Bruce A Molitoris

Department of Medicine/Division of Nephrology

Indiana University

Bruce A Molitoris

My laboratory studies acute and chronic kidney injury from both ischemic and nephrotoxic compounds. We have helped to understand mechanistically, and developed therapeutically, many potential approaches for acute kidney injury. We have also spent the last twenty years developing non-linear microscopy to quantify dynamic cellular and subcellular processes in vivo. This has led to our NIH-P30 Imaging Core O’Brien Center of Excellence beginning in 2002 as a P-50 and continuously renewed as a P-30. These studies have provided quantitative, mechanistic and therapeutic insights into disease processes in animal models. We have developed unique rodent models allowing novel studies and mechanistic insights for the study of albumin filtration and PT endocytosis, processing and transcytosis. These observations led to the development of a company, FAST BioMedical, to translate GFR and plasma volume technology to patients. This approach is being used to answer complex questions with an emphasis on congestive heart failure and cardio-renal syndrome.

Publications