Bart Spee

Publications

• Surgical Resection and Radiofrequency Ablation Initiate Cancer in Cytokeratin-19+- Liver Cells Deficient for P53 and Rb
  Oncotarget. Jun, 2016  |   Pubmed ID: 27323406
• ATGL and DGAT1 Are Involved in the Turnover of Newly Synthesized Triacylglycerols in Hepatic Stellate Cells
  Journal of Lipid Research. Jul, 2016  |   Pubmed ID: 27179362
• The Menkes and Wilson Disease Genes Counteract in Copper Toxicosis in Labrador Retrievers: a New Canine Model for Copper-metabolism Disorders
  Disease Models & Mechanisms. Jan, 2016  |   Pubmed ID: 26747866
• Characterization and Comparison of Canine Multipotent Stromal Cells Derived from Liver and Bone Marrow
  Stem Cells and Development. Jan, 2016  |   Pubmed ID: 26462417
• Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids
  Stem Cell Reports. Oct, 2015  |   Pubmed ID: 26455412
• Role of Long-chain Acyl-CoA Synthetase 4 in Formation of Polyunsaturated Lipid Species in Hepatic Stellate Cells
  Biochimica Et Biophysica Acta. Feb, 2015  |   Pubmed ID: 25500141
• Aberrant Expression of Copper Associated Genes After Copper Accumulation in COMMD1-deficient Dogs
  Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS). Jan, 2015  |   Pubmed ID: 25053573
• Enhanced Wnt/β-catenin and Notch Signalling in the Activated Canine Hepatic Progenitor Cell Niche
  BMC Veterinary Research. Dec, 2014  |   Pubmed ID: 25551829
• Classification of Primary Hepatic Tumours in the Cat
  Veterinary Journal (London, England : 1997). Nov, 2014  |   Pubmed ID: 25439443
• Hepatic Progenitor Cells in Canine and Feline Medicine: Potential for Regenerative Strategies
  BMC Veterinary Research. Jun, 2014  |   Pubmed ID: 24946932
• Aberrant Expression and Distribution of Enzymes of the Urea Cycle and Other Ammonia Metabolizing Pathways in Dogs with Congenital Portosystemic Shunts
  PloS One. 2014  |   Pubmed ID: 24945279
• Keratin 19: a Key Role Player in the Invasion of Human Hepatocellular Carcinomas
  Gut. Apr, 2014  |   Pubmed ID: 23958557
• Potential of Regenerative Medicine Techniques in Canine Hepatology
  The Veterinary Quarterly. Dec, 2013  |   Pubmed ID: 24422896
• Classification of Primary Hepatic Tumours in the Dog
  Veterinary Journal (London, England : 1997). Sep, 2013  |   Pubmed ID: 24011584
• Safety and Efficacy Field Study of Artesunate for Dogs with Non-resectable Tumours
  Anticancer Research. May, 2013  |   Pubmed ID: 23645726
• Altered Subcellular Localization of Heat Shock Protein 90 is Associated with Impaired Expression of the Aryl Hydrocarbon Receptor Pathway in Dogs
  PloS One. 2013  |   Pubmed ID: 23472125
• Aberrant Gene Expression in Dogs with Portosystemic Shunts
  PloS One. 2013  |   Pubmed ID: 23451256
• COMMD1-deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis
  PloS One. 2012  |   Pubmed ID: 22879914
• Macrophage-derived Wnt Opposes Notch Signaling to Specify Hepatic Progenitor Cell Fate in Chronic Liver Disease
  Nature Medicine. Apr, 2012  |   Pubmed ID: 22388089
• Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors
  Gastroenterology. Apr, 2012  |   Pubmed ID: 22178589
• Recombinant Hepatocyte Growth Factor Treatment in a Canine Model of Congenital Liver Hypoplasia
  Liver International : Official Journal of the International Association for the Study of the Liver. Aug, 2011  |   Pubmed ID: 21733083
• Keratin 19 Marks Poor Differentiation and a More Aggressive Behaviour in Canine and Human Hepatocellular Tumours
  Comparative Hepatology. Feb, 2010  |   Pubmed ID: 20167095
• Characterisation of the Liver Progenitor Cell Niche in Liver Diseases: Potential Involvement of Wnt and Notch Signalling
  Gut. Feb, 2010  |   Pubmed ID: 19880964
• Cross-species Immunohistochemical Investigation of the Activation of the Liver Progenitor Cell Niche in Different Types of Liver Disease
  Liver International : Official Journal of the International Association for the Study of the Liver. Sep, 2009  |   Pubmed ID: 19490419
• A GeNorm Algorithm-based Selection of Reference Genes for Quantitative Real-time PCR in Skin Biopsies of Healthy Dogs and Dogs with Atopic Dermatitis
  Veterinary Immunology and Immunopathology. May, 2009  |   Pubmed ID: 19131113
• The Dog Liver Contains a "side Population" of Cells with Hepatic Progenitor-like Characteristics
  Stem Cells and Development. Mar, 2009  |   Pubmed ID: 18680393
• In Vitro Differentiation of Liver Progenitor Cells Derived from Healthy Dog Livers
  Stem Cells and Development. Mar, 2009  |   Pubmed ID: 18454698
• Clinicopathological Study on Cholangiolocellular Carcinoma Suggesting Hepatic Progenitor Cell Origin
  Hepatology (Baltimore, Md.). May, 2008  |   Pubmed ID: 18393293
• In Vitro and in Vivo Bioactivity of Recombinant Canine Hepatocyte Growth Factor
  Veterinary Journal (London, England : 1997). Oct, 2008  |   Pubmed ID: 18314358
• Hepatocyte Growth Factor Improves Viability After H2O2-induced Toxicity in Bile Duct Epithelial Cells
  Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP. Apr, 2008  |   Pubmed ID: 18234561
• Major HGF-mediated Regenerative Pathways Are Similarly Affected in Human and Canine Cirrhosis
  Comparative Hepatology. Jul, 2007  |   Pubmed ID: 17672890
• Copper Metabolism and Oxidative Stress in Chronic Inflammatory and Cholestatic Liver Diseases in Dogs
  Journal of Veterinary Internal Medicine. Sep-Oct, 2006  |   Pubmed ID: 17063700
• Specific Down-regulation of XIAP with RNA Interference Enhances the Sensitivity of Canine Tumor Cell-lines to TRAIL and Doxorubicin
  Molecular Cancer. Sep, 2006  |   Pubmed ID: 16953886
• Development and Evaluation of Canine Reference Genes for Accurate Quantification of Gene Expression
  Analytical Biochemistry. Sep, 2006  |   Pubmed ID: 16844072
• Transforming Growth Factor Beta-1 Signalling in Canine Hepatic Diseases: New Models for Human Fibrotic Liver Pathologies
  Liver International : Official Journal of the International Association for the Study of the Liver. Aug, 2006  |   Pubmed ID: 16842329
• Regenerative and Fibrotic Pathways in Canine Hepatic Portosystemic Shunt and Portal Vein Hypoplasia, New Models for Clinical Hepatocyte Growth Factor Treatment
  Comparative Hepatology. Dec, 2005  |   Pubmed ID: 16336649
• Quantitative PCR Method to Detect a 13-kb Deletion in the MURR1 Gene Associated with Copper Toxicosis and HIV-1 Replication
  Mammalian Genome : Official Journal of the International Mammalian Genome Society. Jun, 2005  |   Pubmed ID: 16075372
• Differential Expression of Copper-associated and Oxidative Stress Related Proteins in a New Variant of Copper Toxicosis in Doberman Pinschers
  Comparative Hepatology. Mar, 2005  |   Pubmed ID: 15790412
• The Establishment and Characterization of the First Canine Hepatocellular Carcinoma Cell Line, Which Resembles Human Oncogenic Expression Patterns
  Comparative Hepatology. Nov, 2004  |   Pubmed ID: 15566568
• Detection of Helicobacter Pylori in Bile of Cats
  FEMS Immunology and Medical Microbiology. Nov, 2004  |   Pubmed ID: 15477044