In JoVE (1)
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Articles by Brennan G. Olson in JoVE
DamID-seq: Genome-wide Mapping of Protein-DNA Interactions by High Throughput Sequencing of Adenine-methylated DNA Fragments Feinan Wu1, Brennan G. Olson1, Jie Yao1 1Department of Cell Biology, Yale University School of Medicine We describe herein an assay by coupling DNA adenine methyltransferase identification (DamID) to high throughput sequencing (DamID-seq). This improved method provides a higher resolution and a wider dynamic range, and allows analyzing DamID-seq data in conjunction with other high throughput sequencing data such as ChIP-seq, RNA-seq, etc.