Bharath Wootla Department of Neurology Mayo Clinic Biography Publications Institution JoVE Articles Bharath Wootla has not added a biography. If you are Bharath Wootla and would like to personalize this page please email our Author Liaison for assistance. Publications A Monoclonal Natural Human IgM Protects Axons in the Absence of Remyelination Journal of Neuroinflammation. 2016 | Pubmed ID: 27126523 Generation of Catalytic Antibodies Is an Intrinsic Property of an Individual's Immune System: A Study on a Large Cohort of Renal Transplant Patients Journal of Immunology (Baltimore, Md. : 1950). May, 2016 | Pubmed ID: 27067006 Recent Advances in Monoclonal Antibody Therapies for Multiple Sclerosis Expert Opinion on Biological Therapy. Jun, 2016 | Pubmed ID: 26914737 Tryptophan Catabolites and Their Impact on Multiple Sclerosis Progression Current Pharmaceutical Design. 2016 | Pubmed ID: 26899126 Tryptophan Metabolites and Their Impact on Multiple Sclerosis Progression Current Pharmaceutical Design. Dec, 2015 | Pubmed ID: 26667001 Antibody-Mediated Oligodendrocyte Remyelination Promotes Axon Health in Progressive Demyelinating Disease Molecular Neurobiology. Sep, 2015 | Pubmed ID: 26409478 Naturally Occurring Monoclonal Antibodies and Their Therapeutic Potential for Neurologic Diseases JAMA Neurology. Nov, 2015 | Pubmed ID: 26389734 A Natural Human IgM That Binds to Gangliosides is Therapeutic in Murine Models of Amyotrophic Lateral Sclerosis Disease Models & Mechanisms. Aug, 2015 | Pubmed ID: 26035393 Abbreviated Exposure to Hypoxia is Sufficient to Induce CNS Dysmyelination, Modulate Spinal Motor Neuron Composition, and Impair Motor Development in Neonatal Mice PloS One. 2015 | Pubmed ID: 26020269 A Single Dose of a Neuron-binding Human Monoclonal Antibody Improves Brainstem NAA Concentrations, a Biomarker for Density of Spinal Cord Axons, in a Model of Progressive Multiple Sclerosis Journal of Neuroinflammation. 2015 | Pubmed ID: 25924771 Polysialic Acid As an Antigen for Monoclonal Antibody HIgM12 to Treat Multiple Sclerosis and Other Neurodegenerative Disorders Journal of Neurochemistry. Sep, 2015 | Pubmed ID: 25866077 Quantitative PCR Analysis of DNA Aptamer Pharmacokinetics in Mice Nucleic Acid Therapeutics. Feb, 2015 | Pubmed ID: 25536292 Deletion of Virus-specific T-cells Enhances Remyelination in a Model of Multiple Sclerosis Journal of Neurology & Translational Neuroscience. 1, 2014 | Pubmed ID: 25383388 Applications of SPR for the Characterization of Molecules Important in the Pathogenesis and Treatment of Neurodegenerative Diseases Expert Review of Neurotherapeutics. Apr, 2014 | Pubmed ID: 24625008 Polyclonal and Monoclonal Antibodies in Clinic Methods in Molecular Biology (Clifton, N.J.). 2014 | Pubmed ID: 24037837 Cellular Targets and Mechanistic Strategies of Remyelination-promoting IgMs As Part of the Naturally Occurring Autoantibody Repertoire Expert Review of Neurotherapeutics. Sep, 2013 | Pubmed ID: 24053345 IVIg Treatment Reduces Catalytic Antibody Titers of Renal Transplanted Patients PloS One. 2013 | Pubmed ID: 23967092 CD8(+) T Cells in Multiple Sclerosis Expert Opinion on Therapeutic Targets. Sep, 2013 | Pubmed ID: 23829711 The Road to Remyelination in Demyelinating Diseases: Current Status and Prospects for Clinical Treatment Expert Review of Clinical Immunology. Jun, 2013 | Pubmed ID: 23730884 PTH-independent Regulation of Blood Calcium Concentration by the Calcium-sensing Receptor The Journal of Clinical Investigation. Sep, 2012 | Pubmed ID: 22886306 High-affinity Binding of Remyelinating Natural Autoantibodies to Myelin-mimicking Lipid Bilayers Revealed by Nanohole Surface Plasmon Resonance Analytical Chemistry. Jul, 2012 | Pubmed ID: 22762372 Is Multiple Sclerosis an Autoimmune Disease? Autoimmune Diseases. 2012 | Pubmed ID: 22666554 Need for a Paradigm Shift in Therapeutic Approaches to CNS Injury Expert Review of Neurotherapeutics. Apr, 2012 | Pubmed ID: 22449213 Deletion of Beta-2-microglobulin Ameliorates Spinal Cord Lesion Load and Promotes Recovery of Brainstem NAA Levels in a Murine Model of Multiple Sclerosis Brain Pathology (Zurich, Switzerland). Sep, 2012 | Pubmed ID: 22335434 Evidence for the Role of B Cells and Immunoglobulins in the Pathogenesis of Multiple Sclerosis Neurology Research International. 2011 | Pubmed ID: 21961063 Autoantibodies with Enzymatic Properties in Human Autoimmune Diseases Journal of Autoimmunity. Sep, 2011 | Pubmed ID: 21624820 Proteolytic Antibodies Activate Factor IX in Patients with Acquired Hemophilia Blood. Feb, 2011 | Pubmed ID: 21131590 Intravenous Immunoglobulin Induces Proliferation and Immunoglobulin Synthesis from B Cells of Patients with Common Variable Immunodeficiency: a Mechanism Underlying the Beneficial Effect of IVIg in Primary Immunodeficiencies Journal of Autoimmunity. Feb, 2011 | Pubmed ID: 20970960 Tissue Kallikrein Permits Early Renal Adaptation to Potassium Load Proceedings of the National Academy of Sciences of the United States of America. Jul, 2010 | Pubmed ID: 20624970 NHE4 is Critical for the Renal Handling of Ammonia in Rodents The Journal of Clinical Investigation. Jun, 2010 | Pubmed ID: 20484819 Factor VIII-hydrolyzing IgG in Acquired and Congenital Hemophilia FEBS Letters. Aug, 2009 | Pubmed ID: 19595998 Varied Immune Response to FVIII: Presence of Proteolytic Antibodies Directed to Factor VIII in Different Human Pathologies Clinical Reviews in Allergy & Immunology. Oct, 2009 | Pubmed ID: 19160072 Hydrolysis of Coagulation Factors by Circulating IgG is Associated with a Reduced Risk for Chronic Allograft Nephropathy in Renal Transplanted Patients Journal of Immunology (Baltimore, Md. : 1950). Jun, 2008 | Pubmed ID: 18523313 Factor VIII Hydrolysis Mediated by Anti-factor VIII Autoantibodies in Acquired Hemophilia Journal of Immunology (Baltimore, Md. : 1950). Jun, 2008 | Pubmed ID: 18490775 Factor VIII Bypasses CD91/LRP for Endocytosis by Dendritic Cells Leading to T-cell Activation Haematologica. Jan, 2008 | Pubmed ID: 18166789 Molecular Characterization of Human B Domain-specific Anti-factor VIII Monoclonal Antibodies Generated in Transgenic Mice Thrombosis and Haemostasis. Jul, 2007 | Pubmed ID: 17598006 A Role for Exposed Mannosylations in Presentation of Human Therapeutic Self-proteins to CD4+ T Lymphocytes Proceedings of the National Academy of Sciences of the United States of America. May, 2007 | Pubmed ID: 17502612 Immune Response Against Therapeutic Factor VIII in Hemophilia A Patients--a Survey of Probable Risk Factors Immunology Letters. May, 2007 | Pubmed ID: 17467813 VWF Protects FVIII from Endocytosis by Dendritic Cells and Subsequent Presentation to Immune Effectors Blood. Jan, 2007 | Pubmed ID: 16985172 Catalytic IgG from Patients with Hemophilia A Inactivate Therapeutic Factor VIII Journal of Immunology (Baltimore, Md. : 1950). Jul, 2006 | Pubmed ID: 16818797 Physiopathology of Catalytic Antibodies: the Case for Factor VIII-hydrolyzing Immunoglobulin G Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis. Jun, 2006 | Pubmed ID: 16651863 Pathophysiology of Catalytic Antibodies Immunology Letters. Feb, 2006 | Pubmed ID: 16427704 Catalytic Antibodies and Severe Sepsis Discovery Medicine. Apr, 2005 | Pubmed ID: 20704912 カッパ（Vκ）に対する抗体の結合特異性軽鎖を含むヒト（IgM抗体）抗体：ポリシアル酸（PSA）ケーススタディとしてNCAMに添付 Jens O. Watzlawik1,2,3, Robert J. Kahoud1,3,5, Bharath Wootla1,2,3, Meghan M. Painter1,2,3, Arthur E. Warrington1,2,3, William A. Carey3,4, Moses Rodriguez1,2,3 1Department of Neurology, Mayo Clinic, 2Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, 3Center for Regenerative Medicine, Neuroregeneration, Mayo Clinic, 4Division of Neonatal Medicine, Mayo Clinic, 5Department of Pediatric and Adolescent Medicine, Mayo Clinic Immunology and Infection
カッパ（Vκ）に対する抗体の結合特異性軽鎖を含むヒト（IgM抗体）抗体：ポリシアル酸（PSA）ケーススタディとしてNCAMに添付 Jens O. Watzlawik1,2,3, Robert J. Kahoud1,3,5, Bharath Wootla1,2,3, Meghan M. Painter1,2,3, Arthur E. Warrington1,2,3, William A. Carey3,4, Moses Rodriguez1,2,3 1Department of Neurology, Mayo Clinic, 2Mayo Clinic Center for Multiple Sclerosis and Autoimmune Neurology, Mayo Clinic, 3Center for Regenerative Medicine, Neuroregeneration, Mayo Clinic, 4Division of Neonatal Medicine, Mayo Clinic, 5Department of Pediatric and Adolescent Medicine, Mayo Clinic Immunology and Infection
