C. David James

Publications

• Challenges in Drug Delivery to Tumors of the Central Nervous System: An Overview of Pharmacological and Surgical Considerations
  Advanced Drug Delivery Reviews. Jan, 2012  |   Pubmed ID: 22306489
• An Experimental Xenograft Mouse Model of Diffuse Pontine Glioma Designed for Therapeutic Testing
  Journal of Neuro-oncology. Jan, 2012  |   Pubmed ID: 22231932
• Clinical Stratification of Glioblastoma Based on Alterations in Retinoblastoma Tumor Suppressor Protein (RB1) and Association with the Proneural Subtype
  Journal of Neuropathology and Experimental Neurology. Jan, 2012  |   Pubmed ID: 22157621
• Hyperpolarized 13C MR Spectroscopic Imaging Can Be Used to Monitor Everolimus Treatment in Vivo in an Orthotopic Rodent Model of Glioblastoma
  NeuroImage. Jan, 2012  |   Pubmed ID: 21807103
• Reduced Phosphocholine and Hyperpolarized Lactate Provide Magnetic Resonance Biomarkers of PI3K/Akt/mTOR Inhibition in Glioblastoma
  Neuro-oncology. Dec, 2011  |   Pubmed ID: 22156546
• Stimulating Anti-tumor Immune Response: the Problem of Regulatory T-cells
  Neuro-oncology. Dec, 2011  |   Pubmed ID: 22113488
• An LXR Agonist Promotes GBM Cell Death Through Inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent Pathway
  Cancer Discovery. Sep, 2011  |   Pubmed ID: 22059152
• Targeted Therapy for BRAFV600E Malignant Astrocytoma
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2011  |   Pubmed ID: 22038996
• Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma from a Distinct Cell of Origin
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Dec, 2011  |   Pubmed ID: 22025148
• Investigation of Intravenous Delivery of Nanoliposomal Topotecan for Activity Against Orthotopic Glioblastoma Xenografts
  Neuro-oncology. Dec, 2011  |   Pubmed ID: 21954443
• Phase I Study of Temsirolimus in Combination with EKB-569 in Patients with Advanced Solid Tumors
  Investigational New Drugs. Sep, 2011  |   Pubmed ID: 21881915
• Mutational Inactivation of STAG2 Causes Aneuploidy in Human Cancer
  Science (New York, N.Y.). Aug, 2011  |   Pubmed ID: 21852505
• Evolution of Mouse Models for Studying CNS Cancer: a Decade of Progress
  Neuro-oncology. Jul, 2011  |   Pubmed ID: 21727207
• Detection of Early Response to Temozolomide Treatment in Brain Tumors Using Hyperpolarized 13C MR Metabolic Imaging
  Journal of Magnetic Resonance Imaging : JMRI. Jun, 2011  |   Pubmed ID: 21590996
• Inhibition of PI3K/mTOR Pathways in Glioblastoma and Implications for Combination Therapy with Temozolomide
  Neuro-oncology. Apr, 2011  |   Pubmed ID: 21317208
• Akt and Autophagy Cooperate to Promote Survival of Drug-resistant Glioma
  Science Signaling. 2010  |   Pubmed ID: 21062993
• Identification of Internalizing Human Single-chain Antibodies Targeting Brain Tumor Sphere Cells
  Molecular Cancer Therapeutics. Jul, 2010  |   Pubmed ID: 20587664
• Tumor-initiating Cells: an Influential Paradigm for Xenograft Research
  Neuro-oncology. Jun, 2010  |   Pubmed ID: 20530515
• Pleiotropic Role for MYCN in Medulloblastoma
  Genes & Development. May, 2010  |   Pubmed ID: 20478998
• A Hierarchy of Self-renewing Tumor-initiating Cell Types in Glioblastoma
  Cancer Cell. Apr, 2010  |   Pubmed ID: 20385361
• Pharmacologic Inhibition of Cyclin-dependent Kinases 4 and 6 Arrests the Growth of Glioblastoma Multiforme Intracranial Xenografts
  Cancer Research. Apr, 2010  |   Pubmed ID: 20354191
• Morphologic and Molecular Characterization of ATRT Xenografts Adapted for Orthotopic Therapeutic Testing
  Neuro-oncology. Apr, 2010  |   Pubmed ID: 20308314
• Hyperpolarized 13C Magnetic Resonance Metabolic Imaging: Application to Brain Tumors
  Neuro-oncology. Feb, 2010  |   Pubmed ID: 20150380
• Noninvasive Detection of Target Modulation Following Phosphatidylinositol 3-kinase Inhibition Using Hyperpolarized 13C Magnetic Resonance Spectroscopy
  Cancer Research. Feb, 2010  |   Pubmed ID: 20145128
• Integrated Genomic Analysis Identifies Clinically Relevant Subtypes of Glioblastoma Characterized by Abnormalities in PDGFRA, IDH1, EGFR, and NF1
  Cancer Cell. Jan, 2010  |   Pubmed ID: 20129251
• Oncogenic BRAF Mutation with CDKN2A Inactivation is Characteristic of a Subset of Pediatric Malignant Astrocytomas
  Cancer Research. Jan, 2010  |   Pubmed ID: 20068183
• Reversing HOXA9 Oncogene Activation by PI3K Inhibition: Epigenetic Mechanism and Prognostic Significance in Human Glioblastoma
  Cancer Research. Jan, 2010  |   Pubmed ID: 20068170
• Immunological Considerations of Modern Animal Models of Malignant Primary Brain Tumors
  Journal of Translational Medicine. 2009  |   Pubmed ID: 19814820
• MicroRNAs in Gliomas: Small Regulators of a Big Problem
  Neuromolecular Medicine. 2009  |   Pubmed ID: 19731102
• Radiosensitizing Effects of Temozolomide Observed in Vivo Only in a Subset of O6-methylguanine-DNA Methyltransferase Methylated Glioblastoma Multiforme Xenografts
  International Journal of Radiation Oncology, Biology, Physics. Sep, 2009  |   Pubmed ID: 19695438
• Fyn and SRC Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients
  Cancer Research. Sep, 2009  |   Pubmed ID: 19690143
• Pathologic Correlates of Primary Central Nervous System Lymphoma Defined in an Orthotopic Xenograft Model
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2009  |   Pubmed ID: 19276270
• Stem Cells for Treating Glioblastoma: How Close to Reality?
  Neuro-oncology. Apr, 2009  |   Pubmed ID: 19237733
• EGFR Signals to MTOR Through PKC and Independently of Akt in Glioma
  Science Signaling. 2009  |   Pubmed ID: 19176518
• Comparative Analyses of Gene Copy Number and MRNA Expression in Glioblastoma Multiforme Tumors and Xenografts
  Neuro-oncology. Oct, 2009  |   Pubmed ID: 19139420
• Phase II Study of Erlotinib Plus Temozolomide During and After Radiation Therapy in Patients with Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Feb, 2009  |   Pubmed ID: 19075262
• Evaluation of MGMT Promoter Methylation Status and Correlation with Temozolomide Response in Orthotopic Glioblastoma Xenograft Model
  Journal of Neuro-oncology. Mar, 2009  |   Pubmed ID: 19011762
• Induction of MGMT Expression is Associated with Temozolomide Resistance in Glioblastoma Xenografts
  Neuro-oncology. Jun, 2009  |   Pubmed ID: 18952979
• P53 Small-molecule Inhibitor Enhances Temozolomide Cytotoxic Activity Against Intracranial Glioblastoma Xenografts
  Cancer Research. Dec, 2008  |   Pubmed ID: 19074867
• Abnormal DNA Methylation of CD133 in Colorectal and Glioblastoma Tumors
  Cancer Research. Oct, 2008  |   Pubmed ID: 18829568
• MiR-124 and MiR-137 Inhibit Proliferation of Glioblastoma Multiforme Cells and Induce Differentiation of Brain Tumor Stem Cells
  BMC Medicine. 2008  |   Pubmed ID: 18577219
• PTEN Loss Does Not Predict for Response to RAD001 (Everolimus) in a Glioblastoma Orthotopic Xenograft Test Panel
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jun, 2008  |   Pubmed ID: 18559622
• Mechanisms of Chemoresistance to Alkylating Agents in Malignant Glioma
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2008  |   Pubmed ID: 18483356
• Increased Expression of the Glioma-associated Antigen ARF4L After Loss of the Tumor Suppressor PTEN. Laboratory Investigation
  Journal of Neurosurgery. Feb, 2008  |   Pubmed ID: 18240926
• An Orthotopic Skull Base Model of Malignant Meningioma
  Brain Pathology (Zurich, Switzerland). Apr, 2008  |   Pubmed ID: 18093250
• Disabled-1 is a Large Common Fragile Site Gene, Inactivated in Multiple Cancers
  Genes, Chromosomes & Cancer. Feb, 2008  |   Pubmed ID: 18008369
• Combination of Measles Virus Virotherapy and Radiation Therapy Has Synergistic Activity in the Treatment of Glioblastoma Multiforme
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2007  |   Pubmed ID: 18056196
• Bioluminescence Monitoring of Intracranial Glioblastoma Xenograft: Response to Primary and Salvage Temozolomide Therapy
  Journal of Neurosurgery. Sep, 2007  |   Pubmed ID: 17886562
• Epidermal Growth Factor Receptor Variant III Status Defines Clinically Distinct Subtypes of Glioblastoma
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jun, 2007  |   Pubmed ID: 17538175
• Identification of Molecular Characteristics Correlated with Glioblastoma Sensitivity to EGFR Kinase Inhibition Through Use of an Intracranial Xenograft Test Panel
  Molecular Cancer Therapeutics. Mar, 2007  |   Pubmed ID: 17363510
• Epidermal Growth Factor Receptor (EGFR)-retargeted Measles Virus Strains Effectively Target EGFR- or EGFRvIII Expressing Gliomas
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Apr, 2007  |   Pubmed ID: 17299404
• Mapping the Future of Neuro-Oncology
  Neuro-oncology. Jan, 2007  |   Pubmed ID: 17170381
• Tumor Suppressor P16 Methylation in Multiple Myeloma: Biological and Clinical Implications
  Blood. Feb, 2007  |   Pubmed ID: 16840723
• Rarity of PTEN Deletions and EGFR Amplification in Malignant Gliomas of Childhood: Results from the Children's Cancer Group 945 Cohort
  Journal of Neurosurgery. Nov, 2006  |   Pubmed ID: 17328268
• Retargeted Oncolytic Measles Strains Entering Via the EGFRvIII Receptor Maintain Significant Antitumor Activity Against Gliomas with Increased Tumor Specificity
  Cancer Research. Dec, 2006  |   Pubmed ID: 17178881
• PIK3CA Gene Mutations in Pediatric and Adult Glioblastoma Multiforme
  Molecular Cancer Research : MCR. Oct, 2006  |   Pubmed ID: 17050665
• Use of an Orthotopic Xenograft Model for Assessing the Effect of Epidermal Growth Factor Receptor Amplification on Glioblastoma Radiation Response
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2006  |   Pubmed ID: 16609043
• Disruption of Parallel and Converging Signaling Pathways Contributes to the Synergistic Antitumor Effects of Simultaneous MTOR and EGFR Inhibition in GBM Cells
  Neoplasia (New York, N.Y.). Oct, 2005  |   Pubmed ID: 16242075
• MTOR Controls FLIPS Translation and TRAIL Sensitivity in Glioblastoma Multiforme Cells
  Molecular and Cellular Biology. Oct, 2005  |   Pubmed ID: 16199861
• Unique Aspects of Mda-7/IL-24 Antitumor Bystander Activity: Establishing a Role for Secretion of MDA-7/IL-24 Protein by Normal Cells
  Oncogene. Nov, 2005  |   Pubmed ID: 16044151
• Patient Tumor EGFR and PDGFRA Gene Amplifications Retained in an Invasive Intracranial Xenograft Model of Glioblastoma Multiforme
  Neuro-oncology. Apr, 2005  |   Pubmed ID: 15831234
• Altered Molecular Pathways in Gliomas: an Overview of Clinically Relevant Issues
  Seminars in Oncology. Oct, 2004  |   Pubmed ID: 15497113
• Immunohistochemical Detection of EGFRvIII in High Malignancy Grade Astrocytomas and Evaluation of Prognostic Significance
  Journal of Neuropathology and Experimental Neurology. Jul, 2004  |   Pubmed ID: 15290895
• Correlation of the Response of Recurrent Malignant Gliomas Treated with Interferon Alpha with Tumor Interferon Alpha Gene Content
  International Journal of Oncology. Aug, 2004  |   Pubmed ID: 15254740
• MDA-7 Regulates Cell Growth and Radiosensitivity in Vitro of Primary (non-established) Human Glioma Cells
  Cancer Biology & Therapy. Aug, 2004  |   Pubmed ID: 15197348
• Contrasting in Vivo and in Vitro Fates of Glioblastoma Cell Subpopulations with Amplified EGFR
  Genes, Chromosomes & Cancer. Jan, 2004  |   Pubmed ID: 14603439
• Genetic and Signaling Pathway Alterations in Glioblastoma: Relevance to Novel Targeted Therapies
  Frontiers in Bioscience : a Journal and Virtual Library. May, 2003  |   Pubmed ID: 12700121
• Lanthionine Synthetase Components C-like 2 Increases Cellular Sensitivity to Adriamycin by Decreasing the Expression of P-glycoprotein Through a Transcription-mediated Mechanism
  Cancer Research. Feb, 2003  |   Pubmed ID: 12566319
• Combination of Epidermal Growth Factor Receptor Targeted Therapy with Radiation Therapy for Malignant Gliomas
  Frontiers in Bioscience : a Journal and Virtual Library. Jan, 2003  |   Pubmed ID: 12456322
• Neuropathology of Genetically Engineered Mice: Consensus Report and Recommendations from an International Forum
  Oncogene. Oct, 2002  |   Pubmed ID: 12386807
• Mucosa-associated Lymphoid Tissue Lymphomas with T(11;18)(q21;q21) and Mucosa-associated Lymphoid Tissue Lymphomas with Aneuploidy Develop Along Different Pathogenetic Pathways
  The American Journal of Pathology. Jul, 2002  |   Pubmed ID: 12107090
• A Chromosomal Region 7p11.2 Transcript Map: Its Development and Application to the Study of EGFR Amplicons in Glioblastoma
  Neuro-oncology. Apr, 2002  |   Pubmed ID: 11916499