Bart Spee Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine Utrecht University Biography Publications Institution JoVE Articles Bart Spee has not added a biography. If you are Bart Spee and would like to personalize this page please email our Author Liaison for assistance. Publications Surgical Resection and Radiofrequency Ablation Initiate Cancer in Cytokeratin-19+- Liver Cells Deficient for P53 and Rb Oncotarget. Jun, 2016 | Pubmed ID: 27323406 ATGL and DGAT1 Are Involved in the Turnover of Newly Synthesized Triacylglycerols in Hepatic Stellate Cells Journal of Lipid Research. Jul, 2016 | Pubmed ID: 27179362 The Menkes and Wilson Disease Genes Counteract in Copper Toxicosis in Labrador Retrievers: a New Canine Model for Copper-metabolism Disorders Disease Models & Mechanisms. Jan, 2016 | Pubmed ID: 26747866 Characterization and Comparison of Canine Multipotent Stromal Cells Derived from Liver and Bone Marrow Stem Cells and Development. Jan, 2016 | Pubmed ID: 26462417 Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids Stem Cell Reports. Oct, 2015 | Pubmed ID: 26455412 Role of Long-chain Acyl-CoA Synthetase 4 in Formation of Polyunsaturated Lipid Species in Hepatic Stellate Cells Biochimica Et Biophysica Acta. Feb, 2015 | Pubmed ID: 25500141 Aberrant Expression of Copper Associated Genes After Copper Accumulation in COMMD1-deficient Dogs Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS). Jan, 2015 | Pubmed ID: 25053573 Enhanced Wnt/β-catenin and Notch Signalling in the Activated Canine Hepatic Progenitor Cell Niche BMC Veterinary Research. Dec, 2014 | Pubmed ID: 25551829 Classification of Primary Hepatic Tumours in the Cat Veterinary Journal (London, England : 1997). Nov, 2014 | Pubmed ID: 25439443 Hepatic Progenitor Cells in Canine and Feline Medicine: Potential for Regenerative Strategies BMC Veterinary Research. Jun, 2014 | Pubmed ID: 24946932 Aberrant Expression and Distribution of Enzymes of the Urea Cycle and Other Ammonia Metabolizing Pathways in Dogs with Congenital Portosystemic Shunts PloS One. 2014 | Pubmed ID: 24945279 Keratin 19: a Key Role Player in the Invasion of Human Hepatocellular Carcinomas Gut. Apr, 2014 | Pubmed ID: 23958557 Potential of Regenerative Medicine Techniques in Canine Hepatology The Veterinary Quarterly. Dec, 2013 | Pubmed ID: 24422896 Classification of Primary Hepatic Tumours in the Dog Veterinary Journal (London, England : 1997). Sep, 2013 | Pubmed ID: 24011584 Safety and Efficacy Field Study of Artesunate for Dogs with Non-resectable Tumours Anticancer Research. May, 2013 | Pubmed ID: 23645726 Altered Subcellular Localization of Heat Shock Protein 90 is Associated with Impaired Expression of the Aryl Hydrocarbon Receptor Pathway in Dogs PloS One. 2013 | Pubmed ID: 23472125 Aberrant Gene Expression in Dogs with Portosystemic Shunts PloS One. 2013 | Pubmed ID: 23451256 COMMD1-deficient Dogs Accumulate Copper in Hepatocytes and Provide a Good Model for Chronic Hepatitis and Fibrosis PloS One. 2012 | Pubmed ID: 22879914 Macrophage-derived Wnt Opposes Notch Signaling to Specify Hepatic Progenitor Cell Fate in Chronic Liver Disease Nature Medicine. Apr, 2012 | Pubmed ID: 22388089 Genomic and Genetic Characterization of Cholangiocarcinoma Identifies Therapeutic Targets for Tyrosine Kinase Inhibitors Gastroenterology. Apr, 2012 | Pubmed ID: 22178589 Recombinant Hepatocyte Growth Factor Treatment in a Canine Model of Congenital Liver Hypoplasia Liver International : Official Journal of the International Association for the Study of the Liver. Aug, 2011 | Pubmed ID: 21733083 Keratin 19 Marks Poor Differentiation and a More Aggressive Behaviour in Canine and Human Hepatocellular Tumours Comparative Hepatology. Feb, 2010 | Pubmed ID: 20167095 Characterisation of the Liver Progenitor Cell Niche in Liver Diseases: Potential Involvement of Wnt and Notch Signalling Gut. Feb, 2010 | Pubmed ID: 19880964 Cross-species Immunohistochemical Investigation of the Activation of the Liver Progenitor Cell Niche in Different Types of Liver Disease Liver International : Official Journal of the International Association for the Study of the Liver. Sep, 2009 | Pubmed ID: 19490419 A GeNorm Algorithm-based Selection of Reference Genes for Quantitative Real-time PCR in Skin Biopsies of Healthy Dogs and Dogs with Atopic Dermatitis Veterinary Immunology and Immunopathology. May, 2009 | Pubmed ID: 19131113 The Dog Liver Contains a "side Population" of Cells with Hepatic Progenitor-like Characteristics Stem Cells and Development. Mar, 2009 | Pubmed ID: 18680393 In Vitro Differentiation of Liver Progenitor Cells Derived from Healthy Dog Livers Stem Cells and Development. Mar, 2009 | Pubmed ID: 18454698 Clinicopathological Study on Cholangiolocellular Carcinoma Suggesting Hepatic Progenitor Cell Origin Hepatology (Baltimore, Md.). May, 2008 | Pubmed ID: 18393293 In Vitro and in Vivo Bioactivity of Recombinant Canine Hepatocyte Growth Factor Veterinary Journal (London, England : 1997). Oct, 2008 | Pubmed ID: 18314358 Hepatocyte Growth Factor Improves Viability After H2O2-induced Toxicity in Bile Duct Epithelial Cells Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP. Apr, 2008 | Pubmed ID: 18234561 Major HGF-mediated Regenerative Pathways Are Similarly Affected in Human and Canine Cirrhosis Comparative Hepatology. Jul, 2007 | Pubmed ID: 17672890 Copper Metabolism and Oxidative Stress in Chronic Inflammatory and Cholestatic Liver Diseases in Dogs Journal of Veterinary Internal Medicine. Sep-Oct, 2006 | Pubmed ID: 17063700 Specific Down-regulation of XIAP with RNA Interference Enhances the Sensitivity of Canine Tumor Cell-lines to TRAIL and Doxorubicin Molecular Cancer. Sep, 2006 | Pubmed ID: 16953886 Development and Evaluation of Canine Reference Genes for Accurate Quantification of Gene Expression Analytical Biochemistry. Sep, 2006 | Pubmed ID: 16844072 Transforming Growth Factor Beta-1 Signalling in Canine Hepatic Diseases: New Models for Human Fibrotic Liver Pathologies Liver International : Official Journal of the International Association for the Study of the Liver. Aug, 2006 | Pubmed ID: 16842329 Regenerative and Fibrotic Pathways in Canine Hepatic Portosystemic Shunt and Portal Vein Hypoplasia, New Models for Clinical Hepatocyte Growth Factor Treatment Comparative Hepatology. Dec, 2005 | Pubmed ID: 16336649 Quantitative PCR Method to Detect a 13-kb Deletion in the MURR1 Gene Associated with Copper Toxicosis and HIV-1 Replication Mammalian Genome : Official Journal of the International Mammalian Genome Society. Jun, 2005 | Pubmed ID: 16075372 Differential Expression of Copper-associated and Oxidative Stress Related Proteins in a New Variant of Copper Toxicosis in Doberman Pinschers Comparative Hepatology. Mar, 2005 | Pubmed ID: 15790412 The Establishment and Characterization of the First Canine Hepatocellular Carcinoma Cell Line, Which Resembles Human Oncogenic Expression Patterns Comparative Hepatology. Nov, 2004 | Pubmed ID: 15566568 Detection of Helicobacter Pylori in Bile of Cats FEMS Immunology and Medical Microbiology. Nov, 2004 | Pubmed ID: 15477044 Aislamiento y cultivo de células endoteliales primarias de las arterias y venas caninas Loes A. Oosterhoff1, Hedwig S. Kruitwagen1, Bart Spee1, Frank G. van Steenbeek1 1Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University Medicine
Aislamiento y cultivo de células endoteliales primarias de las arterias y venas caninas Loes A. Oosterhoff1, Hedwig S. Kruitwagen1, Bart Spee1, Frank G. van Steenbeek1 1Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University Medicine