Bärbel Rohrer

Publications

• Mechanisms of Extracellular Vesicle Uptake in Stressed Retinal Pigment Epithelial Cell Monolayers
  Biochimica Et Biophysica Acta. Molecular Basis of Disease. Mar, 2020  |   Pubmed ID: 31740401
• Increased Nonexudative Age-Related Macular Degeneration Diagnosis Among Medicare Beneficiaries With Rheumatoid Arthritis
  Investigative Ophthalmology & Visual Science. 08, 2019  |   Pubmed ID: 31412111
• An Improved Method for Isolation of Mitochondria from Cell Lines That Enables Reconstitution of Calcium-dependent Processes
  Analytical Biochemistry. 07, 2019  |   Pubmed ID: 31022379
• The Exocyst Acting Through the Primary Cilium is Necessary for Renal Ciliogenesis, Cystogenesis, and Tubulogenesis
  The Journal of Biological Chemistry. 04, 2019  |   Pubmed ID: 30824539
• Association of Age-related Macular Degeneration with Complement Activation Products, Smoking, and Single Nucleotide Polymorphisms in South Carolinians of European and African Descent
  Molecular Vision. 2019  |   Pubmed ID: 30820144
• Inhibition of the Alternative Complement Pathway Accelerates Repair Processes in the Murine Model of Choroidal Neovascularization
  Molecular Immunology. 04, 2019  |   Pubmed ID: 30763805
• Correction: Mechanisms of Bystander Effects in Retinal Pigment Epithelium Cell Networks
  Cell Death & Disease. Jul, 2018  |   Pubmed ID: 30013064
• Anaphylatoxin Signaling in Retinal Pigment and Choroidal Endothelial Cells: Characteristics and Relevance to Age-Related Macular Degeneration
  Advances in Experimental Medicine and Biology. 2018  |   Pubmed ID: 29721926
• Extracellular Vesicle-mediated Long-range Communication in Stressed Retinal Pigment Epithelial Cell Monolayers
  Biochimica Et Biophysica Acta. Molecular Basis of Disease. Aug, 2018  |   Pubmed ID: 29684588
• Encapsulated Cell Technology-Based Delivery of a Complement Inhibitor Reduces Choroidal Neovascularization in a Mouse Model
  Translational Vision Science & Technology. Mar, 2018  |   Pubmed ID: 29576927
• Proteome and Metabolome of Subretinal Fluid in Central Serous Chorioretinopathy and Rhegmatogenous Retinal Detachment: A Pilot Case Study
  Translational Vision Science & Technology. Jan, 2018  |   Pubmed ID: 29359109
• Delivery of CR2-fH Using AAV Vector Therapy As Treatment Strategy in the Mouse Model of Choroidal Neovascularization
  Molecular Therapy. Methods & Clinical Development. Jun, 2018  |   Pubmed ID: 29234687
• The Retinol Binding Protein Receptor 2 (Rbpr2) is Required for Photoreceptor Outer Segment Morphogenesis and Visual Function in Zebrafish
  Scientific Reports. 11, 2017  |   Pubmed ID: 29176573
• Mechanisms of Bystander Effects in Retinal Pigment Epithelium Cell Networks
  Cell Death & Disease. 10, 2017  |   Pubmed ID: 28981111
• The Exocyst is Required for Photoreceptor Ciliogenesis and Retinal Development
  The Journal of Biological Chemistry. 09, 2017  |   Pubmed ID: 28729419
• Anaphylatoxins Activate Ca, Akt/PI3-Kinase, and FOXO1/FoxP3 in the Retinal Pigment Epithelium
  Frontiers in Immunology. 2017  |   Pubmed ID: 28663750
• New Insights on Complement Inhibitor CD59 in Mouse Laser-Induced Choroidal Neovascularization: Mislocalization After Injury and Targeted Delivery for Protein Replacement
  Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. 06, 2017  |   Pubmed ID: 28333572
• Bystander Effects Elicited by Single-cell Photo-oxidative Blue-light Stimulation in Retinal Pigment Epithelium Cell Networks
  Cell Death Discovery. 2017  |   Pubmed ID: 28179989
• Targeting the Tight Junction Protein, Zonula Occludens-1, with the Connexin43 Mimetic Peptide, αCT1, Reduces VEGF-dependent RPE Pathophysiology
  Journal of Molecular Medicine (Berlin, Germany). 05, 2017  |   Pubmed ID: 28132078
• Retinal Pre-Conditioning by CD59a Knockout Protects Against Light-Induced Photoreceptor Degeneration
  PloS One. 2016  |   Pubmed ID: 27893831
• Calpain Inhibition Reduces Structural and Functional Impairment of Retinal Ganglion Cells in Experimental Optic Neuritis
  Journal of Neurochemistry. 10, 2016  |   Pubmed ID: 27513991
• New Therapeutic and Diagnostic Opportunities for Injured Tissue-specific Targeting of Complement Inhibitors and Imaging Modalities
  Seminars in Immunology. Jun, 2016  |   Pubmed ID: 27282113
• A Targeted Inhibitor of the Alternative Complement Pathway Accelerates Recovery From Smoke-Induced Ocular Injury
  Investigative Ophthalmology & Visual Science. Apr, 2016  |   Pubmed ID: 27064393
• Connecting the Innate and Adaptive Immune Responses in Mouse Choroidal Neovascularization Via the Anaphylatoxin C5a and γδT-cells
  Scientific Reports. Mar, 2016  |   Pubmed ID: 27029558
• Reduced Metabolic Capacity in Aged Primary Retinal Pigment Epithelium (RPE) is Correlated with Increased Susceptibility to Oxidative Stress
  Advances in Experimental Medicine and Biology. 2016  |   Pubmed ID: 26427491
• Small Molecules That Protect Mitochondrial Function from Metabolic Stress Decelerate Loss of Photoreceptor Cells in Murine Retinal Degeneration Models
  Advances in Experimental Medicine and Biology. 2016  |   Pubmed ID: 26427445
• Interrelation Between Oxidative Stress and Complement Activation in Models of Age-Related Macular Degeneration
  Advances in Experimental Medicine and Biology. 2016  |   Pubmed ID: 26427398
• Local Production of the Alternative Pathway Component Factor B is Sufficient to Promote Laser-induced Choroidal Neovascularization
  Investigative Ophthalmology & Visual Science. Jan, 2015  |   Pubmed ID: 25593023
• Quantitative Analysis of Mitochondrial Morphology and Membrane Potential in Living Cells Using High-content Imaging, Machine Learning, and Morphological Binning
  Biochimica Et Biophysica Acta. Feb, 2015  |   Pubmed ID: 25447550
• Activation of Endogenously Expressed Ion Channels by Active Complement in the Retinal Pigment Epithelium
  Pflugers Archiv : European Journal of Physiology. Oct, 2015  |   Pubmed ID: 25427445
• A Comparative Analysis of C57BL/6J and 6N Substrains; Chemokine/cytokine Expression and Susceptibility to Laser-induced Choroidal Neovascularization
  Experimental Eye Research. Dec, 2014  |   Pubmed ID: 25305577
• Smoke Exposure Causes Endoplasmic Reticulum Stress and Lipid Accumulation in Retinal Pigment Epithelium Through Oxidative Stress and Complement Activation
  The Journal of Biological Chemistry. May, 2014  |   Pubmed ID: 24711457
• A Mechanistic Review of Cigarette Smoke and Age-related Macular Degeneration
  Advances in Experimental Medicine and Biology. 2014  |   Pubmed ID: 24664711
• Prolonged SRC Kinase Activation, a Mechanism to Turn Transient, Sublytic Complement Activation into a Sustained Pathological Condition in Retinal Pigment Epithelium Cells
  Advances in Experimental Medicine and Biology. 2014  |   Pubmed ID: 24664702
• Alternative Complement Pathway Deficiency Ameliorates Chronic Smoke-induced Functional and Morphological Ocular Injury
  PloS One. 2013  |   Pubmed ID: 23825688
• The Role of the Immune Response in Age-related Macular Degeneration
  International Journal of Inflammation. 2013  |   Pubmed ID: 23762772
• Explant Cultures of Rpe65-/- Mouse Retina: a Model to Investigate Cone Opsin Trafficking
  Molecular Vision. 2013  |   Pubmed ID: 23734084
• Detection of Complement Activation Using Monoclonal Antibodies Against C3d
  The Journal of Clinical Investigation. May, 2013  |   Pubmed ID: 23619360
• Oxidative Stress Sensitizes Retinal Pigmented Epithelial (RPE) Cells to Complement-mediated Injury in a Natural Antibody-, Lectin Pathway-, and Phospholipid Epitope-dependent Manner
  The Journal of Biological Chemistry. May, 2013  |   Pubmed ID: 23493397
• Early Alterations in Mitochondrial Reserve Capacity; a Means to Predict Subsequent Photoreceptor Cell Death
  Journal of Bioenergetics and Biomembranes. Feb, 2013  |   Pubmed ID: 23090843
• Revealing Functionally Coherent Subsets Using a Spectral Clustering and an Information Integration Approach
  BMC Systems Biology. 2012  |   Pubmed ID: 23282411
• Matrix Metalloproteinase Activity Creates Pro-angiogenic Environment in Primary Human Retinal Pigment Epithelial Cells Exposed to Complement
  Investigative Ophthalmology & Visual Science. Apr, 2012  |   Pubmed ID: 22408008
• Systemic Human CR2-targeted Complement Alternative Pathway Inhibitor Ameliorates Mouse Laser-induced Choroidal Neovascularization
  Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics. Aug, 2012  |   Pubmed ID: 22309197
• Sublytic Membrane-attack-complex Activation and VEGF Secretion in Retinal Pigment Epithelial Cells
  Advances in Experimental Medicine and Biology. 2012  |   Pubmed ID: 22183311
• Sublytic Membrane-attack-complex (MAC) Activation Alters Regulated Rather Than Constitutive Vascular Endothelial Growth Factor (VEGF) Secretion in Retinal Pigment Epithelium Monolayers
  The Journal of Biological Chemistry. Jul, 2011  |   Pubmed ID: 21566137
• Central Nervous System Dysfunction in a Mouse Model of FA2H Deficiency
  Glia. Jul, 2011  |   Pubmed ID: 21491498
• Differential Effects of Rapamycin on Rods and Cones During Light-induced Stress in Albino Mice
  Investigative Ophthalmology & Visual Science. May, 2011  |   Pubmed ID: 21273550
• The Alternative Pathway is Required, but Not Alone Sufficient, for Retinal Pathology in Mouse Laser-induced Choroidal Neovascularization
  Molecular Immunology. Mar, 2011  |   Pubmed ID: 21257205
• Gene Therapy Rescues Cone Structure and Function in the 3-month-old Rd12 Mouse: a Model for Midcourse RPE65 Leber Congenital Amaurosis
  Investigative Ophthalmology & Visual Science. Jan, 2011  |   Pubmed ID: 21169527
• A Targeted Inhibitor of the Complement Alternative Pathway Reduces RPE Injury and Angiogenesis in Models of Age-related Macular Degeneration
  Advances in Experimental Medicine and Biology. 2010  |   Pubmed ID: 20711712
• Photoreceptor Structure and Function is Maintained in Organotypic Cultures of Mouse Retinas
  Molecular Vision. Jun, 2010  |   Pubmed ID: 20664685
• Self-complementary AAV-mediated Gene Therapy Restores Cone Function and Prevents Cone Degeneration in Two Models of Rpe65 Deficiency
  Gene Therapy. Jul, 2010  |   Pubmed ID: 20237510
• Cone Outer Segment Morphology and Cone Function in the Rpe65-/- Nrl-/- Mouse Retina Are Amenable to Retinoid Replacement
  Investigative Ophthalmology & Visual Science. Oct, 2009  |   Pubmed ID: 19407011
• Oxidative Stress Renders Retinal Pigment Epithelial Cells Susceptible to Complement-mediated Injury
  The Journal of Biological Chemistry. Jun, 2009  |   Pubmed ID: 19386604
• A Targeted Inhibitor of the Alternative Complement Pathway Reduces Angiogenesis in a Mouse Model of Age-related Macular Degeneration
  Investigative Ophthalmology & Visual Science. Jul, 2009  |   Pubmed ID: 19264882
• Identification of Candidate Genes for Human Retinal Degeneration Loci Using Differentially Expressed Genes from Mouse Photoreceptor Dystrophy Models
  Molecular Vision. Sep, 2008  |   Pubmed ID: 18776951
• Eliminating Complement Factor D Reduces Photoreceptor Susceptibility to Light-induced Damage
  Investigative Ophthalmology & Visual Science. Nov, 2007  |   Pubmed ID: 17962484
• Paradoxical Role of BDNF: BDNF+/- Retinas Are Protected Against Light Damage-mediated Stress
  Investigative Ophthalmology & Visual Science. Jun, 2007  |   Pubmed ID: 17525224
• Apoptosis and Autophagy in Photoreceptors Exposed to Oxidative Stress
  Autophagy. Sep-Oct, 2007  |   Pubmed ID: 17471016
• Sustained Elevation of Intracellular CGMP Causes Oxidative Stress Triggering Calpain-mediated Apoptosis in Photoreceptor Degeneration
  Current Eye Research. Mar, 2007  |   Pubmed ID: 17453946
• Autophagy is One of the Multiple Mechanisms Active in Photoreceptor Degeneration
  Autophagy. Jan-Feb, 2007  |   Pubmed ID: 17102584
• Classical Complement Activation and Acquired Immune Response Pathways Are Not Essential for Retinal Degeneration in the Rd1 Mouse
  Experimental Eye Research. Jan, 2007  |   Pubmed ID: 17069800
• Rod and Cone Pigment Regeneration in RPE65-/- Mice
  Advances in Experimental Medicine and Biology. 2006  |   Pubmed ID: 17249562
• Multiple, Parallel Cellular Suicide Mechanisms Participate in Photoreceptor Cell Death
  Experimental Eye Research. Aug, 2006  |   Pubmed ID: 16626700
• 11-cis-retinal Reduces Constitutive Opsin Phosphorylation and Improves Quantum Catch in Retinoid-deficient Mouse Rod Photoreceptors
  The Journal of Biological Chemistry. Oct, 2002  |   Pubmed ID: 12176991