Brandon J. Biesiadecki

Publications

• Post-translational Modification Patterns on β-myosin Heavy Chain Are Altered in Ischemic and Nonischemic Human Hearts
  ELife. 05, 2022  |   Pubmed ID: 35502901
• Heart Failure in Humans Reduces Contractile Force in Myocardium From Both Ventricles
  JACC. Basic to Translational Science. Aug, 2020  |   Pubmed ID: 32875169
• Mutations in the Tropomyosin Binding Region of TNT1 Disrupt Its Role in Contractile Inhibition and Stimulate Cardiac Dysfunction
  Proceedings of the National Academy of Sciences of the United States of America. 08, 2020  |   Pubmed ID: 32690703
• Site-specific Acetyl-mimetic Modification of Cardiac Troponin I Modulates Myofilament Relaxation and Calcium Sensitivity
  Journal of Molecular and Cellular Cardiology. 02, 2020  |   Pubmed ID: 31981571
• Impaired Neuronal Sodium Channels Cause Intranodal Conduction Failure and Reentrant Arrhythmias in Human Sinoatrial Node
  Nature Communications. 01, 2020  |   Pubmed ID: 31980605
• Current and Future Directions of Myofilament Regulation
  Archives of Biochemistry and Biophysics. 05, 2019  |   Pubmed ID: 31051122
• Troponin I Modulation of Cardiac Performance: Plasticity in the Survival Switch
  Archives of Biochemistry and Biophysics. 03, 2019  |   Pubmed ID: 30684464
• 3-Chlorodiphenylamine Activates Cardiac Troponin by a Mechanism Distinct from Bepridil or TFP
  The Journal of General Physiology. 01, 2019  |   Pubmed ID: 30442775
• Assessment of PKA and PKC Inhibitors on Force and Kinetics of Non-failing and Failing Human Myocardium
  Life Sciences. Dec, 2018  |   Pubmed ID: 30399377
• Secondary Phosphorylation in Myocytes Expressing FLAG-tagged and Non-tagged Phospho-mimetic Cardiac Troponin I
  Data in Brief. Dec, 2017  |   Pubmed ID: 29071293
• Functional Communication Between PKC-targeted Cardiac Troponin I Phosphorylation Sites
  Archives of Biochemistry and Biophysics. 08, 2017  |   Pubmed ID: 28587770
• Myofilament Calcium Sensitivity: Consequences of the Effective Concentration of Troponin I
  Frontiers in Physiology. 2016  |   Pubmed ID: 28066265
• Myofilament Calcium Sensitivity: Role in Regulation of Cardiac Contraction and Relaxation
  Frontiers in Physiology. 2016  |   Pubmed ID: 28018228
• Adenosine-Induced Atrial Fibrillation: Localized Reentrant Drivers in Lateral Right Atria Due to Heterogeneous Expression of Adenosine A1 Receptors and GIRK4 Subunits in the Human Heart
  Circulation. Aug, 2016  |   Pubmed ID: 27462069
• The Need for Speed: Mice, Men, and Myocardial Kinetic Reserve
  Circulation Research. 07, 2016  |   Pubmed ID: 27458197
• Myofilament Modulation of Contraction
  Archives of Biochemistry and Biophysics. 07, 2016  |   Pubmed ID: 27156968
• Rationally Engineered Troponin C Modulates in Vivo Cardiac Function and Performance in Health and Disease
  Nature Communications. Feb, 2016  |   Pubmed ID: 26908229
• Should We Treat Heart Failure with Phosphatase Inhibitors? Better to Start at the End
  Journal of Molecular and Cellular Cardiology. Dec, 2015  |   Pubmed ID: 26497613
• Nucleotide and Protein Sequences for Dog Masticatory Tropomyosin Identify a Novel Tpm4 Gene Product
  Journal of Muscle Research and Cell Motility. Oct, 2015  |   Pubmed ID: 26400443
• Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart
  Circulation. Arrhythmia and Electrophysiology. Oct, 2015  |   Pubmed ID: 26304511
• Dissociation of Calcium Transients and Force Development Following a Change in Stimulation Frequency in Isolated Rabbit Myocardium
  BioMed Research International. 2015  |   Pubmed ID: 25961020
• Obligatory Role of Neuronal Nitric Oxide Synthase in the Heart's Antioxidant Adaptation with Exercise
  Journal of Molecular and Cellular Cardiology. Apr, 2015  |   Pubmed ID: 25595735
• Tri-modal Regulation of Cardiac Muscle Relaxation; Intracellular Calcium Decline, Thin Filament Deactivation, and Cross-bridge Cycling Kinetics
  Biophysical Reviews. Dec, 2014  |   Pubmed ID: 28510030
• Cardiac Troponin I Tyrosine 26 Phosphorylation Decreases Myofilament Ca2+ Sensitivity and Accelerates Deactivation
  Journal of Molecular and Cellular Cardiology. Nov, 2014  |   Pubmed ID: 25252176
• Upregulation of Adenosine A1 Receptors Facilitates Sinoatrial Node Dysfunction in Chronic Canine Heart Failure by Exacerbating Nodal Conduction Abnormalities Revealed by Novel Dual-sided Intramural Optical Mapping
  Circulation. Jul, 2014  |   Pubmed ID: 24838362
• Combined Troponin I Ser-150 and Ser-23/24 Phosphorylation Sustains Thin Filament Ca(2+) Sensitivity and Accelerates Deactivation in an Acidic Environment
  Journal of Molecular and Cellular Cardiology. Jul, 2014  |   Pubmed ID: 24657721
• Desensitization of Myofilaments to Ca2+ As a Therapeutic Target for Hypertrophic Cardiomyopathy with Mutations in Thin Filament Proteins
  Circulation. Cardiovascular Genetics. Apr, 2014  |   Pubmed ID: 24585742
• Protein Kinase C Phosphomimetics Alter Thin Filament Ca2+ Binding Properties
  PloS One. 2014  |   Pubmed ID: 24466001
• Ryanodine Receptor Phosphorylation by Oxidized CaMKII Contributes to the Cardiotoxic Effects of Cardiac Glycosides
  Cardiovascular Research. Jan, 2014  |   Pubmed ID: 24104877
• Tropomyosin Ser-283 Pseudo-phosphorylation Slows Myofibril Relaxation
  Archives of Biochemistry and Biophysics. Jul, 2013  |   Pubmed ID: 23232082
• Effects of Increased Systolic Ca(2+) and β-adrenergic Stimulation on Ca(2+) Transient Decline in NOS1 Knockout Cardiac Myocytes
  Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. Dec, 2012  |   Pubmed ID: 22960389
• Advanced Glycation End Product Cross-link Breaker Attenuates Diabetes-induced Cardiac Dysfunction by Improving Sarcoplasmic Reticulum Calcium Handling
  Frontiers in Physiology. 2012  |   Pubmed ID: 22934044
• The Rates of Ca2+ Dissociation and Cross-bridge Detachment from Ventricular Myofibrils As Reported by a Fluorescent Cardiac Troponin C
  The Journal of Biological Chemistry. Aug, 2012  |   Pubmed ID: 22718768
• Staurosporine Inhibits Frequency-dependent Myofilament Desensitization in Intact Rabbit Cardiac Trabeculae
  Biochemistry Research International. 2012  |   Pubmed ID: 22649731
• Engineered Troponin C Constructs Correct Disease-related Cardiac Myofilament Calcium Sensitivity
  The Journal of Biological Chemistry. Jun, 2012  |   Pubmed ID: 22511780
• AMP-activated Protein Kinase Phosphorylates Cardiac Troponin I at Ser-150 to Increase Myofilament Calcium Sensitivity and Blunt PKA-dependent Function
  The Journal of Biological Chemistry. Jun, 2012  |   Pubmed ID: 22493448
• Effects of Increased Preload on the Force-frequency Response and Contractile Kinetics in Early Stages of Cardiac Muscle Hypertrophy
  American Journal of Physiology. Heart and Circulatory Physiology. Jun, 2012  |   Pubmed ID: 22467304
• A High-throughput Solid-phase Microplate Protein-binding Assay to Investigate Interactions Between Myofilament Proteins
  Journal of Biomedicine & Biotechnology. 2011  |   Pubmed ID: 22190850
• Increased Phosphorylation of Tropomyosin, Troponin I, and Myosin Light Chain-2 After Stretch in Rabbit Ventricular Myocardium Under Physiological Conditions
  Journal of Molecular and Cellular Cardiology. May, 2010  |   Pubmed ID: 20298699
• Protein Phosphatase 2A Regulatory Subunit B56α Limits Phosphatase Activity in the Heart
  Science Signaling.   |   Pubmed ID: 26198358