Barbara Gatto Department of Pharmaceutical and Pharmacological Sciences University of Padova Biography Publications Institution JoVE Articles Barbara Gatto has not added a biography. If you are Barbara Gatto and would like to personalize this page please email our Author Liaison for assistance. Publications Multifaceted Aspects of HIV-1 Nucleocapsid Inhibition by TAR-Targeting Peptidyl-Anthraquinones Bearing Terminal Aromatic Moieties Viruses. Sep, 2022 | Pubmed ID: 36298688 Decoding Mechanism of Action and Sensitivity to Drug Candidates from Integrated Transcriptome and Chromatin State ELife. Aug, 2022 | Pubmed ID: 36043458 Computationally Driven Discovery of SARS-CoV-2 M Inhibitors: from Design to Experimental Validation Chemical Science. Mar, 2022 | Pubmed ID: 35432906 In Vitro Evaluation of Bis-3-Chloropiperidines As RNA Modulators Targeting TAR and TAR-Protein Interaction International Journal of Molecular Sciences. Jan, 2022 | Pubmed ID: 35054766 B-CePs As Cross-linking Probes for the Investigation of RNA Higher-order Structure Nucleic Acids Research. Jul, 2021 | Pubmed ID: 34125908 Bis-3-Chloropiperidines Targeting TAR RNA As A Novel Strategy to Impair the HIV-1 Nucleocapsid Protein Molecules (Basel, Switzerland). Mar, 2021 | Pubmed ID: 33810333 Appended Aromatic Moieties in Flexible Bis-3-chloropiperidines Confer Tropism Against Pancreatic Cancer Cells ChemMedChem. Mar, 2021 | Pubmed ID: 33200541 Aromatic Linkers Unleash the Antiproliferative Potential of 3-Chloropiperidines Against Pancreatic Cancer Cells ChemMedChem. Nov, 2020 | Pubmed ID: 32744774 Multiple Inhibition of HIV-1 Proteins by 2,6-Dipeptidyl-anthraquinone Conjugates Targeting the PBS RNA ACS Medicinal Chemistry Letters. May, 2020 | Pubmed ID: 32435410 Behind the Mirror: Chirality Tunes the Reactivity and Cytotoxicity of Chloropiperidines As Potential Anticancer Agents ACS Medicinal Chemistry Letters. Apr, 2019 | Pubmed ID: 30996795 Identification of Novel 2-benzoxazolinone Derivatives with Specific Inhibitory Activity Against the HIV-1 Nucleocapsid Protein European Journal of Medicinal Chemistry. Feb, 2018 | Pubmed ID: 29324338 Direct and Topoisomerase II Mediated DNA Damage by Bis-3-chloropiperidines: The Importance of Being an Earnest G ChemMedChem. Sep, 2017 | Pubmed ID: 28724198 Virtual Cross-Linking of the Active Nemorubicin Metabolite PNU-159682 to Double-Stranded DNA Chemical Research in Toxicology. Feb, 2017 | Pubmed ID: 28068470 Synthesis and Evaluation of a Bis-3-chloropiperidine Derivative Incorporating an Anthraquinone Pharmacophore Bioorganic & Medicinal Chemistry Letters. Oct, 2015 | Pubmed ID: 26342869 Bis-3-chloropiperidines Containing Bridging Lysine Linkers: Influence of Side Chain Structure on DNA Alkylating Activity Bioorganic & Medicinal Chemistry. Mar, 2015 | Pubmed ID: 25693786 Synthesis and DNA Cleavage Activity of Bis-3-chloropiperidines As Alkylating Agents ChemMedChem. Sep, 2014 | Pubmed ID: 24616300 Enzymatic Formation of PEGylated Oligonucleotides Bioconjugate Chemistry. Feb, 2014 | Pubmed ID: 24450424 Development of a Multiplex Sandwich Aptamer Microarray for the Detection of VEGF165 and Thrombin Sensors (Basel, Switzerland). 2013 | Pubmed ID: 24097233 Development and Optimization of a Thrombin Sandwich Aptamer Microarray Microarrays (Basel, Switzerland). Aug, 2012 | Pubmed ID: 27605338 Ellagic Acid and Polyhydroxylated Urolithins Are Potent Catalytic Inhibitors of Human Topoisomerase II: an in Vitro Study Journal of Agricultural and Food Chemistry. Sep, 2012 | Pubmed ID: 22924519 Human Thrombin Detection Through a Sandwich Aptamer Microarray: Interaction Analysis in Solution and in Solid Phase Sensors (Basel, Switzerland). 2011 | Pubmed ID: 22163703 The Evolving World of Protein-G-quadruplex Recognition: a Medicinal Chemist's Perspective Biochimie. Aug, 2011 | Pubmed ID: 21549174 Studies of Anti-HIV Transcription Inhibitor Quinolones: Identification of Potent N1-vinyl Derivatives ChemMedChem. Nov, 2010 | Pubmed ID: 20928882 Rational Design, Synthesis, and DNA Binding Properties of Novel Sequence-selective Peptidyl Congeners of Ametantrone ChemMedChem. Jul, 2010 | Pubmed ID: 20458714 The 6-aminoquinolone WC5 Inhibits Human Cytomegalovirus Replication at an Early Stage by Interfering with the Transactivating Activity of Viral Immediate-early 2 Protein Antimicrobial Agents and Chemotherapy. May, 2010 | Pubmed ID: 20194695 Inhibition of Subgenomic Hepatitis C Virus RNA Replication by Acridone Derivatives: Identification of an NS3 Helicase Inhibitor Journal of Medicinal Chemistry. May, 2009 | Pubmed ID: 19388645 2-Phenylquinolones As Inhibitors of the HIV-1 Tat-TAR Interaction ChemMedChem. Jun, 2009 | Pubmed ID: 19283692 Synthesis and Biological Evaluation of 2-phenylquinolones Targeted at Tat/TAR Recognition Bioorganic & Medicinal Chemistry Letters. Feb, 2009 | Pubmed ID: 19109014 Effective DNA Inhibitors of Cathepsin G by in Vitro Selection International Journal of Molecular Sciences. Jun, 2008 | Pubmed ID: 19325843 Atacicept, a Homodimeric Fusion Protein for the Potential Treatment of Diseases Triggered by Plasma Cells Current Opinion in Investigational Drugs (London, England : 2000). Nov, 2008 | Pubmed ID: 18951301 Perylene Side Chains Modulate G-quadruplex Conformation in Biologically Relevant DNA Sequences Bioorganic & Medicinal Chemistry. Oct, 2008 | Pubmed ID: 18819816 From Proteins to Nucleic Acid-based Drugs: the Role of Biotech in Anti-VEGF Therapy Anti-cancer Agents in Medicinal Chemistry. Jul, 2006 | Pubmed ID: 16842232 Biologics Targeted at TNF: Design, Production and Challenges Reumatismo. 2006 | Pubmed ID: 16829986 Clerocidin Interacts with the Cleavage Complex of Streptococcus Pneumoniae Topoisomerase IV to Induce Selective Irreversible DNA Damage Nucleic Acids Research. 2006 | Pubmed ID: 16614448 Antiviral 6-amino-quinolones: Molecular Basis for Potency and Selectivity Bioorganic & Medicinal Chemistry Letters. Oct, 2005 | Pubmed ID: 16054362 Monoclonal Antibodies in Cancer Therapy Current Medicinal Chemistry. Anti-cancer Agents. Sep, 2004 | Pubmed ID: 15379694 Inhibition of Human Immunodeficiency Virus Type 1 Tat-trans-activation-responsive Region Interaction by an Antiviral Quinolone Derivative Antimicrobial Agents and Chemotherapy. May, 2004 | Pubmed ID: 15105155 Effects of Common Buffer Systems on Drug Activity: the Case of Clerocidin Chemical Research in Toxicology. Apr, 2004 | Pubmed ID: 15089091 Clerocidin Alkylates DNA Through Its Epoxide Function: Evidence for a Fine Tuned Mechanism of Action Nucleic Acids Research. Sep, 2003 | Pubmed ID: 12930966 Involvement of P53 in Specific Anti-neuroectodermal Tumor Activity of Aloe-emodin International Journal of Cancer. Journal International Du Cancer. Oct, 2003 | Pubmed ID: 12918060 Design, Synthesis, and Biological Properties of New Bis(acridine-4-carboxamides) As Anticancer Agents Journal of Medicinal Chemistry. Jul, 2003 | Pubmed ID: 12825949 Drugs Acting on the Beta Isoform of Human Topoisomerase II (p180) Current Medicinal Chemistry. Anti-cancer Agents. May, 2003 | Pubmed ID: 12769776 New Anti-human Immunodeficiency Virus Type 1 6-aminoquinolones: Mechanism of Action Antimicrobial Agents and Chemotherapy. Mar, 2003 | Pubmed ID: 12604517 Sequence-specific Interactions of Drugs Interfering with the Topoisomerase-DNA Cleavage Complex Biochimica Et Biophysica Acta. Jul, 2002 | Pubmed ID: 12084456 2,6-Di(omega-aminoalkyl)-2,5,6,7-tetrahydropyrazolo[3,4,5-mn]pyrimido[5,6,1-de]acridine-5,7-diones: Novel, Potent, Cytotoxic, and DNA-binding Agents Journal of Medicinal Chemistry. Jan, 2002 | Pubmed ID: 11806721 The Topoisomerase II Poison Clerocidin Alkylates Non-paired Guanines of DNA: Implications for Irreversible Stimulation of DNA Cleavage Nucleic Acids Research. Oct, 2001 | Pubmed ID: 11600711 Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping (Video) | JoVE Alice Sosic1, Cristina Dal Lago1, Richard Göttlich2, Barbara Gatto1 1Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 2Institute of Organic Chemistry, Justus Liebig University Giessen JoVE 65373 Biochemistry 뉴 클레오 캡시드 소둔 매개 전기 영동 (NAME) 분석은 HIV-1 뉴 클레오 캡시드 억제제의 신속한 식별을 할 수 있습니다 Alice Sosic1, Marta Cappellini1, Matteo Scalabrin2, Barbara Gatto1 1Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 2The RNA Institute, SUNY Albany Immunology and Infection
Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping (Video) | JoVE Alice Sosic1, Cristina Dal Lago1, Richard Göttlich2, Barbara Gatto1 1Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 2Institute of Organic Chemistry, Justus Liebig University Giessen JoVE 65373 Biochemistry
뉴 클레오 캡시드 소둔 매개 전기 영동 (NAME) 분석은 HIV-1 뉴 클레오 캡시드 억제제의 신속한 식별을 할 수 있습니다 Alice Sosic1, Marta Cappellini1, Matteo Scalabrin2, Barbara Gatto1 1Department of Pharmaceutical and Pharmacological Sciences, University of Padova, 2The RNA Institute, SUNY Albany Immunology and Infection