Birgit Schilling Biography Publications JoVE Articles Birgit Schilling has not added a biography. If you are Birgit Schilling and would like to personalize this page please email our Author Liaison for assistance. Publications Cytotrophoblast Extracellular Vesicles Enhance Decidual Cell Secretion of Immune Modulators Via TNF-alpha Development (Cambridge, England). Aug, 2020 | Pubmed ID: 32747437 Translational Control of One-carbon Metabolism Underpins Ribosomal Protein Phenotypes in Cell Division and Longevity ELife. May, 2020 | Pubmed ID: 32432546 The Power of Proteomics to Monitor Senescence-associated Secretory Phenotypes and Beyond: Toward Clinical Applications Expert Review of Proteomics. Apr, 2020 | Pubmed ID: 32425074 Abundances of Transcripts, Proteins, and Metabolites in the Cell Cycle of Budding Yeast Reveal Coordinate Control of Lipid Metabolism Molecular Biology of the Cell. 05, 2020 | Pubmed ID: 32129706 Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics Journal of Proteome Research. Apr, 2020 | Pubmed ID: 31984744 Activating Transcription Factor 4 (ATF4) Promotes Skeletal Muscle Atrophy by Forming a Heterodimer with the Transcriptional Regulator C/EBPβ The Journal of Biological Chemistry. Feb, 2020 | Pubmed ID: 31953319 A Proteomic Atlas of Senescence-associated Secretomes for Aging Biomarker Development PLoS Biology. Jan, 2020 | Pubmed ID: 31945054 Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species Scientific Reports. Oct, 2019 | Pubmed ID: 31659173 Dietary Sugars Alter Hepatic Fatty Acid Oxidation Via Transcriptional and Post-translational Modifications of Mitochondrial Proteins Cell Metabolism. Oct, 2019 | Pubmed ID: 31577934 Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect Against AKI Journal of the American Society of Nephrology : JASN. Dec, 2019 | Pubmed ID: 31575700 SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells Cell Reports. Sep, 2019 | Pubmed ID: 31553904 Accumulation of "Old Proteins" and the Critical Need for MS-based Protein Turnover Measurements in Aging and Longevity Proteomics. Aug, 2019 | Pubmed ID: 31408259 Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions Frontiers in Microbiology. 2019 | Pubmed ID: 31354686 High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31087289 Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation Molecular Cell. 05, 2019 | Pubmed ID: 31000437 Correction for Christensen Et Al., "Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli" MBio. 04, 2019 | Pubmed ID: 30967468 JNK Modifies Neuronal Metabolism to Promote Proteostasis and Longevity Aging Cell. 06, 2019 | Pubmed ID: 30810280 Global Lysine Acetylation in Results from Growth Conditions That Favor Acetate Fermentation Journal of Bacteriology. 05, 2019 | Pubmed ID: 30782634 Temporal Dynamics of Liver Mitochondrial Protein Acetylation and Succinylation and Metabolites Due to High Fat Diet And/or Excess Glucose or Fructose PloS One. 2018 | Pubmed ID: 30586434 Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli MBio. 10, 2018 | Pubmed ID: 30352934 Identifying Ubiquitinated Proteins and Aggregates Aging. 10, 2018 | Pubmed ID: 30335616 Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves MTOR Malonylation Cell Metabolism. 12, 2018 | Pubmed ID: 30146486 Simultaneous Quantification of the Acetylome and Succinylome by 'One-Pot' Affinity Enrichment Proteomics. 09, 2018 | Pubmed ID: 30035354 Removing 4E-BP Enables Synapses to Refine Without Postsynaptic Activity Cell Reports. 04, 2018 | Pubmed ID: 29617653 Protein Turnover in Aging and Longevity Proteomics. Mar, 2018 | Pubmed ID: 29453826 An Acetylatable Lysine Controls CRP Function in E. Coli Molecular Microbiology. Jan, 2018 | Pubmed ID: 29105190 Ancient Regulatory Role of Lysine Acetylation in Central Metabolism MBio. Nov, 2017 | Pubmed ID: 29184018 Characterization of Inner and Outer Membrane Proteins FromStrains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates MBio. Oct, 2017 | Pubmed ID: 29018123 Multi-laboratory Assessment of Reproducibility, Qualitative and Quantitative Performance of SWATH-mass Spectrometry Nature Communications. 08, 2017 | Pubmed ID: 28827567 PIQED: Automated Identification and Quantification of Protein Modifications from DIA-MS Data Nature Methods. Jun, 2017 | Pubmed ID: 28661500 Identification and Characterization of AckA-dependent Protein Acetylation in Neisseria Gonorrhoeae PloS One. 2017 | Pubmed ID: 28654654 MSstatsQC: Longitudinal System Suitability Monitoring and Quality Control for Targeted Proteomic Experiments Molecular & Cellular Proteomics : MCP. Jul, 2017 | Pubmed ID: 28483925 Clinical Applications of Quantitative Proteomics Using Targeted and Untargeted Data-independent Acquisition Techniques Expert Review of Proteomics. 05, 2017 | Pubmed ID: 28436239 Generation of High-Quality SWATHAcquisition Data for Label-free Quantitative Proteomics Studies Using TripleTOFMass Spectrometers Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28188533 Vitamin D Promotes Protein Homeostasis and Longevity Via the Stress Response Pathway Genes Skn-1, Ire-1, and Xbp-1 Cell Reports. 10, 2016 | Pubmed ID: 27783938 Stable Nuclear Expression of ATP8 and ATP6 Genes Rescues a MtDNA Complex V Null Mutant Nucleic Acids Research. Nov, 2016 | Pubmed ID: 27596602 Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH) Journal of the American Society for Mass Spectrometry. Nov, 2016 | Pubmed ID: 27590315 Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4 The Journal of Biological Chemistry. 08, 2016 | Pubmed ID: 27358404 Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss Neuron. 04, 2016 | Pubmed ID: 27041503 Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows Analytical Chemistry. Oct, 2015 | Pubmed ID: 26398777 Critical Role of Acetylation in Tau-mediated Neurodegeneration and Cognitive Deficits Nature Medicine. Oct, 2015 | Pubmed ID: 26390242 Protein Acetylation Dynamics in Response to Carbon Overflow in Escherichia Coli Molecular Microbiology. Dec, 2015 | Pubmed ID: 26264774 SIRT1 Deacetylates RORγt and Enhances Th17 Cell Generation The Journal of Experimental Medicine. May, 2015 | Pubmed ID: 25918343 Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma Molecular & Cellular Proteomics : MCP. Sep, 2015 | Pubmed ID: 25693799 Iron Promotes Protein Insolubility and Aging in C. Elegans Aging. Nov, 2014 | Pubmed ID: 25554795 Panorama: a Targeted Proteomics Knowledge Base Journal of Proteome Research. Sep, 2014 | Pubmed ID: 25102069 RPL24: a Potential Therapeutic Target Whose Depletion or Acetylation Inhibits Polysome Assembly and Cancer Cell Growth Oncotarget. Jul, 2014 | Pubmed ID: 24970821 Variation and Quantification Among a Target Set of Phosphopeptides in Human Plasma by Multiple Reaction Monitoring and SWATH-MS2 Data-independent Acquisition Electrophoresis. Dec, 2014 | Pubmed ID: 24853916 Structural, Kinetic and Proteomic Characterization of Acetyl Phosphate-dependent Bacterial Protein Acetylation PloS One. 2014 | Pubmed ID: 24756028 Phosphoprotein Secretome of Tumor Cells As a Source of Candidates for Breast Cancer Biomarkers in Plasma Molecular & Cellular Proteomics : MCP. Apr, 2014 | Pubmed ID: 24505115 Site-specific Acylation Changes in the Lipid A of Escherichia Coli LpxL Mutants Grown at High Temperatures Innate Immunity. Apr, 2014 | Pubmed ID: 23812252 Label-Free Quantitation and Mapping of the ErbB2 Tumor Receptor by Multiple Protease Digestion with Data-Dependent (MS1) and Data-Independent (MS2) Acquisitions International Journal of Proteomics. 2013 | Pubmed ID: 23710360 Label-free Quantitative Proteomics of the Lysine Acetylome in Mitochondria Identifies Substrates of SIRT3 in Metabolic Pathways Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23576753 Ligand Binding Promotes CDK-dependent Phosphorylation of ER-alpha on Hinge Serine 294 but Inhibits Ligand-independent Phosphorylation of Serine 305 Molecular Cancer Research : MCR. Aug, 2012 | Pubmed ID: 22669764 Ubiquitin-specific Peptidase 9, X-linked (USP9X) Modulates Activity of Mammalian Target of Rapamycin (mTOR) The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22544753 Platform-independent and Label-free Quantitation of Proteomic Data Using MS1 Extracted Ion Chromatograms in Skyline: Application to Protein Acetylation and Phosphorylation Molecular & Cellular Proteomics : MCP. May, 2012 | Pubmed ID: 22454539 Ein Lektin Chromatographie/Masse Spektrometrie Entdeckung Workflow Bezeichnet Vermeintliche Biomarker Aggressive Brustkrebserkrankungen Journal of Proteome Research. Feb, 2012 | Pubmed ID: 22309216 Massenspektrometrische Bestimmung Neuartiger Lysin Acetylierung Standorte in Chorea Huntington Molecular & Cellular Proteomics : MCP. Oct, 2011 | Pubmed ID: 21685499 ScanRanker: Beurteilung Der Tandem-Massenspektren über Sequenz Zu Kennzeichnen Journal of Proteome Research. Jul, 2011 | Pubmed ID: 21520941 Zuversichtlich Kennung Des 3-Nitrotyrosine-Modifikationen in Massenspektren Verschiedenen Massenspektrometrie-Plattformen Journal of Proteomics. Oct, 2011 | Pubmed ID: 21514405 Ein Lektin-Affinität-Workflow Für Glycosite-spezifische, Krebs-in Verbindung Stehenden Kohlenhydrat-Strukturen Im Blutplasma Enthalten Trypsin Verdaut Analytical Biochemistry. Jan, 2011 | Pubmed ID: 20705048 Identifizierung Von Neuen Modulatoren Und Protein Veränderungen Nicht Apoptotische Programmierten Zelltod Journal of Cellular Biochemistry. Dec, 2010 | Pubmed ID: 20830744 Gezielte Quantitative Bestimmung Der Standortspezifischen Cystein Oxidation in Endogene Proteine Mit Einer Differenziellen Alkylierung Und Mehrere Reaktion Massenspektrometrie Ansatz Überwachung Molecular & Cellular Proteomics : MCP. Jul, 2010 | Pubmed ID: 20233844 Wiederholbarkeit Und Vergleichbarkeit in Proteomic Identifikationen Durch Flüssige Chromatographie-Tandem-Massenspektrometrie Journal of Proteome Research. Feb, 2010 | Pubmed ID: 19921851 Ringversuch Studie Charakterisierung Einer Hefe-Leistungsstandard Für LC-MS-Plattform-Performance-benchmarking Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19858499 Performance-Kennzahlen Für Flüssige Chromatographie-Tandem-Massenspektrometrie-Systeme Im Proteomics Analysen Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19837981 Das Mycobacterium Bovis Bacille Calmette-Guerin Phagosom Proteome Molecular & Cellular Proteomics : MCP. Jan, 2010 | Pubmed ID: 19815536 Vorzugsweise Erhöhte Nitrierung Von Alpha-Synuclein in Tyrosin-39 in Einem Zellulären Oxidativen Modell Der Parkinson-Krankheit Analytical Chemistry. Sep, 2009 | Pubmed ID: 19697948 Multisite Beurteilung Der Genauigkeit Und Reproduzierbarkeit Der Mehrere Reaktion Überwachung-basierte Messungen Der Proteine Im Plasma Nature Biotechnology. Jul, 2009 | Pubmed ID: 19561596 IDPicker 2.0: Verbesserte Protein Assembly Mit Hohen Diskriminierung Peptid Identifikation Filtern Journal of Proteome Research. Aug, 2009 | Pubmed ID: 19522537 Systematische Zuordnung Der Posttranslationale Modifikationen Im Menschlichen Östrogen-Rezeptor-Alpha Mit Schwerpunkt Auf Neuartige Phosphorylierung Websites Molecular & Cellular Proteomics : MCP. Mar, 2009 | Pubmed ID: 18984578 Eine Neuartige Serin-Phosphorylierung-Site Entdeckt in Der N-terminalen Domäne Des Östrogen-Rezeptors Isoliert Von Menschlichen Brustkrebszellen Journal of the American Society for Mass Spectrometry. May, 2008 | Pubmed ID: 18367407 Partielle Acetylierung Lysin Rückstände Verbessert Intraprotein Vernetzung Analytical Chemistry. Feb, 2008 | Pubmed ID: 18201069 Ermittlung Von LpxL, Einem Späten Acyltransferase Von Francisella Tularensis Infection and Immunity. Nov, 2007 | Pubmed ID: 17724076 Mitochondrialer Oxidativer Stress Verursacht Hyperphosphorylation Von Tau PloS One. 2007 | Pubmed ID: 17579710 Kleine Immunopurification Der Cytochrom-C-Oxidase Eine Hochdurchsatz-multiplexing-Analyse Der Enzymaktivität Und Betrag Biotechnology and Applied Biochemistry. Dec, 2007 | Pubmed ID: 17508937 Charakterisierung Von Lipid Eine Acylierung Muster in Francisella Tularensis, Francisella Novicida Und Francisella Philomiragia Multiple-Bühne Mit Massenspektrometrie Und Matrix-unterstützte Laser-Desorption/Ionisation Auf Einer Geschossdecke Vakuumquelle Lineare Ionenfalle Analytical Chemistry. Feb, 2007 | Pubmed ID: 17263332 Neuartige Wege Chinon-induzierte Spannung in Brustkrebszellen Zugeordnet Drug Metabolism Reviews. 2006 | Pubmed ID: 17145690 Chorea Huntington-Phosphorylierung-Websites Durch Massenspektrometrie Zugeordnet. Modulation Der Spaltung Und Toxizität The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16782707 Proteomanalyse Der Succinat-Dehydrogenase Und Ubiquinol-Cytochrom-c-Reduktase (Komplex II Und III) Isoliert Durch Immunpräzipitation Aus Rinder-und-Maus-Mitochondrien Biochimica Et Biophysica Acta. Feb, 2006 | Pubmed ID: 16120479 Ein Pilot Proteomik Studium Der Amyloid-Precursor-Interaktoren Bei Alzheimer-Krankheit Annals of Neurology. Aug, 2005 | Pubmed ID: 16049941 Die Massenspektrometrische Identifizierung Einer Neuartigen Phosphorylierungsstelle in Untereinheit NDUFA10 Von Rinder-mitochondrialen Komplex I FEBS Letters. Apr, 2005 | Pubmed ID: 15848193 Schnelle Reinigung Und Massenspektrometrische Charakterisierung Der Mitochondrialen NADH-Dehydrogenase (Komplex I) Aus Gehirn Von Nagetieren Und Einer Dopaminergen Neuronalen Zelllinie Molecular & Cellular Proteomics : MCP. Jan, 2005 | Pubmed ID: 15591592 Neuen Modifikation Von Lipid A Von Francisella Tularensis Infection and Immunity. Sep, 2004 | Pubmed ID: 15322031 Eine Neuartige Lectin, DLTA, Wird Für Die Expression Eines Vollständigen Serumresistenz Phänotyp Haemophilus Ducreyi Erforderlich Infection and Immunity. Jun, 2004 | Pubmed ID: 15155648 Proteomik Und Immunchemische Charakterisierung Von Einer Rolle Für Stathmin in Der Adulten Neurogenese FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2004 | Pubmed ID: 14769823 Molekulare Komponenten Eines Zelltod Durch Endoplasmatischen Retikulum Stress Aktiviert The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14561754 Isotopenmarkierte Vernetzungsreagenzien: Auflösung Der Masse Entartung Bei Der Identifizierung Von Peptiden Vernetzt Bioorganic & Medicinal Chemistry Letters. Nov, 2003 | Pubmed ID: 14592499 Phosphospezifischer Proteolyse Für Die Zuordnung Von Seiten Der Protein-Phosphorylierung Nature Biotechnology. Sep, 2003 | Pubmed ID: 12923550 MS2Assign, Automatisierte Zuordnung Und Nomenklatur Der Tandem-Massenspektren Von Chemisch Vernetzten Peptide Journal of the American Society for Mass Spectrometry. Aug, 2003 | Pubmed ID: 12892908 Cathepsin L in Sekretorischen Vesikeln Funktionen Als Prohormon-Verarbeitung Enzym Für Die Produktion Des Enkephalin Peptid Neurotransmitter Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12869695 Metabolic Einbau Von Nichtnatürlichen Sialinsäuren in Haemophilus Ducreyi Lipooligosaccharide Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12615992 Charakterisierung Von Lipooligosaccharide Aus Haemophilus Ducreyi, Die Polylactosamin-Wiederholungen Journal of the American Society for Mass Spectrometry. Jun, 2002 | Pubmed ID: 12056572 Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology Gleichzeitige Affinitätsanreicherung von zwei posttranslationalen Modifikationen für Quantifizierung und Standortlokalisierung Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology Quantifizierung der standortspezifischen Protein Lysin Acetylierung und Succinylation Stöchiometrie mittels Massenspektrometrie Daten-unabhängige Übernahme Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology A Lectin HPLC-Methode zur selektiven glykosylierte Peptide aus komplexen biologischen Proben Enrich Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology
Gleichzeitige Affinitätsanreicherung von zwei posttranslationalen Modifikationen für Quantifizierung und Standortlokalisierung Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology
Quantifizierung der standortspezifischen Protein Lysin Acetylierung und Succinylation Stöchiometrie mittels Massenspektrometrie Daten-unabhängige Übernahme Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology
A Lectin HPLC-Methode zur selektiven glykosylierte Peptide aus komplexen biologischen Proben Enrich Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology