2011  |   Pubmed ID: 21438126
• Stat1 is a Suppressor of ErbB2/Neu-mediated Cellular Transformation and Mouse Mammary Gland Tumor Formation
  Cell Cycle (Georgetown, Tex.). Mar, 2011  |   Pubmed ID: 21311224
• HDAC Pharmacological Inhibition Promotes Cell Death Through the EIF2α Kinases PKR and GCN2
  Aging. Oct, 2010  |   Pubmed ID: 21076179
• EIF2{alpha} Kinase PKR Modulates the Hypoxic Response by Stat3-dependent Transcriptional Suppression of HIF-1{alpha}
  Cancer Research. Oct, 2010  |   Pubmed ID: 20924113
• Phosphorylation of EIF2α at Serine 51 is an Important Determinant of Cell Survival and Adaptation to Glucose Deficiency
  Molecular Biology of the Cell. Sep, 2010  |   Pubmed ID: 20660158
• STAT1 Represses Skp2 Gene Transcription to Promote P27Kip1 Stabilization in Ras-transformed Cells
  Molecular Cancer Research : MCR. May, 2010  |   Pubmed ID: 20407011
• Tumor Suppression by PTEN Requires the Activation of the PKR-eIF2alpha Phosphorylation Pathway
  Science Signaling. Dec, 2009  |   Pubmed ID: 20029030
• PKR is Not a Universal Target of Tumor Suppressor P53 in Response to Genotoxic Stress
  Cell Cycle (Georgetown, Tex.). Nov, 2009  |   Pubmed ID: 19838063
• Stat1 Phosphorylation Determines Ras Oncogenicity by Regulating P27 Kip1
  PloS One. 2008  |   Pubmed ID: 18941537
• The EIF2alpha Kinases Inhibit Vesicular Stomatitis Virus Replication Independently of EIF2alpha Phosphorylation
  Cell Cycle (Georgetown, Tex.). Aug, 2008  |   Pubmed ID: 18677106
• Modulation of the Eukaryotic Initiation Factor 2 Alpha-subunit Kinase PERK by Tyrosine Phosphorylation
  The Journal of Biological Chemistry. Jan, 2008  |   Pubmed ID: 17998206
• The EIF2alpha Kinases PERK and PKR Activate Glycogen Synthase Kinase 3 to Promote the Proteasomal Degradation of P53
  The Journal of Biological Chemistry. Oct, 2007  |   Pubmed ID: 17785458
• A Novel Function of EIF2alpha Kinases As Inducers of the Phosphoinositide-3 Kinase Signaling Pathway
  Molecular Biology of the Cell. Sep, 2007  |   Pubmed ID: 17596516
• Expression of the Subgenomic Hepatitis C Virus Replicon Alters Iron Homeostasis in Huh7 Cells
  Journal of Hepatology. Jul, 2007  |   Pubmed ID: 17399844
• Interferons Induce Tyrosine Phosphorylation of the EIF2alpha Kinase PKR Through Activation of Jak1 and Tyk2
  EMBO Reports. Mar, 2007  |   Pubmed ID: 17290288
• Initiation of Protein Synthesis by Hepatitis C Virus is Refractory to Reduced EIF2.GTP.Met-tRNA(i)(Met) Ternary Complex Availability
  Molecular Biology of the Cell. Nov, 2006  |   Pubmed ID: 16928960
• The Catalytic Activity of the Eukaryotic Initiation Factor-2alpha Kinase PKR is Required to Negatively Regulate Stat1 and Stat3 Via Activation of the T-cell Protein-tyrosine Phosphatase
  The Journal of Biological Chemistry. Apr, 2006  |   Pubmed ID: 16431927
• Tyrosine Phosphorylation Acts As a Molecular Switch to Full-scale Activation of the EIF2alpha RNA-dependent Protein Kinase
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2006  |   Pubmed ID: 16373505
• Endoplasmic Reticulum Stress Accelerates P53 Degradation by the Cooperative Actions of Hdm2 and Glycogen Synthase Kinase 3beta
  Molecular and Cellular Biology. Nov, 2005  |   Pubmed ID: 16227590
• Iron Inactivates the RNA Polymerase NS5B and Suppresses Subgenomic Replication of Hepatitis C Virus
  The Journal of Biological Chemistry. Mar, 2005  |   Pubmed ID: 15637067
• Control of Tumor Suppressor P53 Function by Endoplasmic Reticulum Stress
  Cell Cycle (Georgetown, Tex.). May, 2004  |   Pubmed ID: 15107622
• Control of Alpha Subunit of Eukaryotic Translation Initiation Factor 2 (eIF2 Alpha) Phosphorylation by the Human Papillomavirus Type 18 E6 Oncoprotein: Implications for EIF2 Alpha-dependent Gene Expression and Cell Death
  Molecular and Cellular Biology. Apr, 2004  |   Pubmed ID: 15060162
• Endoplasmic Reticulum Stress Induces P53 Cytoplasmic Localization and Prevents P53-dependent Apoptosis by a Pathway Involving Glycogen Synthase Kinase-3beta
  Genes & Development. Feb, 2004  |   Pubmed ID: 14744935
• PKR-dependent Mechanisms of Gene Expression from a Subgenomic Hepatitis C Virus Clone
  Journal of Virology. Nov, 2002  |   Pubmed ID: 12368306
• Functional Characterization of Pkr Gene Products Expressed in Cells from Mice with a Targeted Deletion of the N Terminus or C Terminus Domain of PKR
  The Journal of Biological Chemistry. Oct, 2002  |   Pubmed ID: 12161430