Birgit Schilling Biography Publications JoVE Articles Birgit Schilling has not added a biography. If you are Birgit Schilling and would like to personalize this page please email our Author Liaison for assistance. Publications Cytotrophoblast Extracellular Vesicles Enhance Decidual Cell Secretion of Immune Modulators Via TNF-alpha Development (Cambridge, England). Aug, 2020 | Pubmed ID: 32747437 Translational Control of One-carbon Metabolism Underpins Ribosomal Protein Phenotypes in Cell Division and Longevity ELife. May, 2020 | Pubmed ID: 32432546 The Power of Proteomics to Monitor Senescence-associated Secretory Phenotypes and Beyond: Toward Clinical Applications Expert Review of Proteomics. Apr, 2020 | Pubmed ID: 32425074 Abundances of Transcripts, Proteins, and Metabolites in the Cell Cycle of Budding Yeast Reveal Coordinate Control of Lipid Metabolism Molecular Biology of the Cell. 05, 2020 | Pubmed ID: 32129706 Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics Journal of Proteome Research. Apr, 2020 | Pubmed ID: 31984744 Activating Transcription Factor 4 (ATF4) Promotes Skeletal Muscle Atrophy by Forming a Heterodimer with the Transcriptional Regulator C/EBPβ The Journal of Biological Chemistry. Feb, 2020 | Pubmed ID: 31953319 A Proteomic Atlas of Senescence-associated Secretomes for Aging Biomarker Development PLoS Biology. Jan, 2020 | Pubmed ID: 31945054 Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species Scientific Reports. Oct, 2019 | Pubmed ID: 31659173 Dietary Sugars Alter Hepatic Fatty Acid Oxidation Via Transcriptional and Post-translational Modifications of Mitochondrial Proteins Cell Metabolism. Oct, 2019 | Pubmed ID: 31577934 Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect Against AKI Journal of the American Society of Nephrology : JASN. Dec, 2019 | Pubmed ID: 31575700 SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells Cell Reports. Sep, 2019 | Pubmed ID: 31553904 Accumulation of "Old Proteins" and the Critical Need for MS-based Protein Turnover Measurements in Aging and Longevity Proteomics. Aug, 2019 | Pubmed ID: 31408259 Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions Frontiers in Microbiology. 2019 | Pubmed ID: 31354686 High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31087289 Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation Molecular Cell. 05, 2019 | Pubmed ID: 31000437 Correction for Christensen Et Al., "Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli" MBio. 04, 2019 | Pubmed ID: 30967468 JNK Modifies Neuronal Metabolism to Promote Proteostasis and Longevity Aging Cell. 06, 2019 | Pubmed ID: 30810280 Global Lysine Acetylation in Results from Growth Conditions That Favor Acetate Fermentation Journal of Bacteriology. 05, 2019 | Pubmed ID: 30782634 Temporal Dynamics of Liver Mitochondrial Protein Acetylation and Succinylation and Metabolites Due to High Fat Diet And/or Excess Glucose or Fructose PloS One. 2018 | Pubmed ID: 30586434 Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli MBio. 10, 2018 | Pubmed ID: 30352934 Identifying Ubiquitinated Proteins and Aggregates Aging. 10, 2018 | Pubmed ID: 30335616 Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves MTOR Malonylation Cell Metabolism. 12, 2018 | Pubmed ID: 30146486 Simultaneous Quantification of the Acetylome and Succinylome by 'One-Pot' Affinity Enrichment Proteomics. 09, 2018 | Pubmed ID: 30035354 Removing 4E-BP Enables Synapses to Refine Without Postsynaptic Activity Cell Reports. 04, 2018 | Pubmed ID: 29617653 Protein Turnover in Aging and Longevity Proteomics. Mar, 2018 | Pubmed ID: 29453826 An Acetylatable Lysine Controls CRP Function in E. Coli Molecular Microbiology. Jan, 2018 | Pubmed ID: 29105190 Ancient Regulatory Role of Lysine Acetylation in Central Metabolism MBio. Nov, 2017 | Pubmed ID: 29184018 Characterization of Inner and Outer Membrane Proteins FromStrains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates MBio. Oct, 2017 | Pubmed ID: 29018123 Multi-laboratory Assessment of Reproducibility, Qualitative and Quantitative Performance of SWATH-mass Spectrometry Nature Communications. 08, 2017 | Pubmed ID: 28827567 PIQED: Automated Identification and Quantification of Protein Modifications from DIA-MS Data Nature Methods. Jun, 2017 | Pubmed ID: 28661500 Identification and Characterization of AckA-dependent Protein Acetylation in Neisseria Gonorrhoeae PloS One. 2017 | Pubmed ID: 28654654 MSstatsQC: Longitudinal System Suitability Monitoring and Quality Control for Targeted Proteomic Experiments Molecular & Cellular Proteomics : MCP. Jul, 2017 | Pubmed ID: 28483925 Clinical Applications of Quantitative Proteomics Using Targeted and Untargeted Data-independent Acquisition Techniques Expert Review of Proteomics. 05, 2017 | Pubmed ID: 28436239 Generation of High-Quality SWATHAcquisition Data for Label-free Quantitative Proteomics Studies Using TripleTOFMass Spectrometers Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28188533 Vitamin D Promotes Protein Homeostasis and Longevity Via the Stress Response Pathway Genes Skn-1, Ire-1, and Xbp-1 Cell Reports. 10, 2016 | Pubmed ID: 27783938 Stable Nuclear Expression of ATP8 and ATP6 Genes Rescues a MtDNA Complex V Null Mutant Nucleic Acids Research. Nov, 2016 | Pubmed ID: 27596602 Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH) Journal of the American Society for Mass Spectrometry. Nov, 2016 | Pubmed ID: 27590315 Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4 The Journal of Biological Chemistry. 08, 2016 | Pubmed ID: 27358404 Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss Neuron. 04, 2016 | Pubmed ID: 27041503 Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows Analytical Chemistry. Oct, 2015 | Pubmed ID: 26398777 Critical Role of Acetylation in Tau-mediated Neurodegeneration and Cognitive Deficits Nature Medicine. Oct, 2015 | Pubmed ID: 26390242 Protein Acetylation Dynamics in Response to Carbon Overflow in Escherichia Coli Molecular Microbiology. Dec, 2015 | Pubmed ID: 26264774 SIRT1 Deacetylates RORγt and Enhances Th17 Cell Generation The Journal of Experimental Medicine. May, 2015 | Pubmed ID: 25918343 Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma Molecular & Cellular Proteomics : MCP. Sep, 2015 | Pubmed ID: 25693799 Iron Promotes Protein Insolubility and Aging in C. Elegans Aging. Nov, 2014 | Pubmed ID: 25554795 Panorama: a Targeted Proteomics Knowledge Base Journal of Proteome Research. Sep, 2014 | Pubmed ID: 25102069 RPL24: a Potential Therapeutic Target Whose Depletion or Acetylation Inhibits Polysome Assembly and Cancer Cell Growth Oncotarget. Jul, 2014 | Pubmed ID: 24970821 Variation and Quantification Among a Target Set of Phosphopeptides in Human Plasma by Multiple Reaction Monitoring and SWATH-MS2 Data-independent Acquisition Electrophoresis. Dec, 2014 | Pubmed ID: 24853916 Structural, Kinetic and Proteomic Characterization of Acetyl Phosphate-dependent Bacterial Protein Acetylation PloS One. 2014 | Pubmed ID: 24756028 Phosphoprotein Secretome of Tumor Cells As a Source of Candidates for Breast Cancer Biomarkers in Plasma Molecular & Cellular Proteomics : MCP. Apr, 2014 | Pubmed ID: 24505115 Site-specific Acylation Changes in the Lipid A of Escherichia Coli LpxL Mutants Grown at High Temperatures Innate Immunity. Apr, 2014 | Pubmed ID: 23812252 Label-Free Quantitation and Mapping of the ErbB2 Tumor Receptor by Multiple Protease Digestion with Data-Dependent (MS1) and Data-Independent (MS2) Acquisitions International Journal of Proteomics. 2013 | Pubmed ID: 23710360 Label-free Quantitative Proteomics of the Lysine Acetylome in Mitochondria Identifies Substrates of SIRT3 in Metabolic Pathways Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23576753 Ligand Binding Promotes CDK-dependent Phosphorylation of ER-alpha on Hinge Serine 294 but Inhibits Ligand-independent Phosphorylation of Serine 305 Molecular Cancer Research : MCR. Aug, 2012 | Pubmed ID: 22669764 Ubiquitin-specific Peptidase 9, X-linked (USP9X) Modulates Activity of Mammalian Target of Rapamycin (mTOR) The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22544753 Platform-independent and Label-free Quantitation of Proteomic Data Using MS1 Extracted Ion Chromatograms in Skyline: Application to Protein Acetylation and Phosphorylation Molecular & Cellular Proteomics : MCP. May, 2012 | Pubmed ID: 22454539 Un Flujo De Descubrimiento De Lectinas Cromatografía/masa Espectrometría Identifica Posibles Biomarcadores Del Cáncer De Mama Agresivo Journal of Proteome Research. Feb, 2012 | Pubmed ID: 22309216 Espectrometría De Masa Identificación De Sitios De Acetilación De Novela De La Lisina En La Huntingtina Molecular & Cellular Proteomics : MCP. Oct, 2011 | Pubmed ID: 21685499 ScanRanker: Evaluación De La Calidad De La Espectrometría De Masas De Tándem Mediante La Secuencia De Marcado Journal of Proteome Research. Jul, 2011 | Pubmed ID: 21520941 Segura De Identificación De Modificaciones De 3-nitrotirosina En Masa Espectrales Datos En Múltiples Plataformas De Espectrometría De Masas Journal of Proteomics. Oct, 2011 | Pubmed ID: 21514405 Un Flujo De Trabajo De Afinidad De Lectina Orientación Glycosite Específicos, Relacionados Con El Cáncer Estructuras De Carbohidratos En La Tripsina Digerido Con Plasma Humano Analytical Biochemistry. Jan, 2011 | Pubmed ID: 20705048 Identificación De Moduladores Nuevos Y Alteraciones De La Proteína En No-apoptotic Había Programada Muerte Celular Journal of Cellular Biochemistry. Dec, 2010 | Pubmed ID: 20830744 Cuantificación Específica De Oxidación De Cisteína Site-specific En Proteínas Endógenas Usando Una Alquilación Diferencial Y Seguimiento De Enfoque De Espectrometría De Masas De La Reacción Múltiples Molecular & Cellular Proteomics : MCP. Jul, 2010 | Pubmed ID: 20233844 La Repetibilidad Y La Reproducibilidad En Las Identificaciones Proteómico Por Cromatografía Líquido-espectrometría De Masas En Tándem Journal of Proteome Research. Feb, 2010 | Pubmed ID: 19921851 Estudio Interlaboratorios Caracterización De La Norma De Desempeño Levadura De Rendimiento De La Plataforma De Evaluación Comparativa De LC-MS Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19858499 Métricas De Rendimiento Para Los Sistemas De Líquidos En Tándem Cromatografía-espectrometría De Masas En El Análisis De Proteómica Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19837981 El Proteoma De Fagosoma Mycobacterium Bovis Bacille Calmette-Guerin Molecular & Cellular Proteomics : MCP. Jan, 2010 | Pubmed ID: 19815536 Nitración Preferencial Aumentada De Alfa-sinucleína En Tirosina-39 En Un Modelo Celular Oxidativo De La Enfermedad De Parkinson Analytical Chemistry. Sep, 2009 | Pubmed ID: 19697948 Multi-sitio De Evaluación De La Precisión Y La Reproducibilidad De Los Múltiples De Reacción a Base De Monitoreo-Las Mediciones De Proteínas En El Plasma Nature Biotechnology. Jul, 2009 | Pubmed ID: 19561596 IDPicker 2.0: Asamblea Proteína Mejorada Con Identificación De Péptidos De Alta Discriminación De Filtrado Journal of Proteome Research. Aug, 2009 | Pubmed ID: 19522537 Mapeo Sistemático De Modificaciones Postraduccionales En Receptor De Estrógenos Humanos-alfa Con énfasis En Los Sitios De Fosforilación De Novela Molecular & Cellular Proteomics : MCP. Mar, 2009 | Pubmed ID: 18984578 Un Sitio De Fosforilación De Serina Novela Detectado En El Dominio N-terminal Del Receptor De Estrógeno Aislado De Las Células De Cáncer De Mama Humano Journal of the American Society for Mass Spectrometry. May, 2008 | Pubmed ID: 18367407 Acetilación Parcial De Residuos De Lisina Mejora Intraprotein Cross-linking Analytical Chemistry. Feb, 2008 | Pubmed ID: 18201069 Identificación De LpxL, Una Tarde Aciltransferasa De Francisella Tularensis Infection and Immunity. Nov, 2007 | Pubmed ID: 17724076 El Estrés Oxidativo Mitocondrial Causa Hiperfosforilación De Tau PloS One. 2007 | Pubmed ID: 17579710 Immunopurification En Pequeña Escala De La Citocromo C Oxidasa Para Un Análisis De Multiplexación De Alto Rendimiento De La Actividad Enzimática Y La Cantidad Biotechnology and Applied Biochemistry. Dec, 2007 | Pubmed ID: 17508937 Caracterización De Patrones De Acilación De Lípido A Francisella Tularensis, Francisella Novicida Y Francisella Philomiragia Usando Espectrometría De Múltiples Etapas Y Láser Asistida Por Matriz Desorción/ionización En Una Trampa De Iones Lineal Intermedia Fuente De Vacío Analytical Chemistry. Feb, 2007 | Pubmed ID: 17263332 Novela Vías Asociadas Con El Estrés De Quinona-inducida En Células De Cáncer De Mama Drug Metabolism Reviews. 2006 | Pubmed ID: 17145690 Sitios De Fosforilación De Huntingtina Asignados Por Espectrometría De Masas. Modulación De Escote Y Toxicidad The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16782707 Análisis Proteómico De La Succinato Deshidrogenasa Y Ubiquinol-citocromo C Reductasa (complejo II Y III) Aislada Por Inmunoprecipitación De Mitocondrias De Corazón De Bovino Y El Ratón Biochimica Et Biophysica Acta. Feb, 2006 | Pubmed ID: 16120479 Un Estudio Piloto Proteómico De Los Interactianos Precursora De Amiloide En La Enfermedad De Alzheimer Annals of Neurology. Aug, 2005 | Pubmed ID: 16049941 Identificación De Espectrometría De Masa De Una Novela Fosforilación Web En La Subunidad NDUFA10 De Bovino Mitocondrial Del Complejo I FEBS Letters. Apr, 2005 | Pubmed ID: 15848193 Rápida Purificación Y Caracterización De Espectrometría De Masa De Mitocondrial NADH Deshidrogenasa (complejo I) De Cerebro De Roedor Y Una Línea De Células Neuronales Dopaminérgicas Molecular & Cellular Proteomics : MCP. Jan, 2005 | Pubmed ID: 15591592 Nueva Modificación Del Lípido A De Francisella Tularensis Infection and Immunity. Sep, 2004 | Pubmed ID: 15322031 Una Novela Lectinas, DltA, Es Necesario Para La Expresión De Un Fenotipo De Resistencia Suero Completo En Haemophilus Ducreyi Infection and Immunity. Jun, 2004 | Pubmed ID: 15155648 Proteómica Y Caracterización Inmunoquímica De Un Papel Estatmina En La Neurogénesis Adulta FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2004 | Pubmed ID: 14769823 Componentes Moleculares De Un Camino De Muerte Celular Activado Por El Estrés Del Retículo Endoplasmático The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14561754 Isotópicamente Etiquetada Reactivos De Reticulación: Resolución De Masa Degeneración En La Identificación De Péptidos De Reticulado Bioorganic & Medicinal Chemistry Letters. Nov, 2003 | Pubmed ID: 14592499 Proteólisis De Phosphospecific Para El Mapeo De Sitios De Fosforilación De La Proteína Nature Biotechnology. Sep, 2003 | Pubmed ID: 12923550 MS2Assign, Automatizar La Asignación Y Nomenclatura De La Espectrometría De Masas De Tándem De Químicamente Reticulado Péptidos Journal of the American Society for Mass Spectrometry. Aug, 2003 | Pubmed ID: 12892908 Catepsina L En Vesículas Secretoras Funciona Como Una Enzima De La Prohormona Procesamiento Para La Producción Del Neurotransmisor Péptido Encefalina Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12869695 Metabólico Incorporación De Antinaturales ácidos Siálicos Haemophilus Ducreyi Lipooligosaccharides Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12615992 Caracterización De Lipooligosaccharides De Haemophilus Ducreyi Que Contiene Polylactosamine Repite Journal of the American Society for Mass Spectrometry. Jun, 2002 | Pubmed ID: 12056572 Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology Enriquecimiento de afinidad simultánea de dos modificaciones post-traduccionales para la cuantificación y la localización del sitio Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology Cuantificación de proteína específica lisina acetilación y Succinylation estequiometría usando Spectrometry total de la adquisición de datos-independiente Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology Una lectina Método HPLC para enriquecer péptidos selectivamente glicosilada de muestras biológicas complejas Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology
Enriquecimiento de afinidad simultánea de dos modificaciones post-traduccionales para la cuantificación y la localización del sitio Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology
Cuantificación de proteína específica lisina acetilación y Succinylation estequiometría usando Spectrometry total de la adquisición de datos-independiente Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology
Una lectina Método HPLC para enriquecer péptidos selectivamente glicosilada de muestras biológicas complejas Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology