Birgitta R. Knudsen

Publications

• Rolling Circle Enhanced Detection of Specific Restriction Endonuclease Activities in Crude Cell Extracts
  Sensors (Basel, Switzerland). Oct, 2022  |   Pubmed ID: 36298113
• Topoisomerase 1 Inhibits MYC Promoter Activity by Inducing G-quadruplex Formation
  Nucleic Acids Research. Jun, 2022  |   Pubmed ID: 35687110
• Genetic and Molecular Characterization of the Immortalized Murine Hepatic Stellate Cell Line GRX
  Cells. Apr, 2022  |   Pubmed ID: 35563813
• TDP1 and TOP1 As Targets in Anticancer Treatment of NSCLC: Activity and Protein Level in Normal and Tumor Tissue from 150 NSCLC Patients Correlated to Clinical Data
  Lung Cancer (Amsterdam, Netherlands). Feb, 2022  |   Pubmed ID: 34974222
• Synthesis of Hybrid Phosphorated Indenoquinolines and Biological Evaluation As Topoisomerase I Inhibitors and Antiproliferative Agents
  Bioorganic & Medicinal Chemistry Letters. Feb, 2022  |   Pubmed ID: 34952177
• Simple and Fast DNA Based Sensor System for Screening of Small-Molecule Compounds Targeting Eukaryotic Topoisomerase 1
  Pharmaceutics. Aug, 2021  |   Pubmed ID: 34452216
• Hybrid Quinolinyl Phosphonates As Heterocyclic Carboxylate Isosteres: Synthesis and Biological Evaluation Against Topoisomerase 1B (TOP1B)
  Pharmaceuticals (Basel, Switzerland). Aug, 2021  |   Pubmed ID: 34451880
• A Dual-Sensor-Based Screening System for In Vitro Selection of TDP1 Inhibitors
  Sensors (Basel, Switzerland). Jul, 2021  |   Pubmed ID: 34300575
• Fused Chromeno and Quinolino[1,8]naphthyridines: Synthesis and Biological Evaluation As Topoisomerase I Inhibitors and Antiproliferative Agents
  Bioorganic & Medicinal Chemistry. Jun, 2021  |   Pubmed ID: 33962152
• Different Camptothecin Sensitivities in Subpopulations of Colon Cancer Cells Correlate with Expression of Different Phospho-Isoforms of Topoisomerase I with Different Activities
  Cancers. May, 2020  |   Pubmed ID: 32423158
• DNA Flowerstructure Co-localizes with Human Pathogens in Infected Macrophages
  Nucleic Acids Research. Jun, 2020  |   Pubmed ID: 32402089
• Synthesis of Novel Hybrid Quinolino[4,3-b][1,5]naphthyridines and Quinolino[4,3-b][1,5]naphthyridin-6(5H)-one Derivatives and Biological Evaluation As Topoisomerase I Inhibitors and Antiproliferatives
  European Journal of Medicinal Chemistry. Jun, 2020  |   Pubmed ID: 32279049
• Topoisomerase I Activity and Sensitivity to Camptothecin in Breast Cancer-derived Cells: a Comparative Study
  BMC Cancer. Nov, 2019  |   Pubmed ID: 31783818
• Enzymatic Activity in Single Cells
  Methods in Enzymology. 2019  |   Pubmed ID: 31668235
• A New DNA Sensor System for Specific and Quantitative Detection of Mycobacteria
  Nanoscale. Jan, 2019  |   Pubmed ID: 30556557
• Detection of the Malaria Causing Plasmodium Parasite in Saliva from Infected Patients Using Topoisomerase I Activity As a Biomarker
  Scientific Reports. Mar, 2018  |   Pubmed ID: 29515150
• Characterization of Camptothecin-induced Genomic Changes in the Camptothecin-resistant T-ALL-derived Cell Line CPT-K5
  Cancer Genomics & Proteomics. 2018  |   Pubmed ID: 29496689
• On-slide Detection of Enzymatic Activities in Selected Single Cells
  Nanoscale. Sep, 2017  |   Pubmed ID: 28872165
• Interlinked DNA Nano-circles for Measuring Topoisomerase II Activity at the Level of Single Decatenation Events
  Nucleic Acids Research. Jul, 2017  |   Pubmed ID: 28541438
• The Effects of Dithiothreitol on DNA
  Sensors (Basel, Switzerland). May, 2017  |   Pubmed ID: 28538659
• Advantages of an Optical Nanosensor System for the Mechanistic Analysis of a Novel Topoisomerase I Targeting Drug: a Case Study
  Nanoscale. Feb, 2017  |   Pubmed ID: 28094391
• Novel DNA Sensor System for Highly Sensitive and Quantitative Retrovirus Detection Using Virus Encoded Integrase As a Biomarker
  Nanoscale. Jan, 2017  |   Pubmed ID: 27934981
• Optimized Detection of Plasmodium Falciparum Topoisomerase I Enzyme Activity in a Complex Biological Sample by the Use of Molecular Beacons
  Sensors (Basel, Switzerland). Nov, 2016  |   Pubmed ID: 27854277
• DNA Hairpins Promote Temperature Controlled Cargo Encapsulation in a Truncated Octahedral Nanocage Structure Family
  Nanoscale. Jul, 2016  |   Pubmed ID: 27341703
• Characterization of DNA Topoisomerase I in Three SN-38 Resistant Human Colon Cancer Cell Lines Reveals a New Pair of Resistance-associated Mutations
  Journal of Experimental & Clinical Cancer Research : CR. Mar, 2016  |   Pubmed ID: 27029323
• Synthesis and Biological Evaluation of Indeno[1,5]naphthyridines As Topoisomerase I (TopI) Inhibitors with Antiproliferative Activity
  European Journal of Medicinal Chemistry. Jun, 2016  |   Pubmed ID: 27017547
• Molecular Characterization of Irinotecan (SN-38) Resistant Human Breast Cancer Cell Lines
  BMC Cancer. Jan, 2016  |   Pubmed ID: 26801902
• Specific Detection of the Cleavage Activity of Mycobacterial Enzymes Using a Quantum Dot Based DNA Nanosensor
  Nanoscale. Jan, 2016  |   Pubmed ID: 26616006
• Microfluidics-Enabled Enzyme Activity Measurement in Single Cells
  Methods in Molecular Biology (Clifton, N.J.). 2015  |   Pubmed ID: 26542724
• Real-Time Label-Free Direct Electronic Monitoring of Topoisomerase Enzyme Binding Kinetics on Graphene
  ACS Nano. Nov, 2015  |   Pubmed ID: 26445172
• Correlation Between Topoisomerase I and Tyrosyl-DNA Phosphodiesterase 1 Activities in Non-small Cell Lung Cancer Tissue
  Experimental and Molecular Pathology. Aug, 2015  |   Pubmed ID: 25987486
• Real-time Investigation of Human Topoisomerase I Reaction Kinetics Using an Optical Sensor: a Fast Method for Drug Screening and Determination of Active Enzyme Concentrations
  Nanoscale. Jun, 2015  |   Pubmed ID: 25963854
• NanoCluster Beacons As Reporter Probes in Rolling Circle Enhanced Enzyme Activity Detection
  Nanoscale. May, 2015  |   Pubmed ID: 25901841
• Decreased Camptothecin Sensitivity of the Stem-cell-like Fraction of Caco2 Cells Correlates with an Altered Phosphorylation Pattern of Topoisomerase I
  PloS One. 2014  |   Pubmed ID: 24960044
• Synthesis of Fluorosurfactants for Emulsion-based Biological Applications
  ACS Nano. Apr, 2014  |   Pubmed ID: 24646088
• Rolling Circle Amplification-based Detection of Human Topoisomerase I Activity on Magnetic Beads
  Analytical Biochemistry. Apr, 2014  |   Pubmed ID: 24525043
• Topoisomerase I As a Biomarker: Detection of Activity at the Single Molecule Level
  Sensors (Basel, Switzerland). Jan, 2014  |   Pubmed ID: 24434877
• Real-time Detection of TDP1 Activity Using a Fluorophore-quencher Coupled DNA-biosensor
  Biosensors & Bioelectronics. Oct, 2013  |   Pubmed ID: 23693093
• Quantum Dot-based Nanosensors for Diagnosis Via Enzyme Activity Measurement
  Expert Review of Molecular Diagnostics. May, 2013  |   Pubmed ID: 23638819
• DNA-based Sensor for Real-time Measurement of the Enzymatic Activity of Human Topoisomerase I
  Sensors (Basel, Switzerland). Mar, 2013  |   Pubmed ID: 23529147
• Droplet Microfluidics Platform for Highly Sensitive and Quantitative Detection of Malaria-causing Plasmodium Parasites Based on Enzyme Activity Measurement
  ACS Nano. Dec, 2012  |   Pubmed ID: 23121492
• マイクロ流体を介した単一分子レベルの酵素活性の等温の検出。
  Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference. Aug, 2011  |   Pubmed ID: 22255034
• Peptide Inhibition of Topoisomerase IB from Plasmodium Falciparum
  Molecular Biology International. 2011  |   Pubmed ID: 22091414
• マイクロ流体を用いた希少または単一のセル内の単一の酵素イベントの検出。
  ACS Nano. Oct, 2011  |   Pubmed ID: 21936557
• Strategies for Highly Sensitive Biomarker Detection by Rolling Circle Amplification of Signals from Nucleic Acid Composed Sensors
  Integrative Biology : Quantitative Biosciences from Nano to Macro. Oct, 2011  |   Pubmed ID: 21927767
• The Geometry of DNA Supercoils Modulates the DNA Cleavage Activity of Human Topoisomerase I
  Nucleic Acids Research. Feb, 2011  |   Pubmed ID: 20855291
• Topoisomerase I Deficiency Results in Chromosomal Alterations in Cervical Cancer Cells
  Anticancer Research. Sep, 2010  |   Pubmed ID: 20944095
• Multiplexed Detection of Site Specific Recombinase and DNA Topoisomerase Activities at the Single Molecule Level
  ACS Nano. Dec, 2009  |   Pubmed ID: 19950974
• Single-molecule Detection of Human Topoisomerase I Cleavage-ligation Activity
  ACS Nano. Jan, 2009  |   Pubmed ID: 19206270
• Tryptophane-205 of Human Topoisomerase I is Essential for Camptothecin Inhibition of Negative but Not Positive Supercoil Removal
  Nucleic Acids Research. 2007  |   Pubmed ID: 17827209
• Dynamics of Human DNA Topoisomerases IIalpha and IIbeta in Living Cells
  The Journal of Cell Biology. Apr, 2002  |   Pubmed ID: 11927602